ACE inhibitors and their influence on inflammation, bronchial reactivity and cough.

Abstract:

:Orally active angiotensin converting enzyme (ACE) inhibitors have been successfully used in the treatment of congestive heart failure and hypertension. However, adverse skin reactions, such as angioneurotic oedema have been reported following such medication. Furthermore, these drugs have been associated with a persistent dry cough in subjects without previous known bronchial hyper-reactivity. There is reason to believe that an ACE inhibitor-induced cough is due to an irritant inflammatory state in the airways of susceptible individuals and that this might have pathophysiological features in common with the cough seen as an early symptom of asthma. All inflammatory responses--wheal and flare reactions, airway reactivity, and infiltration by neutrophils and eosinophils--were enhanced by ACE inhibitors in a dose-dependent manner. Other ACE inhibitors might have different proinflammatory profiles.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Andersson RG,Persson K

doi

10.1093/eurheartj/15.suppl_c.52

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

52-6

eissn

0195-668X

issn

1522-9645

journal_volume

15 Suppl C

pub_type

临床试验,杂志文章,随机对照试验
  • Efficacy and safety of reduced-dose non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: a meta-analysis of randomized controlled trials.

    abstract:AIMS:Non-vitamin K antagonist oral anticoagulants (NOACs) require dose reductions according to patient or clinical factors for patients with atrial fibrillation (AF). In this meta-analysis, we aimed to assess outcomes with reduced-dose NOACs when given as pre-specified in pivotal trials. METHODS AND RESULTS:Aggregated...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析

    doi:10.1093/eurheartj/ehy802

    authors: Wang KL,Lopes RD,Patel MR,Büller HR,Tan DS,Chiang CE,Giugliano RP

    更新日期:2019-05-14 00:00:00

  • Myocardial hydatid cyst ruptured into the pericardium: cross-sectional echocardiographic study and surgical treatment.

    abstract::We describe a patient with a large intramyocardial hydatid cyst lying in the postero-lateral segment of the left ventricle near the atrioventricular groove level which ruptured into the pericardial sac, resulting in cardiac tamponade. Cross-sectional echocardiographic examination from a modified four-chamber apical vi...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/9.7.819

    authors: De Martini M,Nador F,Binda A,Arpesani A,Odero A,Lotto A

    更新日期:1988-07-01 00:00:00

  • Imaging techniques for the assessment of myocardial hibernation. Report of a Study Group of the European Society of Cardiology.

    abstract::This report of an ESC Study Group reviews current knowledge on myocardial hibernation and relevant imaging techniques, and provides an algorithm for investigation and management when a patient presents with ischaemic left ventricular dysfunction. It covers the definitions of myocardial viability, stunning and hibernat...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.ehj.2004.03.012

    authors: Underwood SR,Bax JJ,vom Dahl J,Henein MY,Knuuti J,van Rossum AC,Schwarz ER,Vanoverschelde JL,van der Wall EE,Wijns W,Study Group of the European Society of Cardiology.

    更新日期:2004-05-01 00:00:00

  • C-reactive protein: relation to total mortality, cardiovascular mortality and cardiovascular risk factors in men.

    abstract:BACKGROUND:There is much interest in reported associations between serum C-reactive protein and incident ischaemic heart disease. It is uncertain what this association represents. We aimed to assess the effect of confounding from a number of different sources in the Caerphilly Prospective Heart Disease Study and in par...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1999.1982

    authors: Mendall MA,Strachan DP,Butland BK,Ballam L,Morris J,Sweetnam PM,Elwood PC

    更新日期:2000-10-01 00:00:00

  • Acute administration of captopril lowers the natriuretic and diuretic response to a loop diuretic in patients with chronic cardiac failure.

    abstract::Angiotensin-converting enzyme inhibitors suppress plasma concentrations of the sodium retaining hormones angiotensin II and aldosterone. This action should potentiate the natriuretic and diuretic effects of loop diuretics. Some studies indicate, however, that the introduction of angiotensin-converting enzyme inhibitor...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/12.8.924

    authors: Flapan AD,Davies E,Waugh C,Williams BC,Shaw TR,Edwards CR

    更新日期:1991-08-01 00:00:00

  • Causes-of-death analysis of patients with cardiac resynchronization therapy: an analysis of the CeRtiTuDe cohort study.

