Cardioprotective effect of calcineurin inhibition in an animal model of renal disease.


AIMS:Chronic kidney disease is directly associated with cardiovascular complications. Heart remodelling, including fibrosis, hypertrophy, and decreased vascularization, is frequently present in renal diseases. Our objective was to investigate the impact of calcineurin inhibitors (CNI) on cardiac remodelling and function in a rat model of renal disease. METHODS AND RESULTS:Male Sprague Dawley rats were divided into six groups: sham-operated rats, 5/6 nephrectomized rats (Nx) treated with vehicle, CNI (cyclosporine A 5.0 or 7.5, or tacrolimus 0.5 mg/kg/day) or hydralazine (20 mg/kg twice a day) for 14 days, starting on the day of surgery. Creatinine clearance was significantly lower and blood pressure significantly higher in Nx rats when compared with controls. Morphological and echocardiographic analyses revealed increased left ventricular hypertrophy and decreased number of capillaries in Nx rats. Treatment with CNI affected neither the renal function nor the blood pressure, but prevented the development of cardiac hypertrophy and improved vascularization. In addition, regional blood volume improved as confirmed by contrast agent-based echocardiography. Hydralazine treatment did not avoid heart remodelling in this model. Gene expression analysis verified a decrease in hypertrophic genes in the heart of CNI-treated rats, while pro-angiogenic and stem cell-related genes were upregulated. Moreover, mobilization of stem/progenitor cells was increased through manipulation of the CD26/SDF-1 system. CONCLUSION:We conclude from our studies that CNI-treatment significantly prevented cardiac remodelling and improved heart function in Nx rats without affecting renal function and blood pressure. This sheds new light on possible therapeutic strategies for renal patients at high cardiovascular risk.


Eur Heart J


European heart journal


Di Marco GS,Reuter S,Kentrup D,Ting L,Ting L,Grabner A,Jacobi AM,Pavenstädt H,Baba HA,Tiemann K,Brand M




Has Abstract


2011-08-01 00:00:00














  • Intravenous streptokinase in acute myocardial infarction (I.S.A.M.): assessment of left ventricular function 1 and 7 months after infarction by radionuclide ventriculography.

    abstract::I.S.A.M. was a prospective, placebo-controlled, double-blind multicentre trial of high-dose short-term intravenous streptokinase in acute myocardial infarction (AMI) within 6 h of the onset of symptoms. Determination of left ventricular ejection fraction (LVEF) by radionuclide ventriculography was performed 1 and 7 mo...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Voth E,Tebbe U,Schicha H,Neumann P,Schröder R,Neuhaus KL,Emrich D

    更新日期:1990-10-01 00:00:00

  • Myocardial changes in pressure overload-induced left ventricular hypertrophy. A study on tissue composition, polyploidization and multinucleation.

    abstract::Morphological changes in human myocardium associated with pressure overload-induced left ventricular hypertrophy were studied in 22 normal and 21 hypertrophic hearts obtained at autopsy. Samples were obtained from the left lateral ventricular wall, half way between the apex and the base. Myocyte dimensions, polyploidi...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Vliegen HW,van der Laarse A,Cornelisse CJ,Eulderink F

    更新日期:1991-04-01 00:00:00

  • Natural variability of pulmonary haemodynamics.

    abstract::In the interpretation of the effect of a drug or intervention in a single patient, it is desirable to know the spontaneous fluctuations of the variable under study. A few studies have determined pulmonary haemodynamic variability in acute and short-term intervals. It seems reasonable to adopt a confidence limit of 6 m...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Schrijen F,Jezková J

    更新日期:1988-09-01 00:00:00

  • Transthyretin cardiac amyloidosis in continental Western Europe: an insight through the Transthyretin Amyloidosis Outcomes Survey (THAOS).

    abstract:AIMS:Transthyretin amyloidosis (ATTR amyloidosis) is a heterogeneous disorder with cardiac, neurologic, and mixed phenotypes. We describe the phenotypic and genotypic profiles of this disease in continental Western Europe as it appears from the Transthyretin Amyloidosis Survey (THAOS). METHODS AND RESULTS:THAOS is an ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Damy T,Kristen AV,Suhr OB,Maurer MS,Planté-Bordeneuve V,Yu CR,Ong ML,Coelho T,Rapezzi C,THAOS Investigators.

