The multicentre trial philosophy in stress echocardiography: lessons learned from the EPIC study. EPIC-EDIC Study Project. Echo Persantine International Cooperative Study. Echo-Dobutamine International Cooperative Study.

Abstract:

:The scientific assessment of diagnostic tests should not be based upon a small series of results published by the best academic institutions, but ought to require large scale, multicentre validation founded on grass roots institutions with real doctors, real patients and real problems. To this purpose, an international network of stress echo laboratories has been organized, and within a few years has collected data from thousands of studies using pharmacological stress echocardiography, performed with either dipyridamole (EPIC: Echo Persantine International Cooperative Study) or dobutamine (EDIC: Echo Dobutamine International Cooperative Study) stresses. In a widely deregulated field, all network laboratories have agreed: to pass a quality control examination on stress echo reading before entering the study; to adopt an identical drug infusion protocol; to code similarly the LV segments; and to adopt a common scoring system for wall motion analysis. A minimum amount of historical, clinical, and-when available-stress electrocardiographic, angiographic and follow-up data have been collected on each patient, and disseminated in the various centres, facilitating the creation of an international stress echo language that will help, not only the production of high quality scientific data, but also the build up of a common stress echo lab, with a standardized way of making the studies, unifying the methods and terminology, and archiving data. To date, we have 50 echo laboratories from 15 nations across four continents (Europe, America, Asia and Africa) actively involved in this project. These data will ultimately fill the gap between the academic theory of journals and the pragmatic experience of daily life in a busy echocardiographic laboratory.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Picano E,Sicari R,Landi P,Raciti M,Pingitore A,Vassalle C,Mathias W Jr,Lowenstein J,Petix N,Gigli G

doi

10.1093/eurheartj/16.suppl_j.2

subject

Has Abstract,Author List Incomplete

pub_date

1995-10-01 00:00:00

pages

2-4

eissn

0195-668X

issn

1522-9645

journal_volume

16 Suppl J

pub_type

杂志文章,评审
  • Changes of fluid-dynamic parameters in peripheral stenoses with transcutaneous interventions.

    abstract:UNLABELLED:Peripheral vessels provide a useful in vivo haemodynamic model allowing evaluation of local intravascular fluid dynamics. Velocity measurements using a 0.018 inch Doppler-tipped angioplasty guidewire, quantitative angiography and laboratory data were gathered from 45 patients with a total of 48 percutaneous ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/16.suppl_j.60

    authors: Wellnhofer E,Biamino G,Sauer HU,Trebeljahr A,Stalke J,Ragg C,Oswald H,Gotze S,Fleck E,Felix R

    更新日期:1995-10-01 00:00:00

  • Transcoronary gradients of vascular miRNAs and coronary atherosclerotic plaque characteristics.

    abstract:AIMS:Circulating microRNAs (miRs) may reflect pathophysiologically relevant processes in the atherosclerotically diseased coronary arterial wall. Given the unmet medical need to identify patients with an unstable plaque phenotype, we determined the relation of circulating atherosclerosis-regulatory miRs with plaque phe...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehw047

    authors: Leistner DM,Boeckel JN,Reis SM,Thome CE,De Rosa R,Keller T,Palapies L,Fichtlscherer S,Dimmeler S,Zeiher AM

    更新日期:2016-06-07 00:00:00

  • Comprehensive cardiac rehabilitation: is it cost-effective?

    abstract::A major challenge for all health care systems is to identify the most efficient use of limited and finite resources available for health care. Economic evaluation provides a balance sheet of the benefits, harms and costs for making choices between alternative health care services and is one strategy to assist decision...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

    authors: Oldridge NB

    更新日期:1998-11-01 00:00:00

  • Predictors of major bleeding in acute coronary syndromes: the Global Registry of Acute Coronary Events (GRACE).

    abstract:AIMS:There have been no large observational studies attempting to identify predictors of major bleeding in patients with acute coronary syndromes (ACS), particularly from a multinational perspective. The objective of our study was thus to develop a prediction rule for the identification of patients with ACS at higher r...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0195-668x(03)00485-8

    authors: Moscucci M,Fox KA,Cannon CP,Klein W,López-Sendón J,Montalescot G,White K,Goldberg RJ

    更新日期:2003-10-01 00:00:00

  • A double-blind, parallel-group comparison of flosequinan and enalapril in the treatment of chronic heart failure.

    abstract::The effects of flosequinan and enalapril on exercise capacity (bicycle exercise duration), quality-of-life symptomatology (visual analogue scales) and New York Heart Association (NYHA) grading, were compared in 61 patients with chronic heart failure (NYHA, grade III). Bicycle exercise duration improved similarly with ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a060320

    authors: Silke B,Tennet H,Fischer-Hansen J,Keller N,Heikkila J,Salminen K

    更新日期:1992-08-01 00:00:00

  • Decreased no-reflow in patients with anterior myocardial infarction and pre-infarction angina.

