The haemodynamic side-effects of ionic and non-ionic contrast media in the presence of pulmonary hypertension: experimental and clinical investigation.

Abstract:

:The haemodynamic side-effects of ionic (amidotrizoate) and non-ionic (iopamidol) contrast media after injection into the right atrium were compared in experimental and clinical studies. Pulmonary hypertension was induced in 10 dogs by embolization of the pulmonary vascular bed with agar-agar solution (mean pulmonary artery pressure = 44.2 mmHg). Iopamidol (1.5 ml kg-1) caused a moderate decrease in pulmonary and systemic vascular resistance, slight increases in right ventricular end-diastolic pressure and a marked rise in right ventricular contractility (dP/dtmax). Amidotrizoate (1.5 ml kg-1) caused considerable systemic vasodilation and initial increases in pulmonary vascular resistance and pressure followed by a substantial increase in right ventricular end-diastolic pressure and a decrease in contractility. Central and peripheral haemodynamics were measured in 20 patients with pulmonary hypertension (mean pulmonary artery pressure = 38.1 mmHg) due to valvular heart disease before and following injections with 40 ml of both types of contrast medium in randomized order. Heart rate, cardiac output and right atrial pressure rose significantly more after amidotrizoate and this contrast medium caused more extensive systemic vasodilation and a larger decrease in aortic pressure as compared to iopamidol. Pulmonary artery pressure went up moderately with both contrast media. It is concluded that non-ionic low-osmolality contrast media like iopamidol induce less pronounced haemodynamic alterations, in particular less increase in right ventricular filling pressure. This may be beneficial to patients with pulmonary hypertension undergoing angiocardiography or digital subtraction angiography.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Schräder R,Hellige G,Kaltenbach M,Kober G

doi

10.1093/oxfordjournals.eurheartj.a062219

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

1322-31

issue

12

eissn

0195-668X

issn

1522-9645

journal_volume

8

pub_type

临床试验,杂志文章,随机对照试验
  • Silent healing of spontaneous plaque disruption demonstrated by intracoronary ultrasound.

    abstract::Intracoronary ultrasound was performed at diagnostic coronary angiography and 10 days later in a 45-year-old patient with a 3-day history of acute inferior myocardial infarction. Coronary angiography showed considerable stenosis (80%) in the distal right coronary artery (RCA) (pre the crux) and what appeared to be a d...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061061

    authors: Ge J,Haude M,Görge G,Liu F,Erbel R

    更新日期:1995-08-01 00:00:00

  • Comparative study of echo- and angiocardiographically determined regional left ventricular wall motion in recent myocardial infarction.

    abstract::We have studied regional left ventricular (LV) wall motion with M-mode, cross-sectional (2D) echocardiography and LV angiography in 50 patients with a recent myocardial infarction. Regional LV wall motion was evaluated according to a 9-segment model. 2D echocardiography permitted information from all, M-mode echocardi...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061703

    authors: Lindvall K,Hamsten A,Landou C,Szamosi A,de Faire U

    更新日期:1984-07-01 00:00:00

  • Low-density lipoprotein cholesterol targeting with pitavastatin + ezetimibe for patients with acute coronary syndrome and dyslipidaemia: the HIJ-PROPER study, a prospective, open-label, randomized trial.

    abstract:Aims:To elucidate the effects of intensive LDL-C lowering treatment with a standard dose of statin and ezetimibe in patients with dyslipidaemia and high risk of coronary events, targeting LDL-C less than 70 mg/dL (1.8 mmol/L), compared with standard LDL-C lowering lipid monotherapy targeting less than 100 mg/dL (2.6 mm...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehx162

    authors: Hagiwara N,Kawada-Watanabe E,Koyanagi R,Arashi H,Yamaguchi J,Nakao K,Tobaru T,Tanaka H,Oka T,Endoh Y,Saito K,Uchida T,Matsui K,Ogawa H

    更新日期:2017-08-01 00:00:00

  • Management of acute coronary syndromes. Variations in practice and outcome; findings from the Global Registry of Acute Coronary Events (GRACE).

    abstract:AIMS:Despite advances in the treatment of acute coronary syndromes based on randomized trial data and published guidelines, the extent to which such treatments are applied in practice remains uncertain. Data from clinical trials derive from selected geographical areas and in highly selected populations of patients, and...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2001.3081

    authors: Fox KA,Goodman SG,Klein W,Brieger D,Steg PG,Dabbous O,Avezum A

    更新日期:2002-08-01 00:00:00

  • Echocardiographic criteria to distinguish reversible from irreversible myocardial ischaemia.

