Effects of ranolazine on exercise tolerance and HbA1c in patients with chronic angina and diabetes.

abstract：AIMS:We addressed a potential mechanism of myocardial dysfunction following coronary microembolization at the level of myofibrillar proteins. METHODS AND RESULTS:Anaesthetized pigs underwent intracoronary infusion of microspheres. After 6 h, the microembolized areas (MEA) had decreased systolic wall thickening to 38 +...

journal_title：European heart journal

authors： Canton M,Skyschally A,Menabò R,Boengler K,Gres P,Schulz R,Haude M,Erbel R,Di Lisa F,Heusch G

更新日期：2006-04-01 00:00:00

abstract：:In atrial flutter, chemical conversion with class I drugs is often unsuccessful, whereas class III drugs seem more promising. The different electrophysiological effects of these drugs may explain this discrepancy. To date, only experimental data show the differential effects of these drugs on conversion rate and atria...

journal_title：European heart journal

authors： Crijns HJ,Van Gelder IC,Kingma JH,Dunselman PH,Gosselink AT,Lie KI

更新日期：1994-10-01 00:00:00

abstract：:The steady state plasma concentrations of the two platelet-specific proteins beta-thromboglobulin (BTG) and platelet factor 4 (PF4) were determined in two groups of females: 36 acute myocardial infarction (AMI) survivors, and 38 age-matched control subjects. For the AMI patients the mean BTG and PF4 values were 57 +/-...

journal_title：European heart journal

authors： Kutti J,Johansson S,Eriksson KA,Sigvaldason A,Vedin A,Wadenvik H,Wilhelmsson C

更新日期：1983-05-01 00:00:00

abstract：AIMS:Pulmonary hypertension (PH) represents an important phenotype among the broader spectrum of patients with heart failure with preserved ejection fraction (HFpEF), but its mechanistic basis remains unclear. We hypothesized that activation of endothelin and adrenomedullin, two counterregulatory pathways important in ...

journal_title：European heart journal

authors： Obokata M,Kane GC,Reddy YNV,Melenovsky V,Olson TP,Jarolim P,Borlaug BA

更新日期：2019-12-01 00:00:00

abstract：:Between 1968 and 1984, 78 patients (mean age 43, range 14 to 65 years) underwent combined aortic, mitral and tricuspid surgery (22 triple valve replacements, 56 aortic valve replacements with tricuspid conservative surgery and mitral valve replacement (N = 48), or commissuroplasty (N = 8). Pre-operative consequences o...

journal_title：European heart journal

authors： Michel PL,Houdart E,Ghanem G,Badaoui G,Hage A,Acar J

更新日期：1987-05-01 00:00:00

abstract：:A case of severe iatrogenic fibrous left main coronary artery stenosis following aortic valve replacement (Hall-Kaster prosthesis) is documented clinically, angiographically and histologically. Reported histological data of this rare complication of valve replacement are reviewed. The onset of ischaemic symptoms in th...

journal_title：European heart journal

authors： Prachar H,Mühlbauer J,Pollak H,Enenkel W

更新日期：1988-10-01 00:00:00

abstract：:Chronic kidney disease (CKD) is associated with high cardiovascular risk. CKD patients exhibit a specific lipoprotein pattern termed 'uraemic dyslipidaemia', which is characterized by rather normal low-density lipoprotein cholesterol, low high-density lipoprotein cholesterol, and high triglyceride plasma levels. All t...

journal_title：European heart journal

authors： Speer T,Ridker PM,von Eckardstein A,Schunk SJ,Fliser D

更新日期：2021-01-04 00:00:00

abstract：AIMS:To analyse the relationship between initial exercise parameters and peak oxygen consumption and prognosis in 96 patients with congestive heart failure. METHODS AND RESULTS:Comparison of responses during the initial 6 min of cardiopulmonary exercise testing (Naughton modified protocol) in patients stratified to th...

