Calcium antagonist induced vasodilation in peripheral, coronary and cerebral vasculature as important factors in the treatment of elderly hypertensives.

Abstract:

:Increased arteriolar tone is the pathophysiological hallmark of essential hypertension and is determined by the intracellular free calcium concentration in the vascular smooth muscle cell. Calcium influx is an important determinant of vasoconstriction and excess calcium influx-dependent vasoconstriction has been shown by plethysmographical studies in patients with essential hypertension. Calcium antagonists acutely lower BP by reducing calcium influx, calcium concentration and peripheral resistance. The degree of the attendant sympathetic nerve reflex activation and counter-regulatory mechanisms determines the antihypertensive response of the individual. Chronic monotherapy with a calcium antagonist results in an antihypertensive response, which is directly related to the patient's age and pretreatment BP and indirectly related to plasma renin levels. The resulting reduction in after-load neither leads to reduced cerebral blood flow in hypertensive patients, nor aggravates congestive heart failure. Calcium antagonists are a useful alternative to diuretics, primarily in older patients with low renin levels, either alone or combined with any other antihypertensive drug, and provide effective and safe control of blood pressure.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Erne P,Conen D,Kiowski W,Bolli P,Müller FB,Bühler FR

doi

10.1093/eurheartj/8.suppl_k.49

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

49-56

eissn

0195-668X

issn

1522-9645

journal_volume

8 Suppl K

pub_type

杂志文章,评审
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    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehy695

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