Sodium channel blockers in the treatment of ventricular arrhythmias: different effects in the normal, ischaemic or failing heart?

abstract：AIMS:Despite disparities in pathophysiology and disease manifestation between male and female patients with heart failure, studies focusing on sex differences in biomarkers are scarce. The purpose of this study was to assess sex-specific variation in clinical characteristics and biomarker levels to gain more understand...

journal_title：European heart journal

authors： Meyer S,van der Meer P,van Deursen VM,Jaarsma T,van Veldhuisen DJ,van der Wal MH,Hillege HL,Voors AA

更新日期：2013-08-01 00:00:00

abstract：AIMS :Individuals with low socioeconomic status (SES) face widespread prejudice in society. Whether SES disparities exist in treatment and survival following in-hospital cardiac arrest (IHCA) is unclear. The aim of the current retrospective registry study was to examine SES disparities in IHCA treatment and survival, a...

journal_title：European heart journal

authors： Agerström J,Carlsson M,Bremer A,Herlitz J,Israelsson J,Årestedt K

更新日期：2020-12-21 00:00:00

abstract：:In 2008, The ESC Working Group on Myocardial and Pericardial Diseases proposed an updated classification of cardiomyopathies based on morphological and functional phenotypes and subcategories of familial/genetic and non-familial/non-genetic disease. In this position statement, we propose a framework for the clinical a...

journal_title：European heart journal

authors： Rapezzi C,Arbustini E,Caforio AL,Charron P,Gimeno-Blanes J,Heliö T,Linhart A,Mogensen J,Pinto Y,Ristic A,Seggewiss H,Sinagra G,Tavazzi L,Elliott PM

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:To investigate sources of variability in serial echocardiographic recordings in a core laboratory we assessed the impact of repeated echo recordings, repeated video measurements and measurements made by different investigators. PATIENTS, METHODS:Two investigators each recorded and analysed two-dimensional ec...

journal_title：European heart journal

authors： Otterstad JE,Froeland G,St John Sutton M,Holme I

更新日期：1997-03-01 00:00:00

abstract：:In this study, the acute haemodynamic effects of angiotensin converting enzyme (ACE) inhibition with intravenous enalaprilat alone or in combination with preload restoration were determined in patients with severe heart failure complicating acute myocardial infarction. Ten patients with raised pulmonary arterial wedge...

journal_title：European heart journal

authors： Tohmo H,Karanko M,Korpilahti K

更新日期：1994-04-01 00:00:00

abstract：AIMS:Patients with chronic kidney disease (CKD) pose a worldwide growing burden to health care systems due to accelerated atherosclerosis and subsequent high cardiovascular (CV) morbidity. Atherogenesis is prominently driven by monocytes and monocyte-derived macrophages. The expression of CD14 and CD16 characterizes th...

journal_title：European heart journal

authors： Rogacev KS,Seiler S,Zawada AM,Reichart B,Herath E,Roth D,Ulrich C,Fliser D,Heine GH

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Following hospitalization with a range of cardiovascular disorders, substantial variation has been noted in clinical outcome, both between and within countries. OBJECTIVES:To examine the variation, between hospitals, in the clinical outcomes of death and readmission following hospitalization with heart fail...

journal_title：European heart journal

authors： Stewart S,Demers C,Murdoch DR,McIntyre K,MacLeod ME,Kendrick S,Capewell S,McMurray JJ

更新日期：2002-04-01 00:00:00

abstract：Aims:To characterize the relationship between blood pressure (BP) or heart rate and mortality and morbidity in chronic obstructive pulmonary disease (COPD). Methods and results:We performed post hoc analysis of baseline BP or heart rate and all-cause mortality and cardiovascular events in the SUMMIT trial. SUMMIT was ...

journal_title：European heart journal

authors： Byrd JB,Newby DE,Anderson JA,Calverley PMA,Celli BR,Cowans NJ,Crim C,Martinez FJ,Vestbo J,Yates J,Brook RD,SUMMIT Investigators.

更新日期：2018-09-01 00:00:00

abstract：:A time-domain signal-averaged ECG was performed in 52 patients with arrhythmogenic right ventricular dysplasia (ARVD) proven by angiography, in 45 control subjects with normal hearts, and in 132 patients with various types of ventricular arrhythmias and no evidence of cardiac disease during routine cardiac examination...

journal_title：European heart journal

authors： Leclercq JF,Coumel P

更新日期：1993-09-01 00:00:00

abstract：:A possibility that can be advanced to explain the antihypertensive effect of beta-blocking drugs is that they act through the baroreflex control of the cardiovascular system. In 38 essential hypertensive patients we measured 1) The lengthening and shortening in R-R interval caused by stimulation or deactivation of art...

