Abstract:
:Bisoprolol is a new cardioselective beta-blocker with a long half-life. The efficacy of once daily bisoprolol (10 mg) and atenolol (100 mg) was assessed in 20 patients with stable angina using a placebo controlled double-blind randomized crossover protocol. Efficacy was assessed by computer assisted treadmill exercise testing with monitoring of leads CM5 and CC5, carried out 22-24 h after the last dose. The mean +/- SEM exercise time on placebo was 6.5 +/- 0.4 min increasing to 7.8 +/- 0.5 min on bisoprolol (P less than 0.001) and 8.6 +/- 0.6 mins on atenolol (P less than 0.001). The time to 1 mm ST depression in CM5 and CC5 was also prolonged significantly with both drugs. The mean basal resting heart rate of 84 +/- 4 bpm decreased to 63 +/- 2 bpm on bisoprolol (P less than 0.001) and 64 +/- 3 bpm on atenolol (P less than 0.001), with a significant decrease in the peak exercise heart rate seen with both drugs (P less than 0.001). The peak rate-pressure product was 175 +/- 8 after placebo, 146 +/- 7 (P less than 0.001) with bisoprolol and 149 +/- 5 (P less than 0.001) after atenolol. One patient was withdrawn because he suffered a myocardial infarction. Eighteen patients were prescribed bisoprolol 10 mg once a day for 6 weeks and an exercise test was performed at the end of this period. Bisoprolol retained its efficacy at the end of this period and was well tolerated.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Kohli RS,Khurmi NS,Kardash MM,Hughes LO,Lahiri A,Raftery EBdoi
10.1093/oxfordjournals.eurheartj.a061771subject
Has Abstractpub_date
1985-10-01 00:00:00pages
845-50issue
10eissn
0195-668Xissn
1522-9645journal_volume
6pub_type
临床试验,杂志文章,随机对照试验abstract::This report concerns a patient with cardiac manifestation of Whipple's disease. For the first time, the gene that encodes the 16s rRNA of Tropheryma whippelii was identified in a native aortic valve by means of a polymerase chain reaction technique. DNA amplification gives evidence of Tropheryma whippelii as a causati...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060928
更新日期:1995-03-01 00:00:00
abstract:AIMS:To examine the relations between genetic loci, plasma lipoprotein(a) [Lp(a)] levels, and cardiovascular disease (CVD) risk among diabetic patients and compare with the observations in the general population. METHODS AND RESULTS:In two prospective cohorts of patients with type 2 diabetes (n= 2308) from the Nurses'...
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abstract:AIM:In this study we sought to determine the safety, feasibility and prognostic value of pharmacological stress echocardiography performed in a primary care cardiology centre, populated by unselected patients evaluated with the aid of limited financial and technological resources. METHODS AND RESULTS:The study populat...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.1998.1096
更新日期:1998-11-01 00:00:00
abstract::Twenty-nine men with chronic stable angina pectoris were investigated using stress electrocardiography (ECG) and stress transthoracic echocardiography by means of transoesophageal stimulation of the left atrium. At rest and after each stimulated frequency, ECG and 2-dimensional echocardiography combined with Doppler w...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.10.1344
更新日期:1993-10-01 00:00:00
abstract::A necessary part of the strategy of modification of hypercholesterolaemia to prevent coronary heart disease (CHD) is the detection and treatment, by diet or by drugs, of high risk individuals. There are several drawbacks to this approach: (1) the cost of screening to find individuals at risk and of monitoring by physi...
journal_title:European heart journal
pub_type: 杂志文章,评审
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abstract::Stephan Achenbach reviews the history of coronary computer tomography angiography and discusses its further evolution. ...
journal_title:European heart journal
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abstract:AIMS:Emerging evidence indicates that nuclear receptors play a critical regulatory role in cardiovascular physiology/pathology. Recently, farnesoid-X-receptor (FXR), a member of the metabolic nuclear receptor superfamily, has been demonstrated to be expressed in vascular cells, with important roles in vascular physiolo...
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doi:10.1093/eurheartj/ehs011
更新日期:2013-06-01 00:00:00
abstract::Although the main cardiac complication in patients with rheumatoid arthritis is subclinical pericarditis, mononuclear cell infiltrations into myocardium may cause cardiac arrhythmias and conduction defects. In order to examine these problems we evaluated 70 patients (53 women and 17 men) aged 18-83 years (average 56.7...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061005
更新日期:1995-06-01 00:00:00
abstract::The haemodynamic side-effects of ionic (amidotrizoate) and non-ionic (iopamidol) contrast media after injection into the right atrium were compared in experimental and clinical studies. Pulmonary hypertension was induced in 10 dogs by embolization of the pulmonary vascular bed with agar-agar solution (mean pulmonary a...
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1987-12-01 00:00:00
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更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-11-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/12.suppl_f.10
更新日期:1991-12-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/ehq067
更新日期:2010-04-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060249
更新日期:1992-06-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/oxfordjournals.eurheartj.a059628
更新日期:1990-11-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1016/j.ehj.2004.09.003
更新日期:2004-11-01 00:00:00
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doi:10.1093/eurheartj/eht156
更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060895
更新日期:1995-02-01 00:00:00
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更新日期:1984-12-01 00:00:00
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更新日期:2005-09-01 00:00:00
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