Patient differences related to management in general practice and the hospital: a cross-sectional study of heart failure in the community.


AIM:To compare patients treated for heart failure in relation to the management in general practices versus hospital admission. METHODS AND RESULTS:Twelve randomly selected general practices (GP) were screened for patients receiving ACE-inhibitor, digoxin, or loop diuretic treatment. The first 500 volunteers of 959 potential subjects were invited to a cardiac examination after exclusion of 235 frail, physically or mentally disabled patients. A diagnosis of heart failure during hospital admission (Hospital-HF, n = 102) was more related (p < 0.05) to male sex (45% vs. 21%), advanced age (73 vs. 70 years), breathlessness (75% vs. 62%), LV systolic dysfunction (47% vs. 20%), objective cardiac abnormality (92% vs. 65%) and higher 4-year mortality (33% vs. 15%) than patients taking loop diuretics due to signs and symptoms of heart failure in GP (GP-HF). Patients without clinical heart failure (n = 301) had the same survival but less symptoms and cardiac abnormalities than GP-HF patients. CONCLUSION:A surplus morbidity and mortality was related to a hospital-based rather than a GP based diagnosis of HF. Patients managed in GP were different from patients entering previous clinical trials of heart failure. We estimate that the pool of patients hospitalised with systolic heart failure would be increased from 1.3 to 1.4 more if all patients from primary care were included.


Eur Heart J


European heart journal


Nielsen OW,McDonagh T,Cowburn P,Blue L,Robb SD,Dargie H




Has Abstract


2004-10-01 00:00:00














  • Efficacy of once daily bisoprolol in stable angina pectoris: an objective comparison with atenolol and long term follow-up.

    abstract::Bisoprolol is a new cardioselective beta-blocker with a long half-life. The efficacy of once daily bisoprolol (10 mg) and atenolol (100 mg) was assessed in 20 patients with stable angina using a placebo controlled double-blind randomized crossover protocol. Efficacy was assessed by computer assisted treadmill exercise...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kohli RS,Khurmi NS,Kardash MM,Hughes LO,Lahiri A,Raftery EB

    更新日期:1985-10-01 00:00:00

  • Molecular imaging-guided repair after acute myocardial infarction by targeting the chemokine receptor CXCR4.

    abstract:AIMS :Balance between inflammatory and reparative leucocytes allows optimal healing after myocardial infarction (MI). Interindividual heterogeneity evokes variable functional outcome complicating targeted therapy. We aimed to characterize infarct chemokine CXC-motif receptor 4 (CXCR4) expression using positron emission...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Hess A,Derlin T,Koenig T,Diekmann J,Wittneben A,Wang Y,Wester HJ,Ross TL,Wollert KC,Bauersachs J,Bengel FM,Thackeray JT

    更新日期:2020-10-01 00:00:00

  • Autonomic, ischaemic, circadian and rhythmic factors as causes of the spontaneous variability of ventricular arrhythmias.

    abstract::Ventricular arrhythmias present with strongly varying intensity. This spontaneous variability makes it difficult to use one of the existing arrhythmia grading systems for risk or therapy efficacy studies. We attempted to explain the variability by the changing autonomic, ischaemic, circadian, and rhythmic factors. Fou...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Janssen MJ,Swenne CA,Manger Cats V,van Bemmel JH,Bruschke AV

    更新日期:1995-05-01 00:00:00

  • Cardio-Oncology Services: rationale, organization, and implementation.

    abstract:AIMS:Anticancer therapies have extended the lives of millions of patients with malignancies, but for some this benefit is tempered by adverse cardiovascular (CV) effects. Cardiotoxicity may occur early or late after treatment initiation or termination. The extent of this cardiotoxicity is variable, depending on the typ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Lancellotti P,Suter TM,López-Fernández T,Galderisi M,Lyon AR,Van der Meer P,Cohen Solal A,Zamorano JL,Jerusalem G,Moonen M,Aboyans V,Bax JJ,Asteggiano R

