Resting and exertional haemodynamic effects of buccal nitroglycerin: acute and chronic discontinuous treatment in post-myocardial infarction patients with heart failure.

Abstract:

:The resting and exertional haemodynamic effects of acute and chronic discontinuous (one tablet every 6 h) treatment with 5 mg of buccal nitroglycerin (BN) have been assessed in nine postinfarction heart failure patients. At rest, pulmonary artery (PAP), pulmonary wedge (PWP), and right atrial pressures (RAP) were reduced by 42%, 55% and 77%, respectively, after the first dose and by 26%, 32% and 45%, respectively, after the chronic (three weeks) treatment with BN. During exercise, at the same workload, PAP, PWP and RAP were significantly reduced by 44%, 54% and 62%, respectively, after acute treatment and by 28%, 34% and 44%, respectively, after chronic treatment. The maximal workload (Kgm) increased by 179% and 166% and the exercise time increased by 78% and 71% after acute and chronic therapy, respectively. At the maximal workload, after acute BN, overall haemodynamics were better than in the basal state. PAP, PWP and RAP were still reduced by 19%, 31% and 31%, respectively, after acute treatment, while after chronic phase the results did not differ from control. The severity of cardiac failure, according to the Weber classification, was reduced by acute and chronic therapy. We can conclude that the buccal nitroglycerin showed clear efficacy in improving overall haemodynamic parameters both at rest and during exercise in post-myocardial infarction patients with heart failure. The discontinuous treatment maintained the effect of nitroglycerin without clear evidence of tolerance during chronic therapy.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Opasich C,Riccardi G,Febo O,Tramarin R,Lepore AM,Luca C,Cobelli F,Specchia G

doi

10.1093/oxfordjournals.eurheartj.a062493

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

252-8

issue

3

eissn

0195-668X

issn

1522-9645

journal_volume

9

pub_type

杂志文章
  • Effect of fish oil on ventricular tachyarrhythmia in three studies in patients with implantable cardioverter defibrillators.

    abstract:AIMS:To determine the effects of omega-3 polyunsaturated fatty acids (omega-3 PUFAs) from fish on the incidence of recurrent ventricular arrhythmia in implantable cardioverter defibrillator (ICD) patients by combining results from published trials. METHODS AND RESULTS:We searched in the Medline, EMBASE, and Cochrane d...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/eurheartj/ehp003

    authors: Brouwer IA,Raitt MH,Dullemeijer C,Kraemer DF,Zock PL,Morris C,Katan MB,Connor WE,Camm JA,Schouten EG,McAnulty J

    更新日期:2009-04-01 00:00:00

  • Importance of functional food compounds in cardioprotection through action on the epigenome.

    abstract::Food constituents can either promote cardiovascular health or serve in its demise. In view of the lack of more effective pharmacological interventions in cardiovascular disease (CVDs), attention has focused on the potential protective effects of diet. Food components and their metabolites are emerging as major regulat...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehy597

    authors: Lionetti V,Tuana BS,Casieri V,Parikh M,Pierce GN

    更新日期:2019-02-14 00:00:00

  • Hypertrophy or hyperplasia in cardiac muscle. Post-mortem human morphometric study.

    abstract::In 103 hearts with various forms of cardiac muscle hypertrophy the following parameters were estimated: diameter, length, volume, density and number of myocytes, and density of myocyte nuclei. The values of all histometric parameters correlated well with left ventricular (LV) weight up to 350 g. In heavier hearts thes...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.1.40

    authors: Grajek S,Lesiak M,Pyda M,Zajac M,Paradowski S,Kaczmarek E

    更新日期:1993-01-01 00:00:00

  • Temporal trends of the gaps in post-myocardial infarction secondary prevention strategies of co-morbid and elderly populations vs. younger counterparts: an analysis of three successive cohorts between 2003 and 2008.

    abstract::Aims Epidemiological studies reported two contrasting trends: on one hand, a significant improvement in the use of evidence-based treatments of patients discharged with a myocardial infarction (MI). On the other hand, the increasing number of elderly and co-morbid patients who are usually less treated. The aim of this...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr410

    authors: Macchia A,Romero M,D'Ettorre A,Mariani J,Tognoni G

    更新日期:2012-02-01 00:00:00

  • Use of abciximab in interventional cardiology.

    abstract::The advent of platelet membrane glycoprotein (GP) IIb/IIIa inhibitors has changed the landscape of interventional cardiology. Given the commercial availability of abciximab and expected regulatory approvals for other receptor blockers, defining appropriate use of these agents in the interventional setting is mandated....