    abstract:AIMS:The choice of resynchronization therapy between with (CRT-D) and without (CRT-P) a defibrillator remains a contentious issue. Cause-of-death analysis among CRT-P, compared with CRT-D, patients could help evaluate the extent to which CRT-P patients would have additionally benefited from a defibrillator in a daily c...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehv455

    authors: Marijon E,Leclercq C,Narayanan K,Boveda S,Klug D,Lacaze-Gadonneix J,Defaye P,Jacob S,Piot O,Deharo JC,Perier MC,Mulak G,Hermida JS,Milliez P,Gras D,Cesari O,Hidden-Lucet F,Anselme F,Chevalier P,Maury P,Sadoul N,

    更新日期:2015-11-01 00:00:00

  • Impaired myocardial perfusion and perfusion reserve associated with increased coronary resistance in persistent idiopathic atrial fibrillation.

    abstract:AIMS:Patients with atrial fibrillation (AF) present with symptoms of myocardial ischaemia despite exclusion of coronary artery disease. A small vessel disease has been suggested. We quantified myocardial perfusion, perfusion reserve, and coronary vascular resistance (CVR) in AF patients using positron emission tomograp...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehm246

    authors: Range FT,Schäfers M,Acil T,Schäfers KP,Kies P,Paul M,Hermann S,Brisse B,Breithardt G,Schober O,Wichter T

    更新日期:2007-09-01 00:00:00

  • Value of exercise radionuclide ventriculography and thallium-201 scintigraphy in evaluating successful coronary angioplasty: comparison with coronary flow reserve, translesional gradient and percent diameter stenosis.

    abstract::Assessment of percutaneous transluminal coronary angioplasty (PTCA) by early radionuclide exercise test was evaluated for 11 arteries undergoing a successful procedure. Exercise thallium-201 (Tl-201) and radionuclide ventriculography (RNV) were performed within 3 days before and after PTCA and compared to % diameter s...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062282

    authors: Legrand V,Aueron FM,Bates ER,O'Neill WW,Hodgson JM,Mancini GB,Vogel RA

    更新日期:1987-04-01 00:00:00

  • Gastrointestinal bleeding in high risk survivors of myocardial infarction: the VALIANT Trial.

    abstract:AIMS:The risk of gastrointestinal (GI) bleeding limits the use of antiplatelet and anticoagulant drugs. Risk factors for GI bleeding in post- myocardial infarction (MI) patients have not been well defined. We sought to identify risk factors for GI bleeding in patients following MI. METHODS AND RESULTS:The VALsartan In...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehp256

    authors: Moukarbel GV,Signorovitch JE,Pfeffer MA,McMurray JJ,White HD,Maggioni AP,Velazquez EJ,Califf RM,Scheiman JM,Solomon SD

    更新日期:2009-09-01 00:00:00

  • Stress echocardiography: personnel and technical equipment.

    abstract::In recent years, stress echocardiography has gained broad acceptance as a non-invasive method for the diagnosis of coronary artery disease. Facing different protocols, dosages and instrumentation, official guidelines for the performance, standardization and quality control of stress echocardiograms are needed; however...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/18.suppl_d.43

    authors: Ketteler T,Krahwinkel W,Gödke J,Wolfertz J,Scheuble L,Hoffmeister T,Gülker H

    更新日期:1997-06-01 00:00:00

  • Relationship of aortic regurgitant velocity slope and pressure half-time to severity of aortic regurgitation under changing haemodynamic conditions.

    abstract::The slope and pressure half-time of the aortic regurgitant velocity spectrum have been used as non-invasive markers of regurgitant severity. Recent in vitro and theoretical work, however, has suggested a confounding effect of systemic vascular resistance and left ventricular compliance on these parameters. To study th...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060567

    authors: Griffin BP,Flachskampf FA,Reimold SC,Lee RT,Thomas JD

    更新日期:1994-05-01 00:00:00

  • Long-term clinical variation of NT-proBNP in stable chronic heart failure patients.

