Amiodarone prophylaxis for atrial fibrillation of high-risk patients after coronary bypass grafting: a prospective, double-blinded, placebo-controlled, randomized study.


AIMS:Atrial fibrillation (AF) occurs often in patients after coronary artery bypass grafting (CABG) and can result in increased morbidity and mortality. Previous studies using P-wave signal-averaged electrocardiogram (P-SAECG) have shown that patients with a longer filtered P-wave duration (FPD) have a high risk of AF after CABG. We have shown that patients with an FPD > or = 124 ms and a root-mean-square voltage of the last 20 ms of the P-wave 20 < or = 3.7 microV have an increased risk of AF after surgery. Accordingly, the aim of this study was to investigate whether or not prophylactic peri-operative administration of amiodarone could reduce the incidence of AF in this high-risk group undergoing CABG identified by P-SAECG. METHODS AND RESULTS:In this prospective, double-blinded, placebo-controlled, randomized study, 110 patients received either amiodarone (n = 55) or placebo (n = 55). During CABG, two patients of both groups died. Amiodarone was given as 600 mg oral single dose one day before and from days 2 through 7 after surgery. In addition, amiodarone was also administered intravenously during surgery in a 300-mg bolus for 1 h and as a total maintenance dose of 20 mg/kg weight over 24 h on the first day following surgery. The primary endpoint was the occurrence of AF after CABG. The secondary endpoint was the hospitalization length of stay after CABG. The baseline characteristics were similar in both treatment groups. The incidence of post-operative AF was significantly higher in the placebo group compared with the amiodarone group (85 vs. 34% of patients, P < 0.0001). The prophylactic therapy with amiodarone significantly reduced the intensive care (1.8 +/- 1.7 vs. 2.4 +/- 1.5 days, P = 0.001) and hospitalization length of stay (11.3 +/- 3.4 vs. 13.0 +/- 4.3 days, P = 0.03). In the amiodarone group, concentrations of amiodarone and desethylamiodarone differed significantly between patients with AF and sinus rhythm (amiodarone: 0.96 +/- 0.5 vs. 0.62 +/- 0.4 microg/mL, P = 0.02; desethylamiodarone: 0.65 +/- 0.2 vs. 0.48 +/- 0.1 microg/mL, P = 0.04). CONCLUSION:The incidence of post-operative AF among high-risk patients was significantly reduced by a prophylactic amiodarone treatment resulting in a shorter time of intensive care unit and hospital stay. Our data supports the prophylactic use of amiodarone in peri-operative period in patients at high risk for AF after CABG.


Eur Heart J


European heart journal


Budeus M,Hennersdorf M,Perings S,Röhlen S,Schnitzler S,Felix O,Reimert K,Feindt P,Gams E,Lehmann N,Wieneke H,Sack S,Erbel R,Perings C




Has Abstract


2006-07-01 00:00:00














  • Cardiac anatomy, function and metabolism in elite cyclists assessed by magnetic resonance imaging and spectroscopy.

    abstract::We investigated whether left ventricular hypertrophy in elite cyclists is associated with functional changes or abnormal energy metabolism. Left ventricular hypertrophy is a powerful risk factor for sudden cardiac death with different prognostic significance among the various geometric forms. Cyclists may have a combi...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Pluim BM,Chin JC,De Roos A,Doornbos J,Siebelink HM,Van der Laarse A,Vliegen HW,Lamerichs RM,Bruschke AV,Van der Wall EE

    更新日期:1996-08-01 00:00:00

  • Late potentials in arrhythmogenic right ventricular dysplasia. Prevalence, diagnostic and prognostic values.

    abstract::A time-domain signal-averaged ECG was performed in 52 patients with arrhythmogenic right ventricular dysplasia (ARVD) proven by angiography, in 45 control subjects with normal hearts, and in 132 patients with various types of ventricular arrhythmias and no evidence of cardiac disease during routine cardiac examination...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Leclercq JF,Coumel P

