abstract：:Patent foramen ovale (PFO) is implicated in the pathogenesis of a number of medical conditions but to date only one official position paper related to left circulation thromboembolism has been published. This interdisciplinary paper, prepared with the involvement of eight European scientific societies, reviews the ava...

journal_title：European heart journal

authors： Pristipino C,Germonpré P,Toni D,Sievert H,Meier B,D'Ascenzo F,Berti S,Onorato EM,Bedogni F,Mas JL,Scacciatella P,Hildick-Smith D,Gaita F,Kyrle PA,Thomson J,Derumeaux G,Sibbing D,Chessa M,Hornung M,Zamorano J,Dudek

更新日期：2021-01-28 00:00:00

abstract：:Chronic kidney disease (CKD) is associated with high cardiovascular risk. CKD patients exhibit a specific lipoprotein pattern termed 'uraemic dyslipidaemia', which is characterized by rather normal low-density lipoprotein cholesterol, low high-density lipoprotein cholesterol, and high triglyceride plasma levels. All t...

journal_title：European heart journal

authors： Speer T,Ridker PM,von Eckardstein A,Schunk SJ,Fliser D

更新日期：2021-01-04 00:00:00

abstract：AIMS :Individuals with low socioeconomic status (SES) face widespread prejudice in society. Whether SES disparities exist in treatment and survival following in-hospital cardiac arrest (IHCA) is unclear. The aim of the current retrospective registry study was to examine SES disparities in IHCA treatment and survival, a...

journal_title：European heart journal

authors： Agerström J,Carlsson M,Bremer A,Herlitz J,Israelsson J,Årestedt K

更新日期：2020-12-21 00:00:00

abstract：:Hypercholesterolaemia is an important risk factor for cardiovascular disease. Both total and LDL cholesterol levels are three-fold higher at the end of the first year of life and about four-fold higher in adulthood compared with the neonatal period. In the USA, only 25% of infants are exclusively breastfed and simple ...

journal_title：European heart journal

authors： Zubin Maslov P,Hill JA,Lüscher TF,Narula J

更新日期：2020-12-16 00:00:00

abstract：AIMS:The purpose of this study was to develop a practical risk score to predict poor neurological outcome after out-of-hospital cardiac arrest (OOHCA) for use on arrival to a Heart Attack Centre. METHODS AND RESULTS:From May 2012 to December 2017, 1055 patients had OOHCA in our region, of whom 373 patients were includ...

journal_title：European heart journal

authors： Pareek N,Kordis P,Beckley-Hoelscher N,Pimenta D,Kocjancic ST,Jazbec A,Nevett J,Fothergill R,Kalra S,Lockie T,Shah AM,Byrne J,Noc M,MacCarthy P

更新日期：2020-12-14 00:00:00

abstract：AIMS:White matter hyperintensities (WMH) progress with age and hypertension, but the key period of exposure to elevated blood pressure (BP), and the relative role of systolic BP (SBP) vs. diastolic BP (DBP), remains unclear. This study aims to determine the relationship between WMH and concurrent vs. past BP. METHODS ...

journal_title：European heart journal

authors： Wartolowska KA,Webb AJS

更新日期：2020-11-26 00:00:00

abstract：AIMS:This prospective, randomized, controlled, multicentre study aimed to evaluate efficacy and safety of exercise training in patients with pulmonary arterial (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). METHODS AND RESULTS:For the first time a specialized PAH/CTEPH rehabilitation programme was im...

journal_title：European heart journal

authors： Grünig E,MacKenzie A,Peacock AJ,Eichstaedt CA,Benjamin N,Nechwatal R,Ulrich S,Saxer S,Bussotti M,Sommaruga M,Ghio S,Gumbiene L,Palevičiūtė E,Jurevičienė E,Cittadini A,Stanziola AA,Marra AM,Kovacs G,Olschewski H,Barb

