ACE inhibitors and their influence on inflammation, bronchial reactivity and cough.


:Orally active angiotensin converting enzyme (ACE) inhibitors have been successfully used in the treatment of congestive heart failure and hypertension. However, adverse skin reactions, such as angioneurotic oedema have been reported following such medication. Furthermore, these drugs have been associated with a persistent dry cough in subjects without previous known bronchial hyper-reactivity. There is reason to believe that an ACE inhibitor-induced cough is due to an irritant inflammatory state in the airways of susceptible individuals and that this might have pathophysiological features in common with the cough seen as an early symptom of asthma. All inflammatory responses--wheal and flare reactions, airway reactivity, and infiltration by neutrophils and eosinophils--were enhanced by ACE inhibitors in a dose-dependent manner. Other ACE inhibitors might have different proinflammatory profiles.


Eur Heart J


European heart journal


Andersson RG,Persson K




Has Abstract


1994-08-01 00:00:00








15 Suppl C


  • Myocardial beta-adrenoceptor down-regulation early after infarction is associated with long-term incidence of congestive heart failure.

    abstract:AIMS:Adverse left ventricular (LV) remodelling after myocardial infarction (MI) frequently leads to congestive heart failure (CHF). We have previously shown that myocardial beta-adrenoceptor density (beta-ARD) is reduced soon after acute MI and correlates with LV dilatation in the short term. The aim of the present stu...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Gaemperli O,Liga R,Spyrou N,Rosen SD,Foale R,Kooner JS,Rimoldi OE,Camici PG

    更新日期:2010-07-01 00:00:00

  • Classification and characterization of cardiac isomyosins.

    abstract::The structural properties of cardiac isomyosins from several species were compared using native gel electrophoresis, analysis of proteolytic digests, analysis of monoclonal antibody reactivity to specific proteolytic fragments on electroblots and S1 nuclease mapping with cDNA probes. The structure of specific regions ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Clark WA,Everett AW,Chizzonite RA,Eisenberg BR,Zak R

    更新日期:1984-12-01 00:00:00

  • Acute effects of night-time noise exposure on blood pressure in populations living near airports.

    abstract:AIMS:Within the framework of the HYENA (hypertension and exposure to noise near airports) project we investigated the effect of short-term changes of transportation or indoor noise levels on blood pressure (BP) and heart rate (HR) during night-time sleep in 140 subjects living near four major European airports. METHOD...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Haralabidis AS,Dimakopoulou K,Vigna-Taglianti F,Giampaolo M,Borgini A,Dudley ML,Pershagen G,Bluhm G,Houthuijs D,Babisch W,Velonakis M,Katsouyanni K,Jarup L,HYENA Consortium.

    更新日期:2008-03-01 00:00:00

  • International variation in invasive care of the elderly with acute coronary syndromes.

    abstract:AIMS:To explore variations in invasive care of the elderly with acute coronary syndromes across international practice. METHODS AND RESULTS:Using combined populations from the SYMPHONY and 2nd SYMPHONY trials, we describe 30-day cardiac catheterization in elderly (> or = 75 years; n = 1794) vs. younger patients (< 75 ...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Alexander KP,Newby LK,Bhapkar MV,White HD,Hochman JS,Pfisterer ME,Moliterno DJ,Peterson ED,Van de Werf F,Armstrong PW,Califf RM,Symphony and 2nd Symphony Investigators.

    更新日期:2006-07-01 00:00:00

  • Low-dose oral sotalol for monomorphic ventricular tachycardia: effects during programmed electrical stimulation and follow-up.

    abstract::The effects of oral sotalol were compared with the findings obtained in the baseline study of a group of 26 consecutive patients with sustained monomorphic ventricular tachycardia or ventricular fibrillation and inducible ventricular tachycardia. The mean age was 62 years and the mean ejection fraction 33%. The number...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Jordaens LJ,Palmer A,Clement DL

    更新日期:1989-03-01 00:00:00

  • Stent thrombosis and restenosis: what have we learned and where are we going? The Andreas Grüntzig Lecture ESC 2014.

    abstract::Modern-day stenting procedures leverage advances in pharmacotherapy and device innovation. Patients treated with contemporary antiplatelet agents, peri-procedural antithrombin therapy and new-generation drug-eluting stents (DES) have excellent outcomes over the short to medium term. Indeed, coupled with the reducing c...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Byrne RA,Joner M,Kastrati A

    更新日期:2015-12-14 00:00:00

  • Molecular determinants of myocardial hypertrophy and failure: alternative pathways for beneficial and maladaptive hypertrophy.