journal_title：European heart journal

authors： de Vries RJ,van Veldhuisen DJ,Dunselman PH,van der Veer N,Crijns HJ

更新日期：1997-12-01 00:00:00

abstract：:Two patients with myocardial bridging of the left anterior descending coronary artery associated with myocardial infarction are described. One of them died from acute cerebral emboli related to cardiac thrombosis in a left ventricular aneurysm. The other died suddenly while sleeping. Both patients were found to have a...

journal_title：European heart journal

authors： Bestetti RB,Costa RS,Zucolotto S,Oliveira JS

更新日期：1989-06-01 00:00:00

abstract：AIMS:This study investigated the functional outcome of wall-thinned, akinetic myocardium after revascularization and evaluated the accuracy of dobutamine echocardiography in predicting post-revascularization functional recovery with the assessment of end-diastolic wall thickness in chronic ischaemic patients. METHODS ...

journal_title：European heart journal

authors： Furukawa T,Haque T,Takahashi M,Kinoshita M

更新日期：1997-05-01 00:00:00

abstract：AIMS:Coronary artery dissections are common findings following percutaneous transluminal coronary angioplasty and occur with an incidence of approximately 20% to 40%. The purpose of this study was to evaluate the impact of intravascular ultrasound for the prediction of severe dissections by pre-interventional analysis ...

journal_title：European heart journal

authors： Athanasiadis A,Haase KK,Wullen B,Treusch AW,Mahrholdt H,Voelker W,Baumbach A,Oberhoff M,Karsch KR

更新日期：1998-06-01 00:00:00

abstract：AIMS:Rotablation is a widely used technique for the treatment of complex coronary artery lesions but is so far only poorly supported by controlled studies. The Comparison of Balloon-Angioplasty versus Rotational Atherectomy study (COBRA) is a multicentre, prospective, randomized trial to compare short- and long-term ef...

journal_title：European heart journal

authors： Dill T,Dietz U,Hamm CW,Küchler R,Rupprecht HJ,Haude M,Cyran J,Ozbek C,Kuck KH,Berger J,Erbel R

更新日期：2000-11-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) occurs often in patients after coronary artery bypass grafting (CABG) and can result in increased morbidity and mortality. Previous studies using P-wave signal-averaged electrocardiogram (P-SAECG) have shown that patients with a longer filtered P-wave duration (FPD) have a high risk of AF ...

journal_title：European heart journal

authors： Budeus M,Hennersdorf M,Perings S,Röhlen S,Schnitzler S,Felix O,Reimert K,Feindt P,Gams E,Lehmann N,Wieneke H,Sack S,Erbel R,Perings C

更新日期：2006-07-01 00:00:00

abstract：AIMS:Anaemia is often observed in patients with chronic heart failure (CHF), and it may be associated with a worse prognosis. Aim of this study was to identify the individual mechanisms of anaemia in CHF patients. METHODS AND RESULTS:One hundred and forty-eight consecutive patients with haemoglobin concentration <13 g...

journal_title：European heart journal

authors： Opasich C,Cazzola M,Scelsi L,De Feo S,Bosimini E,Lagioia R,Febo O,Ferrari R,Fucili A,Moratti R,Tramarin R,Tavazzi L

更新日期：2005-11-01 00:00:00

abstract：AIMS:We examined the geographic variations in InTIME-II, a randomized double-blind trial comparing alteplase with lanoteplase for myocardial infarction. METHODS AND RESULTS:We compared baseline characteristics, management, and outcomes in four regions (Western Europe, Eastern Europe, North America, and Latin America) ...

journal_title：European heart journal

authors： Giugliano RP,Llevadot J,Wilcox RG,Gurfinkel EP,McCabe CH,Charlesworth A,Thompson SL,Antman EM,Braunwald E,InTIME (Intravenous nPA for Treatment of Infarcting Myocardium Early) II Investigators.