    更新日期:1993-09-01 00:00:00

  • Cardiovascular critical event pathways for the progression of heart failure; a report from the ATLAS study.

    abstract:AIMS:To determine the sequence of critical cardiovascular events in the progression of heart failure, and whether aetiology or high-dose vs low-dose lisinopril affected these pathways. METHODS AND RESULTS:This was a post-hoc investigation of the ATLAS database, which comprised 3164 patients with chronic heart failure,...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Cleland JG,Thygesen K,Uretsky BF,Armstrong P,Horowitz JD,Massie B,Packer M,Poole-Wilson PA,Rydén L,ATLAS investigators.

    更新日期:2001-09-01 00:00:00

  • Serial electrophysiologic studies after single chamber atrial pacemaker implantation in patients with symptomatic sinus node dysfunction.

    abstract::After single chamber atrial pacemaker implantation, serial electrophysiologic studies were performed noninvasively at intervals of 3 months over a total period of 3 years in 24 patients with symptomatic sinus node dysfunction. All patients underwent invasive electrophysiologic studies before pacemaker implantation and...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: van Mechelen R,Segers A,Hagemeijer F

    更新日期:1984-08-01 00:00:00

  • Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs.

    abstract:AIM:Heart disease is recognized as a consequence of dysregulation of cardiac gene regulatory networks. Previously, unappreciated components of such networks are the long non-coding RNAs (lncRNAs). Their roles in the heart remain to be elucidated. Thus, this study aimed to systematically characterize the cardiac long no...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Ounzain S,Micheletti R,Beckmann T,Schroen B,Alexanian M,Pezzuto I,Crippa S,Nemir M,Sarre A,Johnson R,Dauvillier J,Burdet F,Ibberson M,Guigó R,Xenarios I,Heymans S,Pedrazzini T

    更新日期:2015-02-07 00:00:00

  • Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC).

    abstract::Non-thrombotic PE does not represent a distinct clinical syndrome. It may be due to a variety of embolic materials and result in a wide spectrum of clinical presentations, making the diagnosis difficult. With the exception of severe air and fat embolism, the haemodynamic consequences of non-thrombotic emboli are usual...

    journal_title:European heart journal

    pub_type: 杂志文章,实务指引


    authors: Torbicki A,Perrier A,Konstantinides S,Agnelli G,Galiè N,Pruszczyk P,Bengel F,Brady AJ,Ferreira D,Janssens U,Klepetko W,Mayer E,Remy-Jardin M,Bassand JP,ESC Committee for Practice Guidelines (CPG).

    更新日期:2008-09-01 00:00:00

  • Left ventricular thrombosis and arterial embolism after thrombolysis in acute anterior myocardial infarction: predictors and effects of adjunctive antithrombotic therapy.

    abstract::The prevalence of left ventricular (LV) thrombosis and incidence of arterial embolism after acute anterior myocardial infarction (AAMI) treated with streptokinase 1.5 x 10(6) IU intravenously was studied in 136 patients enrolled consecutively in five cardiological centres. Adjunctive antithrombotic therapy was adminis...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Kontny F,Dale J,Hegrenaes L,Lem P,Søberg T,Morstøl T

    更新日期:1993-11-01 00:00:00

  • Beta adrenergic blockade does not improve effort tolerance in patients with mitral stenosis in sinus rhythm.

    abstract:OBJECTIVES:This study was designed to assess the effects of beta-blockade on cardiopulmonary exercise performance in symptomatic patients with tight mitral stenosis in sinus rhythm. BACKGROUND:The role of beta-blockers in these patients has been controversial and assessment of effort tolerance using treadmill exercise...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Patel JJ,Dyer RB,Mitha AS

    更新日期:1995-09-01 00:00:00

  • Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients.

