Long-term tracking of cardiovascular risk factors among men and women in a large population-based health system: the Vorarlberg Health Monitoring & Promotion Programme.


AIMS:To document tracking patterns, if any, over time, of classical cardiovascular risk factors in men and women participants in the Vorarlberg Health Monitoring and Promotion Programme (VHM&PP) METHODS AND RESULTS: 67,413 men and 82,237 women underwent a total of 45,4448 standardised examinations in the 15 year period 1985-1999. Measures included were systolic and diastolic blood pressure, height, weight and fasting sample for total cholesterol, triglycerides, gamma-gt and blood glucose. Tracking coefficients were calculated by multivariable regression models using the GEE estimation method. All variables showed evidence of significant tracking over time, whether estimated in 10-year age bands or among individuals categorized as being at high risk using cut-points proposed by international guidelines. Effects were most marked for body mass index (0.87, SE0.005 in men and 0.89, SE0.003 in women), and were also associated with increasing age. Women who died during follow-up showed stronger tracking patterns for triglycerides and gamma-gt and weaker effects for blood pressure, but there was no effect on patterns according to survival in men. Tracking coefficients were weaker among initially high-risk individuals. CONCLUSIONS:This is the largest study yet of adults to demonstrate significant tracking effects of cardiovascular risk factors over time. The strength of this effect should be considered in assessing effectiveness of risk factor modification programmes. The study is novel too in highlighting more fully differences according to gender and social circumstances and in taking account of the impact on long-term survival.


Eur Heart J


European heart journal


Ulmer H,Kelleher C,Diem G,Concin H




Has Abstract


2003-06-01 00:00:00














  • Relationship between HDL-cholesterol and apolipoprotein A1 and the severity of coronary artery disease.

    abstract:INTRODUCTION:We investigated whether apolipoprotein A1 (ApoA1) could better identify patients with severe vessel damage than HDL-cholesterol in a population with recent acute myocardial infarction (AMI). METHODS:One hundred and forty-one male patients (mean age: 54.3 +/- 7.3 years) who had undergone coronary angiograp...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Garfagnini A,Devoto G,Rosselli P,Boggiano P,Venturini M

    更新日期:1995-04-01 00:00:00

  • Personalized cardiovascular disease prevention by applying individualized prediction of treatment effects.

    abstract::Large-scale randomized clinical trials have established the efficacy of cholesterol-lowering, blood pressure-lowering, and anti-platelet therapy to prevent cardiovascular diseases. A challenge for clinicians is to apply group-level evidence from these trials to individual patients. Trials typically report a single tre...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: van der Leeuw J,Ridker PM,van der Graaf Y,Visseren FL

    更新日期:2014-04-01 00:00:00

  • Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease.

    abstract:AIMS:This study was designed to compare the degree of inhibition of platelet aggregation (IPA) of prasugrel with that of clopidogrel in stable aspirin-treated patients with coronary artery disease (CAD). METHODS AND RESULTS:Subjects (n=101) were randomly assigned to the following loading dose (LD) (day 1)/maintenance ...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Jernberg T,Payne CD,Winters KJ,Darstein C,Brandt JT,Jakubowski JA,Naganuma H,Siegbahn A,Wallentin L

    更新日期:2006-05-01 00:00:00

  • Prevalence and significance of asymmetric septal hypertrophy in hypertension: an echocardiographic and clinical study.

    abstract::To assess the prevalence of asymmetric septal hypertrophy (ASH) in hypertensive patients, 613 echocardiographic examinations performed over a period of one year were reviewed. Asymmetric septal hypertrophy (defined by an echocardiographic interventricular septum to left ventricular free wall thickness ratio of greater...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Wicker P,Roudaut R,Haissaguere M,Villega-Arino P,Clementy J,Dallocchio M

    更新日期:1983-11-01 00:00:00

  • Origin and evaluation of depressed inotropism in hypertensive cardiomyopathy.

    abstract::Left ventricular pressure overload results in the development of left ventricular hypertrophy (LVH) which is considered an adaptive mechanism of the heart to normalize systolic wall-stress. Impairment of both contractility and relaxation occurs, implying that the hypertrophied myocardium is very sensitive to ischaemia...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Viallard JF,Bonoron-Adele S,Dos Santos P,Coste P,Besse P

    更新日期:1993-11-01 00:00:00

  • Transthyretin cardiac amyloidosis in continental Western Europe: an insight through the Transthyretin Amyloidosis Outcomes Survey (THAOS).

    abstract:AIMS:Transthyretin amyloidosis (ATTR amyloidosis) is a heterogeneous disorder with cardiac, neurologic, and mixed phenotypes. We describe the phenotypic and genotypic profiles of this disease in continental Western Europe as it appears from the Transthyretin Amyloidosis Survey (THAOS). METHODS AND RESULTS:THAOS is an ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Damy T,Kristen AV,Suhr OB,Maurer MS,Planté-Bordeneuve V,Yu CR,Ong ML,Coelho T,Rapezzi C,THAOS Investigators.