    更新日期:2019-06-07 00:00:00

  • The Belgian Improvement Study on Oral Anticoagulation Therapy: a randomized clinical trial.

    abstract:AIMS:In Belgium, general practitioners (GPs) mainly manage oral anticoagulation therapy. To improve the quality of oral anticoagulation management by GPs and to compare different models and interventions, a randomized clinical trial was performed. METHODS AND RESULTS:Stratified randomization divided 66 GP-practices in...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Claes N,Buntinx F,Vijgen J,Arnout J,Vermylen J,Fieuws S,Van Loon H

    更新日期:2005-10-01 00:00:00

  • Characterization of relevant membrane antigens by two-dimensional immunoblot and n-terminal sequence analysis in patients with myocarditis.

    abstract::In myocarditis an antigen-specific immune response to cardiac epitopes has been demonstrated by several investigators. In 25 patients with histologically proven myocarditis, autoantibodies to cardiac tissue were observed in 65% by immunofluorescence assay. By immunoblot analysis 46% of sera reacted with cardiac tissue...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Pankuweit S,Lottspeich F,Maisch B

    更新日期:1995-12-01 00:00:00

  • Systolic time intervals as indicators for cardiac function in rat models for heart failure.

    abstract::Measurement of the pre-ejection period (PEP) can give valuable information on myocardial function in rats. Depressed cardiac function is accompanied by prolongation of PEP, which shortens when cardiac function improves. Left ventricular ejection time (LVET) may be shortened with ageing in spontaneously hypertensive ra...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Schoemaker RG,Smits JF

    更新日期:1990-12-01 00:00:00

  • Relationship between the degree of coronary artery disease and of left ventricular function and the duration of the QT-interval in ECG.

    abstract::Advanced coronary artery disease (CAD), impaired left ventricular function and prolongation of the QT-interval are considered risk factors for sudden cardiac death in CAD-patients. So far, however, there are no studies investigating in detail whether there is a correlation between the QT-interval and changes in corona...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Krämer B,Brill M,Brühn A,Kübler W

    更新日期:1986-01-01 00:00:00

  • Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort.

    abstract:AIM:Cross-sectional studies reported associations between short leucocyte telomere length (LTL) and measures of vascular and cardiac damage. However, the contribution of LTL dynamics to the age-related process of cardiovascular (CV) remodelling remains unknown. In this study, we explored whether the rate of LTL shorten...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Masi S,D'Aiuto F,Martin-Ruiz C,Kahn T,Wong A,Ghosh AK,Whincup P,Kuh D,Hughes A,von Zglinicki T,Hardy R,Deanfield JE,NSHD scientific and data collection teams.

    更新日期:2014-12-07 00:00:00

  • Implications of variability in definition and reporting of major bleeding in randomized trials of oral P2Y12 inhibitors for acute coronary syndromes.

    abstract:AIMS:Various definitions of major bleeding have been used to evaluate safety in randomized controlled trials of antiplatelet therapy. We compared the definitions and rates of major bleeding in phase III randomized controlled trials of oral P2Y(12) inhibitors in the management of patients with acute coronary syndromes (...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审


    authors: Quinlan DJ,Eikelboom JW,Goodman SG,Welsh RC,Fitchett DH,Théroux P,Mehta SR

    更新日期:2011-09-01 00:00:00

  • Cytomegalovirus-associated heart muscle disease.

    abstract::Human cytomegalovirus (CMV) can persist in many organs after primary infection. Not only is it suspected to cause morbidity during reactivation in patients under immunosuppression, but it may also induce long-term latency by chronic disease, e.g. in the myocardium. Endomyocardial biopsies of 27 patients with active my...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Schönian U,Crombach M,Maser S,Maisch B

    更新日期:1995-12-01 00:00:00

  • Pneumococcal endocarditis.

