Abstract:
:Increased arteriolar tone is the pathophysiological hallmark of essential hypertension and is determined by the intracellular free calcium concentration in the vascular smooth muscle cell. Calcium influx is an important determinant of vasoconstriction and excess calcium influx-dependent vasoconstriction has been shown by plethysmographical studies in patients with essential hypertension. Calcium antagonists acutely lower BP by reducing calcium influx, calcium concentration and peripheral resistance. The degree of the attendant sympathetic nerve reflex activation and counter-regulatory mechanisms determines the antihypertensive response of the individual. Chronic monotherapy with a calcium antagonist results in an antihypertensive response, which is directly related to the patient's age and pretreatment BP and indirectly related to plasma renin levels. The resulting reduction in after-load neither leads to reduced cerebral blood flow in hypertensive patients, nor aggravates congestive heart failure. Calcium antagonists are a useful alternative to diuretics, primarily in older patients with low renin levels, either alone or combined with any other antihypertensive drug, and provide effective and safe control of blood pressure.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Erne P,Conen D,Kiowski W,Bolli P,Müller FB,Bühler FRdoi
10.1093/eurheartj/8.suppl_k.49subject
Has Abstractpub_date
1987-11-01 00:00:00pages
49-56eissn
0195-668Xissn
1522-9645journal_volume
8 Suppl Kpub_type
杂志文章,评审abstract::Plasma neuropeptide Y-like immunoreactivity (NPY-LI) is elevated in patients with acute myocardial ischaemia and congestive heart failure (CHF) owing to increased activity of the sympathetic nervous system. The prognostic value of plasma NPY-LI with regard to mortality was studied in 324 random patients admitted to a ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060526
更新日期:1994-04-01 00:00:00
abstract:AIMS:The association of body weight and weight change with mortality and cardiovascular (CV) outcome in patients with diabetes mellitus (DM) is not clearly established. We assessed the relationship between weight, weight change, and outcomes in patients with established CV risk factors and type 2 DM or pre-diabetes. M...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehaa293
更新日期:2020-07-21 00:00:00
abstract::In order to assess the value of pulsed Doppler echocardiography in detection of valvular regurgitation, 63 patients were evaluated for aortic and/or mitral regurgitation using pulsed Doppler echocardiography and selective cineangiography. The Doppler study was considered as positive when a turbulent flow was detected ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061674
更新日期:1984-05-01 00:00:00
abstract:AIMS:Atrial fibrillation (AF) occurs often in patients after coronary artery bypass grafting (CABG) and can result in increased morbidity and mortality. Previous studies using P-wave signal-averaged electrocardiogram (P-SAECG) have shown that patients with a longer filtered P-wave duration (FPD) have a high risk of AF ...
journal_title:European heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1093/eurheartj/ehl082
更新日期:2006-07-01 00:00:00
abstract:Aims:Atrial fibrillation (AFib) and atrial flutter (AFlut) are common arrhythmias with increased use of invasive procedures. A steady re-evaluation of relevant safety endpoints is recommended and both quality management and pay-for-performance programs are evolving. Therefore, the aims of this study were (i) to investi...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehy528
更新日期:2018-11-21 00:00:00
abstract::To study the haemodynamic and neurohumoral effects of nisoldipine (2 X 10 mg) vs captopril (3 X 25 mg), 24 patients with heart failure (New York Heart Association class II and III) due to coronary artery disease were treated in a randomized double-blind trial over 3 months. Both drugs were well tolerated. Clinical sta...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/oxfordjournals.eurheartj.a059786
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Tissue Doppler echocardiography reveals characteristic patterns of myocardial velocities within systole and diastole which are not well understood. AIM:The purpose of this study was to determine the relationship of myocardial velocity patterns, as assessed by tissue Doppler echocardiography, to the contract...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a015236
更新日期:1997-02-01 00:00:00
abstract:AIMS:The Tako-Tsubo cardiomyopathy (TTC) is characterized by a transient contractile dysfunction that has been assigned to excessive catecholamine levels after episodes of severe emotional or physical stress. Several studies have indicated that beta-adrenoceptor stimulation is associated with alteration in gene express...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehp240
更新日期:2009-09-01 00:00:00
abstract:AIMS:Transthyretin amyloidosis (ATTR amyloidosis) is a heterogeneous disorder with cardiac, neurologic, and mixed phenotypes. We describe the phenotypic and genotypic profiles of this disease in continental Western Europe as it appears from the Transthyretin Amyloidosis Survey (THAOS). METHODS AND RESULTS:THAOS is an ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehz173
更新日期:2019-04-01 00:00:00
abstract::A previously described nitroglycerin-induced heparin resistance could not be verified by in-vitro experiments or in a randomized, double-blind, crossover trial in healthy volunteers. A clinically relevant attenuation of the anticoagulant effect of a heparin bolus (40 U.kg-1) by a concomitant infusion of nitroglycerin ...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/oxfordjournals.eurheartj.a060182
更新日期:1992-03-01 00:00:00
abstract:AIMS:To analyse whether the proportion of patients with lone atrial fibrillation engaged in chronic sport practice was higher than that observed in the general population. METHODS AND RESULTS:The records of 1160 patients, seen at the arrhythmia outpatient clinic, were reviewed. A total of 70 patients (6%) suffered lon...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.2001.2802
更新日期:2002-03-01 00:00:00
abstract::Angiotensin II (AII) has been implicated as an important factor in the pathophysiology of heart diseases. Following the recent identification of two subtypes of the AII receptor in cardiac tissue of animals, we investigated the possible occurrence of these, or similar, subtypes in human atrial tissue. In right-atrial ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a015008
更新日期:1996-07-01 00:00:00
abstract::We investigated cardiovascular and coronary responses to intravenous infusions of adrenaline, which raised arterial concentrations in a stepwise fashion from basal to about 5-6 nmol.l-1, in 11 non-rejecting heart transplanted patients, and in eight intact innervated subjects. Cardiac adrenaline extraction and noradren...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.4.474
