Hypertrophy or hyperplasia in cardiac muscle. Post-mortem human morphometric study.

abstract：AIMS:Dysregulation of the bone morphogenetic protein receptor type 2 (BMPR2) is a hallmark feature that has been described in several forms of pulmonary hypertension. We recently identified the microRNA miR-20a within a highly conserved pathway as a regulator of the expression of BMPR2. To address the pathophysiologica...

journal_title：European heart journal

authors： Brock M,Samillan VJ,Trenkmann M,Schwarzwald C,Ulrich S,Gay RE,Gassmann M,Ostergaard L,Gay S,Speich R,Huber LC

更新日期：2014-12-01 00:00:00

abstract：AIMS:Cardiac dyssynchrony is common in patients with heart failure, whether or not they have ischaemic heart disease (IHD). The effect of the underlying cause of cardiac dysfunction on the response to cardiac resynchronization therapy (CRT) is unknown. This issue was addressed using data from the CARE-HF trial. METHOD...

journal_title：European heart journal

authors： Wikstrom G,Blomström-Lundqvist C,Andren B,Lönnerholm S,Blomström P,Freemantle N,Remp T,Cleland JG,CARE-HF study investigators.

更新日期：2009-04-01 00:00:00

abstract：Aims:Congenital heart defects (CHD) affect almost 1% of all live born children and the number of adults with CHD is increasing. In families where CHD has occurred previously, estimates of recurrence risk, and the type of recurring malformation are important for counselling and clinical decision-making, but the recurren...

journal_title：European heart journal

authors： Ellesøe SG,Workman CT,Bouvagnet P,Loffredo CA,McBride KL,Hinton RB,van Engelen K,Gertsen EC,Mulder BJM,Postma AV,Anderson RH,Hjortdal VE,Brunak S,Larsen LA

更新日期：2018-03-21 00:00:00

abstract：:The structural properties of cardiac isomyosins from several species were compared using native gel electrophoresis, analysis of proteolytic digests, analysis of monoclonal antibody reactivity to specific proteolytic fragments on electroblots and S1 nuclease mapping with cDNA probes. The structure of specific regions ...

journal_title：European heart journal

authors： Clark WA,Everett AW,Chizzonite RA,Eisenberg BR,Zak R

更新日期：1984-12-01 00:00:00

abstract：:The safety of calcium antagonists has recently become a controversial issue among cardiologists. Thus, the role of calcium antagonists in the treatment of myocardial infarction and in secondary cardiovascular prevention is under review. As a consequence, the concept that the words 'calcium antagonists' comprise variou...

journal_title：European heart journal

authors： Ferrari R

更新日期：1997-01-01 00:00:00

abstract：:The class III antiarrhythmic drug dofetilide is known to prolong action potential duration by specific blockade of the delayed rectifier potassium channel Ik. As dofetilide is likely to be used in the treatment of atrial arrhythmias it is important to determine the relative sensitivity of the atrium and ventricle in m...

journal_title：European heart journal

authors： Sedgwick ML,Dalrymple I,Rae AP,Cobbe SM

更新日期：1995-11-01 00:00:00

abstract：:Randomized clinical trials (RCTs) are the definitive contributors to evidence-based medicine. RCTs assessing serious outcomes in cardiovascular disease have grown, with 'megatrials' becoming more common with the realization that wrong conclusions resulted from random error in inadequately sized trials. Simple design a...

journal_title：European heart journal

authors： Hilbrich L,Sleight P

更新日期：2006-09-01 00:00:00

abstract：:The haemodynamic effects of intravenous frusemide (1 mg/kg) were studied in 22 male patients with left ventricular failure following acute myocardial infarction. Radiographic pulmonary oedema was present in all patients and their average left heart filling pressure was 20 mmHg. Bolus injection of the drug was followed...

journal_title：European heart journal

authors： Nelson GI,Ahuja RC,Silke B,Okoli RC,Hussain M,Taylor SH

更新日期：1983-10-01 00:00:00

abstract：AIMS:Coronary artery dissections are common findings following percutaneous transluminal coronary angioplasty and occur with an incidence of approximately 20% to 40%. The purpose of this study was to evaluate the impact of intravascular ultrasound for the prediction of severe dissections by pre-interventional analysis ...

journal_title：European heart journal

authors： Athanasiadis A,Haase KK,Wullen B,Treusch AW,Mahrholdt H,Voelker W,Baumbach A,Oberhoff M,Karsch KR

更新日期：1998-06-01 00:00:00

abstract：:Orally active angiotensin converting enzyme (ACE) inhibitors have been successfully used in the treatment of congestive heart failure and hypertension. However, adverse skin reactions, such as angioneurotic oedema have been reported following such medication. Furthermore, these drugs have been associated with a persis...

journal_title：European heart journal

authors： Andersson RG,Persson K

更新日期：1994-08-01 00:00:00

abstract：:Several targets for heart failure therapy may be met through different mechanisms which are not necessarily associated. In the Australia/New Zealand Heart Failure Research Collaborative Group Study, patients with chronic stable heart failure of ischaemic aetiology on treatment including ACE inhibitors were randomized ...