    abstract:AIMS:The population with stable coronary artery disease (SCAD) is growing but validated models to guide their clinical management are lacking. We developed and validated prognostic models for all-cause mortality and non-fatal myocardial infarction (MI) or coronary death in SCAD. METHODS AND RESULTS:Models were develop...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Rapsomaniki E,Shah A,Perel P,Denaxas S,George J,Nicholas O,Udumyan R,Feder GS,Hingorani AD,Timmis A,Smeeth L,Hemingway H

    更新日期:2014-04-01 00:00:00

  • N-methylethanolamine attenuates cardiac fibrosis and improves diastolic function: inhibition of phospholipase D as a possible mechanism.

    abstract:AIM:Ventricular fibrosis is promoted by many effectors that chronically activate phospholipase D (PLD), and induces cardiac dysfunction and heart failure in cardiovascular diseases. Since ethanolamine is a product of PLD, we hypothesised that an administration of an analogue of ethanolamine, N-methylethanolamine (MEA),...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Yamamoto K,Takahashi Y,Mano T,Sakata Y,Nishikawa N,Yoshida J,Oishi Y,Hori M,Miwa T,Inoue S,Masuyama T

    更新日期:2004-07-01 00:00:00

  • Delayed improvement of myocardial function after recanalization of a chronic coronary occlusion in a patient with intractable heart failure.

    abstract::This case report describes the delayed improvement of left ventricular function by recanalization of an occluded coronary artery in a patient with intractable heart failure and three-vessel disease. The left anterior descending coronary artery was occluded distal to the first septal branch, the dominant right coronary...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Klein HH,Neuhaus KL

    更新日期:1990-03-01 00:00:00

  • Fibrinogen and cerebrovascular disease.

    abstract::The importance of fibrinogen has been identified in two prospective observational studies. Reactive elevations in fibrinogen levels that occur within hours of a major stroke invalidate most cross-sectional case-control studies evaluating fibrinogen as a risk factor. However, as no elevation is seen following fresh epi...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Qizilbash N

    更新日期:1995-03-01 00:00:00

  • ACE inhibitors and their influence on inflammation, bronchial reactivity and cough.

    abstract::Orally active angiotensin converting enzyme (ACE) inhibitors have been successfully used in the treatment of congestive heart failure and hypertension. However, adverse skin reactions, such as angioneurotic oedema have been reported following such medication. Furthermore, these drugs have been associated with a persis...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Andersson RG,Persson K

    更新日期:1994-08-01 00:00:00

  • Telemonitoring in chronic heart failure.

    abstract::Clinical management of refractory heart failure remains challenging, with a high rate of rehospitalizations despite advances in medical and device therapy. Care can be provided in person, via telehomecare (by telephone), or telemonitoring, which involves wireless technology for remote follow-up. Telemonitoring wireles...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Hasan A,Paul V

    更新日期:2011-06-01 00:00:00

  • Haemodynamic effects of high doses of insulin during acute left ventricular failure in dogs.

    abstract::Haemodynamic effects of pharmacological doses of insulin during acute ischaemic heart failure were studied in 8 dogs. Severe depression of left ventricular function was induced by the injection of 50 micron plastic microspheres into the left main coronary artery. This was demonstrated by a significant increase in left...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Reikerås O,Gunnes P,Sørlie D,Ekroth R,Jorde R,Mjøs OD

    更新日期:1985-05-01 00:00:00

  • Impact of design of coronary stents and length of dual antiplatelet therapies on ischaemic and bleeding events: a network meta-analysis of 64 randomized controlled trials and 102 735 patients.

    abstract:Aims:The differential impact on ischaemic and bleeding events of the type of drug-eluting stent [durable polymer stents [DES] vs. biodegradable polymer stents vs. bioresorbable scaffolds (BRS)] and length of dual antiplatelet therapy (DAPT) remains to be defined. Methods and results:Randomized controlled trials compar...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审


    authors: D'Ascenzo F,Iannaccone M,Saint-Hilary G,Bertaina M,Schulz-Schüpke S,Wahn Lee C,Chieffo A,Helft G,Gili S,Barbero U,Biondi Zoccai G,Moretti C,Ugo F,D'Amico M,Garbo R,Stone G,Rettegno S,Omedè P,Conrotto F,Templin C,C