更新日期：2020-11-24 00:00:00

abstract：AIMS:We estimated the association between outdoor light at night at the residence and risk of coronary heart disease (CHD) within a prospective cohort of older adults in Hong Kong. METHODS AND RESULTS:Over a median of 11 years of follow-up, we identified 3772 incident CHD hospitalizations and 1695 CHD deaths. Annual l...

journal_title：European heart journal

authors： Sun S,Cao W,Ge Y,Ran J,Sun F,Zeng Q,Guo M,Huang J,Lee RS,Tian L,Wellenius GA

更新日期：2020-11-17 00:00:00

abstract：AIMS:Statins reduce cardiovascular risk in patients with acute coronary syndrome (ACS) and normal-to-moderately impaired renal function. It is not known whether proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors provide similar benefit across a range of renal function. We determined whether effects of the...

journal_title：European heart journal

authors： Tuñón J,Steg PG,Bhatt DL,Bittner VA,Díaz R,Goodman SG,Jukema JW,Kim YU,Li QH,Mueller C,Parkhomenko A,Pordy R,Sritara P,Szarek M,White HD,Zeiher AM,Schwartz GG,ODYSSEY OUTCOMES Investigators.

更新日期：2020-11-07 00:00:00

abstract：:Cardiac troponins (cTns) I and T have long been the most successful cardiac-specific circulating biomarkers in cardiovascular (CV) medicine, having changed dramatically the diagnosis of acute myocardial infarction, while being independent predictors of outcome in several cardiac conditions and non-cardiac conditions. ...

journal_title：European heart journal

authors： Farmakis D,Mueller C,Apple FS

更新日期：2020-11-01 00:00:00

abstract：:Nucleic acid-based therapeutics are currently developed at large scale for prevention and management of cardiovascular diseases (CVDs), since: (i) genetic studies have highlighted novel therapeutic targets suggested to be causal for CVD; (ii) there is a substantial recent progress in delivery, efficacy, and safety of ...

journal_title：European heart journal

authors： Landmesser U,Poller W,Tsimikas S,Most P,Paneni F,Lüscher TF

更新日期：2020-10-21 00:00:00

abstract：:The incidence of cardiogenic shock (CS) has increased remarkably over the past decade and remains a challenging condition with mortality rates of ∼50%. Cardiogenic shock encompasses cardiac contractile dysfunction; however, it is also a multiorgan dysfunction syndrome, often complicated by a systemic inflammatory resp...

journal_title：European heart journal

authors： Iborra-Egea O,Rueda F,García-García C,Borràs E,Sabidó E,Bayes-Genis A

更新日期：2020-10-14 00:00:00

abstract：AIMS :Balance between inflammatory and reparative leucocytes allows optimal healing after myocardial infarction (MI). Interindividual heterogeneity evokes variable functional outcome complicating targeted therapy. We aimed to characterize infarct chemokine CXC-motif receptor 4 (CXCR4) expression using positron emission...

journal_title：European heart journal

authors： Hess A,Derlin T,Koenig T,Diekmann J,Wittneben A,Wang Y,Wester HJ,Ross TL,Wollert KC,Bauersachs J,Bengel FM,Thackeray JT

更新日期：2020-10-01 00:00:00

abstract：:This state-of-the-art review aims to provide an up-to-date look at breakthrough omic technologies that are helping to unravel heart failure (HF) disease mechanisms and heterogeneity. Genomics, transcriptomics, proteomics, and metabolomics in HF are reviewed in depth. In addition, there is a thorough, expert discussion...

journal_title：European heart journal

authors： Bayes-Genis A,Liu PP,Lanfear DE,de Boer RA,González A,Thum T,Emdin M,Januzzi JL

更新日期：2020-09-21 00:00:00

abstract：AIM:We tested the hypothesis that dapagliflozin may regress left ventricular hypertrophy (LVH) in people with type 2 diabetes (T2D). METHODS AND RESULTS:We randomly assigned 66 people (mean age 67 ± 7 years, 38 males) with T2D, LVH, and controlled blood pressure (BP) to receive dapagliflozin 10 mg once daily or placeb...