journal_title：European heart journal

authors： Sharpe N,Doughty RN

更新日期：1998-02-01 00:00:00

abstract：AIMS:In animal models of obesity and diabetes mellitus, myocardial TG accumulation is associated with decreased myocardial function. In the physiologically ageing heart, myocardial triglyceride (TG) accumulation may also occur due to reduced myocardial fatty acid oxidation. The role of myocardial TG in the ageing human...

journal_title：European heart journal

authors： van der Meer RW,Rijzewijk LJ,Diamant M,Hammer S,Schär M,Bax JJ,Smit JW,Romijn JA,de Roos A,Lamb HJ

更新日期：2008-06-01 00:00:00

abstract：:This study was undertaken to assess the effects of hypothermia and chemical cardioplegia on the functional recovery of hypertrophied non-failing rat hearts subjected to an extended period of global ischaemia. Left ventricular hypertrophy was produced by constriction of the abdominal aorta. Hearts were studied an avera...

journal_title：European heart journal

authors： Grousset C,Menasche P,Apstein CS,Mouas C,Marotte F,Piwnica A

更新日期：1984-12-01 00:00:00

abstract：:In this study, the acute haemodynamic effects of angiotensin converting enzyme (ACE) inhibition with intravenous enalaprilat alone or in combination with preload restoration were determined in patients with severe heart failure complicating acute myocardial infarction. Ten patients with raised pulmonary arterial wedge...

journal_title：European heart journal

authors： Tohmo H,Karanko M,Korpilahti K

更新日期：1994-04-01 00:00:00

abstract：:Cardiac hypertrophy was induced in rats either by isoprenaline treatment or by experimental abdominal aortic stenosis. In both models, the UTP content increased in the hypertrophying heart, while the ATP level remained depressed. The rate of net synthesis of uracil nucleotides, estimated by phosphate incorporation int...

journal_title：European heart journal

authors： Rossi A,Aussedat J,Olivarès J,Ray A,Verdys M

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:Stent thrombosis (ST) is a rare but serious complication following percutaneous coronary intervention. Analysis of thrombus composition from patients undergoing catheter thrombectomy may provide important insights into the pathological processes leading to thrombus formation. We performed a large-scale multi...

journal_title：European heart journal

authors： Riegger J,Byrne RA,Joner M,Chandraratne S,Gershlick AH,Ten Berg JM,Adriaenssens T,Guagliumi G,Godschalk TC,Neumann FJ,Trenk D,Feldman LJ,Steg PG,Desmet W,Alfonso F,Goodall AH,Wojdyla R,Dudek D,Philippi V,Opinaldo S

更新日期：2016-05-14 00:00:00

abstract：:Tricuspid regurgitation (TR) is the most common lesion of the tricuspid valve (TV). Mild TR is common and usually is benign. However, moderate or severe TR can lead to irreversible myocardial damage and adverse outcomes. Despite these findings, few patients with significant TR undergo surgery. The treatment of functio...

journal_title：European heart journal

authors： Arsalan M,Walther T,Smith RL 2nd,Grayburn PA

更新日期：2017-03-01 00:00:00

abstract：AIMS:To document tracking patterns, if any, over time, of classical cardiovascular risk factors in men and women participants in the Vorarlberg Health Monitoring and Promotion Programme (VHM&PP) METHODS AND RESULTS: 67,413 men and 82,237 women underwent a total of 45,4448 standardised examinations in the 15 year period...

journal_title：European heart journal

authors： Ulmer H,Kelleher C,Diem G,Concin H

更新日期：2003-06-01 00:00:00

abstract：:The scientific assessment of diagnostic tests should not be based upon a small series of results published by the best academic institutions, but ought to require large scale, multicentre validation founded on grass roots institutions with real doctors, real patients and real problems. To this purpose, an internationa...

journal_title：European heart journal

authors： Picano E,Sicari R,Landi P,Raciti M,Pingitore A,Vassalle C,Mathias W Jr,Lowenstein J,Petix N,Gigli G

更新日期：1995-10-01 00:00:00

abstract：AIMS:The vast majority of acute heart failure (AHF) trials to date have targeted dyspnoea. However, they enrolled patients relatively late and did not standardize their methods of dyspnoea measurement. URGENT Dyspnoea was designed to determine changes in dyspnoea in response to initial, standard therapy in patients pre...

journal_title：European heart journal

authors： Mebazaa A,Pang PS,Tavares M,Collins SP,Storrow AB,Laribi S,Andre S,Mark Courtney D,Hasa J,Spinar J,Masip J,Frank Peacock W,Sliwa K,Gayat E,Filippatos G,Cleland JG,Gheorghiade M

更新日期：2010-04-01 00:00:00

abstract：AIMS:Midwall myocardial fibrosis on cardiovascular magnetic resonance (CMR) is a marker of early ventricular decompensation and adverse outcomes in aortic stenosis (AS). We aimed to develop and validate a novel clinical score using variables associated with midwall fibrosis. METHODS AND RESULTS:One hundred forty-seven...

