Cardioprotective effect of calcineurin inhibition in an animal model of renal disease.


AIMS:Chronic kidney disease is directly associated with cardiovascular complications. Heart remodelling, including fibrosis, hypertrophy, and decreased vascularization, is frequently present in renal diseases. Our objective was to investigate the impact of calcineurin inhibitors (CNI) on cardiac remodelling and function in a rat model of renal disease. METHODS AND RESULTS:Male Sprague Dawley rats were divided into six groups: sham-operated rats, 5/6 nephrectomized rats (Nx) treated with vehicle, CNI (cyclosporine A 5.0 or 7.5, or tacrolimus 0.5 mg/kg/day) or hydralazine (20 mg/kg twice a day) for 14 days, starting on the day of surgery. Creatinine clearance was significantly lower and blood pressure significantly higher in Nx rats when compared with controls. Morphological and echocardiographic analyses revealed increased left ventricular hypertrophy and decreased number of capillaries in Nx rats. Treatment with CNI affected neither the renal function nor the blood pressure, but prevented the development of cardiac hypertrophy and improved vascularization. In addition, regional blood volume improved as confirmed by contrast agent-based echocardiography. Hydralazine treatment did not avoid heart remodelling in this model. Gene expression analysis verified a decrease in hypertrophic genes in the heart of CNI-treated rats, while pro-angiogenic and stem cell-related genes were upregulated. Moreover, mobilization of stem/progenitor cells was increased through manipulation of the CD26/SDF-1 system. CONCLUSION:We conclude from our studies that CNI-treatment significantly prevented cardiac remodelling and improved heart function in Nx rats without affecting renal function and blood pressure. This sheds new light on possible therapeutic strategies for renal patients at high cardiovascular risk.


Eur Heart J


European heart journal


Di Marco GS,Reuter S,Kentrup D,Ting L,Ting L,Grabner A,Jacobi AM,Pavenstädt H,Baba HA,Tiemann K,Brand M




Has Abstract


2011-08-01 00:00:00














  • The relationship between markers of extracellular cardiac matrix turnover: infarct healing and left ventricular remodelling following primary PCI in patients with first-time STEMI.

    abstract:AIMS:We investigated the temporal changes in circulating levels of markers of extracellular cardiac matrix (ECCM) turnover and their relationship with infarct size (IS), ejection fraction (EF), and left ventricular (LV) volumes, determined by serial cardiac magnetic resonance (CMR) imaging in patients with first-time S...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Manhenke C,Ueland T,Jugdutt BI,Godang K,Aukrust P,Dickstein K,Ørn S

    更新日期:2014-02-01 00:00:00

  • Diagnostic performance of body mass index to detect obesity in patients with coronary artery disease.

    abstract:BACKGROUND:Emerging evidence suggests that a mildly elevated body mass index (BMI), is related to improved survival and fewer cardiovascular events in patients with coronary artery disease (CAD). We hypothesize that these results are related to the poor diagnostic performance of BMI to detect adiposity, especially in t...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Romero-Corral A,Somers VK,Sierra-Johnson J,Jensen MD,Thomas RJ,Squires RW,Allison TG,Korinek J,Lopez-Jimenez F

    更新日期:2007-09-01 00:00:00

  • Infarct size, left ventricular function, and prognosis in women compared to men after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: results from an individual patient-level pooled analysis of 10 randomized trial

    abstract:Aim:Studies have reported less favourable outcomes in women compared with men after primary percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI). Whether sex-specific differences in the magnitude or prognostic impact of infarct size or post-infarction cardiac function explain t...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审


    authors: Kosmidou I,Redfors B,Selker HP,Thiele H,Patel MR,Udelson JE,Magnus Ohman E,Eitel I,Granger CB,Maehara A,Kirtane A,Généreux P,Jenkins PL,Ben-Yehuda O,Mintz GS,Stone GW

    更新日期:2017-06-01 00:00:00

  • Effects of lovastatin on progression of non-dilated and dilated coronary segments and on restenosis in patients after PTCA. The cholesterol lowering atherosclerosis PTCA trial (CLAPT).

    abstract:OBJECTIVES:The Cholesterol Lowering Atherosclerosis PTCA Trial (CLAPT) is a prospective, randomized trial with blinded angiographic end-points to assess the effect of 2-year's treatment with lovastatin initiated 4 weeks prior to PTCA, compared to usual care on non-dilated coronary segments and on dilated coronary lesio...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Kleemann A,Eckert S,von Eckardstein A,Lepper W,Schernikau U,Gleichmann U,Hanrath P,Fleck E,Neiss A,Kerber S,Assmann G,Breithardt G,CLAPT Study.