journal_title：European heart journal

authors： Brown AJM,Gandy S,McCrimmon R,Houston JG,Struthers AD,Lang CC

更新日期：2020-09-21 00:00:00

abstract：AIMS:Patients with pulmonary hypertension (PHT) are often excluded from surgical therapies for tricuspid regurgitation (TR). Transcatheter tricuspid valve repair (TTVR) with the MitraClip™ technique is a novel treatment option for these patients. We aimed to assess the role of PHT in severe TR and its implications for ...

journal_title：European heart journal

authors： Lurz P,Orban M,Besler C,Braun D,Schlotter F,Noack T,Desch S,Karam N,Kresoja KP,Hagl C,Borger M,Nabauer M,Massberg S,Thiele H,Hausleiter J,Rommel KP

更新日期：2020-08-01 00:00:00

abstract：AIMS:The association of body weight and weight change with mortality and cardiovascular (CV) outcome in patients with diabetes mellitus (DM) is not clearly established. We assessed the relationship between weight, weight change, and outcomes in patients with established CV risk factors and type 2 DM or pre-diabetes. M...

journal_title：European heart journal

authors： Doehner W,Gerstein HC,Ried J,Jung H,Asbrand C,Hess S,Anker SD

更新日期：2020-07-21 00:00:00

abstract：AIM:The present study aimed to assess the benefits of two-stent techniques for patients with DEFINITION criteria-defined complex coronary bifurcation lesions. METHODS AND RESULTS:In total, 653 patients with complex bifurcation lesions at 49 international centres were randomly assigned to undergo the systematic two-ste...

journal_title：European heart journal

authors： Zhang JJ,Ye F,Xu K,Kan J,Tao L,Santoso T,Munawar M,Tresukosol D,Li L,Sheiban I,Li F,Tian NL,Rodríguez AE,Paiboon C,Lavarra F,Lu S,Vichairuangthum K,Zeng H,Chen L,Zhang R,Ding S,Gao F,Jin Z,Hong L,Ma L,We

更新日期：2020-07-14 00:00:00

abstract：AIMS:Here, we aimed to determine the therapeutic effect of longevity-associated variant (LAV)-BPIFB4 gene therapy on atherosclerosis. METHODS AND RESULTS:ApoE knockout mice (ApoE-/-) fed a high-fat diet were randomly allocated to receive LAV-BPIFB4, wild-type (WT)-BPIFB4, or empty vector via adeno-associated viral vec...

journal_title：European heart journal

authors： Puca AA,Carrizzo A,Spinelli C,Damato A,Ambrosio M,Villa F,Ferrario A,Maciag A,Fornai F,Lenzi P,Valenti V,di Nonno F,Accarino G,Madonna M,Forte M,Calì G,Baragetti A,Norata GD,Catapano AL,Cattaneo M,Izzo R,Trimarc

更新日期：2020-07-07 00:00:00

abstract：AIMS:Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism is tied with various risk factors for AAD including hypertension, atherosclerosis, and hypercholesterolaemia although direct correlation between the two rema...

journal_title：European heart journal

authors： Yang K,Ren J,Li X,Wang Z,Xue L,Cui S,Sang W,Xu T,Zhang J,Yu J,Liu Z,Shang H,Pang J,Huang X,Chen Y,Xu F

更新日期：2020-07-07 00:00:00

abstract：AIMS :In the last decade, transcatheter aortic valve (TAV) replacement determined a paradigm shift in the treatment of patients with severe symptomatic aortic stenosis. Data on long-term TAV performance are still limited. We sought to evaluate the clinical and haemodynamic outcomes of the CoreValve self-expandable valv...

journal_title：European heart journal

authors： Testa L,Latib A,Brambilla N,De Marco F,Fiorina C,Adamo M,Giannini C,Angelillis M,Barbanti M,Sgroi C,Poli A,Ferrara E,Bruschi G,Russo CF,Matteo M,De Felice F,Musto C,Curello S,Colombo A,Tamburino C,Petronio AS,Be