    更新日期:2019-04-01 00:00:00

  • N-terminal pro-B-type natriuretic peptide and the prediction of primary cardiovascular events: results from 15-year follow-up of WOSCOPS.

    abstract:AIMS:To test whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) was independently associated with, and improved the prediction of, cardiovascular disease (CVD) in a primary prevention cohort. METHODS AND RESULTS:In the West of Scotland Coronary Prevention Study (WOSCOPS), a cohort of middle-aged men with hy...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Welsh P,Doolin O,Willeit P,Packard C,Macfarlane P,Cobbe S,Gudnason V,Di Angelantonio E,Ford I,Sattar N

    更新日期:2013-02-01 00:00:00

  • Clinical significance of the ST-segment response and other early exercise test variables in uncomplicated vs complicated myocardial infarction.

    abstract::An exercise test was performed in 455 patients in the third week after acute myocardial infarction (AMI). One hundred and seventeen (26%) of them were considered as having a complicated AMI. During a follow-up of 4.5 years their mortality was 49% vs 23% in the remaining patients with uncomplicated AMI. The survival of...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Saunamaki KI,Andersen JD

    更新日期:1987-06-01 00:00:00

  • Effects of the new class III antiarrhythmic drug dofetilide on the atrial and ventricular intracardiac monophasic action potential in patients with angina pectoris.

    abstract::The class III antiarrhythmic drug dofetilide is known to prolong action potential duration by specific blockade of the delayed rectifier potassium channel Ik. As dofetilide is likely to be used in the treatment of atrial arrhythmias it is important to determine the relative sensitivity of the atrium and ventricle in m...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sedgwick ML,Dalrymple I,Rae AP,Cobbe SM

    更新日期:1995-11-01 00:00:00

  • Shock in acute myocardial infarction: the Cape Horn for trials?

    abstract::Despite therapeutic improvements, cardiogenic shock (CS) remains the most common cause of death in patients with acute myocardial infarction (AMI). In addition to percutaneous coronary intervention, inotropes, fluids, adjunctive medication, intra-aortic balloon counterpulsation, and also assist devices are widely used...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Thiele H,Allam B,Chatellier G,Schuler G,Lafont A

    更新日期:2010-08-01 00:00:00

  • MicroRNA profiling unveils hyperglycaemic memory in the diabetic heart.

    abstract:AIMS:Recent randomized trials suggest that intensive glycaemic control fails to reduce heart failure-related events in patients with diabetes. The molecular cues underlying persistent myocardial damage despite normoglycaemia restoration remain elusive. MicroRNAs (miRNAs), a class of small non-coding RNAs, orchestrate t...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Costantino S,Paneni F,Lüscher TF,Cosentino F

    更新日期:2016-02-07 00:00:00

  • Right coronary artery flow impairment in patients with pulmonary hypertension.

    abstract:AIMS:This study investigates whether increased right ventricular (RV) pressure in pulmonary hypertension (PH) impairs right coronary artery (RCA) flow and RV perfusion. METHODS:In 25 subjects, five patients with idiopathic pulmonary arterial hypertension, nine patients with chronic thromboembolic pulmonary arterial hy...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: van Wolferen SA,Marcus JT,Westerhof N,Spreeuwenberg MD,Marques KM,Bronzwaer JG,Henkens IR,Gan CT,Boonstra A,Postmus PE,Vonk-Noordegraaf A

    更新日期:2008-01-01 00:00:00

  • Geographic variation in patient and hospital characteristics, management, and clinical outcomes in ST-elevation myocardial infarction treated with fibrinolysis. Results from InTIME-II.

    abstract:AIMS:We examined the geographic variations in InTIME-II, a randomized double-blind trial comparing alteplase with lanoteplase for myocardial infarction. METHODS AND RESULTS:We compared baseline characteristics, management, and outcomes in four regions (Western Europe, Eastern Europe, North America, and Latin America) ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Giugliano RP,Llevadot J,Wilcox RG,Gurfinkel EP,McCabe CH,Charlesworth A,Thompson SL,Antman EM,Braunwald E,InTIME (Intravenous nPA for Treatment of Infarcting Myocardium Early) II Investigators.

