The relationship between markers of extracellular cardiac matrix turnover: infarct healing and left ventricular remodelling following primary PCI in patients with first-time STEMI.

Abstract:

AIMS:We investigated the temporal changes in circulating levels of markers of extracellular cardiac matrix (ECCM) turnover and their relationship with infarct size (IS), ejection fraction (EF), and left ventricular (LV) volumes, determined by serial cardiac magnetic resonance (CMR) imaging in patients with first-time ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS:Forty-two patients with a first-time STEMI, successfully revascularized by primary percutaneous coronary intervention (pPCI) had serum samples taken prior to pPCI, 2, 7 days, 2 months, and 1 year following STEMI for the analysis of the markers of collagen synthesis, and collagen degradation. Late enhancement and cine CMR was performed on Days 2, 7, 2 months, and 1-year post-STEMI. There was a significant increase in type I collagen degradation following STEMI that was not accompanied by an increase in collagen type I synthesis until 2 months and 1 year. In contrast to the delay in type I collagen synthesis, there was an immediate increase in type III collagen synthesis that was sustained for 1 year. N-terminal procollagen type I levels assessed prior to pPCI were predictive of adverse LV remodelling at all CMR time-points. CONCLUSIONS:Our findings indicate a net type I collagen breakdown in the first week following STEMI compensated by an early increase in collagen type III synthesis. There is an increase in both type I and III collagen synthesis markers at 2 months and 1 year, indicating a persistent increase in collagen turnover even in these apparently successfully treated patients.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Manhenke C,Ueland T,Jugdutt BI,Godang K,Aukrust P,Dickstein K,Ørn S

doi

10.1093/eurheartj/eht482

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

395-402

issue

6

eissn

0195-668X

issn

1522-9645

pii

eht482

journal_volume

35

pub_type

临床试验,杂志文章,随机对照试验
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    更新日期:2005-06-01 00:00:00

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    doi:10.1093/oxfordjournals.eurheartj.a060150

    authors: Vignati G,Mauri L,Lunati M,Gasparini M,Figini A

    更新日期:1992-02-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059904

    authors: Di Biase M,Tritto M,Sabato G,Pitzalis MV,Rizzon P

    更新日期:1991-03-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehl041

    authors: Elliott PM,Gimeno JR,Tomé MT,Shah J,Ward D,Thaman R,Mogensen J,McKenna WJ

    更新日期:2006-08-01 00:00:00

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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    authors: Guermonprez JL,Blin P,Peterlongo F

    更新日期:1993-07-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

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    更新日期:2012-09-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062071

    authors: Bolognesi R,Benedini G,Ferrari R,Visioli O

    更新日期:1986-04-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1093/eurheartj/10.suppl_d.29

    authors: Iliceto S,Izzi M,De Martino G,Rizzon P

    更新日期:1989-09-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2004-01-01 00:00:00

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    doi:10.1093/oxfordjournals.eurheartj.a061656

    authors: Santinelli V,Chiariello M,Condorelli M

    更新日期:1984-04-01 00:00:00

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    pub_type: 杂志文章,多中心研究,随机对照试验

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    authors: Becker RC,Bassand JP,Budaj A,Wojdyla DM,James SK,Cornel JH,French J,Held C,Horrow J,Husted S,Lopez-Sendon J,Lassila R,Mahaffey KW,Storey RF,Harrington RA,Wallentin L

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    doi:10.1093/eurheartj/9.suppl_n.65

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    更新日期:1988-12-01 00:00:00

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    pub_type: 杂志文章

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehs060

    authors: Brock M,Samillan VJ,Trenkmann M,Schwarzwald C,Ulrich S,Gay RE,Gassmann M,Ostergaard L,Gay S,Speich R,Huber LC

    更新日期:2014-12-01 00:00:00

  • Clinical update: Remaining challenges and opportunities for improvement in percutaneous transradial coronary procedures.

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    pub_type: 杂志文章,评审

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    更新日期:2012-10-01 00:00:00

  • Cardiovascular disease risk factors in relation to suicide mortality in Asia: prospective cohort study of over one million Korean men and women.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr229

    authors: Jee SH,Kivimaki M,Kang HC,Park IS,Samet JM,Batty GD

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    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa868

    authors: Zubin Maslov P,Hill JA,Lüscher TF,Narula J

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  • Personalising the decision for prolonged dual antiplatelet therapy: development, validation and potential impact of prognostic models for cardiovascular events and bleeding in myocardial infarction survivors.

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    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehw683

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    更新日期:2017-04-07 00:00:00

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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/11.suppl_f.43

    authors: Castaigne AD,Hervé C,Duval-Moulin AM,Gaillard M,Dubois-Randé JL,Lellouche D

    更新日期:1990-08-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehl117

    authors: Ripa RS,Wang Y,Jørgensen E,Johnsen HE,Hesse B,Kastrup J

    更新日期:2006-08-01 00:00:00

  • Left ventricular systolic function assessment in secondary mitral regurgitation: left ventricular ejection fraction vs. speckle tracking global longitudinal strain.

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    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehv680

    authors: Kamperidis V,Marsan NA,Delgado V,Bax JJ

    更新日期:2016-03-07 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/18.suppl_d.117

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    更新日期:1997-06-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.6.751

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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    authors: Klootwijk P,Lenderink T,Meij S,Boersma H,Melkert R,Umans VA,Stibbe J,Müller EJ,Poortermans KJ,Deckers JW,Simoons ML

    更新日期:1999-08-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/eurheartj/12.12.1266

    authors: James MA,Papouchado M,Jones JV

    更新日期:1991-12-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehw270

    authors: Daubert C,Behar N,Martins RP,Mabo P,Leclercq C

    更新日期:2017-05-14 00:00:00

  • Adenosine technetium-99m sestamibi (SPECT) for the early assessment of jeopardized myocardium after acute myocardial infarction.

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    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061074

    authors: Claeys MJ,Vrints CJ,Krug B,Bosmans JM,Blockx PP,Bossaert LL,Snoeck JP

    更新日期:1995-09-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehy481

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    更新日期:2018-10-07 00:00:00

  • The European Study of Epidemiology and Treatment of Cardiac Inflammatory Disease (ESETCID).

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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/16.suppl_o.173

    authors: Maisch B,Hufnagel G,Schönian U,Hengstenberg C

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