    更新日期:2017-11-07 00:00:00

  • Left atrial ball thrombus in combined mitral-aortic valve disease.

    abstract::This report describes a patient with left atrial ball thrombus which was detected during echocardiographic evaluation of combined mitral-aortic valve disease. Surgical correction was performed entirely on the basis of the echocardiographic diagnosis. ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Schäfer RO,Evers G,Morgan P,Thiel H

    更新日期:1992-02-01 00:00:00

  • Left ventricular systolic function assessment in secondary mitral regurgitation: left ventricular ejection fraction vs. speckle tracking global longitudinal strain.

    abstract:AIMS:Left ventricular (LV) ejection fraction (LVEF) is currently considered for the decision making of patients with mitral regurgitation (MR). However, LVEF represents change in LV volume between end-diastole and end-systole but does not characterize the intrinsic function of the myocardium. In contrast, speckle-track...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Kamperidis V,Marsan NA,Delgado V,Bax JJ

    更新日期:2016-03-07 00:00:00

  • Autonomic, ischaemic, circadian and rhythmic factors as causes of the spontaneous variability of ventricular arrhythmias.

    abstract::Ventricular arrhythmias present with strongly varying intensity. This spontaneous variability makes it difficult to use one of the existing arrhythmia grading systems for risk or therapy efficacy studies. We attempted to explain the variability by the changing autonomic, ischaemic, circadian, and rhythmic factors. Fou...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Janssen MJ,Swenne CA,Manger Cats V,van Bemmel JH,Bruschke AV

    更新日期:1995-05-01 00:00:00

  • Acute coronary syndromes in patients with pre-existing moderate to severe valvular disease of the heart: lessons from the Euro-Heart Survey of acute coronary syndromes.

    abstract:AIM:To determine the frequency of pre-existing valvular disease (VD) among patients with acute coronary syndromes (ACS) and to compare the clinical characteristics, clinical course, treatment, and outcomes of ACS patients with and without pre-existing VD. METHODS AND RESULTS:The Euro Heart Survey ACS prospectively enr...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Hasdai D,Lev EI,Behar S,Boyko V,Danchin N,Vahanian A,Battler A

    更新日期:2003-04-01 00:00:00

  • C-reactive protein, infarct size, microvascular obstruction, and left-ventricular remodelling following acute myocardial infarction.

    abstract:AIMS:This study assessed the relationship between inflammatory mediators and indices of infarct size and left-ventricular (LV) remodelling following successful primary percutaneous coronary intervention (PCI) in patients with first time ST elevation myocardial infarction (MI). METHODS AND RESULTS:Forty-two patients ad...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Ørn S,Manhenke C,Ueland T,Damås JK,Mollnes TE,Edvardsen T,Aukrust P,Dickstein K

    更新日期:2009-05-01 00:00:00

  • The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function.

    abstract:AIMS:In animal models of obesity and diabetes mellitus, myocardial TG accumulation is associated with decreased myocardial function. In the physiologically ageing heart, myocardial triglyceride (TG) accumulation may also occur due to reduced myocardial fatty acid oxidation. The role of myocardial TG in the ageing human...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: van der Meer RW,Rijzewijk LJ,Diamant M,Hammer S,Schär M,Bax JJ,Smit JW,Romijn JA,de Roos A,Lamb HJ

    更新日期:2008-06-01 00:00:00

  • Correlation between inducibility of sustained ventricular tachycardia and QRS duration.

    abstract::Some studies provide a link between the width of QRS complexes and late potentials occurring at the end of the QRS complex in signal-averaged recordings. The purpose of this study was to compare three methods of QRS duration measurement: the conventional 12 lead ECG, the Frank vectorcardiogram (VCG) and the signal-ave...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Brembilla-Perrot B