    更新日期:2019-04-01 00:00:00

  • Dyspnoea and exercise intolerance during cardiopulmonary exercise testing in patients with univentricular heart. The effects of chronic hypoxaemia and Fontan procedure.

    abstract:BACKGROUND:Patients with univentricular hearts have decreased exercise tolerance and may demonstrate exertional dyspnoea. It is not known if chronic hypoxaemia exacerbates exercise intolerance and contributes to symptomatic limitation. The extent to which surgical correction of a right-to-left shunt by a Fontan-type pr...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Iserin L,Chua TP,Chambers J,Coats AJ,Somerville J

    更新日期:1997-08-01 00:00:00

  • The left atrial appendage: from embryology to prevention of thromboembolism.

    abstract::The left atrial appendage (LAA) is the main source of thromboembolism in patients with non-valvular atrial fibrillation (AF). As such, the LAA can be the target of specific occluding device therapies. Optimal management of patients with AF includes a comprehensive knowledge of the many aspects related to LAA structure...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Patti G,Pengo V,Marcucci R,Cirillo P,Renda G,Santilli F,Calabrò P,De Caterina AR,Cavallari I,Ricottini E,Parato VM,Zoppellaro G,Di Gioia G,Sedati P,Cicchitti V,Davì G,Golia E,Pariggiano I,Simeone P,Abbate R,Prisco

    更新日期:2017-03-21 00:00:00

  • Shock in acute myocardial infarction: the Cape Horn for trials?

    abstract::Despite therapeutic improvements, cardiogenic shock (CS) remains the most common cause of death in patients with acute myocardial infarction (AMI). In addition to percutaneous coronary intervention, inotropes, fluids, adjunctive medication, intra-aortic balloon counterpulsation, and also assist devices are widely used...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Thiele H,Allam B,Chatellier G,Schuler G,Lafont A

    更新日期:2010-08-01 00:00:00

  • Echo Doppler evaluation of right ventricular dysplasia.

    abstract::Two-dimensional echocardiography (2D echo) and Doppler were performed in a group of patients who had a high probability of having right ventricular (RV) dysplasia (left bundle branch block arrhythmias, no signs of cardiopulmonary diseases) and in a group of age-matched normals. 2D echo showed RV morphofunctional abnor...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Iliceto S,Izzi M,De Martino G,Rizzon P

    更新日期:1989-09-01 00:00:00

  • More is not better in the early care of acute myocardial infarction: a prospective cohort analysis on administrative databases.

    abstract:AIMS:To assess the outcome and costs of patients with acute myocardial infarction (AMI) after initial admission to hospitals with or without catheterization facilities in Belgium. METHODS AND RESULTS:From a nationwide hospital register, we retrieved the data of 34 961 patients discharged during 1999-2001 with a princi...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Van Brabandt H,Camberlin C,Vrijens F,Parmentier Y,Ramaekers D,Bonneux L

    更新日期:2006-11-01 00:00:00

  • Temporal trends of the gaps in post-myocardial infarction secondary prevention strategies of co-morbid and elderly populations vs. younger counterparts: an analysis of three successive cohorts between 2003 and 2008.

    abstract::Aims Epidemiological studies reported two contrasting trends: on one hand, a significant improvement in the use of evidence-based treatments of patients discharged with a myocardial infarction (MI). On the other hand, the increasing number of elderly and co-morbid patients who are usually less treated. The aim of this...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Macchia A,Romero M,D'Ettorre A,Mariani J,Tognoni G

    更新日期:2012-02-01 00:00:00

  • Sodium channel blockers in the treatment of ventricular arrhythmias: different effects in the normal, ischaemic or failing heart?

    abstract::In past decades, numerous experimental and clinical studies have improved our knowledge of the electrophysiological effects of sodium channel blockers, as well as of the mechanisms of arrhythmogenesis. However, the mechanisms of antiarrhythmic as well as potentially proarrhythmic drug action have been less well clarif...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Haverkamp W,Hindricks G,Fechtrup C,Borggrefe M,Breithardt G

    更新日期:1991-12-01 00:00:00

  • Effects of diuretics on renal excretory function.

    abstract::From a clinicopharmacological standpoint, the urinary excretory potency of diuretics should be assessed comparatively, on the basis of placebo-controlled changes in 24 h natriuresis, following single oral doses administered to healthy adult subjects who are in steady-state habitual external sodium balance. The potency...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Reyes AJ

    更新日期:1992-12-01 00:00:00

  • The effects of oral isosorbide 5-mononitrate on mortality following acute myocardial infarction: a multicentre study.

    abstract::We have conducted a randomized, double-blind, placebo-controlled multicentre trial of oral isosorbide 5-mononitrate (ISMN) in 360 patients with suspected acute myocardial infarction. Patients were stratified prior to analysis according to the presence or absence of left ventricular failure on admission. ISMN caused a ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Fitzgerald LJ,Bennett ED

    更新日期:1990-02-01 00:00:00

  • Left ventricular systolic and diastolic function assessed by tissue Doppler imaging and outcome in asymptomatic aortic stenosis.

    abstract:AIMS:Left ventricular (LV) hypertrophy and abnormal non-invasive measures of LV diastolic function are common in patients with severe aortic stenosis (AS) but their prognostic importance is uncertain. This study aimed to determine whether tissue Doppler measures of LV systolic and/or diastolic function or echocardiogra...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Stewart RA,Kerr AJ,Whalley GA,Legget ME,Zeng I,Williams MJ,Lainchbury J,Hamer A,Doughty R,Richards MA,White HD,New Zealand Heart Valve Study Investigators.