    abstract::This treatise reviews two-dimensional echocardiographic criteria which have been developed to describe and distinguish reversible vs irreversible myocardial ischaemia. It also discusses the new pathophysiologic concepts such as 'hibernating' and 'decapitated' myocardium, and also 'reperfusion injury' and 'stunned' myo...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/9.suppl_f.29

    authors: Corday E,Hajduczki I,O'Byrne GT,Kar S,Areeda J,Corday SR

    更新日期:1988-04-01 00:00:00

  • Pathogenetic mechanisms and epidemiology of Chlamydia pneumoniae.

    abstract::The antibody prevalence data indicate that C. pneumoniae infections are common worldwide and more frequently occur in middle-aged and elderly males than in females. C. pneumoniae infections are first acquired in childhood in heavily populated areas, whereas in northern countries, first infections are generally at teen...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

    authors: Leinonen M

    更新日期:1993-12-01 00:00:00

  • Acute intervention with captopril during thrombolysis in patients with first anterior myocardial infarction. Results from the Captopril and Thrombolysis Study (CATS).

    abstract::The study was designed to examine the safety and efficacy of acute interventional use of captopril on left ventricular volumes, ventricular arrhythmias and neurohormones during thrombolysis in patients with a first anterior myocardial infarction, within 6 h of onset of symptoms. Left ventricular dysfunction and progno...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a060608

    authors: Kingma JH,van Gilst WH,Peels CH,Dambrink JH,Verheugt FW,Wielenga RP

    更新日期:1994-07-01 00:00:00

  • Abnormalities in intracellular Ca2+ regulation contribute to the pathomechanism of Tako-Tsubo cardiomyopathy.

    abstract:AIMS:The Tako-Tsubo cardiomyopathy (TTC) is characterized by a transient contractile dysfunction that has been assigned to excessive catecholamine levels after episodes of severe emotional or physical stress. Several studies have indicated that beta-adrenoceptor stimulation is associated with alteration in gene express...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehp240

    authors: Nef HM,Möllmann H,Troidl C,Kostin S,Voss S,Hilpert P,Behrens CB,Rolf A,Rixe J,Weber M,Hamm CW,Elsässer A

    更新日期:2009-09-01 00:00:00

  • A mechanism of cardiac pain suppression by spinal cord stimulation: implications for patients with angina pectoris.

    abstract::Clinical reports show that electrical stimulation of the spinal cord reduces symptoms of angina pectoris, but so far have not provided evidence on the mechanisms involved. The hypothesis for this study was that inhibition of spinothalamic tract transmission may account for this result. Extracellular potentials of 28 s...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.1.96

    authors: Chandler MJ,Brennan TJ,Garrison DW,Kim KS,Schwartz PJ,Foreman RD

    更新日期:1993-01-01 00:00:00

  • Strict blood glucose control with insulin during intensive care after cardiac surgery: impact on 4-years survival, dependency on medical care, and quality-of-life.

    abstract:AIMS:To document the impact of intensive insulin therapy during intensive care on long-term (4 years) outcome of high-risk cardiac surgery patients. METHODS AND RESULTS:In this pre-planned sub-analysis and follow-up study of a large, randomized controlled trial on the effects of intensive insulin therapy during critic...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehi855

    authors: Ingels C,Debaveye Y,Milants I,Buelens E,Peeraer A,Devriendt Y,Vanhoutte T,Van Damme A,Schetz M,Wouters PJ,Van den Berghe G

    更新日期:2006-11-01 00:00:00

  • A novel risk prediction score in atrial fibrillation for a net clinical outcome from the ENGAGE AF-TIMI 48 randomized clinical trial.

    abstract:Aims:The choice between initiating a non-vitamin K antagonist oral anticoagulant (NOAC) and a vitamin K antagonist (VKA) in patients with atrial fibrillation (AF) may be challenging. To assist in this decision, we developed a risk score to identify patients for whom a therapeutic benefit of NOACs over VKA is predicted....

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehw565

    authors: Fanola CL,Giugliano RP,Ruff CT,Trevisan M,Nordio F,Mercuri MF,Antman EM,Braunwald E

    更新日期:2017-03-21 00:00:00

  • Dilated cardiomyopathy and the level of alcohol consumption: a planned multicentre case-control study.

    abstract::The association between clinical or environmental factors and dilated cardiomyopathy (DCM) has been assessed in a planned case-control study. Patients and controls were men aged between 20 and 65 years, matched for age, profession and geographic location. DCM was defined by strict radiologic and angiographic criteria ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062099

    authors: Komajda M,Richard JL,Bouhour JB,Sacrez A,Bourdonnec C,Gerbaux A,Rozensztajn L,Lablanche JM,Matinat D,Morand P

    更新日期:1986-06-01 00:00:00

  • Clinical course and prognosis of patients with typical and atypical hypertrophic obstructive and with hypertrophic non-obstructive cardiomyopathy.

