Heart failure and chronic obstructive pulmonary disease: the challenges facing physicians and health services.

Abstract:

:Pulmonary disease is common in patients with heart failure, through shared risk factors and pathophysiological mechanisms. Adverse pulmonary vascular remodelling and chronic systemic inflammation characterize both diseases. Concurrent chronic obstructive pulmonary disease presents diagnostic and therapeutic challenges, and is associated with increased morbidity and mortality. The cornerstones of therapy are beta-blockers and beta-agonists, whose pharmacological properties are diametrically opposed. Each disease is implicated in exacerbations of the other condition, greatly increasing hospitalizations and associated health care costs. Such multimorbidity is a key challenge for health-care systems oriented towards the treatment of individual diseases. Early identification and treatment of cardiopulmonary disease may alleviate this burden. However, diagnostic and therapeutic strategies require further validation in patients with both conditions.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Hawkins NM,Virani S,Ceconi C

doi

10.1093/eurheartj/eht192

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

2795-803

issue

36

eissn

0195-668X

issn

1522-9645

pii

eht192

journal_volume

34

pub_type

杂志文章,评审