    abstract:AIMS:Here, the aim is to assess long-term clinical variation (CV) of N-terminal pro-brain natriuretic peptide (NT-proBNP) in stable chronic heart failure (CHF) patients. The proposed use of NT-proBNP for monitoring of CHF patients will require accurate information about long-term CV of the peptide. METHODS AND RESULTS...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehl449

    authors: Schou M,Gustafsson F,Kjaer A,Hildebrandt PR

    更新日期:2007-01-01 00:00:00

  • Comparison of the Framingham risk function-based coronary chart with risk function from an Italian population study.

    abstract:AIMS:The aim is to compare the coronary risk chart published by the European Task Force for Prevention of Coronary Heart Disease and produced using a Framingham risk function, with a risk function derived from an Italian population study. METHODS AND RESULTS:Coronary risk function in this study was the result of longi...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1999.1864

    authors: Menotti A,Puddu PE,Lanti M

    更新日期:2000-03-01 00:00:00

  • Single infusion of intravenous cibenzoline in the treatment of supraventricular tachyarrhythmias following heart surgery. A double-blind placebo-controlled parallel study.

    abstract::The efficacy and safety of a single infusion of cibenzoline, a class I antiarrhythmic drug, were assessed in 86 patients presenting with a supraventricular tachyarrhythmia following heart surgery in a placebo-controlled double-blind parallel study. Cibenzoline was effective in 13 patients (30%) vs three patients (6.9%...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a060664

    authors: Ollitrault J,Quilliet L,Scheck F,Lelong B,Richard A,Jarry G,Guize L

    更新日期:1994-09-01 00:00:00

  • High-grade atrioventricular block in acute coronary syndromes: insights from the Global Registry of Acute Coronary Events.

    abstract:BACKGROUND:While prior work has suggested that a high-grade atrioventricular block (HAVB) in the setting of an acute coronary syndrome (ACS) is associated with in-hospital death, limited information is available on the incidence of, and death associated with, HAVB in ACS patients receiving contemporary management. MET...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehu357

    authors: Singh SM,FitzGerald G,Yan AT,Brieger D,Fox KA,López-Sendón J,Yan RT,Eagle KA,Steg PG,Budaj A,Goodman SG

    更新日期:2015-04-21 00:00:00

  • Mortality of patients excluded from the Danish Verapamil Infarction Trail II. The DAVIT-II Study Group.

    abstract::The 18 month mortality rate in 2180 patients excluded from the Danish Verapamil Infarction Trail II (DAVIT II) was 25.6%. In non-consenters (n = 368) this was 15.0% compared with 13.85 in 897 placebo-treated patients (hazard ratio 1.09 [P = 0.60] when adjusting for sex and age). The increased mortality rate in exclude...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1093/eurheartj/14.3.377

    authors: Madsen JK,Hansen JF

    更新日期:1993-03-01 00:00:00

  • Current therapy and outcome of Eisenmenger syndrome: data of the German National Register for congenital heart defects.

    abstract:AIMS:We aimed to assess the contemporary outcome of Eisenmenger syndrome (ES), delineate the use of disease targeting therapies (DTT) in these patients and to investigate the effect of treatment on outcome in the community. METHODS AND RESULTS:Patients with ES were systematically identified from the German National Re...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehv743

    authors: Diller GP,Körten MA,Bauer UM,Miera O,Tutarel O,Kaemmerer H,Berger F,Baumgartner H,German Competence Network for Congenital Heart Defects Investigators.