    abstract::In a total of 339 patients with hypertrophic cardiomyopathies (typical HOCM, n = 224; atypical HOCM, n = 30; HNCM, n = 80) the clinical course, the Sokolow-Lyon index in the ECG and the prognosis as demonstrated by cumulative survival rates were analysed to get more differentiated information for the characterization ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/4.suppl_f.145

    authors: Loogen F,Kuhn H,Gietzen F,Lösse B,Schulte HD,Bircks W

    更新日期:1983-11-01 00:00:00

  • Single infusion of intravenous cibenzoline in the treatment of supraventricular tachyarrhythmias following heart surgery. A double-blind placebo-controlled parallel study.

    abstract::The efficacy and safety of a single infusion of cibenzoline, a class I antiarrhythmic drug, were assessed in 86 patients presenting with a supraventricular tachyarrhythmia following heart surgery in a placebo-controlled double-blind parallel study. Cibenzoline was effective in 13 patients (30%) vs three patients (6.9%...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a060664

    authors: Ollitrault J,Quilliet L,Scheck F,Lelong B,Richard A,Jarry G,Guize L

    更新日期:1994-09-01 00:00:00

  • Endothelium-derived nitric oxide: the endogenous nitrovasodilator in the human cardiovascular system.

    abstract::The L-arginine pathway within endothelial cells in the blood vessel wall is the source of production of the endogenous nitrovasodilator, nitric oxide (NO). NO is released under basal conditions and in response to various stimuli such as shear stress and in response to platelet-derived products, coagulation factors and...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/12.suppl_e.2

    authors: Lüscher TF

    更新日期:1991-11-01 00:00:00

  • Ineligibility for predischarge exercise testing after myocardial infarction in the elderly: implications for prognosis.

    abstract::This study describes the clinical profile and prognosis of elderly patients not eligible for predischarge exercise testing. The database consisted of 133 patients 55-64 years of age, and 111 patients older than 64 years of age who survived an acute myocardial infarction. Follow-up was one year. In the younger age grou...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/5.suppl_e.97

    authors: Deckers JW,Fioretti P,Brower RW,Simoons ML,Baardman T,Hugenholtz PG

    更新日期:1984-11-01 00:00:00

  • Anomalous origin of the left anterior descending coronary artery from the right sinus of Valsalva associated with effort angina pectoris.

    abstract::A 54-year-old man suffering from effort angina pectoris had an anomalous origin of the left anterior descending coronary artery (LAD) from the right sinus of Valsalva (RSV). The anomalous LAD with a small ostium and without other significant narrowing initially ran into the interventricular septum and subsequently the...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.1.129

    authors: Takenaka T,Horimoto M,Fujiwara M

    更新日期:1993-01-01 00:00:00

  • NT-proBNP has a high negative predictive value to rule-out short-term cardiovascular events in patients with diabetes mellitus.

    abstract:AIMS:This study evaluated the predictive value of NT-proBNP for patients with diabetes mellitus and compared the prognostic aptitude of this neurohumoral marker to traditional markers of cardiovascular events. METHODS AND RESULTS:A prospective observational study was conducted in 631 diabetic patients. The composite e...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehn334

    authors: Huelsmann M,Neuhold S,Strunk G,Moertl D,Berger R,Prager R,Abrahamian H,Riedl M,Pacher R,Luger A,Clodi M

    更新日期:2008-09-01 00:00:00

  • Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial.

    abstract:AIMS:To examine the extent of platelet inhibition by prasugrel vs. clopidogrel in a TRITON-TIMI 38 substudy. METHODS AND RESULTS:TRITON-TIMI 38 randomized acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) to prasugrel or standard dose clopidogrel. Selected sites prospectively e...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehp159

    authors: Michelson AD,Frelinger AL 3rd,Braunwald E,Downey WE,Angiolillo DJ,Xenopoulos NP,Jakubowski JA,Li Y,Murphy SA,Qin J,McCabe CH,Antman EM,Wiviott SD,TRITON-TIMI 38 Investigators.

    更新日期:2009-07-01 00:00:00

  • Heart failure and chronic obstructive pulmonary disease: the challenges facing physicians and health services.

    abstract::Pulmonary disease is common in patients with heart failure, through shared risk factors and pathophysiological mechanisms. Adverse pulmonary vascular remodelling and chronic systemic inflammation characterize both diseases. Concurrent chronic obstructive pulmonary disease presents diagnostic and therapeutic challenges...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/eht192

    authors: Hawkins NM,Virani S,Ceconi C

    更新日期:2013-09-01 00:00:00

  • Improved monitoring of myocardial ischaemia during major vascular surgery using transoesophageal echocardiography.

    abstract::As regional wall motion abnormality (RWA) is the first sign of ischaemia, transoesophageal echocardiography was evaluated as a monitoring device in 51 patients undergoing abdominal aortic surgery. Wall motion of the entire left ventricular wall (nine segments) was semiquantitatively evaluated 15 min before and after a...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060309

    authors: Koolen JJ,Visser CA,Reichert SL,Jaarsma WJ,Kromhout JG,van Wezel HB,Dunning AJ