    更新日期:1994-01-01 00:00:00

  • Value of exercise radionuclide ventriculography and thallium-201 scintigraphy in evaluating successful coronary angioplasty: comparison with coronary flow reserve, translesional gradient and percent diameter stenosis.

    abstract::Assessment of percutaneous transluminal coronary angioplasty (PTCA) by early radionuclide exercise test was evaluated for 11 arteries undergoing a successful procedure. Exercise thallium-201 (Tl-201) and radionuclide ventriculography (RNV) were performed within 3 days before and after PTCA and compared to % diameter s...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Legrand V,Aueron FM,Bates ER,O'Neill WW,Hodgson JM,Mancini GB,Vogel RA

    更新日期:1987-04-01 00:00:00

  • Greater decreases in cholesterol levels among individuals with high cardiovascular risk than among the general population: the northern Sweden MONICA study 1994 to 2014.

    abstract:AIM:Decreasing cholesterol levels in Western populations is the main reason for decreasing mortality due to coronary heart disease. Our aim was to analyze trends in cholesterol levels in the population during a period of 20 years in relation to previous cardiovascular disease (CVD), other cardiovascular risk factors, a...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Eriksson M,Forslund AS,Jansson JH,Söderberg S,Wennberg M,Eliasson M

    更新日期:2016-07-01 00:00:00

  • Substantial between-hospital variation in outcome following first emergency admission for heart failure.

    abstract:BACKGROUND:Following hospitalization with a range of cardiovascular disorders, substantial variation has been noted in clinical outcome, both between and within countries. OBJECTIVES:To examine the variation, between hospitals, in the clinical outcomes of death and readmission following hospitalization with heart fail...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Stewart S,Demers C,Murdoch DR,McIntyre K,MacLeod ME,Kendrick S,Capewell S,McMurray JJ

    更新日期:2002-04-01 00:00:00

  • Diastolic heart failure.

    abstract::Diastolic heart disease is common and appears to be the primary abnormality in a substantial proportion of all patients with CHF. The epidemiology and natural history of the condition appears different to that of systolic heart failure, resulting in significant morbidity although contributing little to overall mortali...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Wheeldon NM,Clarkson P,MacDonald TM

    更新日期:1994-12-01 00:00:00

  • Effects of nisoldipine on left ventricular function during exercise or cold pressor stress.

    abstract::The effects of a single oral dose of nisoldipine, 10 mg, were investigated in two groups of patients. Firstly, the effects of nisoldipine on exercise left ventricular function were assessed in 20 patients with chronic stable angina and coronary disease. Secondly, the effects of nisoldipine on the left ventricular resp...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Dymond DS,Caplin JL,O'Keefe JC,Banim S

    更新日期:1987-11-01 00:00:00

  • Arterial stiffening is a heritable trait associated with arterial dilation but not wall thickening: a longitudinal study in the twins UK cohort.

    abstract:Aims:Vascular ageing is characterized by arterial stiffening, dilation, and arterial wall thickening. We investigated the extent to which these changes are related and their heritability during 5 year follow-up in the Twins UK cohort. Methods and results:Carotid-femoral pulse wave velocity (PWVcf), carotid diameter, c...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Cecelja M,Jiang B,Keehn L,Hussain T,Silva Vieira M,Phinikaridou A,Greil G,Spector TD,Chowienczyk P

    更新日期:2018-06-21 00:00:00

  • Should we SHIFT our thinking about digoxin? Observations on ivabradine and heart rate reduction in heart failure.

    abstract:AIMS:The importance of heart rate in the pathophysiology of heart failure with reduced LVEF has recently attracted attention. In particular, the findings of the Systolic Heart failure treatment with the I(f) inhibitor ivabradine Trial (SHIFT) have put special emphasis on heart rate reduction with ivabradine for improve...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Castagno D,Petrie MC,Claggett B,McMurray J

    更新日期:2012-05-01 00:00:00