更新日期：2020-05-21 00:00:00

abstract：AIMS:Myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI). Sparse data exist on the use of cardiovascular magnetic resonance (CMR) in ICI-associated myocarditis. In this study, the CMR characteristics and the association between CMR features and cardiovascular events among patients with...

journal_title：European heart journal

authors： Zhang L,Awadalla M,Mahmood SS,Nohria A,Hassan MZO,Thuny F,Zlotoff DA,Murphy SP,Stone JR,Golden DLA,Alvi RM,Rokicki A,Jones-O'Connor M,Cohen JV,Heinzerling LM,Mulligan C,Armanious M,Barac A,Forrestal BJ,Sullivan RJ,

更新日期：2020-05-07 00:00:00

abstract：AIMS:To assess the reported prevalence of left ventricular non-compaction (LVNC) in different adult cohorts, taking in to consideration the role of diagnostic criteria and imaging modalities used. METHODS AND RESULTS:A systematic review and meta-analysis of studies reporting LVNC prevalence in adults. Studies were sou...

journal_title：European heart journal

authors： Ross SB,Jones K,Blanch B,Puranik R,McGeechan K,Barratt A,Semsarian C

更新日期：2020-04-07 00:00:00

abstract：AIMS:The relative benefits of computed tomography coronary angiography (CTCA)-guided management in women and men with suspected angina due to coronary heart disease (CHD) are uncertain. METHODS AND RESULTS:In this post hoc analysis of an open-label parallel-group multicentre trial, we recruited 4146 patients referred ...

journal_title：European heart journal

authors： Mangion K,Adamson PD,Williams MC,Hunter A,Pawade T,Shah ASV,Lewis S,Boon NA,Flather M,Forbes J,McLean S,Roditi G,van Beek EJR,Timmis AD,Newby DE,McAllister DA,Berry C

更新日期：2020-04-01 00:00:00

abstract：AIMS:Recent data from national registries suggest that acute heart failure (AHF) outcomes might vary in men and women, however, it is not known whether this observation is universal. The aim of this study was to evaluate the association of biological sex and 1-year all-cause mortality in patients with AHF in various re...

journal_title：European heart journal

authors： Motiejūnaitė J,Akiyama E,Cohen-Solal A,Maggioni AP,Mueller C,Choi DJ,Kavoliūnienė A,Čelutkienė J,Parenica J,Lassus J,Kajimoto K,Sato N,Miró Ò,Peacock WF,Matsue Y,Voors AA,Lam CSP,Ezekowitz JA,Ahmed A,Fonarow GC,Ga

更新日期：2020-04-01 00:00:00

abstract：AIMS:Right ventricular dysfunction (RVD) is an important determinant of functional status and survival in various diseases states. Data are sparse on the epidemiology and outcome of patients with severe RVD. This study examined the characteristics, aetiology, and survival of patients with severe RVD. METHODS AND RESUL...

journal_title：European heart journal

authors： Padang R,Chandrashekar N,Indrabhinduwat M,Scott CG,Luis SA,Chandrasekaran K,Michelena HI,Nkomo VT,Pislaru SV,Pellikka PA,Kane GC

更新日期：2020-03-21 00:00:00

abstract：:The understanding of atrial fibrillation (AF) evolved from a sole rhythm disturbance towards the complex concept of a cardiomyopathy based on arrhythmia substrates. There is evidence that atrial fibrosis can be visualized using late gadolinium enhancement cardiac magnetic resonance imaging and that it is a powerful pr...

journal_title：European heart journal

authors： Sohns C,Marrouche NF

更新日期：2020-03-07 00:00:00

abstract：AIMS:Nuclear receptors and their cofactors regulate key pathophysiological processes in atherosclerosis development. The transcriptional activity of these nuclear receptors is controlled by the nuclear receptor corepressors (NCOR), scaffolding proteins that form the basis of large corepressor complexes. Studies with pr...