更新日期:1993-04-01 00:00:00
abstract:AIMS:Ivabradine, a new I(f) inhibitor which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent. Ivabradine has shown anti-ischaemic and anti-anginal activity in a placebo-controlled trial. The objective of this study was to compare the anti-anginal and anti-ischaemic...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/ehi586
更新日期:2005-12-01 00:00:00
abstract:AIMS:Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening wo...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehz300
更新日期:2019-07-01 00:00:00
abstract:Aims:Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by right ventricular myocardial replacement and life-threatening ventricular arrhythmias. Desmosomal gene mutations are sometimes identified, but clinical and genetic diagnosis remains challenging. Desmosomal skin disorders can be caused by de...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehy567
更新日期:2018-11-21 00:00:00
abstract::The rationale for beta-blockade in heart failure is now well established. Heart failure mortality, which is predicted by neurohormonal activation, remains high despite modern treatment including ACE inhibition, and additional neurohormonal blockade has further therapeutic potential. Previous clinical trial experience ...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/17.suppl_b.39
更新日期:1996-04-01 00:00:00
abstract:AIMS:This study compares the functional outcome and cardiorespiratory response to exercise, in patients who have undergone arterial switch for transposition of the great arteries, with normal controls and patients who have undergone atrial switch operation. METHODS AND RESULTS:Fifteen patients who had undergone arteri...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.2000.2425
更新日期:2001-06-01 00:00:00
abstract:AIMS:Our aims were to evaluate the distribution of troponin I concentrations in population cohorts across Europe, to characterize the association with cardiovascular outcomes, to determine the predictive value beyond the variables used in the ESC SCORE, to test a potentially clinically relevant cut-off value, and to ev...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehw172
更新日期:2016-08-07 00:00:00
abstract:BACKGROUND:In the acute phase of myocardial infarction (acute MI) marked endothelial damage occurs within the first 24h following thrombolysis with streptokinase. We investigated whether this is associated with a change in levels of vascular endothelial growth factor (VEGF, possibly marking angiogenesis) in the first 2...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.2002.3312
更新日期:2002-10-01 00:00:00
abstract:AIMS:We examined the left lateral ridge (LLR) between the orifices of the left pulmonary veins and the left atrial appendage for a better understanding of its structural composition relevant to ablations for atrial fibrillation (AF). METHODS AND RESULTS:The LLR and its surrounding areas were studied in 40 heart specim...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehm606
更新日期:2008-02-01 00:00:00
abstract::Twenty-one patients with stable effort angina pectoris were randomized in a crossover study to 4 weeks traditional Chinese acupuncture or placebo tablet treatment. The patients had at least five anginal attacks per week in spite of intensive treatment. Acupuncture was given three times per week at main points Neiguan ...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/oxfordjournals.eurheartj.a059865
更新日期:1991-02-01 00:00:00
abstract::Out of 84,609 Europeans in the ERICA sample (EHJ 9, Suppl I) 18,931 had adequate 6-year follow-up data so that coronary heart disease (CHD) mortality could be assessed in relation to five risk factors (age, cholesterol, systolic blood pressure, body mass index and cigarette smoking) measured at baseline. In view of kn...
journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
abstract::Considerable effort and large sums of money have been spent on constructing a risk profile for sudden death in the myocardial infarction survivor at the time of discharge from hospital. However, these patients are only a minority among those dying suddenly outside hospital. The majority of sudden death victims cannot ...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/16.suppl_g.7
更新日期:1995-08-01 00:00:00
abstract:AIMS:There have been substantial declines in cerebrovascular disease mortality across much of Europe, mirroring trends in deaths from cardiovascular disease as a whole. No study has investigated trends in cerebrovascular disease, and its subtypes within all European countries. This study aimed to examine sex-specific t...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehy378
更新日期:2019-03-01 00:00:00
abstract:Aims:This study aimed to investigate the association between smoking cessation, post-cessation body mass index (BMI) change and risk of myocardial infarction (MI) and stroke in men. Methods and results:A prospective cohort study using the National Health Insurance Service (NHIS) data set collected from 2002 to 2013 wa...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehx761
更新日期:2018-05-01 00:00:00
abstract:Aims:The ESC-EHRA Atrial Fibrillation Ablation Long-Term registry is a prospective, multinational study that aims at providing an accurate picture of contemporary real-world ablation for atrial fibrillation (AFib) and its outcome. Methods and results:A total of 104 centres in 27 European countries participated and wer...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehw564
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:The Cholesterol Lowering Atherosclerosis PTCA Trial (CLAPT) is a prospective, randomized trial with blinded angiographic end-points to assess the effect of 2-year's treatment with lovastatin initiated 4 weeks prior to PTCA, compared to usual care on non-dilated coronary segments and on dilated coronary lesio...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1053/euhj.1999.1483
更新日期:1999-10-01 00:00:00
abstract::Haemodynamic effects of pharmacological doses of insulin during acute ischaemic heart failure were studied in 8 dogs. Severe depression of left ventricular function was induced by the injection of 50 micron plastic microspheres into the left main coronary artery. This was demonstrated by a significant increase in left...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061885
更新日期:1985-05-01 00:00:00
abstract:AIMS:To investigate the association of estimated total daily sleep duration and daytime nap duration with deaths and major cardiovascular events. METHODS AND RESULTS:We estimated the durations of total daily sleep and daytime naps based on the amount of time in bed and self-reported napping time and examined the assoc...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehy695
更新日期:2019-05-21 00:00:00