    abstract:AIMS:Pre-infarction angina is associated with better outcome after myocardial infarction. The aim of this study was to assess whether pre-infarction angina is associated with decreased no-reflow after coronary recanalization. METHODS AND RESULTS:Twenty-three patients underwent intracoronary myocardial contrast echocar...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1999.1714

    authors: Karila-Cohen D,Czitrom D,Brochet E,Faraggi M,Seknadji P,Himbert D,Juliard JM,Assayag P,Steg PG

    更新日期:1999-12-01 00:00:00

  • A frequent variant in the ABCA1 gene is associated with increased coronary heart disease risk and a better response to statin treatment in familial hypercholesterolemia patients.

    abstract:AIMS:Statins are essential for the reduction of risk of coronary heart disease (CHD) in familial hypercholesterolemia (FH). One of many genes influenced by statin treatment is the ATP-binding cassette transporter A1 (ABCA1) gene, which plays an important role in metabolism of high-density lipoprotein (HDL). The present...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq208

    authors: Versmissen J,Oosterveer DM,Yazdanpanah M,Mulder M,Dehghan A,Defesche JC,Kastelein JJ,Sijbrands EJ

    更新日期:2011-02-01 00:00:00

  • Anti-ischaemic intervention with verapamil in patients recovering from acute myocardial infarction.

    abstract::The present review discusses the prognostic significance of post-infarction angina pectoris, and the significance of post-infarction intervention with verapamil on the prevalence of post-infarction ischaemia and prognosis. Angina pectoris during the first month after acute myocardial infarction (AMI) was found to be a...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/16.suppl_h.13

    authors: Jespersen CM

    更新日期:1995-08-01 00:00:00

  • Value and limitations of aortic valve resistance with particular consideration of low flow-low gradient aortic stenosis: an in vitro study.

    abstract:BACKGROUND:The calculation of valve resistance (R) rather than aortic valve area (AVA) has been proposed for the assessment of aortic stenosis (AS), based on the claim that it is less flow-dependent. Even more importantly, valve resistance has been reported to distinguish between truly severe and "pseudosevere" AS in p...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ehj.2004.02.011

    authors: Mascherbauer J,Schima H,Rosenhek R,Czerny M,Maurer G,Baumgartner H

    更新日期:2004-05-01 00:00:00

  • New diagnostic criteria for infective endocarditis. A study of sensitivity and specificity.

    abstract:OBJECTIVE:The purpose of this study was to determine the sensitivity and specificity of new criteria proposed by Duke University for case definition of infective endocarditis as compared to the previously accepted Von Reyn criteria. PATIENTS:A total of 143 consecutive suspected cases of infective endocarditis in 137 f...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015411

    authors: Cecchi E,Parrini I,Chinaglia A,Pomari F,Brusasco G,Bobbio M,Trinchero R,Brusca A

    更新日期:1997-07-01 00:00:00

  • Atrial fibrillation and cardiac fibrosis.

    abstract::The understanding of atrial fibrillation (AF) evolved from a sole rhythm disturbance towards the complex concept of a cardiomyopathy based on arrhythmia substrates. There is evidence that atrial fibrosis can be visualized using late gadolinium enhancement cardiac magnetic resonance imaging and that it is a powerful pr...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehz786

    authors: Sohns C,Marrouche NF

    更新日期:2020-03-07 00:00:00

  • Is relaxation really impaired in cardiac failure?

    abstract::Impaired relaxation of the ventricle has been described in hypertrophy and in ischemic heart disease. Some of these abnormalities are transient, but all occur at an early stage of the disease. The underlying mechanisms may vary depending on the etiology of the disease, and, except for ischemic heart disease, true myoc...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/4.suppl_a.43

    authors: Brutsaert DL

    更新日期:1983-01-01 00:00:00

  • Prediction of outcome by neurohumoral activation, the six-minute walk test and the Minnesota Living with Heart Failure Questionnaire in an outpatient cohort with congestive heart failure.

    abstract:AIMS:To compare the precursor of atrial and brain natriuretic peptide (N-ANP, N-BNP), brain natriuretic peptide (BNP), big endothelin-1, the 6-min walk test and the Minnesota Living with Heart Failure Questionnaire (LHFQ) with regard to short-term outcome in an ambulatory heart failure population. METHODS AND RESULTS:...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2001.3115

    authors: Hülsmann M,Berger R,Sturm B,Bojic A,Woloszczuk W,Bergler-Klein J,Pacher R

    更新日期:2002-06-01 00:00:00

  • Ischaemic cardiac outcomes in patients with atrial fibrillation treated with vitamin K antagonism or factor Xa inhibition: results from the ROCKET AF trial.

    abstract:AIMS:We investigated the prevalence of prior myocardial infarction (MI) and incidence of ischaemic cardiovascular (CV) events among atrial fibrillation (AF) patients. METHODS AND RESULTS:In ROCKET AF, 14 264 patients with nonvalvular AF were randomized to rivaroxaban or warfarin. The key efficacy outcome for these ana...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/eht428

    authors: Mahaffey KW,Stevens SR,White HD,Nessel CC,Goodman SG,Piccini JP,Patel MR,Becker RC,Halperin JL,Hacke W,Singer DE,Hankey GJ,Califf RM,Fox KA,Breithardt G,ROCKET AF Investigators.

