Sudden cardiac death while taking amiodarone therapy: the role of abnormal repolarization.

Abstract:

:Torsade de pointes may occur as a complication of amiodarone therapy. We report a patient receiving amiodarone who was resuscitated from cardiovascular collapse and documented ventricular fibrillation. At subsequent electrophysiology study, while the patient was taking amiodarone therapy, monophasic action potentials with early after depolarisations were recorded which were not present when the patient was restudied 6 weeks after discontinuation of amiodarone. Early after-depolarisations may be important in the genesis of polymorphic ventricular tachycardia complicating amiodarone therapy.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Morgan JM,Lopes A,Rowland E

doi

10.1093/oxfordjournals.eurheartj.a059849

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

1144-7

issue

10

eissn

0195-668X

issn

1522-9645

journal_volume

12

pub_type

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