Prospective, randomized trial of bioresorbable scaffolds vs. everolimus-eluting stents in patients undergoing coronary stenting for myocardial infarction: the Intracoronary Scaffold Assessment a Randomized evaluation of Absorb in Myocardial Infarction (IS

Abstract:

Aims:Bioresorbable scaffolds (BRS) provide short-term coronary artery scaffolding and drug delivery. Although prior trials showed a higher rate of device failure compared with conventional drug-eluting stents (DES), only a single trial investigated patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (MI). We aimed to compare outcomes with BRS vs. DES in patients undergoing PCI for MI. Methods and results:We did a prospective, randomized, multicentre, non-inferiority, clinical trial of everolimus-eluting BRS vs. durable polymer everolimus-eluting stents (EES) in patients with acute MI. Patients were eligible for enrolment if they presented with ST-elevation MI, or non-ST-elevation MI with thrombosis visual at angiography and were randomly allocated to treatment with BRS or EES in 2:1 proportion. Angiographic follow-up was scheduled at 6-8 months and clinical follow-up was done at 12 months. The primary endpoint was percentage diameter stenosis in-segment at follow-up. A total of 262 patients were enrolled and were allocated to BRS (n = 173) or EES (n = 89). Angiographic follow-up was available for 213 (81.3%) patients. Mean diameter stenosis was 24.6 ± 12.2% with BRS vs. 27.3 ± 11.7% with EES (mean difference -2.7%, upper limit of one-sided 97.5% confidence limit 0.7%, pre-specified margin of non-inferiority 5%, Pnon-inferiority <0.001). The rate of the device-oriented composite of cardiac death/target vessel MI/target lesion revascularization [BRS: 12 (7.0%) vs. EES: 6 (6.7%), hazard ratio (HR) 1.04, 95% confidence interval (CI) 0.39-2.78] and definite/probable stent thrombosis [3 (1.7%) vs. 2 (2.3%), HR 0.76, 95% CI 0.13-4.56] were comparable in both groups. Conclusion:In patients undergoing PCI for acute MI BRS were non-inferior to EES for percentage diameter stenosis at angiographic follow-up. Rates of clinical events were comparable between the treatment groups, although the study was not powered to detect differences in clinical outcomes. Clinical trial registration:The trial was registered at www.clinicaltrials.gov (NCT01942070).

journal_name

Eur Heart J

journal_title

European heart journal

authors

Byrne RA,Alfonso F,Schneider S,Maeng M,Wiebe J,Kretov E,Bradaric C,Rai H,Cuesta J,Rivero F,Hoppmann P,Schlichtenmaier J,Christiansen EH,Cassese S,Joner M,Schunkert H,Laugwitz KL,Kastrati A

doi

10.1093/eurheartj/ehy710

subject

Has Abstract

pub_date

2019-01-07 00:00:00

pages

167-176

issue

2

eissn

0195-668X

issn

1522-9645

pii

5231946

journal_volume

40

pub_type

杂志文章,随机对照试验
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    doi:10.1093/oxfordjournals.eurheartj.a060362

    authors: Arend SM,Bax JJ,Hermans J,van der Wall EE,Sedney MI

    更新日期:1994-01-01 00:00:00

  • Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts.

    abstract:AIMS:Induced pluripotent stem cells (iPSCs) provide a unique opportunity for the generation of patient-specific cells for use in disease modelling, drug screening, and regenerative medicine. The aim of this study was to compare human-induced pluripotent stem cells (hiPSCs) derived from different somatic cell sources re...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehs203

    authors: Streckfuss-Bömeke K,Wolf F,Azizian A,Stauske M,Tiburcy M,Wagner S,Hübscher D,Dressel R,Chen S,Jende J,Wulf G,Lorenz V,Schön MP,Maier LS,Zimmermann WH,Hasenfuss G,Guan K

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  • Beneficial effect of residual anterograde flow on tissue viability as assessed by positron emission tomography in patients with myocardial infarction.

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    journal_title:European heart journal

    pub_type: 杂志文章

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    authors: Schwaiger M,Brunken RC,Krivokapich J,Child JS,Tillisch JH,Phelps ME,Schelbert HR

    更新日期:1987-09-01 00:00:00

  • Influence of ambulance crew's length of experience on the outcome of out-of-hospital cardiac arrest.

    abstract:AIMS:To investigate whether an ambulance crew's length of experience affected the outcome of out-of-hospital cardiac arrest. METHODS AND RESULTS:This was a population-based, retrospective observational study of attempted resuscitations in 1547 consecutive arrests of cardiac aetiology by Nottinghamshire Emergency Ambul...