    更新日期:1999-10-01 00:00:00

  • Effects of percutaneous balloon mitral valvuloplasty and exercise training on the kinetics of recovery oxygen consumption after exercise in patients with mitral stenosis.

    abstract:AIMS:Kinetics of recovery oxygen consumption after exercise plays an important role in determining exercise capacity. This study was performed to assess the kinetics of recovery oxygen consumption in mitral stenosis and evaluate the effects of percutaneous balloon mitral valvuloplasty and exercise training on the kinet...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lim HY,Lee CW,Park SW,Kim JJ,Song JK,Hong MK,Jin YS,Park SJ

    更新日期:1998-12-01 00:00:00

  • Randomized trial of paclitaxel- and sirolimus-eluting stents in small coronary vessels.

    abstract:AIMS:Sirolimus- and paclitaxel-eluting stents effectively reduce restenosis in small coronary vessels. The relative efficacy of these drug-eluting stents in this high-risk subset is not known. METHODS AND RESULTS:A total of 360 patients undergoing percutaneous coronary intervention for de novo lesions in native corona...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Mehilli J,Dibra A,Kastrati A,Pache J,Dirschinger J,Schömig A,Intracoronary Drug-Eluting Stenting to Abrogate Restenosis in Small Arteries (ISAR-SMART 3) Study Investigators.

    更新日期:2006-02-01 00:00:00

  • Prognosis of ruptured intracranial mycotic aneurysms: a review of 12 cases.

    abstract::Intracranial mycotic aneurysms (IMA) occur in 1-3% of all infective endocarditis. Although spontaneous resolution was evidenced on serial angiograms in many asymptomatic cases, the prognosis, if they rupture, is reported to be worse and partly contingent on the therapeutic approach. Among 12 patients (six acute and si...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Monsuez JJ,Vittecoq D,Rosenbaum A,Goujon C,Wolff M,Witchitz S,Modai J

    更新日期:1989-09-01 00:00:00

  • Genetics of Coxsackie B3 (CVB3) myocarditis.

    abstract::The pathogenic T cell responsible for myocarditis following CVB3 infection differs between BALB/c and DBA/2 mice. Since these two strains are identical at the major histocompatibility (MHC) loci (both H-2d), our aim was to investigate the genetic basis for this difference in T cell immunity, as well as the tissue orig...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Van Houten N,Huber SA

    更新日期:1991-08-01 00:00:00

  • Transient acute ischaemic episodes during or immediately after percutaneous transluminal coronary angioplasty.

    abstract::Transient ischaemic episodes, defined as chest pain with ST segment elevation resolving in less than 15 min, have been encountered in 18 out of 130 patients during or in the 12h following percutaneous transluminal angioplasty (PTCA). During PTCA, ischaemic episodes occurred in 11 patients (8.5%) along with complete co...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Danchin N,Cuilliere M,Cherrier F

    更新日期:1984-05-01 00:00:00

  • Atrial fibrillation and cardiac fibrosis.

    abstract::The understanding of atrial fibrillation (AF) evolved from a sole rhythm disturbance towards the complex concept of a cardiomyopathy based on arrhythmia substrates. There is evidence that atrial fibrosis can be visualized using late gadolinium enhancement cardiac magnetic resonance imaging and that it is a powerful pr...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Sohns C,Marrouche NF

    更新日期:2020-03-07 00:00:00

  • Alpha-adrenergic receptor blockade and hyperaemic response in patients with intermediate coronary stenoses.