更新日期：2001-09-01 00:00:00

abstract：AIMS:High-density lipoproteins (HDLs) are considered as anti-atherogenic. Recent experimental findings suggest that their biological properties can be modified in certain clinical conditions by accumulation of serum amyloid A (SAA). The effect of SAA on the association between HDL-cholesterol (HDL-C) and cardiovascular...

journal_title：European heart journal

authors： Zewinger S,Drechsler C,Kleber ME,Dressel A,Riffel J,Triem S,Lehmann M,Kopecky C,Säemann MD,Lepper PM,Silbernagel G,Scharnagl H,Ritsch A,Thorand B,de las Heras Gala T,Wagenpfeil S,Koenig W,Peters A,Laufs U,Wanner C,

更新日期：2015-11-14 00:00:00

abstract：AIMS:Recent randomized trials suggest that intensive glycaemic control fails to reduce heart failure-related events in patients with diabetes. The molecular cues underlying persistent myocardial damage despite normoglycaemia restoration remain elusive. MicroRNAs (miRNAs), a class of small non-coding RNAs, orchestrate t...

journal_title：European heart journal

authors： Costantino S,Paneni F,Lüscher TF,Cosentino F

更新日期：2016-02-07 00:00:00

abstract：AIMS:The ESC/ACC redefined myocardial infarction as any amount of necrosis caused by ischaemia. The aim of this study was to describe the management and outcomes using 'real-world' data taking the new definition of acute myocardial infarction into account. METHODS AND RESULTS:A total of 2,151 consecutive patients (76....

journal_title：European heart journal

authors： Montalescot G,Dallongeville J,Van Belle E,Rouanet S,Baulac C,Degrandsart A,Vicaut E,OPERA Investigators.

更新日期：2007-06-01 00:00:00

abstract：:In 16 people with essential hypertension, heart rate (HR), blood pressure (BP) and relative cardiac volumes were measured at rest and during submaximal upright exercise before and after 10 mg of sublingual nifedipine using radionuclide ventriculography. In 10 patients who had had no previous therapy (BP 152/103 +/- 5/...

journal_title：European heart journal

authors： Wathen CG,Hannan WJ,Turnbull LW,Muir AL

更新日期：1985-04-01 00:00:00

abstract：AIMS:The importance of heart rate in the pathophysiology of heart failure with reduced LVEF has recently attracted attention. In particular, the findings of the Systolic Heart failure treatment with the I(f) inhibitor ivabradine Trial (SHIFT) have put special emphasis on heart rate reduction with ivabradine for improve...

journal_title：European heart journal

authors： Castagno D,Petrie MC,Claggett B,McMurray J

更新日期：2012-05-01 00:00:00

abstract：AIMS:Large randomized trials have shown that beta-blockers reduce mortality and hospital admissions in patients with heart failure. The effects of beta-blockers in elderly patients with a broad range of left ventricular ejection fraction are uncertain. The SENIORS study was performed to assess effects of the beta-block...

journal_title：European heart journal

authors： Flather MD,Shibata MC,Coats AJ,Van Veldhuisen DJ,Parkhomenko A,Borbola J,Cohen-Solal A,Dumitrascu D,Ferrari R,Lechat P,Soler-Soler J,Tavazzi L,Spinarova L,Toman J,Böhm M,Anker SD,Thompson SG,Poole-Wilson PA,SENIORS In

更新日期：2005-02-01 00:00:00

abstract：AIMS:Long-term randomized comparisons of percutaneous coronary intervention (PCI) to coronary artery bypass grafting (CABG) in left main coronary (LM) disease and/or three-vessel disease (3VD) patients have been limited. This analysis compares 3-year outcomes in LM and/or 3VD patients treated with CABG or PCI with TAXU...

journal_title：European heart journal

authors： Kappetein AP,Feldman TE,Mack MJ,Morice MC,Holmes DR,Ståhle E,Dawkins KD,Mohr FW,Serruys PW,Colombo A