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

    authors: Chronos N,Vahanian A,Betriu A,Emanuelsson H,Goldberg S,Gulba D,van Hout BA

    更新日期:1998-04-01 00:00:00

  • The Journal of Interventional Cardiology.

    abstract::In a small field with an abundance of journals, the Journal of Interventional Cardiology is carving out its niche with articles about technologies on the horizon. ...

    journal_title:European heart journal

    pub_type: 新闻

    doi:

    authors: Taylor J

    更新日期:2012-07-01 00:00:00

  • Association between baseline neutrophil count, clopidogrel therapy, and clinical and angiographic outcomes in patients with ST-elevation myocardial infarction receiving fibrinolytic therapy.

    abstract:AIMS:To investigate the association between neutrophil count, outcomes, and benefit of clopidogrel therapy in ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS:Baseline neutrophil count was measured in 2865 patients in CLARITY-TIMI 28, a randomized trial of clopidogrel vs. placebo in STEMI patients under...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehn112

    authors: O'Donoghue M,Morrow DA,Cannon CP,Guo W,Murphy SA,Gibson CM,Sabatine MS

    更新日期:2008-04-01 00:00:00

  • Thrombolytic therapy in Europe: current status.

    abstract::Thrombolytic therapy is a practical, effective approach to the management of acute myocardial infarction that is widely used in Europe today. Early European trials demonstrated a clear reduction in mortality in patients who received thrombolytic therapy compared with those given conventional treatment. The findings of...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/17.suppl_e.21

    authors: Vahanian A

    更新日期:1996-09-01 00:00:00

  • Role of programmed ventricular stimulation in patients with Brugada syndrome: a meta-analysis of worldwide published data.

    abstract:AIMS:Brugada syndrome (BS) is an ion channelopathy with the risk of sudden cardiac death. The role of programmed ventricular stimulation (PVS) in risk stratification has been controversially discussed. Therefore, we performed a meta-analysis on the prognostic role of PVS in BS. METHODS AND RESULTS:A Medline search unt...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/eurheartj/ehm116

    authors: Paul M,Gerss J,Schulze-Bahr E,Wichter T,Vahlhaus C,Wilde AA,Breithardt G,Eckardt L

    更新日期:2007-09-01 00:00:00

  • The impact of 'Shahal' (a new cardiac emergency service) on subscribers' requests for medical assistance: characteristics and distribution of calls.

    abstract::The objectives of this study were to assess the impact of the new 'Shahal' (pre-hospital cardiac service) on subscribers' 'decision time'. A professional 24-h mobile emergency cardiac service has been set up, monitored by intensive care nurses via a central computerized operation unit. All subscribers carry a cardiobe...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/16.1.129

    authors: Roth A,Herling M,Vishlitzki V

    更新日期:1995-01-01 00:00:00

  • A practical risk score for early prediction of neurological outcome after out-of-hospital cardiac arrest: MIRACLE2.

    abstract:AIMS:The purpose of this study was to develop a practical risk score to predict poor neurological outcome after out-of-hospital cardiac arrest (OOHCA) for use on arrival to a Heart Attack Centre. METHODS AND RESULTS:From May 2012 to December 2017, 1055 patients had OOHCA in our region, of whom 373 patients were includ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa570

    authors: Pareek N,Kordis P,Beckley-Hoelscher N,Pimenta D,Kocjancic ST,Jazbec A,Nevett J,Fothergill R,Kalra S,Lockie T,Shah AM,Byrne J,Noc M,MacCarthy P

    更新日期:2020-12-14 00:00:00

  • Fatalities from myocardial infarction in Nordic countries and Lithuania. The MONICA Investigators.