    更新日期:2014-01-01 00:00:00

  • Environmental tobacco smoke and cardiometabolic risk in young children: results from a survey in south-west Germany.

    abstract:AIMS:We explored the association between exposure to environmental tobacco smoke (ETS) and various cardiometabolic biomarkers in 10-year-old children. METHODS AND RESULTS:A population-based cross-sectional study was carried out. Data on ETS exposure and potential confounders were collected by parental questionnaire. A...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehp180

    authors: Nagel G,Arnold FJ,Wilhelm M,Link B,Zoellner I,Koenig W

    更新日期:2009-08-01 00:00:00

  • Myocardial infarction and the myocyte IGF1 autocrine system.

    abstract::To determine the effects of acute myocardial infarction on the extent and distribution of mural stress on surviving myocardial tissue, coronary artery occlusion was surgically produced in rats. Following haemodynamic measurements in vivo, the characteristics of cardiac anatomy were determined and found to consist of a...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/16.suppl_n.37

    authors: Anversa P,Reiss K,Kajstura J,Cheng W,Li P,Sonnenblick EH,Olivetti G

    更新日期:1995-12-01 00:00:00

  • A case of right coronary artery occlusion, caused by blunt chest trauma and treated with acute coronary artery bypass surgery.

    abstract::A 37-year-old man sustained occlusion of the right coronary artery after a bicycle accident with blunt chest trauma over the left scapula. Acute coronary angiography was performed because of chest pain and ST-segment elevation. Despite surgically successful acute revascularization the patient developed a transmural in...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060033

    authors: Gustavsson CG,Albrechtsson U,Forslind K,Ståhl E,White T

    更新日期:1992-01-01 00:00:00

  • Renovascular hypertension: screening and modern management.

    abstract::The diagnosis and management of patients with renovascular disease and hypertension continue to elude healthcare providers. The advent of novel imaging and interventional techniques, and increased understanding of the pathways leading to irreversible renal injury and renovascular hypertension, have ushered in commenda...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehq510

    authors: Baumgartner I,Lerman LO

    更新日期:2011-07-01 00:00:00

  • Protective effects of cardioplegia on diastolic function of hypertrophied rat hearts after hypothermic ischaemic arrest.

    abstract::This study was undertaken to assess the effects of hypothermia and chemical cardioplegia on the functional recovery of hypertrophied non-failing rat hearts subjected to an extended period of global ischaemia. Left ventricular hypertrophy was produced by constriction of the abdominal aorta. Hearts were studied an avera...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/5.suppl_f.347

    authors: Grousset C,Menasche P,Apstein CS,Mouas C,Marotte F,Piwnica A

    更新日期:1984-12-01 00:00:00

  • Adequacy of endogenous erythropoietin levels and mortality in anaemic heart failure patients.

    abstract:AIMS:We examined the adequacy of endogenous erythropoietin (EPO) levels for the degree of anaemia in patients with chronic heart failure (CHF) and its relation to prognosis. METHODS AND RESULTS:We studied 74 anaemic CHF patients from a cohort of 240 patients. The adequacy of endogenous EPO levels was assessed by deriv...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehn205

    authors: van der Meer P,Lok DJ,Januzzi JL,de la Porte PW,Lipsic E,van Wijngaarden J,Voors AA,van Gilst WH,van Veldhuisen DJ

    更新日期:2008-06-01 00:00:00

  • Influence of captopril on the arterial baroreceptor reflex in patients with heart failure.

    abstract::In 16 male patients with heart failure (NYHA II-III), the influence of a single dose of 25 mg captopril on the carotid sinus baroreceptor reflex was examined. Blood pressure fell significantly by 11 +/- 1.7 mm Hg (P less than 0.001), whereas heart rate remained unchanged (85 +/- 3 vs. 83 +/- 3 beats min-1). Carotid si...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062411

    authors: Osterziel KJ,Röhrig N,Dietz R,Manthey J,Hecht J,Kübler W

    更新日期:1988-10-01 00:00:00

  • The effect of verapamil on major events in patients with impaired cardiac function recovering from acute myocardial infarction. The Danish Study Group on Verapamil in Myocardial Infarction.