更新日期：2011-09-01 00:00:00

abstract：:Previous evidence indicates that cells generate molecules that alter transcription in response to stress. Accordingly, we conducted preliminary experiments to characterize these molecules. Extracts were prepared from normal and experimental canine hearts in which a 100 mmHg gradient was created across the ascending ao...

journal_title：European heart journal

authors： Hammond GL,Lai YK,Markert CL

更新日期：1984-12-01 00:00:00

abstract：AIMS:Reperfusion injury following acute myocardial infarction impacts not only on the myocardium but also on the coronary microcirculation, and microembolization from the culprit lesion contributes to microvascular obstruction. Prior experimental studies have not accounted for microembolization in ischaemia/reperfusion...

journal_title：European heart journal

authors： Skyschally A,Walter B,Heusch G

更新日期：2013-11-01 00:00:00

abstract：:There is mounting evidence to support the influence of inflammation in the pathogenesis of atrial fibrillation (AF). Indeed, AF is associated with increased levels of known inflammatory markers, even after adjustment for confounding factors. The renin-angiotensin-aldosterone system (RAAS) appears to play a key role in...

journal_title：European heart journal

authors： Boos CJ,Anderson RA,Lip GY

更新日期：2006-01-01 00:00:00

abstract：:Antiarrhythmic agents may depress cardiac contractility and worsen heart failure. Flecainide is an effective antiarrhythmic drug, but when administered orally in patients with left ventricular (LV) dysfunction, its effect on LV function is unknown. To assess the effects of flecainide on cardiac function, LV ejection f...

journal_title：European heart journal

authors： Brembilla-Perrot B,Amor M,Auque F,Isaaz K,Terrier de la Chaise A,Bertrand A,Cherrier F,Pernot C

更新日期：1987-07-01 00:00:00

abstract：AIMS:This investigation was set up to study the prevalence of left ventricular hypertrophy in a hypertensive population with reference to a normotensive control group. From the general population 3498 men and women aged 35, 45, 55 and 65 years old were invited to a health examination. Participants with blood pressure a...

journal_title：European heart journal

authors： Tingleff J,Munch M,Jakobsen TJ,Torp-Pedersen C,Olsen ME,Jensen KH,Jørgensen T,Kirchoff M

更新日期：1996-01-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitors suppress plasma concentrations of the sodium retaining hormones angiotensin II and aldosterone. This action should potentiate the natriuretic and diuretic effects of loop diuretics. Some studies indicate, however, that the introduction of angiotensin-converting enzyme inhibitor...

journal_title：European heart journal

authors： Flapan AD,Davies E,Waugh C,Williams BC,Shaw TR,Edwards CR

更新日期：1991-08-01 00:00:00

abstract：:To assess if cold-induced vasoconstriction may persist during exercise and contribute to the development of myocardial ischaemia, we studied 11 patients with exertional angina and angiographically proven coronary artery disease, in all cases involving the proximal portion of the left anterior descending artery. Great ...

journal_title：European heart journal

authors： de Servi S,Mussini A,Angoli L,Ferrario M,Bramucci E,Gavazzi A,Ghio S,Ardissino D,Specchia G

更新日期：1985-03-01 00:00:00

abstract：AIMS:Anecdotal observations suggest that sub-clinical electrophysiological manifestations of arrhythmogenic right ventricular cardiomyopathy (ARVC) develop before detectable structural changes ensue on cardiac imaging. To test this hypothesis, we investigated a murine model with conditional cardiac genetic deletion of ...

journal_title：European heart journal

authors： Gomes J,Finlay M,Ahmed AK,Ciaccio EJ,Asimaki A,Saffitz JE,Quarta G,Nobles M,Syrris P,Chaubey S,McKenna WJ,Tinker A,Lambiase PD

更新日期：2012-08-01 00:00:00