Chronic Traumatic Encephalopathy and Neuropathological Comorbidities.

Abstract:

:With age, the presence of multiple neuropathologies in a single individual becomes increasingly common. Given that traumatic brain injury and the repetitive head impacts (RHIs) that occur in contact sports have been associated with the development of many neurodegenerative diseases, including chronic traumatic encephalopathy (CTE), Alzheimer's disease, Lewy body disease, and amyotrophic lateral sclerosis, it is becoming critical to understand the relationship and interactions between these pathologies. In fact, comorbid pathology is common in CTE and likely influenced by both age and the severity and type of exposure to RHI as well as underlying genetic predisposition. Here, we review the major comorbid pathologies seen with CTE and in former contact sports athletes and discuss what is known about the associations between RHI, age, and the development of neuropathologies. In addition, we examine the distinction between CTE and age-related pathology including primary age-related tauopathy and age-related tau astrogliopathy.

journal_name

Semin Neurol

journal_title

Seminars in neurology

authors

Stein TD,Crary JF

doi

10.1055/s-0040-1713628

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

384-393

issue

4

eissn

0271-8235

issn

1098-9021

journal_volume

40

pub_type

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