Abstract:
:The efficacy and safety of a single infusion of cibenzoline, a class I antiarrhythmic drug, were assessed in 86 patients presenting with a supraventricular tachyarrhythmia following heart surgery in a placebo-controlled double-blind parallel study. Cibenzoline was effective in 13 patients (30%) vs three patients (6.9%) with placebo (P < 0.05). In the non-converted patients, ventricular rate was significantly slowed by cibenzoline (P < 0.05), which also significantly increased the duration of QRS and QT intervals. Transient adverse events were seen in nine patients receiving cibenzoline: moderate hypotension, sweating, right bundle branch block. One patient with decreased left ventricular function had an increased ventricular rate and QRS duration associated with hypotension. There were no severe adverse events. These results suggest that cibenzoline is effective for the treatment of postoperative supraventricular tachyarrhythmias in patients without impairment of ventricular function.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Ollitrault J,Quilliet L,Scheck F,Lelong B,Richard A,Jarry G,Guize Ldoi
10.1093/oxfordjournals.eurheartj.a060664subject
Has Abstractpub_date
1994-09-01 00:00:00pages
1274-8issue
9eissn
0195-668Xissn
1522-9645journal_volume
15pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract::After years of stagnant finances for research, moves are under way to increase research funds in Europe. ...
journal_title:European heart journal
pub_type: 杂志文章
doi:
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journal_title:European heart journal
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pub_type: 杂志文章
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journal_title:European heart journal
pub_type: 杂志文章
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更新日期:1991-09-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1985-10-01 00:00:00
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journal_title:European heart journal
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1995-07-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1990-03-01 00:00:00
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更新日期:1993-01-01 00:00:00
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journal_title:European heart journal
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