Tropical marine neurotoxins: venoms to drugs.

Abstract:

:Neurotoxic venoms are common among tropical marine creatures, which have specialized apparatuses for delivery of the venoms. These include jellyfish and anemones, venomous cone snails, venomous fish, stingrays, sea snakes, and venomous octopuses. Numerous toxic neuropeptides are found within these venoms, and some can discriminate between closely related intracellular targets, a characteristic that makes them useful to define cation channels and attractive for drug development. A synthetic derivative of an omega-conotoxin is now available, representing a new class of analgesics. In general, toxic marine venoms contain proteins that are heat labile, providing opportunity for therapeutic intervention following envenomation, while ingestible seafood toxins are thermostable toxins. Ingestible toxins found in the tropics include those associated with reef fish, pufferfish, and some shellfish, which serve as food-chain vectors for toxins produced by marine microorganisms.

journal_name

Semin Neurol

journal_title

Seminars in neurology

authors

Watters MR

doi

10.1055/s-2005-917664

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

278-89

issue

3

eissn

0271-8235

issn

1098-9021

journal_volume

25

pub_type

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