    更新日期:1992-08-01 00:00:00

  • Potential time saving with pre-hospital intervention in acute myocardial infarction. Report of the European Myocardial Infarction Project (E.M.I.P) Sub-Committee.

    abstract::The European Myocardial Infarction Project (E.M.I.P.) participants have evaluated out-of-hospital coronary care services in different cities within the E.E.C. and concluded that these facilities would support a study within these European centres on pre-hospital intervention in myocardial infarction. Based on a pilot ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1988-02-01 00:00:00

  • Does coronary angioplasty replace, delay, or complement aortocoronary bypass surgery?

    abstract::In single vessel disease angioplasty can replace surgery in the majority of patients. In cases of recurrence at the site of angioplasty or in the case of progression elsewhere, a second intervention can be performed. Thus, in the majority of patients surgery can be replaced; in the minority it can be delayed. In patie...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/8.suppl_f.47

    authors: Kaltenbach M

    更新日期:1987-09-01 00:00:00

  • Why does atrial fibrillation occur?

    abstract::Atrial fibrillation is often associated with atrial enlargement and stretch is known to cause electrophysiological alterations. Acute stretch may, depending on the moment at which it is applied, cause action potential shortening or induce both early and delayed afterdepolarizations which, when large enough, may initia...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/18.suppl_c.12

    authors: Janse MJ

    更新日期:1997-05-01 00:00:00

  • Identification of post acute myocardial infarction patients with potential benefit from prophylactic treatment with amiodarone. A substudy of EMIAT (the European Myocardial Infarct Amiodarone Trial).

    abstract:AIMS:To perform a retrospective analysis of subgroups of patients enrolled into the European Myocardial Infarct Amiodarone Trial (EMIAT) in order to identify patients who might benefit from prophylactic amiodarone treatment and patients in whom amiodarone might be harmful. METHODS:Baseline characteristics of the 1486 ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1997.0823

    authors: Janse MJ,Malik M,Camm AJ,Julian DG,Frangin GA,Schwartz PJ

    更新日期:1998-01-01 00:00:00

  • Doppler ultrasonic measurement of cardiac output: reproducibility and validation.

    abstract::The Doppler ultrasonic estimation of cardiac output in man is reviewed. Minimal requirements for accurate measurements are discussed, and the published results of reproducibility studies and validation studies are summarized and analysed. Analysis of Doppler records has a coefficient of repeat determination of 5-8% fo...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/11.suppl_i.49

    authors: Coats AJ

    更新日期:1990-12-01 00:00:00

  • Resting and exertional haemodynamic effects of buccal nitroglycerin: acute and chronic discontinuous treatment in post-myocardial infarction patients with heart failure.

    abstract::The resting and exertional haemodynamic effects of acute and chronic discontinuous (one tablet every 6 h) treatment with 5 mg of buccal nitroglycerin (BN) have been assessed in nine postinfarction heart failure patients. At rest, pulmonary artery (PAP), pulmonary wedge (PWP), and right atrial pressures (RAP) were redu...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062493

    authors: Opasich C,Riccardi G,Febo O,Tramarin R,Lepore AM,Luca C,Cobelli F,Specchia G

    更新日期:1988-03-01 00:00:00

  • Haemodynamic effects of frusemide and its influence on repetitive rapid volume loading in acute myocardial infarction.

    abstract::The haemodynamic effects of intravenous frusemide (1 mg/kg) were studied in 22 male patients with left ventricular failure following acute myocardial infarction. Radiographic pulmonary oedema was present in all patients and their average left heart filling pressure was 20 mmHg. Bolus injection of the drug was followed...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061382

    authors: Nelson GI,Ahuja RC,Silke B,Okoli RC,Hussain M,Taylor SH

    更新日期:1983-10-01 00:00:00

  • Risk stratification after myocardial infarction: is left ventricular ejection fraction enough to prevent sudden cardiac death?

    abstract::Patients who have experienced a myocardial infarction (MI) are at increased risk of sudden cardiac death (SCD). With the advent of implantable cardioverter-defibrillators (ICDs), accurate risk stratification has become very relevant. Numerous investigations have proven that a reduced left ventricular ejection fraction...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/eht109

    authors: Dagres N,Hindricks G

    更新日期:2013-07-01 00:00:00

  • The Journal of Interventional Cardiology.

    abstract::In a small field with an abundance of journals, the Journal of Interventional Cardiology is carving out its niche with articles about technologies on the horizon. ...

    journal_title:European heart journal

    pub_type: 新闻

    doi:

    authors: Taylor J

    更新日期:2012-07-01 00:00:00