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    pub_type: 杂志文章

    doi:10.1053/euhj.1998.1334

    authors: Soo LH,Gray D,Young T,Skene A,Hampton JR

    更新日期:1999-04-01 00:00:00

  • Effects of percutaneous balloon mitral valvuloplasty and exercise training on the kinetics of recovery oxygen consumption after exercise in patients with mitral stenosis.

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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1998-12-01 00:00:00

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    journal_title:European heart journal

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    authors: Mizuno R,Fujimoto S,Nakano H,Nakajima T,Kimura A,Nakagawa Y,Dohi K

    更新日期:1997-12-01 00:00:00

  • The value of exercise-induced U-wave inversion on ECG chest wall mapping in the identification of individual coronary arterial lesions.

    abstract::Exercise-induced U-wave inversion on chest wall mapping was compared with coronary arteriographic findings in 160 consecutive patients who presented with chest pain suggestive of ischaemic heart disease. ECG recordings were made from 16 points on the chest wall before, during and after exercise. None of the 27 patient...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061883

    authors: Salmasi AM,Salmasi SN,Nicolaides AN,Vecht RJ,Hendry WG,Kidner PH,Besterman EM

    更新日期:1985-05-01 00:00:00

  • Patient differences related to management in general practice and the hospital: a cross-sectional study of heart failure in the community.

    abstract:AIM:To compare patients treated for heart failure in relation to the management in general practices versus hospital admission. METHODS AND RESULTS:Twelve randomly selected general practices (GP) were screened for patients receiving ACE-inhibitor, digoxin, or loop diuretic treatment. The first 500 volunteers of 959 po...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ehj.2004.06.033

    authors: Nielsen OW,McDonagh T,Cowburn P,Blue L,Robb SD,Dargie H

    更新日期:2004-10-01 00:00:00

  • Serum amyloid A: high-density lipoproteins interaction and cardiovascular risk.

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    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehv352

    authors: Zewinger S,Drechsler C,Kleber ME,Dressel A,Riffel J,Triem S,Lehmann M,Kopecky C,Säemann MD,Lepper PM,Silbernagel G,Scharnagl H,Ritsch A,Thorand B,de las Heras Gala T,Wagenpfeil S,Koenig W,Peters A,Laufs U,Wanner C,

    更新日期:2015-11-14 00:00:00

  • Acute vascular toxicity after combination chemotherapy with cisplatin, vinblastine, and bleomycin for testicular cancer.

    abstract::Twenty-one consecutive patients with testicular cancer treated with bleomycin, vinblastine, and cisplatin (PVB) were evaluated for acute vascular ischaemic events during chemotherapy. Angina pectoris occurred in 8/21 (38%) patients, a median 5.6 weeks after initiation of chemotherapy and persisted for 2-7 days. Raynau...

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    doi:10.1093/oxfordjournals.eurheartj.a062542

    authors: Stefenelli T,Kuzmits R,Ulrich W,Glogar D

    更新日期:1988-05-01 00:00:00

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    abstract::Pulsed Doppler tracings of the mitral inflow are often proposed to describe left ventricular function during filling in hypertensive patients. The tracings are determined by the complex interaction of left atrial pressure and left ventricular relaxation, diastolic compliance and contractility of the left atrium. They ...

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    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/11.suppl_g.79

    authors: Diebold B,Cohen A,Zelinsky R,Raffoul H,Foucher A,Guermonprez JL,Peronneau P

    更新日期:1990-11-01 00:00:00

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    authors: Michel PL,Houdart E,Ghanem G,Badaoui G,Hage A,Acar J

    更新日期:1987-05-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehu168

    authors: Ross S,Eikelboom J,Anand SS,Eriksson N,Gerstein HC,Mehta S,Connolly SJ,Rose L,Ridker PM,Wallentin L,Chasman DI,Yusuf S,Paré G

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  • Stent thrombosis and restenosis: what have we learned and where are we going? The Andreas Grüntzig Lecture ESC 2014.

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    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehv511

    authors: Byrne RA,Joner M,Kastrati A

    更新日期:2015-12-14 00:00:00

  • Prognostic value of plasma neuropeptide-Y in coronary care unit patients with and without acute myocardial infarction.

    abstract::Plasma neuropeptide Y-like immunoreactivity (NPY-LI) is elevated in patients with acute myocardial ischaemia and congestive heart failure (CHF) owing to increased activity of the sympathetic nervous system. The prognostic value of plasma NPY-LI with regard to mortality was studied in 324 random patients admitted to a ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060526

    authors: Ullman B,Hulting J,Lundberg JM

    更新日期:1994-04-01 00:00:00

  • Four-day urocortin-I administration has sustained beneficial haemodynamic, hormonal, and renal effects in experimental heart failure.