    更新日期:2010-09-01 00:00:00

  • Impedance cardiography during exercise in patients with coronary heart disease.

    abstract::Impedance cardiography may be a simple way of assessing left ventricular performance during exercise. Measurements were therefore made during exercise testing in 102 consecutive male patients with suspected coronary disease prior to cardiac catheterization. These were subsequently divided into four groups: group A, no...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Thomas SH,Crowther A

    更新日期:1993-02-01 00:00:00

  • Physiological cost of vocational activities after myocardial infarction.

    abstract::Oxygen consumption was measured during 30 min of work in 16 patients, after a myocardial infarction (anterior or posterior), and compared with 16 normal subjects, of the same age, involved in the same activities, in a steel factory. The VO2 at work of the patients was a little lower than in normals. The mean heart rat...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Denolin H,Riviere A

    更新日期:1988-11-01 00:00:00

  • The relationship between markers of extracellular cardiac matrix turnover: infarct healing and left ventricular remodelling following primary PCI in patients with first-time STEMI.

    abstract:AIMS:We investigated the temporal changes in circulating levels of markers of extracellular cardiac matrix (ECCM) turnover and their relationship with infarct size (IS), ejection fraction (EF), and left ventricular (LV) volumes, determined by serial cardiac magnetic resonance (CMR) imaging in patients with first-time S...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Manhenke C,Ueland T,Jugdutt BI,Godang K,Aukrust P,Dickstein K,Ørn S

    更新日期:2014-02-01 00:00:00

  • Single infusion of intravenous cibenzoline in the treatment of supraventricular tachyarrhythmias following heart surgery. A double-blind placebo-controlled parallel study.

    abstract::The efficacy and safety of a single infusion of cibenzoline, a class I antiarrhythmic drug, were assessed in 86 patients presenting with a supraventricular tachyarrhythmia following heart surgery in a placebo-controlled double-blind parallel study. Cibenzoline was effective in 13 patients (30%) vs three patients (6.9%...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Ollitrault J,Quilliet L,Scheck F,Lelong B,Richard A,Jarry G,Guize L

    更新日期:1994-09-01 00:00:00

  • Development and validation of a prognostic risk score for major bleeding in patients undergoing percutaneous coronary intervention via the femoral approach.

    abstract:AIMS:Major bleeding after percutaneous coronary intervention (PCI) is an independent risk factor for early and late mortality. We developed and validated a risk score predictive of major bleeding after PCI using the femoral approach. METHODS AND RESULTS:Baseline clinical and procedural variables from two contemporary,...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Nikolsky E,Mehran R,Dangas G,Fahy M,Na Y,Pocock SJ,Lincoff AM,Stone GW

    更新日期:2007-08-01 00:00:00

  • Two types of left ventricular wall motion abnormalities with distinct clinical features in patients with hypertrophic cardiomyopathy.

    abstract::During the long-term follow-up of patients with hypertrophic cardiomyopathy (HCM), some patients develop left ventricular (LV) wall motion abnormalities in the absence of fixed coronary artery disease. The purpose of this study is to clarify which clinical features in patients with HCM seem to influence gradual develo...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Ishiwata S,Nishiyama S,Nakanishi S,Seki A

    更新日期:1993-12-01 00:00:00

  • Risk prediction of cardiovascular death based on the QTc interval: evaluating age and gender differences in a large primary care population.

    abstract:AIMS:Using a large, contemporary primary care population we aimed to provide absolute long-term risks of cardiovascular death (CVD) based on the QTc interval and to test whether the QTc interval is of value in risk prediction of CVD on an individual level. METHODS AND RESULTS:Digital electrocardiograms from 173 529 pr...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Nielsen JB,Graff C,Rasmussen PV,Pietersen A,Lind B,Olesen MS,Struijk JJ,Haunsø S,Svendsen JH,Køber L,Gerds TA,Holst AG

    更新日期:2014-05-21 00:00:00

  • The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials.