    abstract:BACKGROUND:Maximal hyperaemia is paramount in the diagnosis of patients with coronary artery disease. However in these patients, enhanced alpha-adrenergic microvascular vasoconstriction may preclude adenosine to induce maximal hyperaemia. AIM:To assess the presence and the clinical relevance of residual microvascular ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Barbato E,Bartunek J,Aarnoudse W,Vanderheyden M,Staelens F,Wijns W,Heyndrickx GR,Pijls NH,De Bruyne B

    更新日期:2004-11-01 00:00:00

  • Mortality of patients excluded from the Danish Verapamil Infarction Trail II. The DAVIT-II Study Group.

    abstract::The 18 month mortality rate in 2180 patients excluded from the Danish Verapamil Infarction Trail II (DAVIT II) was 25.6%. In non-consenters (n = 368) this was 15.0% compared with 13.85 in 897 placebo-treated patients (hazard ratio 1.09 [P = 0.60] when adjusting for sex and age). The increased mortality rate in exclude...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章


    authors: Madsen JK,Hansen JF

    更新日期:1993-03-01 00:00:00

  • Functional characteristics of myocardial bridging. A combined angiographic and intracoronary Doppler flow study.

    abstract:AIMS:Combined quantitative coronary angiography and intracoronary Doppler flow velocity measurements were performed to study the underlying haemodynamic mechanisms leading to myocardial ischaemia in patients with myocardial bridging in the absence of coronary artery disease. METHODS AND RESULTS:In 42 symptomatic patie...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Schwarz ER,Klues HG,vom Dahl J,Klein I,Krebs W,Hanrath P

    更新日期:1997-03-01 00:00:00

  • Effect of breathing oxygen-enriched air on exercise performance in patients with precapillary pulmonary hypertension: randomized, sham-controlled cross-over trial.

    abstract:Aims:The purpose of the current trial was to test the hypothesis that breathing oxygen-enriched air increases exercise performance of patients with pulmonary arterial or chronic thrombo-embolic pulmonary hypertension (PAH/CTEPH) and to investigate involved mechanisms. Methods and results:Twenty-two patients with PAH/C...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Ulrich S,Hasler ED,Saxer S,Furian M,Müller-Mottet S,Keusch S,Bloch KE

    更新日期:2017-04-14 00:00:00

  • Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts.

    abstract:AIMS:Growth differentiation factor 11 and/or its homologue growth differentiation factor 8 (GDF11/8) reverses age-related cardiac hypertrophy and vascular ageing in mice. We investigated whether GDF11/8 associates with cardiovascular outcomes, left ventricular hypertrophy (LVH), or age in humans. METHODS AND RESULTS:W...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Olson KA,Beatty AL,Heidecker B,Regan MC,Brody EN,Foreman T,Kato S,Mehler RE,Singer BS,Hveem K,Dalen H,Sterling DG,Lawn RM,Schiller NB,Williams SA,Whooley MA,Ganz P

    更新日期:2015-12-21 00:00:00

  • Inter-scan variability of coronary artery calcium scoring assessed on 64-multidetector computed tomography vs. dual-source computed tomography: a head-to-head comparison.

    abstract:AIMS:Coronary artery calcium (CAC) scoring has emerged as a tool for risk stratification and potentially for monitoring response to risk factor modification. Therefore, repeat measurements should provide robust results and low inter-scanner variability for allowing meaningful comparison. The purpose of this study was t...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Ghadri JR,Goetti R,Fiechter M,Pazhenkottil AP,Küest SM,Nkoulou RN,Windler C,Buechel RR,Herzog BA,Gaemperli O,Templin C,Kaufmann PA

    更新日期:2011-08-01 00:00:00

  • Combination of high-dose furosemide and hydrochlorothiazide in the treatment of refractory congestive heart failure.

    abstract:OBJECTIVE:We studied the synergism between high-dose furosemide and hydrochlorothiazide in patients with severe congestive heart failure and impaired renal function showing diuretic resistance to a daily dose of furosemide of at least 250 mg. DESIGN AND SETTING:An open study. A general hospital in The Netherlands. ME...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章


    authors: Dormans TP,Gerlag PG

    更新日期:1996-12-01 00:00:00

  • From guidelines to clinical practice: the impact of hospital and geographical characteristics on temporal trends in the management of acute coronary syndromes. The Global Registry of Acute Coronary Events (GRACE).

    abstract:AIMS:The extent to which hospital and geographic characteristics influence the time course of uptake of evidence from key clinical trials and practice guidelines is unknown. The gap between evidence and practice is well recognized but the factors influencing this disjunction, and the extent to which such factors are mo...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Fox KA,Goodman SG,Anderson FA Jr,Granger CB,Moscucci M,Flather MD,Spencer F,Budaj A,Dabbous OH,Gore JM,GRACE Investigators.