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    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehi351

    authors: Rademaker MT,Charles CJ,Espiner EA,Frampton CM,Lainchbury JG,Richards AM

    更新日期:2005-10-01 00:00:00

  • The acute effects of intravenous nisoldipine on left ventricular function within 24 h after acute myocardial infarction.

    abstract::Nisoldipine is a calcium antagonist with potent coronary vasodilating effects in patients with chronic stable angina pectoris. We studied the acute effects of nisoldipine in six patients within 24 h (mean 14 +/- 4 h) after the onset of myocardial infarction. Nisoldipine was administered as a 4.5 micrograms kg-1 intrav...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060125

    authors: Chin JC,van der Wall EE,Manger Cats V,van der Laarse A,Blokland JA,Pauwels EJ,Bruschke AV

    更新日期:1992-12-01 00:00:00

  • Electrophysiology of heterotopic heart transplant: experimental study in dogs.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059744

    authors: Alvarez L,Escudero C,Alzueta J,Silva L,Márquez-Montes J,Castillo-Olivares JL

    更新日期:1990-06-01 00:00:00

  • Cytomegalovirus-associated heart muscle disease.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/16.suppl_o.46

    authors: Schönian U,Crombach M,Maser S,Maisch B

    更新日期:1995-12-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/8.suppl_l.25

    authors: van Ginneken AC,Bouman LN,Jongsma HJ,Duivenvoorden JJ,Opthof T,Giles WR

    更新日期:1987-12-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa543

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015345

    authors: Furukawa T,Haque T,Takahashi M,Kinoshita M

    更新日期:1997-05-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

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    authors: O'Donoghue M,Morrow DA,Cannon CP,Guo W,Murphy SA,Gibson CM,Sabatine MS

    更新日期:2008-04-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060780

    authors: Meeder JG,Blanksma PK,Crijns HJ,Anthonio RL,Pruim J,Brouwer J,de Jong RM,van der Wall EE,Vaalburg W,Lie KI

    更新日期:1995-11-01 00:00:00

  • From traditional pharmacological towards nucleic acid-based therapies for cardiovascular diseases.

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    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa229

    authors: Landmesser U,Poller W,Tsimikas S,Most P,Paneni F,Lüscher TF

    更新日期:2020-10-21 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehn577

    authors: Wikstrom G,Blomström-Lundqvist C,Andren B,Lönnerholm S,Blomström P,Freemantle N,Remp T,Cleland JG,CARE-HF study investigators.

    更新日期:2009-04-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehv757

    authors: Ghadri JR,Sarcon A,Diekmann J,Bataiosu DR,Cammann VL,Jurisic S,Napp LC,Jaguszewski M,Scherff F,Brugger P,Jäncke L,Seifert B,Bax JJ,Ruschitzka F,Lüscher TF,Templin C,InterTAK Co-investigators:.

    更新日期:2016-10-01 00:00:00

  • Geographic variation in patient and hospital characteristics, management, and clinical outcomes in ST-elevation myocardial infarction treated with fibrinolysis. Results from InTIME-II.

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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1053/euhj.2001.2583

    authors: Giugliano RP,Llevadot J,Wilcox RG,Gurfinkel EP,McCabe CH,Charlesworth A,Thompson SL,Antman EM,Braunwald E,InTIME (Intravenous nPA for Treatment of Infarcting Myocardium Early) II Investigators.

    更新日期:2001-09-01 00:00:00

  • Atherogenic risk reduction in patients with dyslipidaemia. comparison between bezafibrate and lovastatin.

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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a060769

    authors: Sinzinger H,Pirich C,Kondor P,Etti H

    更新日期:1995-11-01 00:00:00

  • Intermittent hypoxia inhibits clearance of triglyceride-rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnoea.

    abstract:AIMS:Delayed lipoprotein clearance is associated with atherosclerosis. This study examined whether chronic intermittent hypoxia (CIH), a hallmark of obstructive sleep apnoea (OSA), can lead to hyperlipidaemia by inhibiting clearance of triglyceride rich lipoproteins (TRLP). METHODS AND RESULTS:Male C57BL/6J mice on hi...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr097

    authors: Drager LF,Li J,Shin MK,Reinke C,Aggarwal NR,Jun JC,Bevans-Fonti S,Sztalryd C,O'Byrne SM,Kroupa O,Olivecrona G,Blaner WS,Polotsky VY

    更新日期:2012-03-01 00:00:00