    abstract:AIM:To investigate fatalities from myocardial infarction at 28 days and one-year among patients aged 35-64 years in the Nordic and Lithuanian centres participating in the World Health Organization MONICA (Monitoring of Trends and Determinants of Cardiovascular Disease) Project. METHODS AND RESULTS:Altogether 9100 myoc...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015124

    authors: Salomaa VV,Lundberg V,Agnarsson U,Radisauskas R,Kirchhoff M,Wilhelmsen L

    更新日期:1997-01-01 00:00:00

  • Haemodynamic effects of frusemide and its influence on repetitive rapid volume loading in acute myocardial infarction.

    abstract::The haemodynamic effects of intravenous frusemide (1 mg/kg) were studied in 22 male patients with left ventricular failure following acute myocardial infarction. Radiographic pulmonary oedema was present in all patients and their average left heart filling pressure was 20 mmHg. Bolus injection of the drug was followed...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061382

    authors: Nelson GI,Ahuja RC,Silke B,Okoli RC,Hussain M,Taylor SH

    更新日期:1983-10-01 00:00:00

  • The value of exercise-induced U-wave inversion on ECG chest wall mapping in the identification of individual coronary arterial lesions.

    abstract::Exercise-induced U-wave inversion on chest wall mapping was compared with coronary arteriographic findings in 160 consecutive patients who presented with chest pain suggestive of ischaemic heart disease. ECG recordings were made from 16 points on the chest wall before, during and after exercise. None of the 27 patient...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061883

    authors: Salmasi AM,Salmasi SN,Nicolaides AN,Vecht RJ,Hendry WG,Kidner PH,Besterman EM

    更新日期:1985-05-01 00:00:00

  • Patient differences related to management in general practice and the hospital: a cross-sectional study of heart failure in the community.

    abstract:AIM:To compare patients treated for heart failure in relation to the management in general practices versus hospital admission. METHODS AND RESULTS:Twelve randomly selected general practices (GP) were screened for patients receiving ACE-inhibitor, digoxin, or loop diuretic treatment. The first 500 volunteers of 959 po...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ehj.2004.06.033

    authors: Nielsen OW,McDonagh T,Cowburn P,Blue L,Robb SD,Dargie H

    更新日期:2004-10-01 00:00:00

  • Alcohol consumption, sinus tachycardia, and cardiac arrhythmias at the Munich Octoberfest: results from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW).

    abstract:Aims:Alcohol is a risk factor for cardiac arrhythmias. Retrospective analyses suggest supraventricular arrhythmias consecutive to acute alcohol consumption, but prospective data are limited. We intended to prospectively associate acute alcohol consumption with cardiac arrhythmias. Methods and results:At the 2015 Munic...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehx156

    authors: Brunner S,Herbel R,Drobesch C,Peters A,Massberg S,Kääb S,Sinner MF

    更新日期:2017-07-14 00:00:00

  • New electrocardiographic leads and the procainamide test for the detection of the Brugada sign in sudden unexplained death syndrome survivors and their relatives.

    abstract:AIMS:Sudden unexplained death syndrome occurs in previously healthy South-east Asian young adults without any structural cause of death. The common electrocardiographic (ECG) change in sudden unexplained death syndrome survivors is right bundle branch block and ST elevations in leads V(1) to V(3), which are similar to ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2001.2691

    authors: Sangwatanaroj S,Prechawat S,Sunsaneewitayakul B,Sitthisook S,Tosukhowong P,Tungsanga K

    更新日期:2001-12-01 00:00:00

  • Prevalence and prognostic significance of cardiac arrhythmias detected by ambulatory electrocardiography in subjects 85 years of age.

    abstract::24 hour ambulatory electrocardiography was performed in a representative group of people born in 1897. Out of 73 people included in the study, 22 were without known heart disease, 15 had definite ischaemic heart disease (IHD) and 36 symptoms of possible cardiac origin. An R-R interval in excess of 2000 ms was seen in ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062107

    authors: Ingerslev J,Bjerregaard P

    更新日期:1986-07-01 00:00:00

  • Intravenous streptokinase in acute myocardial infarction (I.S.A.M.): assessment of left ventricular function 1 and 7 months after infarction by radionuclide ventriculography.