    abstract::In the Danish Verapamil Infarction Trial II (DAVIT II) intervention with verapamil significantly decreased the first major event rate (i.e. reinfarction or death) in patients recovering from acute myocardial infarction. As calcium channel antagonists might have a detrimental effect in patients with heart failure, the ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/14.4.540

    authors: Jespersen CM

    更新日期:1993-04-01 00:00:00

  • The Journal of Hypertension.

    abstract::Liaison with two important scientific societies in the field of hypertension improves contact with readers. ...

    journal_title:European heart journal

    pub_type: 新闻

    doi:

    authors: Taylor J

    更新日期:2012-05-01 00:00:00

  • Genetic variation at the coronary artery disease risk locus GUCY1A3 modifies cardiovascular disease prevention effects of aspirin.

    abstract:AIMS:Efficacy of aspirin in primary prevention of cardiovascular disease (CVD) may be influenced by a common allele in guanylate cyclase GUCY1A3, which has been shown to modify platelet function and increase CVD risk. METHODS AND RESULTS:We investigated whether homozygotes of the GUCY1A3 rs7692387 risk (G) allele bene...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehz384

    authors: Hall KT,Kessler T,Buring JE,Passow D,Sesso HD,Zee RYL,Ridker PM,Chasman DI,Schunkert H

    更新日期:2019-11-01 00:00:00

  • Neurohormonal and clinical sex differences in heart failure.

    abstract:AIMS:Despite disparities in pathophysiology and disease manifestation between male and female patients with heart failure, studies focusing on sex differences in biomarkers are scarce. The purpose of this study was to assess sex-specific variation in clinical characteristics and biomarker levels to gain more understand...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/eht152

    authors: Meyer S,van der Meer P,van Deursen VM,Jaarsma T,van Veldhuisen DJ,van der Wal MH,Hillege HL,Voors AA

    更新日期:2013-08-01 00:00:00

  • Aetiology and outcomes of severe right ventricular dysfunction.

    abstract:AIMS:Right ventricular dysfunction (RVD) is an important determinant of functional status and survival in various diseases states. Data are sparse on the epidemiology and outcome of patients with severe RVD. This study examined the characteristics, aetiology, and survival of patients with severe RVD. METHODS AND RESUL...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa037

    authors: Padang R,Chandrashekar N,Indrabhinduwat M,Scott CG,Luis SA,Chandrasekaran K,Michelena HI,Nkomo VT,Pislaru SV,Pellikka PA,Kane GC

    更新日期:2020-03-21 00:00:00

  • Endocarditis on a left atrial myxoma.

    abstract::A 55-year-old woman presented with fever and malaise. Three blood cultures were positive for Streptococcus sanguis. A diagnosis of endocarditis was made and the patient was treated with intravenous penicillin and gentamicin. Endocardiography revealed a large left atrial tumour. At operation a myxoma covered by deposit...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060109

    authors: ten Berg JM,Elbers HR,Defauw JJ,Plokker HW

    更新日期:1992-11-01 00:00:00

  • Effects of ranolazine on exercise tolerance and HbA1c in patients with chronic angina and diabetes.

    abstract:AIMS:The anti-anginal efficacy and safety of ranolazine in diabetic and non-diabetic patients included in the Combination Assessment of Ranolazine In Stable Angina (CARISA) trial (JAMA 2004;291:309) were studied. Glycaemic control was also assessed in CARISA and its long-term open-label extension study. METHODS AND RE...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehi495

    authors: Timmis AD,Chaitman BR,Crager M

    更新日期:2006-01-01 00:00:00

  • Hypertrophy or hyperplasia in cardiac muscle. Post-mortem human morphometric study.

    abstract::In 103 hearts with various forms of cardiac muscle hypertrophy the following parameters were estimated: diameter, length, volume, density and number of myocytes, and density of myocyte nuclei. The values of all histometric parameters correlated well with left ventricular (LV) weight up to 350 g. In heavier hearts thes...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.1.40

    authors: Grajek S,Lesiak M,Pyda M,Zajac M,Paradowski S,Kaczmarek E

    更新日期:1993-01-01 00:00:00

  • Local slow potential preceding the surface QRS complex detected at the subvalvular mitral annulus in patients with a left-sided concealed accessory pathway. Incidence, electrophysiological characteristics and the possible mechanism, with demonstration of

    abstract:AIM:We sought to evaluate the incidence and electrophysiological features of the local slow potential preceding the surface QRS complex (pre-QRS potential) which was detected more frequently at successful sites of catheter ablation of left parietal concealed accessory pathways, than at unsuccessful sites. METHODS AND ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1999.1688

    authors: Miyauchi Y,Kobayashi Y,Ino T,Atarashi H

    更新日期:1999-12-01 00:00:00