    abstract::Among 369 patients with native valve infective endocarditis observed during a 14-year period, 17 were related to S: pneumoniae. Fourteen of them were observed in the last 7 years. At the time of admission 13 exhibited purulent meningitis, 6 of them being comatose. An apparent portal of entry was present in 13 patients...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Wolff M,Regnier B,Witchitz S,Gibert C,Amoudry C,Vachon F

    更新日期:1984-10-01 00:00:00

  • Psoriasis and risk of atrial fibrillation and ischaemic stroke: a Danish Nationwide Cohort Study.

    abstract:AIMS:Psoriasis is a chronic inflammatory disease and inflammation contributes to the pathogenesis of atrial fibrillation (AF) and ischaemic stroke. We therefore investigated the risk of these endpoints in patients with psoriasis. METHODS AND RESULTS:Cohort study of the entire Danish population followed from 1997 to 20...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Ahlehoff O,Gislason GH,Jørgensen CH,Lindhardsen J,Charlot M,Olesen JB,Abildstrøm SZ,Skov L,Torp-Pedersen C,Hansen PR

    更新日期:2012-08-01 00:00:00

  • Risk of hospitalization for heart failure in patients with type 2 diabetes newly treated with DPP-4 inhibitors or other oral glucose-lowering medications: a retrospective registry study on 127,555 patients from the Nationwide OsMed Health-DB Database.

    abstract:AIMS:Oral glucose-lowering medications are associated with excess risk of heart failure (HF). Given the absence of comparative data among drug classes, we performed a retrospective study in 32 Health Services of 16 Italian regions accounting for a population of 18 million individuals, to assess the association between ...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Fadini GP,Avogaro A,Degli Esposti L,Russo P,Saragoni S,Buda S,Rosano G,Pecorelli S,Pani L,OsMed Health-DB Network.

    更新日期:2015-09-21 00:00:00

  • The European Study of Epidemiology and Treatment of Cardiac Inflammatory Disease (ESETCID).

    abstract::Diagnosis of myocarditis has improved with the application of new techniques such as immunohistochemistry, polymerase chain reaction, in situ hybridization and Southern blot in endomyocardial biopsies. Treatment of inflammatory heart disease is still difficult and not yet validated by a study with patient numbers suff...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Maisch B,Hufnagel G,Schönian U,Hengstenberg C

    更新日期:1995-12-01 00:00:00

  • Sex associations and computed tomography coronary angiography-guided management in patients with stable chest pain.

    abstract:AIMS:The relative benefits of computed tomography coronary angiography (CTCA)-guided management in women and men with suspected angina due to coronary heart disease (CHD) are uncertain. METHODS AND RESULTS:In this post hoc analysis of an open-label parallel-group multicentre trial, we recruited 4146 patients referred ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Mangion K,Adamson PD,Williams MC,Hunter A,Pawade T,Shah ASV,Lewis S,Boon NA,Flather M,Forbes J,McLean S,Roditi G,van Beek EJR,Timmis AD,Newby DE,McAllister DA,Berry C

    更新日期:2020-04-01 00:00:00

  • Value and limitations of aortic valve resistance with particular consideration of low flow-low gradient aortic stenosis: an in vitro study.

    abstract:BACKGROUND:The calculation of valve resistance (R) rather than aortic valve area (AVA) has been proposed for the assessment of aortic stenosis (AS), based on the claim that it is less flow-dependent. Even more importantly, valve resistance has been reported to distinguish between truly severe and "pseudosevere" AS in p...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Mascherbauer J,Schima H,Rosenhek R,Czerny M,Maurer G,Baumgartner H

    更新日期:2004-05-01 00:00:00

  • Myocardial changes in pressure overload-induced left ventricular hypertrophy. A study on tissue composition, polyploidization and multinucleation.