journal_title：European heart journal

authors： Oppi S,Nusser-Stein S,Blyszczuk P,Wang X,Jomard A,Marzolla V,Yang K,Velagapudi S,Ward LJ,Yuan XM,Geiger MA,Guillaumon AT,Othman A,Hornemann T,Rancic Z,Ryu D,Oosterveer MH,Osto E,Lüscher TF,Stein S

更新日期：2020-03-01 00:00:00

abstract：AIMS:Genome-wide association studies have previously identified INSIG2 as a candidate gene for plasma low-density lipoprotein cholesterol (LDL-c). However, we suspect a role for CCDC93 in the same locus because of its involvement in the recycling of the LDL-receptor (LDLR). METHODS AND RESULTS:Characterization of the ...

journal_title：European heart journal

authors： Rimbert A,Dalila N,Wolters JC,Huijkman N,Smit M,Kloosterhuis N,Riemsma M,van der Veen Y,Singla A,van Dijk F,Biobank-Based Integrative Omics Studies Consortium.,Frikke-Schmidt R,Burstein E,Tybjærg-Hansen A,van de Sluis B,Kui

更新日期：2020-03-01 00:00:00

abstract：AIMS:Clonal haematopoiesis of indeterminate potential (CHIP), defined as the presence of an expanded somatic blood cell clone without other haematological abnormalities, was recently shown to increase with age and is associated with coronary artery disease and calcification. The most commonly mutated CHIP genes, DNMT3A...

journal_title：European heart journal

authors： Mas-Peiro S,Hoffmann J,Fichtlscherer S,Dorsheimer L,Rieger MA,Dimmeler S,Vasa-Nicotera M,Zeiher AM

更新日期：2020-02-21 00:00:00

abstract：AIMS:Positron emission tomography (PET) myocardial perfusion imaging (MPI) can non-invasively measure myocardial blood flow reserve (MBFR). We aimed to examine whether MBFR identifies patients with a survival benefit after revascularization, helping to guide post-test management. METHODS AND RESULTS:We examined all-ca...

journal_title：European heart journal

authors： Patel KK,Spertus JA,Chan PS,Sperry BW,Al Badarin F,Kennedy KF,Thompson RC,Case JA,McGhie AI,Bateman TM

更新日期：2020-02-01 00:00:00

abstract：AIMS:The 2019 report from the European Society of Cardiology (ESC) Atlas provides a contemporary analysis of cardiovascular disease (CVD) statistics across 56 member countries, with particular emphasis on international inequalities in disease burden and healthcare delivery together with estimates of progress towards me...

journal_title：European heart journal

authors： Timmis A,Townsend N,Gale CP,Torbica A,Lettino M,Petersen SE,Mossialos EA,Maggioni AP,Kazakiewicz D,May HT,De Smedt D,Flather M,Zuhlke L,Beltrame JF,Huculeci R,Tavazzi L,Hindricks G,Bax J,Casadei B,Achenbach S,Wrig

更新日期：2020-01-01 00:00:00

abstract：AIMS:Growing data suggest that antibiotic exposure is associated with a long-lasting alteration in gut microbiota, and may be related to subsequent cardiovascular disease (CVD). We investigated associations of life-stage and duration of antibiotic exposure during adulthood with subsequent CVD events. METHODS AND RESUL...

journal_title：European heart journal

authors： Heianza Y,Zheng Y,Ma W,Rimm EB,Albert CM,Hu FB,Rexrode KM,Manson JE,Qi L

更新日期：2019-12-14 00:00:00

abstract：:Recent innovations have the potential to improve rhythm control therapy in patients with atrial fibrillation (AF). Controlled trials provide new evidence on the effectiveness and safety of rhythm control therapy, particularly in patients with AF and heart failure. This review summarizes evidence supporting the use of ...

journal_title：European heart journal

authors： Willems S,Meyer C,de Bono J,Brandes A,Eckardt L,Elvan A,van Gelder I,Goette A,Gulizia M,Haegeli L,Heidbuchel H,Haeusler KG,Kautzner J,Mont L,Ng GA,Szumowski L,Themistoclakis S,Wegscheider K,Kirchhof P

