Disorders of cognition.


:Cognitive complaints are common in any adult neurology practice, and may present in a variety of ways other than classic "memory loss." In this article, the author reviews a simple approach to a symptom-based differential diagnosis, including recognition of impairment in several key cognitive domains as well as associated symptoms such as motor disorders, psychosis, and sleep disturbance. Standard evaluation and management strategies of the most common presentations of cognitive decline in an outpatient setting are reviewed.


Semin Neurol


Seminars in neurology


Woodruff BK




Has Abstract


2011-02-01 00:00:00












  • Predictors of Long-Term Neurodevelopmental Outcome of Hypoxic-Ischemic Encephalopathy Treated with Therapeutic Hypothermia.

    abstract::Hypoxic-ischemic encephalopathy (HIE) is a manifestation of perinatal asphyxial insult that continues to evolve over days to weeks following the initial injury. Therapeutic hypothermia has demonstrated that a proportion of this secondary brain injury may indeed be preventable. However, therapeutic hypothermia has also...

    journal_title:Seminars in neurology

    pub_type: 杂志文章


    authors: Goswami I,Guillot M,Tam EWY

    更新日期:2020-06-01 00:00:00

  • Clinical Presentation of Chronic Traumatic Encephalopathy.

    abstract::Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head impacts (RHI), such as those received in contact/collision sports, blast injury in military veterans, and domestic violence. Currently, CTE can only be diagnosed following death. Although the clinical features of form...

    journal_title:Seminars in neurology

    pub_type: 杂志文章


    authors: Mariani M,Alosco ML,Mez J,Stern RA

    更新日期:2020-08-01 00:00:00

  • Stroke in Pregnancy.

    abstract::Pregnancy and the postpartum period confer an increased risk of stroke. The risk appears to be increased for all strokes during the puerperium and for hemorrhagic strokes during pregnancy. During pregnancy, physiologic systems are under increased stress to accommodate the growing fetus, which results in substantial he...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Sells CM,Feske SK

    更新日期:2017-12-01 00:00:00

  • The irreducible perspectives of consciousness.

    abstract::I argue that there is no mind-brain problem but rather that there are irreducible subjective-objective problems. These include the difference between "inside" and "outside" perspectives on neural states, the creation of subjective neural states with objectified outside objects, and awareness of the self as an object i...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Feinberg TE

    更新日期:1997-06-01 00:00:00

  • Pearls and pitfalls of ethical issues in neurology.

    abstract::The growth of bioethics as a practical, meaningful player in the arena of health care has paralleled that of clinical neurology not only in time but also in interaction between the two disciplines. Almost every advance in neurology has spawned an ethical dilemma, the unraveling of which has brought new insights to bot...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: McQuillen MP

    更新日期:2001-12-01 00:00:00

  • Diagnosis and management of stroke (brain attack).

    abstract::Clinicians commonly encounter patients with cerebrovascular disorders in the hospital. Now, as never before, there are many effective diagnostic and therapeutic modalities. Several examples of typical cases of stroke and transient ischemic attack are presented in order to illustrate a rational approach to diagnosis an...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Demaerschalk BM

    更新日期:2003-09-01 00:00:00

  • Parenteral Treatment of Multiple Sclerosis: The Advent of Monoclonal Antibodies.

    abstract::Improved disease control is critical for enhancing the lives of those living with multiple sclerosis. With specific immunologic targets, monoclonal antibody (mAb) treatments are highly effective options for relapsing forms of multiple sclerosis. The mechanism, efficacy, and current safety profiles are detailed for the...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Singer BA

    更新日期:2016-04-01 00:00:00

  • Pulmonary function screening.

    abstract::Patients who suffer from neuromuscular diseases often have complications from respiratory insufficiencies. Some neuromuscular diseases, for example Landry Guillain-Barré syndrome, may only require temporary tracheal intubation; patients with other neuromuscular diseases, such as amyotrophic lateral sclerosis, may deci...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Gelinas DF

    更新日期:2003-03-01 00:00:00

  • Dopamine agonists.

    abstract::Dopamine agonists provide an effective means of treating early, middle, and late stages of Parkinson's disease. This article outlines the advantages and disadvantages of dopamine agonists as compared with levodopa therapy. The features and costs of the four Food and Drug Administration-approved agonists (bromocriptine...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Tuite P,Ebbitt B

    更新日期:2001-01-01 00:00:00

  • Percutaneous vertebroplasty: an emerging therapy for vertebral compression fractures.