    abstract::Morphological changes in human myocardium associated with pressure overload-induced left ventricular hypertrophy were studied in 22 normal and 21 hypertrophic hearts obtained at autopsy. Samples were obtained from the left lateral ventricular wall, half way between the apex and the base. Myocyte dimensions, polyploidi...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Vliegen HW,van der Laarse A,Cornelisse CJ,Eulderink F

    更新日期:1991-04-01 00:00:00

  • Comparison between abnormalities in segmental endocardial motion and abnormalities in segmental wall thickening after anterior myocardial infarction. A cine-magnetic resonance study.

    abstract::In this study, two patterns of regional contract on of the left ventricle have been studied: endocardial motion and wall thickening, in order to check which of these was the most affected after myocardial infarction. The clinical relevance of this comparison was to assess which parameter of the regional contraction ab...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Germain P,Roul G,Constantinesco A,Coulbois PM,Baruthio J,Mossard JM,Bareiss P,Sacrez A

    更新日期:1996-09-01 00:00:00

  • Use of abciximab in interventional cardiology.

    abstract::The advent of platelet membrane glycoprotein (GP) IIb/IIIa inhibitors has changed the landscape of interventional cardiology. Given the commercial availability of abciximab and expected regulatory approvals for other receptor blockers, defining appropriate use of these agents in the interventional setting is mandated....

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Chronos N,Vahanian A,Betriu A,Emanuelsson H,Goldberg S,Gulba D,van Hout BA

    更新日期:1998-04-01 00:00:00

  • Causes-of-death analysis of patients with cardiac resynchronization therapy: an analysis of the CeRtiTuDe cohort study.

    abstract:AIMS:The choice of resynchronization therapy between with (CRT-D) and without (CRT-P) a defibrillator remains a contentious issue. Cause-of-death analysis among CRT-P, compared with CRT-D, patients could help evaluate the extent to which CRT-P patients would have additionally benefited from a defibrillator in a daily c...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Marijon E,Leclercq C,Narayanan K,Boveda S,Klug D,Lacaze-Gadonneix J,Defaye P,Jacob S,Piot O,Deharo JC,Perier MC,Mulak G,Hermida JS,Milliez P,Gras D,Cesari O,Hidden-Lucet F,Anselme F,Chevalier P,Maury P,Sadoul N,

    更新日期:2015-11-01 00:00:00

  • MicroRNA profiling unveils hyperglycaemic memory in the diabetic heart.

    abstract:AIMS:Recent randomized trials suggest that intensive glycaemic control fails to reduce heart failure-related events in patients with diabetes. The molecular cues underlying persistent myocardial damage despite normoglycaemia restoration remain elusive. MicroRNAs (miRNAs), a class of small non-coding RNAs, orchestrate t...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Costantino S,Paneni F,Lüscher TF,Cosentino F

    更新日期:2016-02-07 00:00:00

  • Risk of dementia in stroke-free patients diagnosed with atrial fibrillation: data from a community-based cohort.

    abstract:AIMS:To estimate the incidence of dementia after the first atrial fibrillation (AF), and its impact on survival in a community-based cohort. METHODS AND RESULTS:Olmsted County, Minnesota adult residents diagnosed with first AF during 1986-2000 were identified, and followed until 2004. The primary outcome was new detec...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Miyasaka Y,Barnes ME,Petersen RC,Cha SS,Bailey KR,Gersh BJ,Casaclang-Verzosa G,Abhayaratna WP,Seward JB,Iwasaka T,Tsang TS

    更新日期:2007-08-01 00:00:00

  • Adequacy of endogenous erythropoietin levels and mortality in anaemic heart failure patients.

    abstract:AIMS:We examined the adequacy of endogenous erythropoietin (EPO) levels for the degree of anaemia in patients with chronic heart failure (CHF) and its relation to prognosis. METHODS AND RESULTS:We studied 74 anaemic CHF patients from a cohort of 240 patients. The adequacy of endogenous EPO levels was assessed by deriv...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: van der Meer P,Lok DJ,Januzzi JL,de la Porte PW,Lipsic E,van Wijngaarden J,Voors AA,van Gilst WH,van Veldhuisen DJ