journal_title：European heart journal

authors： Parati G,Pomidossi G,Grassi G,Gavazzi C,Ramirez A,Gregorini L,Mancia G

更新日期：1983-07-01 00:00:00

abstract：UNLABELLED:Peripheral vessels provide a useful in vivo haemodynamic model allowing evaluation of local intravascular fluid dynamics. Velocity measurements using a 0.018 inch Doppler-tipped angioplasty guidewire, quantitative angiography and laboratory data were gathered from 45 patients with a total of 48 percutaneous ...

journal_title：European heart journal

authors： Wellnhofer E,Biamino G,Sauer HU,Trebeljahr A,Stalke J,Ragg C,Oswald H,Gotze S,Fleck E,Felix R

更新日期：1995-10-01 00:00:00

abstract：:A 45-year-old patient with the Wolff-Parkinson-White syndrome suffering from recurrent intractable reciprocating atrioventricular tachycardia (RAVT) is reported. He used amiodarone, sotalol, quinidine, propafenone and flecainide unsuccessfully. An electrophysiological study (EPS) performed with four catheters localize...

journal_title：European heart journal

authors： Delise P,Bonso A,Raviele A,Cazzin R,Di Pede F,Piccolo E

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Myocardial ischaemia occurs principally in the subendocardial layer, whereas conventional myocardial perfusion imaging provides no information on the transmural myocardial blood flow (MBF) distribution. Subendocardial perfusion measurements and quantification of the transmural perfusion gradient (TPG) could ...

journal_title：European heart journal

authors： Danad I,Raijmakers PG,Harms HJ,Heymans MW,van Royen N,Lubberink M,Boellaard R,van Rossum AC,Lammertsma AA,Knaapen P

更新日期：2014-08-14 00:00:00

abstract：AIMS:Aspirin combined with clopidogrel is the treatment of choice for acute coronary syndromes. Although the maintenance of aspirin until surgery does not affect postoperative bleeding after coronary artery bypass graft (CABG) surgery, the latter may be dramatically increased when clopidogrel is continued over a period...

journal_title：European heart journal

authors： Ouattara A,Bouzguenda H,Le Manach Y,Léger P,Mercadier A,Leprince P,Bonnet N,Montalescot G,Riou B,Coriat P

更新日期：2007-04-01 00:00:00

abstract：:Infective endocarditis is associated with significant morbidity and mortality, with valvular destruction and congestive heart failure being more common in patients with echocardiographically discernible vegetations. The transoesophageal approach affords consistently high quality images with excellent structural resolu...

journal_title：European heart journal

authors： Rohmann S,Erbel R,Görge G,Makowski T,Mohr-Kahaly S,Nixdorff U,Drexler M,Meyer J

更新日期：1992-04-01 00:00:00

abstract：:This study was designed to evaluate the implantation of internal cardioverter/defibrillators under local anaesthesia by electrophysiologists and to compare this to our former experience of implants with general anaesthesia. Forty-seven internal cardioverter/defibrillators were implanted at our institution by electroph...

journal_title：European heart journal

authors： Schmitt C,Alt E,Plewan A,Schömig A

更新日期：1996-11-01 00:00:00

abstract：AIMS:Combined quantitative coronary angiography and intracoronary Doppler flow velocity measurements were performed to study the underlying haemodynamic mechanisms leading to myocardial ischaemia in patients with myocardial bridging in the absence of coronary artery disease. METHODS AND RESULTS:In 42 symptomatic patie...

journal_title：European heart journal

authors： Schwarz ER,Klues HG,vom Dahl J,Klein I,Krebs W,Hanrath P

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Atrial abnormalities in patients with progressive systemic sclerosis have not been evaluated in terms of intra-atrial conduction. We hypothesized that a delay in atrial conduction in these patients might produce diastolic abnormalities as well as atrial arrhythmias. OBJECTIVE:To evaluate the atrial function...

journal_title：European heart journal

authors： Mizuno R,Fujimoto S,Nakano H,Nakajima T,Kimura A,Nakagawa Y,Dohi K

更新日期：1997-12-01 00:00:00

abstract：AIMS:The cardiac extracellular matrix is highly involved in regulating inflammation, remodelling, and function of the heart. Whether matrix alterations relate to the degree of inflammation, fibrosis, and overall rejection in the human transplanted heart remained, until now, unknown. METHODS AND RESULTS:Expression of m...

journal_title：European heart journal

authors： Vanhoutte D,van Almen GC,Van Aelst LN,Van Cleemput J,Droogné W,Jin Y,Van de Werf F,Carmeliet P,Vanhaecke J,Papageorgiou AP,Heymans S

更新日期：2013-07-01 00:00:00

abstract：AIMS:To test the hypothesis that increasing age in patients presenting with high-risk non-ST-segment elevation acute coronary syndromes (NSTE-ACS) does not adversely influence the benefit of an early invasive strategy on major adverse events at 6 months. METHODS AND RESULTS:We report clinical outcomes in young (<70), ...

journal_title：European heart journal

authors： Devlin G,Gore JM,Elliott J,Wijesinghe N,Eagle KA,Avezum A,Huang W,Brieger D,GRACE Investigators.

