Importance of functional food compounds in cardioprotection through action on the epigenome.

Abstract:

:Food constituents can either promote cardiovascular health or serve in its demise. In view of the lack of more effective pharmacological interventions in cardiovascular disease (CVDs), attention has focused on the potential protective effects of diet. Food components and their metabolites are emerging as major regulators of the human epigenome, which is being linked to CVDs. In this review, we summarize data from studies that suggest an important role for bioactive food compounds in cardioprotection and the potential for harnessing the epigenome as a nutrient sensor target in CVDs. While clinical data strongly support a role for effective diet intervention in CVDs protection, studies linking changes to human epigenome are now warranted for mechanistic insight and development of personalized care.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Lionetti V,Tuana BS,Casieri V,Parikh M,Pierce GN

doi

10.1093/eurheartj/ehy597

subject

Has Abstract

pub_date

2019-02-14 00:00:00

pages

575-582

issue

7

eissn

0195-668X

issn

1522-9645

pii

5133009

journal_volume

40

pub_type

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