    abstract::I.S.A.M. was a prospective, placebo-controlled, double-blind multicentre trial of high-dose short-term intravenous streptokinase in acute myocardial infarction (AMI) within 6 h of the onset of symptoms. Determination of left ventricular ejection fraction (LVEF) by radionuclide ventriculography was performed 1 and 7 mo...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/oxfordjournals.eurheartj.a059610

    authors: Voth E,Tebbe U,Schicha H,Neumann P,Schröder R,Neuhaus KL,Emrich D

    更新日期:1990-10-01 00:00:00

  • Treatment and outcomes of patients with evolving myocardial infarction: experiences from the SYNERGY trial.

    abstract:AIMS:Patients with myocardial infarction (MI) presenting immediately after symptom onset may be treated less aggressively due to their non-elevated troponin status. We compared the initial treatment and clinical outcomes of patients presenting with evolving MI (EMI) with those presenting with MI. METHODS AND RESULTS:T...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehm016

    authors: Miller CD,Banerjee A,Mahaffey KW,Kontos MC,Fermann G,Pollack CV Jr,Antman E,Aylward P,Goodman SG,Santos R,Ferguson JJ,Califf RM,Hoekstra JW

    更新日期:2007-05-01 00:00:00

  • Evaluation of recombinant hirudin (CGP 39,393/TMREVASC) in the prevention of restenosis after percutaneous transluminal coronary angioplasty. Rationale and design of the HELVETICA trial, a multicentre randomized double blind heparin controlled study.

    abstract::One of the main areas of interest in interventional cardiology is the understanding, and ultimate prevention of restenosis after an initially successful percutaneous transluminal coronary angioplasty. Restenosis is the recurrence of luminal narrowing following angioplasty, and still frustrates the late results in the ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验,评审

    doi:10.1093/eurheartj/16.suppl_l.56

    authors: Herrman JP,Simon R,Umans VA,Peerboom PF,Keane D,Rijnierse JJ,Bach D,Kobi P,Kerry R,Close P

    更新日期:1995-11-01 00:00:00

  • Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation.

    abstract:AIMS:Transplant-associated coronary artery disease (TxCAD) is a major cause of post-transplant graft failure. The aim of this study was to investigate a possible role of mannose-binding lectin (MBL) deficiency and complement activation in TxCAD. METHODS AND RESULTS:In a prospective study of heart transplant recipients...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehi198

    authors: Fiane AE,Ueland T,Simonsen S,Scott H,Endresen K,Gullestad L,Geiran OR,Haraldsen G,Heggelund L,Andreassen AK,Wergeland R,Frøland S,Aukrust P,Mollnes TE

    更新日期:2005-08-01 00:00:00

  • Alterations in multidirectional myocardial functions in patients with aortic stenosis and preserved ejection fraction: a two-dimensional speckle tracking analysis.

    abstract:AIMS:To identify changes in multidirectional strain and strain rate (SR) in patients with aortic stenosis (AS). METHODS AND RESULTS:A total of 420 patients (age 66.1 ± 14.5 years, 60.7% men) with aortic sclerosis, mild, moderate, and severe AS with preserved left ventricular (LV) ejection fraction [(EF), ≥50%] were in...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr084

    authors: Ng AC,Delgado V,Bertini M,Antoni ML,van Bommel RJ,van Rijnsoever EP,van der Kley F,Ewe SH,Witkowski T,Auger D,Nucifora G,Schuijf JD,Poldermans D,Leung DY,Schalij MJ,Bax JJ

    更新日期:2011-06-01 00:00:00

  • NT-proBNP has a high negative predictive value to rule-out short-term cardiovascular events in patients with diabetes mellitus.