更新日期：2008-05-01 00:00:00

abstract：:Morphological changes in human myocardium associated with pressure overload-induced left ventricular hypertrophy were studied in 22 normal and 21 hypertrophic hearts obtained at autopsy. Samples were obtained from the left lateral ventricular wall, half way between the apex and the base. Myocyte dimensions, polyploidi...

journal_title：European heart journal

authors： Vliegen HW,van der Laarse A,Cornelisse CJ,Eulderink F

更新日期：1991-04-01 00:00:00

abstract：AIMS:Coronary plaque characteristics are associated with ischaemia. Differences in plaque volumes and composition may explain the discordance between coronary stenosis severity and ischaemia. We evaluated the association between coronary stenosis severity, plaque characteristics, coronary computed tomography angiograph...

journal_title：European heart journal

authors： Gaur S,Øvrehus KA,Dey D,Leipsic J,Bøtker HE,Jensen JM,Narula J,Ahmadi A,Achenbach S,Ko BS,Christiansen EH,Kaltoft AK,Berman DS,Bezerra H,Lassen JF,Nørgaard BL

更新日期：2016-04-14 00:00:00

abstract：:Increased arteriolar tone is the pathophysiological hallmark of essential hypertension and is determined by the intracellular free calcium concentration in the vascular smooth muscle cell. Calcium influx is an important determinant of vasoconstriction and excess calcium influx-dependent vasoconstriction has been shown...

journal_title：European heart journal

authors： Erne P,Conen D,Kiowski W,Bolli P,Müller FB,Bühler FR

更新日期：1987-11-01 00:00:00

abstract：:Manifestations of congestive heart failure are frequently observed in patients with coronary disease. However, they may be predominant in patients who have sustained prior myocardial infarction, in whom left ventricular aneurysm or papillary muscle dysfunction may induce left ventricular dysfunction. A small group of ...

journal_title：European heart journal

authors： Bertrand ME,Lablanche JM,Thieuleux FA,Tilmant PY

更新日期：1983-01-01 00:00:00

abstract：AIMS:Positron emission tomography (PET) myocardial perfusion imaging (MPI) can non-invasively measure myocardial blood flow reserve (MBFR). We aimed to examine whether MBFR identifies patients with a survival benefit after revascularization, helping to guide post-test management. METHODS AND RESULTS:We examined all-ca...

journal_title：European heart journal

authors： Patel KK,Spertus JA,Chan PS,Sperry BW,Al Badarin F,Kennedy KF,Thompson RC,Case JA,McGhie AI,Bateman TM

更新日期：2020-02-01 00:00:00

abstract：:The present review summarizes the available information on the effects of the three major classes of antianginal agents (nitrates, calcium and beta-blockers) on myocardial energy metabolism. It also discusses the role of some new molecules (L-carnitine, trimetazidine and ranolazine) that have been proposed as an alter...

journal_title：European heart journal

authors： Chierchia SL,Fragasso G

更新日期：1993-11-01 00:00:00

abstract：AIMS:Growing data suggest that antibiotic exposure is associated with a long-lasting alteration in gut microbiota, and may be related to subsequent cardiovascular disease (CVD). We investigated associations of life-stage and duration of antibiotic exposure during adulthood with subsequent CVD events. METHODS AND RESUL...

journal_title：European heart journal

authors： Heianza Y,Zheng Y,Ma W,Rimm EB,Albert CM,Hu FB,Rexrode KM,Manson JE,Qi L

更新日期：2019-12-14 00:00:00

abstract：:The concentration of cholesterol in peripheral lymph is roughly one tenth of that in the blood plasma of the same subject. In lymph, there is virtually no very low density lipoprotein (VLDL), probably due to low permeability of the vascular endothelium for particles of this size. More than 95% of apo B-containing lipo...

journal_title：European heart journal

authors： Reichl D

更新日期：1990-08-01 00:00:00

abstract：:The safety of calcium antagonists has recently become a controversial issue among cardiologists. Thus, the role of calcium antagonists in the treatment of myocardial infarction and in secondary cardiovascular prevention is under review. As a consequence, the concept that the words 'calcium antagonists' comprise variou...

journal_title：European heart journal

authors： Ferrari R

更新日期：1997-01-01 00:00:00

abstract：:The purpose of this study was to compare rubidium-82 PET with thallium-201 SPECT imaging in 150 patients. Both techniques followed a single dipyridamole-handgrip stress, and images were displayed using the same 3-dimensional format and quantitative colour scale. Coronary arteriography was employed to assign the correc...

journal_title：European heart journal

authors： Marwick TH,Go RT,MacIntyre WJ,Saha GB,Underwood DA

更新日期：1991-10-01 00:00:00