    abstract::Osteoporosis is a debilitating disease that occurs in epidemic proportions in Western societies and has a large economic impact. Percutaneous vertebroplasty is successful in alleviating subacute and chronic pain caused by osteoporotic compression fractures and pathological vertebral fractures from tumor infiltration. ...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Ng PP,Caragine LP Jr,Dowd CF

    更新日期:2002-06-01 00:00:00

  • New Media, Technology and Neurology Education.

    abstract::The use of technology in neurology education has revolutionized many aspects of medical teaching, addressing some important challenges of modern education such as information overload and the unique needs of millennial learners. However, it also has inherent problems, such as depersonalization and high development cos...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Lau KHV,Lakhan SE,Achike F

    更新日期:2018-08-01 00:00:00

  • Treatment and prevention of primary intracerebral hemorrhage.

    abstract::Intracerebral hemorrhage (ICH), which constitutes 10 to 15% of all strokes and affects approximately 65,000 people each year in the United States, has the highest mortality rate of all stroke subtypes. Hypertension, cerebral amyloid angiopathy, and anticoagulation underlie the majority of cases of ICH. Warfarin not on...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Towfighi A,Greenberg SM,Rosand J

    更新日期:2005-12-01 00:00:00

  • The "Sick-but-not-Dead" Phenomenon Applied to Catecholamine Deficiency in Neurodegenerative Diseases.

    abstract::The catecholamines dopamine and norepinephrine are key central neurotransmitters that participate in many neurobehavioral processes and disease states. Norepinephrine is also the main neurotransmitter mediating regulation of the circulation by the sympathetic nervous system. Several neurodegenerative disorders feature...

    journal_title:Seminars in neurology

    pub_type: 杂志文章


    authors: Goldstein DS

    更新日期:2020-10-01 00:00:00

  • Visual Vertigo, Motion Sickness, and Disorientation in Vehicles.

    abstract::Environmental circumstances that result in ambiguity or conflict with the patterns of sensory stimulation may adversely affect the vestibular system. The effect of this conflict in sensory information may be dizziness, a sense of imbalance, nausea, and motion sickness sometimes even to seemingly minor daily head movem...

    journal_title:Seminars in neurology

    pub_type: 杂志文章


    authors: Bronstein AM,Golding JF,Gresty MA

    更新日期:2020-02-01 00:00:00

  • Practical evaluation and diagnosis of headache.

    abstract::Establishing an open and honest physician-patient relationship is essential for the proper evaluation and management of headache disorders. Obtaining a complete headache and medical history is the most important part of the initial diagnostic evaluation. This history should include information about headache onset, pa...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Marks DR,Rapoport AM

    更新日期:1997-01-01 00:00:00

  • Physician-Hastened-Death in Patients with Progressive Neurodegenerative or Neuromuscular Disorders.

    abstract::Physician-hastened-death remains a controversial topic for patients and those who care for them. It is a particularly relevant topic for neurologists who currently, or will in the future, reside in jurisdictions where physician-hastened-death is legal. In this article, I attempt to provide a comprehensive and contempo...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Russell JA

    更新日期:2018-10-01 00:00:00

  • Pearls: multiple sclerosis.

    abstract::Multiple sclerosis (MS) affects more than 500,000 Americans, and it is commonly on the differential diagnosis associated with patient referrals to neurology offices. Diagnostically, there are several nuances to the established criteria. Understanding the usefulness of various tests and the potential diagnoses that can...

    journal_title:Seminars in neurology

    pub_type: 杂志文章


    authors: Frohman EM,Greenberg BM

    更新日期:2010-02-01 00:00:00

  • The optic nerve.

    abstract::The optic nerve is our most important cranial nerve. As it courses from the eyeball to the brain, it is divided into four segments: intraocular, intraorbital, intracanalicular, and intracranial. Four tests are primarily used to assess its functional integrity and detect optic nerve disorders. These tests are described...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Selhorst JB,Chen Y

    更新日期:2009-02-01 00:00:00

  • Emerging therapies in traumatic brain injury.

    abstract::Despite decades of basic and clinical research, treatments to improve outcomes after traumatic brain injury (TBI) are limited. However, based on the recent recognition of the prevalence of mild TBI, and its potential link to neurodegenerative disease, many new and exciting secondary injury mechanisms have been identif...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Kochanek PM,Jackson TC,Ferguson NM,Carlson SW,Simon DW,Brockman EC,Ji J,Bayır H,Poloyac SM,Wagner AK,Kline AE,Empey PE,Clark RS,Jackson EK,Dixon CE