    abstract:AIMS:The effect of statins on risk of heart failure (HF) hospitalization and HF death remains uncertain. We aimed to establish whether statins reduce major HF events. METHODS AND RESULTS:We searched Medline, EMBASE, and the Cochrane Central Register of Controlled Trials for randomized controlled endpoint statin trials...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审


    authors: Preiss D,Campbell RT,Murray HM,Ford I,Packard CJ,Sattar N,Rahimi K,Colhoun HM,Waters DD,LaRosa JC,Amarenco P,Pedersen TR,Tikkanen MJ,Koren MJ,Poulter NR,Sever PS,Ridker PM,MacFadyen JG,Solomon SD,Davis BR,Simpson

    更新日期:2015-06-21 00:00:00

  • Midlife blood pressure is associated with the severity of white matter hyperintensities: analysis of the UK Biobank cohort study.

    abstract:AIMS:White matter hyperintensities (WMH) progress with age and hypertension, but the key period of exposure to elevated blood pressure (BP), and the relative role of systolic BP (SBP) vs. diastolic BP (DBP), remains unclear. This study aims to determine the relationship between WMH and concurrent vs. past BP. METHODS ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Wartolowska KA,Webb AJS

    更新日期:2020-11-26 00:00:00

  • Myocardial catecholamine concentrations in dilated cardiomyopathy and heart failure of different origins.

    abstract::Myocardial catecholamine concentrations were determined in endomyocardial biopsies from patients with heart failure to assess if tissue catecholamine levels relate to the severity of myocardial damage or the aetiology of the underlying disease. Methodological studies revealed a good reproducibility of catecholamine de...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Regitz V,Leuchs B,Bossaller C,Sehested J,Rappolder M,Fleck E

    更新日期:1991-08-01 00:00:00

  • The value of the coefficient of variation in assessing repeat variation in ECG measurements.

    abstract:AIMS:The coefficient of variation is a popular measure for describing the amount of repeat variability present in ECG measurements from recording to recording. However, it can be misleading. The aim of the present study was to assess repeat variation (reclassification) in computer measured ECG criteria, i.e. positive t...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: McLaughlin SC,Aitchison TC,Macfarlane PW

    更新日期:1998-02-01 00:00:00

  • Effect of site, summation and asynchronism of inputs on atrioventricular nodal conduction and refractoriness.

    abstract::The impulses coming from the sinus node synchronically penetrate the AV node via the crista terminalis and inter-atrial septum. Studies in superfused rabbit AV preparations suggest that the crista terminalis is a more effective input than the inter-atrial septum, and that the summation of both inputs facilitates AV no...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Sanchis J,Chorro FJ,Such L,Matamoros J,Monmeneu JV,Cortina J,López Merino V

    更新日期:1993-10-01 00:00:00

  • Pathophysiology of re-entrant dysrhythmias.

    abstract::Re-entry was demonstrated as a self-perpetuating mechanism as early as 1906. It may lead to single-cycle electrocardiographic phenomena as well as reciprocating tachycardias. Factors favouring re-entry are as follows. Unidirectional or temporary local block of conduction, a mechanism always involved in initiation of r...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Olsson SB

    更新日期:1984-09-01 00:00:00

  • Fibrinolytic therapy in bacterial endocarditis: experimental studies in dogs.

    abstract::An investigation was undertaken to assess the value of adding streptokinase therapy to standard penicillin treatment of artificially induced infective endocarditis due to Streptococcus sanguis. In pigs a low-grade infection could be induced which closely simulated streptococcal endocarditis in man, but for technical r...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章


    authors: Dewar HA,Jones MR,Barnes WS,Griffin SG

    更新日期:1986-06-01 00:00:00

  • Childhood appendectomy, tonsillectomy, and risk for premature acute myocardial infarction--a nationwide population-based cohort study.

    abstract:AIMS:Although inflammation contributes to cardiovascular disease, the associations of appendectomy and tonsillectomy, which remove mucosa-associated lymphoid tissue, with risk of acute myocardial infarction (AMI) are unknown. Our aim was to assess the association between these operations performed in childhood and AMI ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Janszky I,Mukamal KJ,Dalman C,Hammar N,Ahnve S

    更新日期:2011-09-01 00:00:00

  • Echocardiographic criteria to distinguish reversible from irreversible myocardial ischaemia.

    abstract::This treatise reviews two-dimensional echocardiographic criteria which have been developed to describe and distinguish reversible vs irreversible myocardial ischaemia. It also discusses the new pathophysiologic concepts such as 'hibernating' and 'decapitated' myocardium, and also 'reperfusion injury' and 'stunned' myo...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Corday E,Hajduczki I,O'Byrne GT,Kar S,Areeda J,Corday SR

    更新日期:1988-04-01 00:00:00