    更新日期:2016-05-07 00:00:00

  • Angina with normal coronary arteries: diagnosis, pathophysiology and treatment.

    abstract::Approximately 20% of patients undergoing diagnostic coronary arteriography for acute or chronic cardiac ischaemia have angiographically normal coronary arteries. The mechanism behind this phenomenon is likely to be the result of a combination of functional or anatomical abnormalities in the coronary microcirculation, ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/17.suppl_g.14

    authors: Chierchia SL,Fragasso G

    更新日期:1996-12-01 00:00:00

  • Impact of restenosis 10 years after coronary angioplasty.

    abstract:AIMS:The aim of the study was to compare the 10-year follow-up results of patients with or without restenosis following single-vessel percutaneous transluminal coronary angioplasty (PTCA). METHODS AND RESULTS:A total of 313 patients with successful PTCA (> or = 20% reduction in luminal diameter narrowing without acute...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1997.0863

    authors: Espinola-Klein C,Rupprecht HJ,Erbel R,Nafe B,Brennecke R,Meyer J

    更新日期:1998-07-01 00:00:00

  • Influence of heart rate, respiration and recipient atrial contraction on pulsed wave transmitral Doppler flow indices in orthotopic heart transplant recipients.

    abstract:AIMS:The study set out to assess the relative contributions of donor heart rate, respiration and recipient atrial contraction on the mean of pulsed wave transmitral Doppler flow indices in orthotopic heart transplant recipients. This would provide information on the theoretical usefulness of pacemaker synchronization o...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015149

    authors: Mannaerts H,Balk A,Roelandt J

    更新日期:1997-10-01 00:00:00

  • Combination reperfusion therapy with abciximab and reduced dose reteplase: results from TIMI 14. The Thrombolysis in Myocardial Infarction (TIMI) 14 Investigators.

    abstract::Aims Abciximab has previously been shown to enhance thrombolysis and improve myocardial perfusion when combined with reduced doses of alteplase. The purpose of the reteplase phase of TIMI 14 was to evaluate the effects of abciximab when used in combination with a reduced dose of reteplase for ST-elevation myocardial i...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1053/euhj.2000.2243

    authors: Antman EM,Gibson CM,de Lemos JA,Giugliano RP,McCabe CH,Coussement P,Menown I,Nienaber CA,Rehders TC,Frey MJ,Van der Wieken R,Andresen D,Scherer J,Anderson K,Van de Werf F,Braunwald E

    更新日期:2000-12-01 00:00:00

  • Supplementation with vitamins C and E suppresses leukocyte oxygen free radical production in patients with myocardial infarction.

    abstract::Clinical studies suggest that neutrophil activation during acute myocardial infarction (MI) aggravates tissue injury. Activated neutrophils are an important source of oxygen free radicals (OFR), the injurious effects of which are counteracted by endogenous antioxidants. We have previously shown in healthy subjects tha...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a061045

    authors: Herbaczyńska-Cedro K,K+osiewicz-Wasek B,Cedro K,Wasek W,Panczenko-Kresowska B,Wartanowicz M

    更新日期:1995-08-01 00:00:00

  • Acute kidney injury following transcatheter aortic valve implantation: predictive factors, prognostic value, and comparison with surgical aortic valve replacement.

    abstract:AIMS:Very few data exist on the occurrence of acute kidney injury (AKI) associated with transcatheter aortic valve implantation (TAVI). The objectives of the present study were (i) to determine the incidence, predictive factors, and prognostic value of AKI following TAVI, and (ii) to compare the occurrence of AKI in TA...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehp552

    authors: Bagur R,Webb JG,Nietlispach F,Dumont E,De Larochellière R,Doyle D,Masson JB,Gutiérrez MJ,Clavel MA,Bertrand OF,Pibarot P,Rodés-Cabau J

    更新日期:2010-04-01 00:00:00

  • Detection of prosthetic valve thrombosis using 111indium platelet imaging.

    abstract::The diagnosis of prosthetic valve thrombosis (PVT) may be difficult in cases without valve obstruction. The aim of this study was to evaluate the diagnostic accuracy of 111indium-labelled autologous platelet imaging in the detection of PVT. We studied 41 patients with 45 prostheses, mechanical (37) or biological (8), ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059721

    authors: Acar J,Vahanian A,Dorent R,Fauchet M,Mundler O,Michel PL,Roger V,Cormier B

    更新日期:1990-05-01 00:00:00

  • Beta adrenergic blockade does not improve effort tolerance in patients with mitral stenosis in sinus rhythm.