    更新日期:2003-08-01 00:00:00

  • Gastrointestinal bleeding in high risk survivors of myocardial infarction: the VALIANT Trial.

    abstract:AIMS:The risk of gastrointestinal (GI) bleeding limits the use of antiplatelet and anticoagulant drugs. Risk factors for GI bleeding in post- myocardial infarction (MI) patients have not been well defined. We sought to identify risk factors for GI bleeding in patients following MI. METHODS AND RESULTS:The VALsartan In...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Moukarbel GV,Signorovitch JE,Pfeffer MA,McMurray JJ,White HD,Maggioni AP,Velazquez EJ,Califf RM,Scheiman JM,Solomon SD

    更新日期:2009-09-01 00:00:00

  • Anomalous coronary arteries coursing between the aorta and pulmonary trunk: clinical indications for coronary artery bypass.

    abstract::Coronary arteries of anomalous origin with subsequent coursing between the aorta and pulmonary trunk can cause ischaemia, infarction or sudden death. However, reports of surgical correction are sparse due to the rarity of ante-mortem diagnosis. We report two cases in which symptoms were related to anomalous origin of ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Thomas D,Salloum J,Montalescot G,Drobinski G,Artigou JY,Grosgogeat Y

    更新日期:1991-07-01 00:00:00

  • Myocardial changes in pressure overload-induced left ventricular hypertrophy. A study on tissue composition, polyploidization and multinucleation.

    abstract::Morphological changes in human myocardium associated with pressure overload-induced left ventricular hypertrophy were studied in 22 normal and 21 hypertrophic hearts obtained at autopsy. Samples were obtained from the left lateral ventricular wall, half way between the apex and the base. Myocyte dimensions, polyploidi...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Vliegen HW,van der Laarse A,Cornelisse CJ,Eulderink F

    更新日期:1991-04-01 00:00:00

  • Multicentre, randomized comparison of two-stent and provisional stenting techniques in patients with complex coronary bifurcation lesions: the DEFINITION II trial.

    abstract:AIM:The present study aimed to assess the benefits of two-stent techniques for patients with DEFINITION criteria-defined complex coronary bifurcation lesions. METHODS AND RESULTS:In total, 653 patients with complex bifurcation lesions at 49 international centres were randomly assigned to undergo the systematic two-ste...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Zhang JJ,Ye F,Xu K,Kan J,Tao L,Santoso T,Munawar M,Tresukosol D,Li L,Sheiban I,Li F,Tian NL,Rodríguez AE,Paiboon C,Lavarra F,Lu S,Vichairuangthum K,Zeng H,Chen L,Zhang R,Ding S,Gao F,Jin Z,Hong L,Ma L,We

    更新日期:2020-07-14 00:00:00

  • Acute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery.

    abstract:AIMS:Vascular endothelial growth factor-A (VEGF-A) is an angiogenic and vasoprotective molecule whose expression is modulated by hypoxia and inflammatory mediators. Here we have tested the hypothesis that plasma levels of VEGF-A are influenced by pre-existing coronary artery disease and by changes in circulating interl...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Cotton JM,Mathur A,Hong Y,Brown AS,Martin JF,Erusalimsky JD

    更新日期:2002-06-01 00:00:00

  • Blood pressure, heart rate, and mortality in chronic obstructive pulmonary disease: the SUMMIT trial.

    abstract:Aims:To characterize the relationship between blood pressure (BP) or heart rate and mortality and morbidity in chronic obstructive pulmonary disease (COPD). Methods and results:We performed post hoc analysis of baseline BP or heart rate and all-cause mortality and cardiovascular events in the SUMMIT trial. SUMMIT was ...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Byrd JB,Newby DE,Anderson JA,Calverley PMA,Celli BR,Cowans NJ,Crim C,Martinez FJ,Vestbo J,Yates J,Brook RD,SUMMIT Investigators.