    更新日期:2015-02-01 00:00:00

  • Infectious etiologies of myelopathy.

    abstract::Myelopathy refers to a spinal cord disorder that presents with motor and/or sensory deficits. Infectious agents that cause myelopathy do so by either direct infection of neural structures (e.g., polio), a parainfectious mechanism (with a presumed autoimmune pathogenesis), or as a result of involvement of structures ad...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Ho EL

    更新日期:2012-04-01 00:00:00

  • Mitochondrial disorders affecting the nervous system.

    abstract::Mitochondrial diseases are multiorgan system disorders and the brain is the most commonly affected organ. The high-energy requirement of the brain leaves it vulnerable to energy failure. All components of the neuraxis including muscle, the neuromuscular junction, peripheral nerve, spinal cord, and brain can be affecte...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Haas RH,Zolkipli Z

    更新日期:2014-07-01 00:00:00

  • Men Are from Mars, Idiopathic Intracranial Hypertension Is from Venous: The Role of Venous Sinus Stenosis and Stenting in Idiopathic Intracranial Hypertension.

    abstract::Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, is a disease primarily affecting obese women of child-bearing age, typically presenting with positional headaches, diplopia from abducens nerve palsies, pulse-synchronous tinnitus, and visual disturbances related to papilledema, including t...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Dinkin M,Oliveira C

    更新日期:2019-12-01 00:00:00

  • Neurology and the Global HIV Epidemic.

    abstract::The vast majority of people living with human immunodeficiency virus (HIV) infection reside in resource-limited settings. As compared with resource-rich settings, there are important differences in the epidemiology and outcomes of HIV infection in resource-limited settings. Nonetheless, little HIV neurology research o...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Meyer AC

    更新日期:2014-02-01 00:00:00

  • The problem of physician-assisted suicide.

    abstract::With the increasing acceptance of the right of patients to refuse life-sustaining treatment, some have argued that terminally ill patients have a corollary right to physician-assisted suicide (PAS) on request. However, there are important moral and legal distinctions between patients' refusals of therapy and requests ...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Bernat JL

    更新日期:1997-01-01 00:00:00

  • Radiomics, Metabolic, and Molecular MRI for Brain Tumors.

    abstract::Magnetic resonance imaging plays a key role in diagnosis and treatment monitoring of brain tumors. Novel imaging techniques that specifically interrogate aspects of underlying tumor biology and biochemical pathways have great potential in neuro-oncology. This review focuses on the emerging role of 2-hydroxyglutarate-t...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Kickingereder P,Andronesi OC

    更新日期:2018-02-01 00:00:00

  • The genetics of dementia.

    abstract::Over the past decade, there has been a dramatic evolution of genetic methodologies that can be used to identify genes contributing to disease. Initially, the focus was primarily on classical linkage analysis; more recently, genomewide association studies, and high-throughput whole genome and whole exome sequencing hav...

    journal_title:Seminars in neurology

    pub_type: 杂志文章


    authors: Farlow JL,Foroud T

    更新日期:2013-09-01 00:00:00

  • Organic delusional syndrome.

    abstract::Delusions may be the most prominent manifestations of brain dysfunction, and a host of medical and neurologic conditions can present with or produce delusions. Recognition of the underlying disorder frequently aids in successful treatment. Comparison of organic delusional syndromes with schizophrenia suggests that lim...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Gorman DG,Cummings JL

    更新日期:1990-09-01 00:00:00

  • The muscular dystrophies.

    abstract::The muscular dystrophies are disorders of progressive muscular degeneration and weakness. As a group they display clinical heterogeneity that reflects the heterogeneity of molecular mechanisms responsible for them, and range from congenital to adulthood onset. Recent advances in the field include improved methods of d...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Flanigan KM

    更新日期:2012-07-01 00:00:00

  • Somatoform disorders.

    abstract::The fields of neurology and psychiatry were originally practiced as a unitary model. As the fields dichotomized patients into "organic" and "functional," patients with medically unexplained symptoms fell between the borderlands. Despite their significant prevalence, somatoform disorders (SDs) are grossly under-recogni...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: LaFrance WC Jr

    更新日期:2009-07-01 00:00:00

  • Carotid endarterectomy.

    abstract::Carotid endarterectomy is an established surgical procedure to prevent stroke. The indications, preoperative evaluation, surgical timing, technical details, complications, and special circumstances for the use of this operation are reviewed. Future developments in the surgical reconstruction of the extracranial caroti...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审


    authors: Pritz MB

    更新日期:1998-01-01 00:00:00