    abstract:OBJECTIVES:This study was designed to assess the effects of beta-blockade on cardiopulmonary exercise performance in symptomatic patients with tight mitral stenosis in sinus rhythm. BACKGROUND:The role of beta-blockers in these patients has been controversial and assessment of effort tolerance using treadmill exercise...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a061084

    authors: Patel JJ,Dyer RB,Mitha AS

    更新日期:1995-09-01 00:00:00

  • Return to work after percutaneous transluminal coronary angioplasty: a continuing problem.

    abstract::Earlier studies have shown that return to work following PTCA is frequent; however PTCA is now performed in patients with more extensive coronary artery disease. The present study was designed to compare the vocational outcome of patients who underwent PTCA in 1980-1982 with that of patients who underwent the procedur...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/10.suppl_g.54

    authors: Danchin N,Juilliere Y,Selton-Suty C,Vaillant G,Pernot C,Gilgenkrantz JM,Villemot JP,Mathieu P,Cherrier F

    更新日期:1989-12-01 00:00:00

  • Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS).

    abstract:AIMS:Large randomized trials have shown that beta-blockers reduce mortality and hospital admissions in patients with heart failure. The effects of beta-blockers in elderly patients with a broad range of left ventricular ejection fraction are uncertain. The SENIORS study was performed to assess effects of the beta-block...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehi115

    authors: Flather MD,Shibata MC,Coats AJ,Van Veldhuisen DJ,Parkhomenko A,Borbola J,Cohen-Solal A,Dumitrascu D,Ferrari R,Lechat P,Soler-Soler J,Tavazzi L,Spinarova L,Toman J,Böhm M,Anker SD,Thompson SG,Poole-Wilson PA,SENIORS In

    更新日期:2005-02-01 00:00:00

  • Ineligibility for predischarge exercise testing after myocardial infarction in the elderly: implications for prognosis.

    abstract::This study describes the clinical profile and prognosis of elderly patients not eligible for predischarge exercise testing. The database consisted of 133 patients 55-64 years of age, and 111 patients older than 64 years of age who survived an acute myocardial infarction. Follow-up was one year. In the younger age grou...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/5.suppl_e.97

    authors: Deckers JW,Fioretti P,Brower RW,Simoons ML,Baardman T,Hugenholtz PG

    更新日期:1984-11-01 00:00:00

  • Strategies to attenuate micro-vascular obstruction during P-PCI: the randomized reperfusion facilitated by local adjunctive therapy in ST-elevation myocardial infarction trial.

    abstract:BACKGROUND:Microvascular obstruction (MVO) following primary percutaneous coronary intervention (PPCI) treatment of ST-segment elevation myocardial infarction (STEMI) contributes to infarct expansion, left ventricular (LV) remodelling, and worse clinical outcomes. The REFLO-STEMI trial tested whether intra-coronary (IC...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehw136

    authors: Nazir SA,McCann GP,Greenwood JP,Kunadian V,Khan JN,Mahmoud IZ,Blackman DJ,Been M,Abrams KR,Shipley L,Wilcox R,Adgey AA,Gershlick AH

    更新日期:2016-06-21 00:00:00

  • Everolimus-eluting bioresorbable vascular scaffolds for treatment of patients presenting with ST-segment elevation myocardial infarction: BVS STEMI first study.

    abstract:AIMS:We evaluated the feasibility and the acute performance of the everolimus-eluting bioresorbable vascular scaffolds (BVS) for the treatment of patients presenting with ST-segment elevation myocardial infarction (STEMI). METHODS AND RESULTS:The present investigation is a prospective, single-arm, single-centre study,...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht546

    authors: Diletti R,Karanasos A,Muramatsu T,Nakatani S,Van Mieghem NM,Onuma Y,Nauta ST,Ishibashi Y,Lenzen MJ,Ligthart J,Schultz C,Regar E,de Jaegere PP,Serruys PW,Zijlstra F,van Geuns RJ

    更新日期:2014-03-01 00:00:00