journal_title：European heart journal

authors： Chin CW,Messika-Zeitoun D,Shah AS,Lefevre G,Bailleul S,Yeung EN,Koo M,Mirsadraee S,Mathieu T,Semple SI,Mills NL,Vahanian A,Newby DE,Dweck MR

更新日期：2016-02-21 00:00:00

abstract：:The early termination of clinical trials, for either benefit or harm, often generates undue enthusiasm or alarm. The enhanced publicity attending early termination of a trial promotes inappropriate interpretations because of the inherent difficulty of a prompt and comprehensive data review. Furthermore, the process of...

journal_title：European heart journal

authors：

更新日期：1994-06-01 00:00:00

abstract：AIM:Cardiosphere-derived cells (CDCs) produce regenerative effects in the post-infarct setting. However, it is unclear whether CDCs are beneficial in non-ischaemic dilated cardiomyopathy (DCM). We tested the effects of CDC transplantation in mice with cardiac-specific Gαq overexpression, which predictably develop progr...

journal_title：European heart journal

authors： Aminzadeh MA,Tseliou E,Sun B,Cheng K,Malliaras K,Makkar RR,Marbán E

更新日期：2015-03-21 00:00:00

abstract：:Congestive heart failure is the most common cause of death in young adults with thalassaemia major. In the present study we compared atrial natriuretic peptide levels (ANP) in 30 asymptomatic patients with thalassaemia major (aged 16.6 +/- 6.4 years), normal left ventricular diastolic cavity dimension and systolic fun...

journal_title：European heart journal

authors： Derchi G,Bellone P,Forni GL,Lupi G,Jappelli S,Randazzo M,Zino V,Vecchio C

更新日期：1992-10-01 00:00:00

abstract：:Cardiac beta-adrenoceptor density and subtype distribution has been determined in different kinds of heart failure. A decrease in cardiac beta-adrenoceptor function appears to be a general phenomenon in all kinds of heart failure. However, cardiac beta 1- and beta 2-adrenoceptors seem to be differentially affected in ...

journal_title：European heart journal

authors： Brodde OE,Zerkowski HR,Borst HG,Maier W,Michel MC

更新日期：1989-06-01 00:00:00

abstract：AIMS:We aimed to assess the increased risk of death and severe vascular events in elderly individuals with subclinical or manifest peripheral arterial disease (PAD), evidenced by low ankle brachial index (ABI < 0.9) in primary care. METHODS AND RESULTS:In this monitored prospective observational study, 6880 representa...

journal_title：European heart journal

authors： Diehm C,Lange S,Darius H,Pittrow D,von Stritzky B,Tepohl G,Haberl RL,Allenberg JR,Dasch B,Trampisch HJ

更新日期：2006-07-01 00:00:00

abstract：:AIMS More intense platelet-directed therapy for acute coronary syndrome (ACS) may increase bleeding risk. The aim of the current analysis was to determine the rate, clinical impact, and predictors of major and fatal bleeding complications in the PLATO study. METHODS AND RESULTS PLATO was a randomized, double-blind, ac...

journal_title：European heart journal

authors： Becker RC,Bassand JP,Budaj A,Wojdyla DM,James SK,Cornel JH,French J,Held C,Horrow J,Husted S,Lopez-Sendon J,Lassila R,Mahaffey KW,Storey RF,Harrington RA,Wallentin L

更新日期：2011-12-01 00:00:00

abstract：:We studied the effects of a chronic increase in flow and of chronic hypertension on regional pulmonary blood volume and extravascular lung density (lung tissue and interstitial water per unit thoracic volume) in one group of patients with intracardiac, left-to-right shunt and in another group with Eisenmenger's syndro...

journal_title：European heart journal

authors： Wollmer P,Rozkovec A,Rhodes CG,Allan RM,Maseri A

更新日期：1984-11-01 00:00:00

abstract：AIMS:To evaluate clinical disease expression, non-invasive diagnosis, and prognosis in families with dominant vs. recessive arrhythmogenic right ventricular cardiomyopathy (ARVC) due to mutations in related desmosomal proteins plakophilin-2 (PKP2) and plakoglobin (JUP), respectively. METHODS AND RESULTS:One hundred an...

journal_title：European heart journal

authors： Antoniades L,Tsatsopoulou A,Anastasakis A,Syrris P,Asimaki A,Panagiotakos D,Zambartas C,Stefanadis C,McKenna WJ,Protonotarios N

更新日期：2006-09-01 00:00:00

abstract：AIMS:Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a key regulator of extracellular matrix degradation. We examined relations of plasma total TIMP-1 to cardiovascular risk factors and echocardiographic left ventricular (LV) structure and function in a community-based sample. METHODS AND RESULTS:We studied 1069 ...

journal_title：European heart journal

authors： Sundström J,Evans JC,Benjamin EJ,Levy D,Larson MG,Sawyer DB,Siwik DA,Colucci WS,Wilson PW,Vasan RS

更新日期：2004-09-01 00:00:00