    abstract::The implementation of molecular biological approaches has led to the discovery of single genetic variations that contribute to the development of cardiac failure. In the present review, the characteristics that are invariably associated with the development of failure in experimental animals and clinical studies are d...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Lips DJ,deWindt LJ,van Kraaij DJ,Doevendans PA

    更新日期:2003-05-01 00:00:00

  • Ventricular rate-adaptive pacing in the elderly.

    abstract::The role of ventricular rate-adaptive pacing (VVIR) in the elderly was investigated in 12 patients with a mean age of 85 +/- 2 years (range 75-95 years) with implanted activity-initiated VVIR pacemakers. Although four patients had significant extracardiac diseases, all were capable of independent walking and self care...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lau CP,Wong CK,Tai YT,Fong PC,Li JP,Chung FL

    更新日期:1992-07-01 00:00:00

  • Personalising the decision for prolonged dual antiplatelet therapy: development, validation and potential impact of prognostic models for cardiovascular events and bleeding in myocardial infarction survivors.

    abstract:Aims:The aim of this study is to develop models to aid the decision to prolong dual antiplatelet therapy (DAPT) that requires balancing an individual patient's potential benefits and harms. Methods and results:Using population-based electronic health records (EHRs) (CALIBER, England, 2000-10), of patients evaluated 1 ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Pasea L,Chung SC,Pujades-Rodriguez M,Moayyeri A,Denaxas S,Fox KAA,Wallentin L,Pocock SJ,Timmis A,Banerjee A,Patel R,Hemingway H

    更新日期:2017-04-07 00:00:00

  • Neurohormonal and clinical sex differences in heart failure.

    abstract:AIMS:Despite disparities in pathophysiology and disease manifestation between male and female patients with heart failure, studies focusing on sex differences in biomarkers are scarce. The purpose of this study was to assess sex-specific variation in clinical characteristics and biomarker levels to gain more understand...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Meyer S,van der Meer P,van Deursen VM,Jaarsma T,van Veldhuisen DJ,van der Wal MH,Hillege HL,Voors AA

    更新日期:2013-08-01 00:00:00

  • Azimilide vs. placebo and sotalol for persistent atrial fibrillation: the A-COMET-II (Azimilide-CardiOversion MaintEnance Trial-II) trial.

    abstract:AIMS:Treatment of atrial fibrillation remains a major clinical challenge owing to the limited efficacy and safety of anti-arrhythmic drugs, particularly in patients with structural heart disease. METHODS AND RESULTS:To evaluate the efficacy of azimilide, a new class III anti-arrhythmic drug, we studied 658 patients wi...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Lombardi F,Borggrefe M,Ruzyllo W,Lüderitz B,A-COMET-II Investigators.

    更新日期:2006-09-01 00:00:00

  • Myocardial damage, inflammation and thrombin inhibition in unstable coronary artery disease.

    abstract:AIM:Unstable coronary artery disease (CAD) is a multifactorial disease involving both thrombotic and inflammatory processes. We have assessed the time-course and the influence of thrombin inhibitors on changes in fibrinogen and C-reactive protein levels, and their relation to myocardial ischaemia in unstable CAD. METH...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Oldgren J,Wallentin L,Grip L,Linder R,Nørgaard BL,Siegbahn A

    更新日期:2003-01-01 00:00:00

  • Regional myocardial perfusion reserve determined using myocardial perfusion magnetic resonance imaging showed a direct correlation with coronary flow velocity reserve by Doppler flow wire.

    abstract:AIMS:Quantitative analysis of rest-stress myocardial perfusion magnetic resonance imaging (MRI) can provide assessments of regional myocardial perfusion reserve (MPR). The purpose of this study was to compare regional MPR determined by myocardial perfusion MRI with coronary flow reserve (CFR) by intracoronary Doppler f...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Kurita T,Sakuma H,Onishi K,Ishida M,Kitagawa K,Yamanaka T,Tanigawa T,Kitamura T,Takeda K,Ito M

    更新日期:2009-02-01 00:00:00

  • Determinants of symptoms and exercise capacity in aortic stenosis: a comparison of resting haemodynamics and valve compliance during dobutamine stress.

    abstract:AIMS:Valve compliance might determine the onset of symptoms better than resting measures of aortic stenosis. This study compared valve compliance measured by dobutamine stress echocardiography with resting haemodynamic variables against the end-point of symptoms at low workload during exercise testing. METHODS AND RES...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Das P,Rimington H,Smeeton N,Chambers J

    更新日期:2003-07-01 00:00:00

  • Cardiovascular magnetic resonance in immune checkpoint inhibitor-associated myocarditis.

