Abstract:
:We investigated cardiovascular and coronary responses to intravenous infusions of adrenaline, which raised arterial concentrations in a stepwise fashion from basal to about 5-6 nmol.l-1, in 11 non-rejecting heart transplanted patients, and in eight intact innervated subjects. Cardiac adrenaline extraction and noradrenaline release rate were also measured. The transplanted patients showed larger increases in heart rate (36 +/- 11% vs 16 +/- 6%, P < 0.0001) and cardiac index (80 +/- 30% vs 56 +/- 19%, P < 0.05), while stroke volume increments were similar in the two groups (32 +/- 17% vs 35 +/- 13%). The study groups did not differ with respect to changes in arterial pressure, cardiac work or peripheral resistances. Coronary sinus blood flow increased to a greater extent in the transplanted group (75 +/- 35% vs 48 +/- 31%, P < 0.05) and myocardial oxygen consumption also tended to increase more in these patients (78 +/- 42% vs 48 +/- 34%, NS). Myocardial adrenaline extraction was greatly reduced in the transplant patients (-6 +/- 25% vs 64 +/- 18%, P < 0.001), while forearm adrenaline extraction was similar in the two groups (41 +/- 22% vs 40 +/- 23%, NS). Cardiac noradrenaline overflow tended to be lower in the transplanted group (12 +/- 62 vs 48 +/- 43 pmol.min-1, NS). There was a wide range of noradrenaline overflow values (-64 to 147 pmol.min-1) and definite high values in three patients. Cardiac noradrenaline overflow was not correlated to heart rate responsiveness to adrenaline. We conclude that patients with cardiac transplantation respond to adrenaline with exaggerated increases in heart rate and thus in cardiac output. High values of cardiac noradrenaline overflow are seen in some transplant recipients and may suggest reinnervation. Signs of reinnervation are not associated with consistently lower heart rate responses to beta-adrenergic stimulation.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Roca J,Cruz Caturla M,Hjemdahl P,Masotti M,Ventura A,Oriol A,Crexells Cdoi
10.1093/eurheartj/14.4.474subject
Has Abstractpub_date
1993-04-01 00:00:00pages
474-83issue
4eissn
0195-668Xissn
1522-9645journal_volume
14pub_type
杂志文章abstract::After single chamber atrial pacemaker implantation, serial electrophysiologic studies were performed noninvasively at intervals of 3 months over a total period of 3 years in 24 patients with symptomatic sinus node dysfunction. All patients underwent invasive electrophysiologic studies before pacemaker implantation and...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061719
更新日期:1984-08-01 00:00:00
abstract::In order to compare different criteria for the definition of late potentials in patients after myocardial infarction, three signal averaged ECG variables, duration of the signal-averaged QRS complex (QRS), root-mean-square voltage of the terminal 40 ms (RMS-40), and the duration of low amplitude signals less than 40 m...
journal_title:European heart journal
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doi:10.1093/oxfordjournals.eurheartj.a060222
更新日期:1992-05-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:
更新日期:1993-11-01 00:00:00
abstract::In a pilot study, a prophylactic regimen including ciprofloxacin and amphotericin B was applied in 102 consecutive patients on artificial respiration for greater than or equal to 5 days to prevent respiratory tract infection with aerobic Gram-negative bacilli. Ciprofloxacin was given twice a day, as 500 mg through a g...
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journal_title:European heart journal
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journal_title:European heart journal
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doi:10.1093/eurheartj/4.suppl_g.41
更新日期:1983-11-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
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更新日期:1990-12-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-08-01 00:00:00
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doi:10.1053/euhj.1998.1189
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pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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pub_type: 新闻
doi:
更新日期:2014-04-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1985-10-01 00:00:00
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更新日期:2012-03-01 00:00:00
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更新日期:1994-12-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-03-07 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1999-08-01 00:00:00
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更新日期:1993-03-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2008-06-01 00:00:00
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更新日期:1992-04-01 00:00:00
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更新日期:1990-08-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-02-01 00:00:00
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更新日期:2010-10-01 00:00:00
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