Single infusion of intravenous cibenzoline in the treatment of supraventricular tachyarrhythmias following heart surgery. A double-blind placebo-controlled parallel study.

Abstract:

:The efficacy and safety of a single infusion of cibenzoline, a class I antiarrhythmic drug, were assessed in 86 patients presenting with a supraventricular tachyarrhythmia following heart surgery in a placebo-controlled double-blind parallel study. Cibenzoline was effective in 13 patients (30%) vs three patients (6.9%) with placebo (P < 0.05). In the non-converted patients, ventricular rate was significantly slowed by cibenzoline (P < 0.05), which also significantly increased the duration of QRS and QT intervals. Transient adverse events were seen in nine patients receiving cibenzoline: moderate hypotension, sweating, right bundle branch block. One patient with decreased left ventricular function had an increased ventricular rate and QRS duration associated with hypotension. There were no severe adverse events. These results suggest that cibenzoline is effective for the treatment of postoperative supraventricular tachyarrhythmias in patients without impairment of ventricular function.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Ollitrault J,Quilliet L,Scheck F,Lelong B,Richard A,Jarry G,Guize L

doi

10.1093/oxfordjournals.eurheartj.a060664

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

1274-8

issue

9

eissn

0195-668X

issn

1522-9645

journal_volume

15

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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