    abstract:AIMS:Myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI). Sparse data exist on the use of cardiovascular magnetic resonance (CMR) in ICI-associated myocarditis. In this study, the CMR characteristics and the association between CMR features and cardiovascular events among patients with...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Zhang L,Awadalla M,Mahmood SS,Nohria A,Hassan MZO,Thuny F,Zlotoff DA,Murphy SP,Stone JR,Golden DLA,Alvi RM,Rokicki A,Jones-O'Connor M,Cohen JV,Heinzerling LM,Mulligan C,Armanious M,Barac A,Forrestal BJ,Sullivan RJ,

    更新日期:2020-05-07 00:00:00

  • Cardiac anatomy, function and metabolism in elite cyclists assessed by magnetic resonance imaging and spectroscopy.

    abstract::We investigated whether left ventricular hypertrophy in elite cyclists is associated with functional changes or abnormal energy metabolism. Left ventricular hypertrophy is a powerful risk factor for sudden cardiac death with different prognostic significance among the various geometric forms. Cyclists may have a combi...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Pluim BM,Chin JC,De Roos A,Doornbos J,Siebelink HM,Van der Laarse A,Vliegen HW,Lamerichs RM,Bruschke AV,Van der Wall EE

    更新日期:1996-08-01 00:00:00

  • Ventricular premature beats in young subjects without evidence of cardiac disease: histological findings.

    abstract::This report describes the results of right ventricle endomyocardial biopsies from 26 subjects (mean age 27 +/- 10 years) with premature ventricular beats and normal cardiac anatomy and mechanical function. Light microscopy examination revealed normal myocardium in 10 subjects (38%), acute myocarditis in two (7%), bord...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Di Biase M,Chiddo A,Caruso G,Tritto M,Marchese A,Rizzon P

    更新日期:1992-06-01 00:00:00

  • The European Study of Epidemiology and Treatment of Cardiac Inflammatory Disease (ESETCID).

    abstract::Diagnosis of myocarditis has improved with the application of new techniques such as immunohistochemistry, polymerase chain reaction, in situ hybridization and Southern blot in endomyocardial biopsies. Treatment of inflammatory heart disease is still difficult and not yet validated by a study with patient numbers suff...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Maisch B,Hufnagel G,Schönian U,Hengstenberg C

    更新日期:1995-12-01 00:00:00

  • Intravenous streptokinase in acute myocardial infarction (I.S.A.M.): assessment of left ventricular function 1 and 7 months after infarction by radionuclide ventriculography.

    abstract::I.S.A.M. was a prospective, placebo-controlled, double-blind multicentre trial of high-dose short-term intravenous streptokinase in acute myocardial infarction (AMI) within 6 h of the onset of symptoms. Determination of left ventricular ejection fraction (LVEF) by radionuclide ventriculography was performed 1 and 7 mo...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Voth E,Tebbe U,Schicha H,Neumann P,Schröder R,Neuhaus KL,Emrich D

    更新日期:1990-10-01 00:00:00

  • Successful catheter ablation by radiofrequency energy of posteroseptal accessory pathway in a patient with drug refractory Wolff-Parkinson-White syndrome.

    abstract::A 45-year-old patient with the Wolff-Parkinson-White syndrome suffering from recurrent intractable reciprocating atrioventricular tachycardia (RAVT) is reported. He used amiodarone, sotalol, quinidine, propafenone and flecainide unsuccessfully. An electrophysiological study (EPS) performed with four catheters localize...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Delise P,Bonso A,Raviele A,Cazzin R,Di Pede F,Piccolo E

    更新日期:1991-12-01 00:00:00

  • Development of nitrate tolerance and usefulness of pulse therapy in a patient with vasospastic angina.

    abstract::In a 58-year-old man with vasospastic angina, we investigated the relationship between the antianginal effects of isosorbide dinitrate (ISDN) and plasma ISDN concentration. Despite adequate plasma ISDN levels, sustained therapy using ISDN tapes and oral ISDN (transcutaneously 160 mg and orally 100 mg ISDN day-1) faile...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Hoshio A,Shirota K,Sawada Y,Doi T,Miyakoda H,Kotake H,Mashiba H

    更新日期:1992-06-01 00:00:00

  • Pathophysiology of re-entrant dysrhythmias.

    abstract::Re-entry was demonstrated as a self-perpetuating mechanism as early as 1906. It may lead to single-cycle electrocardiographic phenomena as well as reciprocating tachycardias. Factors favouring re-entry are as follows. Unidirectional or temporary local block of conduction, a mechanism always involved in initiation of r...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Olsson SB

    更新日期:1984-09-01 00:00:00

  • A frequent variant in the ABCA1 gene is associated with increased coronary heart disease risk and a better response to statin treatment in familial hypercholesterolemia patients.