    abstract:AIMS:This study evaluated the predictive value of NT-proBNP for patients with diabetes mellitus and compared the prognostic aptitude of this neurohumoral marker to traditional markers of cardiovascular events. METHODS AND RESULTS:A prospective observational study was conducted in 631 diabetic patients. The composite e...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehn334

    authors: Huelsmann M,Neuhold S,Strunk G,Moertl D,Berger R,Prager R,Abrahamian H,Riedl M,Pacher R,Luger A,Clodi M

    更新日期:2008-09-01 00:00:00

  • Variable response to atrial pacing after intravenous propranolol in patients with stable exertional angina.

    abstract::The effect of propranolol administration on regional coronary haemodynamics were investigated in 14 patients with stable exertional angina and isolated left anterior descending artery disease. Thermodilution was used to measure great cardiac vein flow (GCVF) and anterior regional coronary resistance (ARCR) under contr...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059640

    authors: De Servi S,Ferrario M,Ghio S,Cioffi P,Angoli L,Bramucci E,Aimè E,Montericcio V,Specchia G

    更新日期:1990-11-01 00:00:00

  • Another step on the road to a European Council for Health Research.

    abstract::The Alliance for Biomedical Research in Europe, co-founded by the European Society of Cardiology, has persuaded the European Parliament to move towards European Union-wide means of better directing and coordinating biomedical research, from the laboratory bench to the marketplace. ...

    journal_title:European heart journal

    pub_type: 新闻

    doi:

    authors: Shurlock B

    更新日期:2014-04-01 00:00:00

  • Relationship of arterial stiffness and early mild diastolic heart failure in general middle and aged population.

    abstract:AIMS:The brachial-ankle pulse wave velocity (baPWV) has been recognized as a marker that reflects arterial stiffness. We conducted an investigation to evaluate whether baPWV is independently associated with early mild diastolic heart failure (DHF) in a general middle and aged population. METHODS AND RESULTS:From 1 Jul...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq296

    authors: Kang S,Fan HM,Li J,Fan LY,Miao AY,Bao Y,Wu LZ,Zhu Y,Zhang DF,Liu ZM

    更新日期:2010-11-01 00:00:00

  • Prognostic significance of infarct core pathology revealed by quantitative non-contrast in comparison with contrast cardiac magnetic resonance imaging in reperfused ST-elevation myocardial infarction survivors.

    abstract:AIMS:To assess the prognostic significance of infarct core tissue characteristics using cardiac magnetic resonance (CMR) imaging in survivors of acute ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS:We performed an observational prospective single centre cohort study in 300 reperfused STEMI patients (m...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehv372

    authors: Carrick D,Haig C,Rauhalammi S,Ahmed N,Mordi I,McEntegart M,Petrie MC,Eteiba H,Hood S,Watkins S,Lindsay M,Mahrous A,Ford I,Tzemos N,Sattar N,Welsh P,Radjenovic A,Oldroyd KG,Berry C

    更新日期:2016-04-01 00:00:00

  • Time-to-treatment significantly affects the extent of ST-segment resolution and myocardial blush in patients with acute myocardial infarction treated by primary angioplasty.

    abstract:AIMS:The prognostic role of time-to-treatment in primary angioplasty is still a matter of debate. The aim of our study was to evaluate the relationship between time-to-treatment and myocardial perfusion in patients with ST-segment-elevation myocardial infarction (STEMI) treated by primary angioplasty. METHODS AND RESU...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ehj.2004.03.021

    authors: De Luca G,van 't Hof AW,de Boer MJ,Ottervanger JP,Hoorntje JC,Gosselink AT,Dambrink JH,Zijlstra F,Suryapranata H

    更新日期:2004-06-01 00:00:00

  • Spectral mapping of the electrocardiogram with Fourier transform for identification of patients with sustained ventricular tachycardia and coronary artery disease.

    abstract::In time domain analysis, detection of late potentials is limited by high pass filtering, noise interference and the necessity to exclude patients with bundle branch block. We therefore used frequency analysis with Fourier transform of multiple segments of the surface electrocardiogram (25 segments, size 80 ms, time sh...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059488

    authors: Haberl R,Jilge G,Pulter R,Steinbeck G

    更新日期:1989-04-01 00:00:00