    更新日期:2018-09-01 00:00:00

  • Imaging techniques for the assessment of myocardial hibernation. Report of a Study Group of the European Society of Cardiology.

    abstract::This report of an ESC Study Group reviews current knowledge on myocardial hibernation and relevant imaging techniques, and provides an algorithm for investigation and management when a patient presents with ischaemic left ventricular dysfunction. It covers the definitions of myocardial viability, stunning and hibernat...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Underwood SR,Bax JJ,vom Dahl J,Henein MY,Knuuti J,van Rossum AC,Schwarz ER,Vanoverschelde JL,van der Wall EE,Wijns W,Study Group of the European Society of Cardiology.

    更新日期:2004-05-01 00:00:00

  • The significance of myocardial ischaemia and verapamil treatment on the prevalence of supraventricular tachyarrhythmias in patients recovering from acute myocardial infarction. Danish Study Group on Verapamil in Myocardial Infarction.

    abstract::Twenty-four hour Holter monitoring and symptom-limited exercise testing were carried out prior to discharge in 157 patients recovering from acute myocardial infarction. Supraventricular arrhythmias (SVT) during Holter monitoring were recorded in 15%, and ST segment depression during exercise in 27%. No association bet...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Jespersen CM,Vaage-Nilsen M,Hansen JF

    更新日期:1992-10-01 00:00:00

  • The short-term effect of intravenous nitroglycerin on haematocrit; an additional benefit in patients with myocardial ischaemia?

    abstract::Organic nitrates exert their effect by direct inhibition of vascular tone, resulting in decreased myocardial oxygen demand and improved oxygen supply. Less well known is the effect of nitrates on blood rheology. To evaluate the haemodiluting effect of intravenous nitroglycerin we studied 70 consecutive patients admitt...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Arend SM,Bax JJ,Hermans J,van der Wall EE,Sedney MI

    更新日期:1994-01-01 00:00:00

  • Minor elevations in troponin I are associated with mortality and adverse cardiac events in patients with atrial fibrillation.

    abstract:AIMS:In patients with atrial fibrillation, minor troponin I elevation is regularly detected; however, the prognostic significance of this finding is unknown. We therefore sought to examine the prognostic value of elevated troponin I in patients with atrial fibrillation. METHODS AND RESULTS:A prospective study was cond...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: van den Bos EJ,Constantinescu AA,van Domburg RT,Akin S,Jordaens LJ,Kofflard MJ

    更新日期:2011-03-01 00:00:00

  • Anticoagulation in women with non-valvular atrial fibrillation in the stroke prevention using an oral thrombin inhibitor (SPORTIF) trials.

    abstract:AIMS:The risk of stroke is greater among women with atrial fibrillation (AF) than men. Warfarin protects against stroke, but treatment-related bleeding occurs more often in women than in men. METHODS AND RESULTS:SPORTIF III (open label, n=3410) and V (double-blind, n=3922) included 2257 women with AF and one or more s...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Gomberg-Maitland M,Wenger NK,Feyzi J,Lengyel M,Volgman AS,Petersen P,Frison L,Halperin JL

    更新日期:2006-08-01 00:00:00

  • Local hospital vs. core-laboratory interpretation of the admission electrocardiogram in acute coronary syndromes: increased mortality in patients with unrecognized ST-elevation myocardial infarction.

    abstract:AIMS:Previous analyses suggest only modest agreement between local site and core-laboratory (core-lab) electrocardiogram (ECG) interpretation in patients with acute coronary syndromes (ACSs); however, this has not been well examined outside of clinical trial populations. METHODS AND RESULTS:Patients (n = 5277 from 51 ...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Vijayaraghavan R,Yan AT,Tan M,Fitchett DH,Georgescu AA,Hassan Q,Langer A,Goodman SG,Canadian Acute Coronary Syndromes Registry Investigators.

    更新日期:2008-01-01 00:00:00