    更新日期:2008-06-01 00:00:00

  • Plasma concentrations of platelet-specific proteins in young female acute myocardial infarction survivors and their age-matched female controls.

    abstract::The steady state plasma concentrations of the two platelet-specific proteins beta-thromboglobulin (BTG) and platelet factor 4 (PF4) were determined in two groups of females: 36 acute myocardial infarction (AMI) survivors, and 38 age-matched control subjects. For the AMI patients the mean BTG and PF4 values were 57 +/-...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Kutti J,Johansson S,Eriksson KA,Sigvaldason A,Vedin A,Wadenvik H,Wilhelmsson C

    更新日期:1983-05-01 00:00:00

  • Serial electrophysiologic studies after single chamber atrial pacemaker implantation in patients with symptomatic sinus node dysfunction.

    abstract::After single chamber atrial pacemaker implantation, serial electrophysiologic studies were performed noninvasively at intervals of 3 months over a total period of 3 years in 24 patients with symptomatic sinus node dysfunction. All patients underwent invasive electrophysiologic studies before pacemaker implantation and...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: van Mechelen R,Segers A,Hagemeijer F

    更新日期:1984-08-01 00:00:00

  • Excimer laser coronary angioplasty: experience with a prototype multifibre catheter in patients with stable angina pectoris.

    abstract::Percutaneous excimer laser coronary angioplasty (ELCA) was performed in a first group of 20 patients with stable angina pectoris caused by significant coronary stenosis, and long-term follow-up was evaluated. Prototype 4 to 5.5 French multifibre catheters with 18-20 quartz fibres of 100 microns diameter, concentricall...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Kochs M,Haerer W,Eggeling T,Hoeher M,Schmidt A,Hombach V

    更新日期:1992-03-01 00:00:00

  • Everolimus-eluting bioresorbable vascular scaffolds for treatment of patients presenting with ST-segment elevation myocardial infarction: BVS STEMI first study.

    abstract:AIMS:We evaluated the feasibility and the acute performance of the everolimus-eluting bioresorbable vascular scaffolds (BVS) for the treatment of patients presenting with ST-segment elevation myocardial infarction (STEMI). METHODS AND RESULTS:The present investigation is a prospective, single-arm, single-centre study,...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Diletti R,Karanasos A,Muramatsu T,Nakatani S,Van Mieghem NM,Onuma Y,Nauta ST,Ishibashi Y,Lenzen MJ,Ligthart J,Schultz C,Regar E,de Jaegere PP,Serruys PW,Zijlstra F,van Geuns RJ

    更新日期:2014-03-01 00:00:00

  • A smoker's paradox in patients hospitalized for heart failure: findings from OPTIMIZE-HF.

    abstract:AIMS:Cigarette smoking is a well-established risk factor for cardiovascular disease yet several studies have shown lower mortality after acute coronary syndromes in smokers compared with non-smokers, the so called 'smoker's paradox'. This study aimed to ascertain the relationship between smoking and clinical outcomes i...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Fonarow GC,Abraham WT,Albert NM,Stough WG,Gheorghiade M,Greenberg BH,O'Connor CM,Nunez E,Yancy CW,Young JB

    更新日期:2008-08-01 00:00:00

  • High-sugar feeding and increasing cholesterol levels in infants.

    abstract::Hypercholesterolaemia is an important risk factor for cardiovascular disease. Both total and LDL cholesterol levels are three-fold higher at the end of the first year of life and about four-fold higher in adulthood compared with the neonatal period. In the USA, only 25% of infants are exclusively breastfed and simple ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Zubin Maslov P,Hill JA,Lüscher TF,Narula J

    更新日期:2020-12-16 00:00:00