更新日期：2019-12-07 00:00:00

abstract：AIMS:Pulmonary hypertension (PH) represents an important phenotype among the broader spectrum of patients with heart failure with preserved ejection fraction (HFpEF), but its mechanistic basis remains unclear. We hypothesized that activation of endothelin and adrenomedullin, two counterregulatory pathways important in ...

journal_title：European heart journal

authors： Obokata M,Kane GC,Reddy YNV,Melenovsky V,Olson TP,Jarolim P,Borlaug BA

更新日期：2019-12-01 00:00:00

abstract：AIMS:Efficacy of aspirin in primary prevention of cardiovascular disease (CVD) may be influenced by a common allele in guanylate cyclase GUCY1A3, which has been shown to modify platelet function and increase CVD risk. METHODS AND RESULTS:We investigated whether homozygotes of the GUCY1A3 rs7692387 risk (G) allele bene...

journal_title：European heart journal

authors： Hall KT,Kessler T,Buring JE,Passow D,Sesso HD,Zee RYL,Ridker PM,Chasman DI,Schunkert H

更新日期：2019-11-01 00:00:00

abstract：AIMS:The present study was done to assess the role of sudden cardiac death (SCD) among the presenting manifestations of and fatalities from cardiac sarcoidosis (CS). METHODS AND RESULTS:We analysed altogether 351 cases of CS presenting from year 1998 through 2015 in Finland. There were 262 patients with a clinical dia...

journal_title：European heart journal

authors： Ekström K,Lehtonen J,Nordenswan HK,Mäyränpää MI,Räisänen-Sokolowski A,Kandolin R,Simonen P,Pietilä-Effati P,Alatalo A,Utriainen S,Rissanen TT,Haataja P,Kokkonen J,Vihinen T,Miettinen H,Kaikkonen K,Kerola T,Kupari M

更新日期：2019-10-01 00:00:00

abstract：AIMS:To assess the impact of MultiPoint™ Pacing (MPP)-programmed according to the physician's discretion-in non-responders to standard biventricular pacing after 6 months. METHODS AND RESULTS:The study enrolled 1921 patients receiving a quadripolar cardiac resynchronization therapy (CRT) system capable of MPP™ therapy...

journal_title：European heart journal

authors： Leclercq C,Burri H,Curnis A,Delnoy PP,Rinaldi CA,Sperzel J,Lee K,Calò L,Vicentini A,Concha JF,Thibault B

更新日期：2019-09-14 00:00:00

abstract：AIMS:Calmodulinopathies are rare life-threatening arrhythmia syndromes which affect mostly young individuals and are, caused by mutations in any of the three genes (CALM 1-3) that encode identical calmodulin proteins. We established the International Calmodulinopathy Registry (ICalmR) to understand the natural history,...

journal_title：European heart journal

authors： Crotti L,Spazzolini C,Tester DJ,Ghidoni A,Baruteau AE,Beckmann BM,Behr ER,Bennett JS,Bezzina CR,Bhuiyan ZA,Celiker A,Cerrone M,Dagradi F,De Ferrari GM,Etheridge SP,Fatah M,Garcia-Pavia P,Al-Ghamdi S,Hamilton RM,Al-H

更新日期：2019-09-14 00:00:00

abstract：AIMS:Subjects with lipoprotein(a) [Lp(a)] elevation have increased arterial wall inflammation and cardiovascular risk. In patients at increased cardiovascular risk, arterial wall inflammation is reduced following lipid-lowering therapy by statin treatment or lipoprotein apheresis. However, it is unknown whether lipid-l...

journal_title：European heart journal

authors： Stiekema LCA,Stroes ESG,Verweij SL,Kassahun H,Chen L,Wasserman SM,Sabatine MS,Mani V,Fayad ZA

更新日期：2019-09-01 00:00:00