Abstract:
AIMS :In the last decade, transcatheter aortic valve (TAV) replacement determined a paradigm shift in the treatment of patients with severe symptomatic aortic stenosis. Data on long-term TAV performance are still limited. We sought to evaluate the clinical and haemodynamic outcomes of the CoreValve self-expandable valve up to 8-year follow-up (FU). METHODS AND RESULTS :Nine hundred and ninety inoperable or high-risk patients were treated with the CoreValve TAV in eight Italian Centres from June 2007 to December 2011. The median FU was 4.4 years (interquartile range 1.4-6.7 years). Longest FU reached 11 years. A total of 728 died within 8-year FU (78.3% mortality from Kaplan-Meier curve analysis). A significant functional improvement was observed in the majority of patients and maintained over time, with 79.3% of surviving patients still classified New York Heart Association class ≤ II at 8 years. Echocardiographic data showed that the mean transprosthetic aortic gradient remained substantially unchanged (9 ± 4 mmHg at discharge, 9 ± 5 mmHg at 8 years, P = 0.495). The rate of Grade 0/1 paravalvular leak was consistent during FU with no significant change from post-procedure to FU ≥5 years in paired analysis (P = 0.164). Structural valve deterioration (SVD) and late bioprosthetic valve failure (BVF) were defined according to a modification of the 2017 EAPCI/ESC/EACTS criteria. In cumulative incidence functions at 8 years, moderate and severe SVD were 3.0% [95% confidence interval (CI) 2.1-4.3%] and 1.6% (95% CI 0.6-3.9%), respectively, while late BVF was 2.5% (95% CI 1.2-5%). CONCLUSION :While TAVs are questioned about long-term performance and durability, the results of the present research provide reassuring 8-year evidence on the CoreValve first-generation self-expandable bioprosthesis.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Testa L,Latib A,Brambilla N,De Marco F,Fiorina C,Adamo M,Giannini C,Angelillis M,Barbanti M,Sgroi C,Poli A,Ferrara E,Bruschi G,Russo CF,Matteo M,De Felice F,Musto C,Curello S,Colombo A,Tamburino C,Petronio AS,Bedoi
10.1093/eurheartj/ehz925subject
Has Abstractpub_date
2020-05-21 00:00:00pages
1876-1886issue
20eissn
0195-668Xissn
1522-9645pii
5697056journal_volume
41pub_type
杂志文章abstract:AIMS:This ancillary analysis of the GISSI-HF database aims at assessing the effect of rosuvastatin on the occurrence of atrial fibrillation (AF) in patients with chronic heart failure (HF) who were not in AF at study entry. METHODS AND RESULTS:GISSI-HF was a double-blind, placebo-controlled trial testing n-3 PUFA and ...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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abstract::A new European Heart Journal, Cardiovascular Pharmacotherapy, was launched at the ESC Congress 2014 in Barcelona and begins publication in February 2014. ...
journal_title:European heart journal
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doi:
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journal_title:European heart journal
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doi:10.1093/oxfordjournals.eurheartj.a062493
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-11-14 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
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更新日期:1997-05-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1988-04-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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