    更新日期:2001-09-01 00:00:00

  • Myocardial damage, inflammation and thrombin inhibition in unstable coronary artery disease.

    abstract:AIM:Unstable coronary artery disease (CAD) is a multifactorial disease involving both thrombotic and inflammatory processes. We have assessed the time-course and the influence of thrombin inhibitors on changes in fibrinogen and C-reactive protein levels, and their relation to myocardial ischaemia in unstable CAD. METH...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Oldgren J,Wallentin L,Grip L,Linder R,Nørgaard BL,Siegbahn A

    更新日期:2003-01-01 00:00:00

  • Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry.

    abstract:AIMS:Calmodulinopathies are rare life-threatening arrhythmia syndromes which affect mostly young individuals and are, caused by mutations in any of the three genes (CALM 1-3) that encode identical calmodulin proteins. We established the International Calmodulinopathy Registry (ICalmR) to understand the natural history,...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Crotti L,Spazzolini C,Tester DJ,Ghidoni A,Baruteau AE,Beckmann BM,Behr ER,Bennett JS,Bezzina CR,Bhuiyan ZA,Celiker A,Cerrone M,Dagradi F,De Ferrari GM,Etheridge SP,Fatah M,Garcia-Pavia P,Al-Ghamdi S,Hamilton RM,Al-H

    更新日期:2019-09-14 00:00:00

  • Arginase I enhances atherosclerotic plaque stabilization by inhibiting inflammation and promoting smooth muscle cell proliferation.

    abstract:AIMS:The aim of this study was to investigate the effect of Arginase I (ArgI) on plaque stabilization in unruptured atherosclerotic plaque and explore its mechanism. METHODS AND RESULTS:The atherosclerotic plaque model was established in New Zealand rabbits by balloon injury of abdominal arteries and a high cholestero...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Wang XP,Zhang W,Liu XQ,Wang WK,Yan F,Dong WQ,Zhang Y,Zhang MX

    更新日期:2014-04-01 00:00:00

  • A new management of syncope: prospective systematic guideline-based evaluation of patients referred urgently to general hospitals.

    abstract:AIMS:The guidelines of the European Society of Cardiology (ESC) define the current standard for the management of syncope, but are still incompletely applied in the clinical setting. METHODS AND RESULTS:Prospective systematic evaluation, on strict adherence to the guidelines, of consecutive patients referred for synco...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Brignole M,Menozzi C,Bartoletti A,Giada F,Lagi A,Ungar A,Ponassi I,Mussi C,Maggi R,Re G,Furlan R,Rovelli G,Ponzi P,Scivales A

    更新日期:2006-01-01 00:00:00

  • The relationship of QRS morphology and mechanical dyssynchrony to long-term outcome following cardiac resynchronization therapy.

    abstract:AIMS:Because benefits of cardiac resynchronization therapy (CRT) appear to be less favourable in non-left bundle branch block (LBBB) patients, this prospective longitudinal study tested the hypothesis that QRS morphology and echocardiographic mechanical dyssynchrony were associated with long-term outcome after CRT. ME...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Hara H,Oyenuga OA,Tanaka H,Adelstein EC,Onishi T,McNamara DM,Schwartzman D,Saba S,Gorcsan J 3rd

    更新日期:2012-11-01 00:00:00

  • Why use a nitrate in 1990?

    abstract::Nitrates are beneficial because they combine coronary and noncoronary effects. They have proven clinical efficacy, relieving symptoms and documented evidence of ischaemia. They can be given to patients by multiple routes and can be easily combined with other anti-ischaemic drugs including aspirin, heparin, calcium ant...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Conti CR

    更新日期:1991-05-01 00:00:00

  • Haemodynamic response to exercise in patients with chest pain and normal coronary angiograms.

    abstract::A series of 42 patients with chest pain but normal coronary angiograms and normal haemodynamics at rest were prospectively classified as typical angina (group 1, N = 9) or atypical angina (group 2, N = 16) or non-anginal chest pain (group 3, N = 17). All patients underwent radionuclide ventriculography and measurement...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Wieshammer S,Delagardelle C,Sigel HA,Henze E,Kress P,Bitter F,Adam WE,Stauch M

    更新日期:1986-08-01 00:00:00

  • Effects of sotalol and d-sotalol on ventricular tachycardia and fibrillation induced by programmed electrical stimulation.

    abstract::It is only in the last few years that the broad-spectrum antiarrhythmic properties of sotalol have become increasingly recognized. Racemic sotalol has potent beta-blocking and class III antiarrhythmic properties, and it has been reported that this drug is able to control supraventricular and ventricular arrhythmias. R...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Aliot E,Sadoul N,De Chillou C

    更新日期:1993-11-01 00:00:00

  • Left ventricular diastolic and systolic function in normotensive obese subjects: influence of degree and duration of obesity.

    abstract::The present study was carried out to evaluate systolic and diastolic parameters in overweight and moderately obese, but otherwise healthy subjects, and in a lean control group, to determine whether degree and duration of obesity can influence left ventricular function. A total of 27 subjects, 17 overweight or with mod...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Scaglione R,Dichiara MA,Indovina A,Lipari R,Ganguzza A,Parrinello G,Capuana G,Merlino G,Licata G

    更新日期:1992-06-01 00:00:00

  • STEMI and NSTEMI: are they so different? 1 year outcomes in acute myocardial infarction as defined by the ESC/ACC definition (the OPERA registry).

    abstract:AIMS:The ESC/ACC redefined myocardial infarction as any amount of necrosis caused by ischaemia. The aim of this study was to describe the management and outcomes using 'real-world' data taking the new definition of acute myocardial infarction into account. METHODS AND RESULTS:A total of 2,151 consecutive patients (76....