    abstract:AIMS:Statins are essential for the reduction of risk of coronary heart disease (CHD) in familial hypercholesterolemia (FH). One of many genes influenced by statin treatment is the ATP-binding cassette transporter A1 (ABCA1) gene, which plays an important role in metabolism of high-density lipoprotein (HDL). The present...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Versmissen J,Oosterveer DM,Yazdanpanah M,Mulder M,Dehghan A,Defesche JC,Kastelein JJ,Sijbrands EJ

    更新日期:2011-02-01 00:00:00

  • Association of cyclooxygenase-2 genetic variant with cardiovascular disease.

    abstract:AIM:A genetic variant (rs20417) of the PTGS2 gene, encoding for COX-2, has been associated with decreased COX-2 activity and a decreased risk of cardiovascular disease (CVD). However, this genetic association and the role of COX-2 in CVD remain controversial. METHODS AND RESULTS:The association of rs20417 with CVD was...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Ross S,Eikelboom J,Anand SS,Eriksson N,Gerstein HC,Mehta S,Connolly SJ,Rose L,Ridker PM,Wallentin L,Chasman DI,Yusuf S,Paré G

    更新日期:2014-09-01 00:00:00

  • Electrocardiographic left ventricular hypertrophy in GUSTO IV ACS: an important risk marker of mortality in women.

    abstract:AIM:To examine the association of left ventricular hypertrophy (LVH) on admission electrocardiography with adverse outcomes in acute coronary syndrome (ACS) patients. METHODS AND RESULTS:A total of 7443 non-ST-elevation ACS patients in Global Utilization of STrategies to Open occluded arteries (GUSTO) IV ACS trial had...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Westerhout CM,Lauer MS,James S,Fu Y,Wallentin L,Armstrong PW,GUSTO IV ACS Investigators.

    更新日期:2007-09-01 00:00:00

  • Prognostic value of plasma neuropeptide-Y in coronary care unit patients with and without acute myocardial infarction.

    abstract::Plasma neuropeptide Y-like immunoreactivity (NPY-LI) is elevated in patients with acute myocardial ischaemia and congestive heart failure (CHF) owing to increased activity of the sympathetic nervous system. The prognostic value of plasma NPY-LI with regard to mortality was studied in 324 random patients admitted to a ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Ullman B,Hulting J,Lundberg JM

    更新日期:1994-04-01 00:00:00

  • New diagnostic criteria for infective endocarditis. A study of sensitivity and specificity.

    abstract:OBJECTIVE:The purpose of this study was to determine the sensitivity and specificity of new criteria proposed by Duke University for case definition of infective endocarditis as compared to the previously accepted Von Reyn criteria. PATIENTS:A total of 143 consecutive suspected cases of infective endocarditis in 137 f...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Cecchi E,Parrini I,Chinaglia A,Pomari F,Brusasco G,Bobbio M,Trinchero R,Brusca A

    更新日期:1997-07-01 00:00:00

  • Prognosis of ruptured intracranial mycotic aneurysms: a review of 12 cases.

    abstract::Intracranial mycotic aneurysms (IMA) occur in 1-3% of all infective endocarditis. Although spontaneous resolution was evidenced on serial angiograms in many asymptomatic cases, the prognosis, if they rupture, is reported to be worse and partly contingent on the therapeutic approach. Among 12 patients (six acute and si...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Monsuez JJ,Vittecoq D,Rosenbaum A,Goujon C,Wolff M,Witchitz S,Modai J

    更新日期:1989-09-01 00:00:00

  • Effect of uniformly prolonged, and increased basic dispersion of repolarization on premature dispersion on ventricular surface in dogs: role of action potential duration and activation time differences.

    abstract::Strong experimental evidence links ventricular fibrillation to an increased temporal dispersion of the recovery of excitability. The effect of an overall prolongation of repolarization and an increased basic dispersion of repolarization on premature dispersion was studied on ventricular surface in 10 dogs. Our observa...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Amlie JP,Kuo CS,Munakata K,Reddy PS,Surawicz B

    更新日期:1985-11-01 00:00:00

  • Dipyridamole in chronic stable angina pectoris; a randomized, double blind, placebo-controlled, parallel group study.

    abstract:BACKGROUND:Oral dipyridamole induces accumulation of endogenous adenosine, which in a hypoxic milieu exerts experimentally an angiogenic effect on coronary collateral circulation. A meta-analysis of 13 randomized placebo-controlled trials published between 1960 and 1992 showed evidence of benefit for dipyridamole in th...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Picano E,PISA (Persantin In Stable Angina) study group.

    更新日期:2001-10-01 00:00:00