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Montalescot G,Dallongeville J,Van Belle E,Rouanet S,Baulac C,Degrandsart A,Vicaut E,OPERA Investigators.

    更新日期:2007-06-01 00:00:00

  • Ischaemic threshold and haemodynamic changes during angina at rest in patients with unstable angina.

    abstract::To examine whether increases in heart rate might be a common trigger of angina at rest, changes in heart rate, blood pressure and rate-pressure product during pain were compared with the ischaemic threshold (heart rate with ST segment shift > = 1 mm), determined by atrial pacing, in 272 patients with unstable angina. ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Figueras J,Lidón RM,Serés L

    更新日期:1993-09-01 00:00:00

  • Comparison between abnormalities in segmental endocardial motion and abnormalities in segmental wall thickening after anterior myocardial infarction. A cine-magnetic resonance study.

    abstract::In this study, two patterns of regional contract on of the left ventricle have been studied: endocardial motion and wall thickening, in order to check which of these was the most affected after myocardial infarction. The clinical relevance of this comparison was to assess which parameter of the regional contraction ab...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Germain P,Roul G,Constantinesco A,Coulbois PM,Baruthio J,Mossard JM,Bareiss P,Sacrez A

    更新日期:1996-09-01 00:00:00

  • Detection of prosthetic valve thrombosis using 111indium platelet imaging.

    abstract::The diagnosis of prosthetic valve thrombosis (PVT) may be difficult in cases without valve obstruction. The aim of this study was to evaluate the diagnostic accuracy of 111indium-labelled autologous platelet imaging in the detection of PVT. We studied 41 patients with 45 prostheses, mechanical (37) or biological (8), ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Acar J,Vahanian A,Dorent R,Fauchet M,Mundler O,Michel PL,Roger V,Cormier B

    更新日期:1990-05-01 00:00:00

  • Cardiac anatomy, function and metabolism in elite cyclists assessed by magnetic resonance imaging and spectroscopy.

    abstract::We investigated whether left ventricular hypertrophy in elite cyclists is associated with functional changes or abnormal energy metabolism. Left ventricular hypertrophy is a powerful risk factor for sudden cardiac death with different prognostic significance among the various geometric forms. Cyclists may have a combi...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Pluim BM,Chin JC,De Roos A,Doornbos J,Siebelink HM,Van der Laarse A,Vliegen HW,Lamerichs RM,Bruschke AV,Van der Wall EE

    更新日期:1996-08-01 00:00:00

  • Mortality and repeat interventions up until 20 years after aorto-coronary bypass surgery with saphenous vein grafts. A follow-up study of 1041 patients.

    abstract:AIMS:To determine very long-term survival and incidence of recurrent interventions following aorto-coronary bypass surgery using venous grafts. METHODS AND RESULTS:A group of 1041 consecutive patients operated upon between 1971 and 1980 were followed for a median of 19 years (range 13-26). Peri-operative mortality was...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Veldkamp RF,Valk SD,van Domburg RT,van Herwerden LA,Meeter K

    更新日期:2000-05-01 00:00:00

  • Fibrinogen and cerebrovascular disease.

    abstract::The importance of fibrinogen has been identified in two prospective observational studies. Reactive elevations in fibrinogen levels that occur within hours of a major stroke invalidate most cross-sectional case-control studies evaluating fibrinogen as a risk factor. However, as no elevation is seen following fresh epi...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Qizilbash N

    更新日期:1995-03-01 00:00:00

  • Abnormalities in intracellular Ca2+ regulation contribute to the pathomechanism of Tako-Tsubo cardiomyopathy.

    abstract:AIMS:The Tako-Tsubo cardiomyopathy (TTC) is characterized by a transient contractile dysfunction that has been assigned to excessive catecholamine levels after episodes of severe emotional or physical stress. Several studies have indicated that beta-adrenoceptor stimulation is associated with alteration in gene express...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Nef HM,Möllmann H,Troidl C,Kostin S,Voss S,Hilpert P,Behrens CB,Rolf A,Rixe J,Weber M,Hamm CW,Elsässer A

    更新日期:2009-09-01 00:00:00