Abstract:
:Intracoronary blood flow velocity measurements with a Doppler balloon catheter and the radiographic assessment of myocardial perfusion with contrast media, before and after the intracoronary administration of papaverine, have previously been used to investigate regional coronary flow reserve. In the present study we applied both techniques in 21 patients to measure coronary flow reserve in the setting of coronary angioplasty. Pre-angioplasty (N = 14) and post-angioplasty (N = 19) measurements of coronary flow reserve were obtained by digital subtraction cineangiography in the myocardial region supplied by the dilated coronary artery, and with the Doppler probe in the proximal part of the dilated vessel. The reactive hyperaemia following the final balloon inflation was recorded with the Doppler balloon catheter still positioned across the stenotic lesion. Coronary stenosis geometry was quantified with the Cardiovascular Angiography Analysis System. When the epicardial stenosis was the only factor causing a reduction in coronary flow reserve, flow reserve measured with both digital subtraction cineangiography and with the Doppler probe correlated well with the cross-sectional area at the site of obstruction, r = 0.88, SEE = 0.36 and r = 0.77, SEE = 0.45 respectively. In contrast, when other factors decreasing coronary flow reserve were present (intimal dissection, left ventricular hypertrophy, previous myocardial infarction, collaterals) measurements obtained with both techniques correlated poorly with cross-sectional area (r = 0.55, SEE = 0.57, and r = 0.59, SEE = 0.50). Flow reserve measurements obtained with digital subtraction cineangiography correlated well with the measurements obtained with the Doppler probe (r = 0.85, SEE = 0.38, and r = 0.87, SEE = 0.34), although the two approaches have methodologically nothing in common and their respective regions of interest (myocardium for the radiographic technique and intracoronary lumen for the Doppler technique) are basically different. Furthermore, the reactive hyperaemia following the final balloon inflation was related to the flow reserve measured with both the angiographic technique (r = 0.85, SEE = 0.34) and the Doppler technique (r = 0.83, SEE = 0.32) using pharmacologically induced coronary vasodilation with intracoronary papaverine. This suggests that the same quantity of coronary flow reserve that can be recruited pharmacologically can be recruited by ischaemia following a transluminal occlusion.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Serruys PW,Zijlstra F,Laarman GJ,Reiber HH,Beatt K,Roelandt Jdoi
10.1093/oxfordjournals.eurheartj.a059557subject
Has Abstractpub_date
1989-08-01 00:00:00pages
725-36issue
8eissn
0195-668Xissn
1522-9645journal_volume
10pub_type
杂志文章abstract:AIMS:To assess the diagnostic accuracy of 256-row computed tomographic angiography (CTA) in patients with suspected coronary artery disease (CAD). Non-invasive imaging of the coronary artery by CTA has increasingly been used in recent years. The accuracy of 256-row CTA has not yet been studied. We sought to assess the ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehq072
更新日期:2010-08-01 00:00:00
abstract:AIMS:We investigated the influence of type one cannabinoid receptor (CB1) deficiency on acute heart failure (AHF) and the underlying mechanism. Acute heart failure syndrome is an important clinical problem because of its high morbidity and mortality rates. Activation of CB1 induces vascular dilation and reinforces the ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehr246
更新日期:2012-12-01 00:00:00
abstract:AIMS:Although embolic protection devices reduce complications during saphenous vein graft (SVG) stenting, adverse events still occur in approximately 10% of patients. IIb/IIIa antagonists have not been proven effective during SVG intervention. We hypothesized that adjunctive use of these agents might enhance the effica...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/ehi736
更新日期:2006-04-01 00:00:00
abstract:AIMS:Non-vitamin K antagonist oral anticoagulants (NOACs) require dose reductions according to patient or clinical factors for patients with atrial fibrillation (AF). In this meta-analysis, we aimed to assess outcomes with reduced-dose NOACs when given as pre-specified in pivotal trials. METHODS AND RESULTS:Aggregated...
journal_title:European heart journal
pub_type: 杂志文章,meta分析
doi:10.1093/eurheartj/ehy802
更新日期:2019-05-14 00:00:00
abstract:AIMS:The study set out to assess the relative contributions of donor heart rate, respiration and recipient atrial contraction on the mean of pulsed wave transmitral Doppler flow indices in orthotopic heart transplant recipients. This would provide information on the theoretical usefulness of pacemaker synchronization o...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a015149
更新日期:1997-10-01 00:00:00
abstract:AIMS:The anti-anginal efficacy and safety of ranolazine in diabetic and non-diabetic patients included in the Combination Assessment of Ranolazine In Stable Angina (CARISA) trial (JAMA 2004;291:309) were studied. Glycaemic control was also assessed in CARISA and its long-term open-label extension study. METHODS AND RE...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/ehi495
更新日期:2006-01-01 00:00:00
abstract::Five patients with recurrent tachycardias exhibiting right bundle branch block with left axis deviation were referred for investigation. In each case, a supraventricular mechanism was suspected. During sinus rhythm the QRS morphology and axis (-10 to +60 degrees) and HV intervals were normal. Tachycardia was initiated...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061589
更新日期:1984-11-01 00:00:00
abstract::There is no certain way of obtaining one of the European Society of Cardiology grants for research or clinical training offered each year, but Prof. Stavros Konstantinides (Centre for Thrombosis and Haemostasis, Johannes Gutenberg University, Mainz, Germany), who chairs the European Society of Cardiology Credentials C...
journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:2014-05-14 00:00:00
abstract::Patients who have an accessory pathway (AP) of atrioventricular (AV) conduction may develop circus movement tachycardia otherwise known as atrioventricular re-entrant tachycardia (AVRT). Orthodromic AVRT is the most common form. It occurs as a result of antegrade conduction through the normal AV conduction system and ...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:
更新日期:1998-05-01 00:00:00
abstract::To investigate the antianginal efficacy and tolerability of felodipine, a new dihydropyridine calcium antagonist, 20 patients with stable exertional angina, not completely controlled by beta-blocker monotherapy, entered a randomized, double-blind, placebo-controlled, crossover study. Patients on standard beta-blocker ...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/oxfordjournals.eurheartj.a059628
更新日期:1990-11-01 00:00:00
abstract:AIMS:Growing data suggest that antibiotic exposure is associated with a long-lasting alteration in gut microbiota, and may be related to subsequent cardiovascular disease (CVD). We investigated associations of life-stage and duration of antibiotic exposure during adulthood with subsequent CVD events. METHODS AND RESUL...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehz231
更新日期:2019-12-14 00:00:00
abstract:AIMS:Left ventricular outflow tract obstruction (LVOTO) is associated with reduced survival in patients with hypertrophic cardiomyopathy (HCM). The influence of LVOTO on survival from SD in relation to other recognized clinical risk markers is unknown. METHODS AND RESULTS:A total of 917 patients with HCM (554 males, 4...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehl041
更新日期:2006-08-01 00:00:00
abstract::Impedance cardiography may be a simple way of assessing left ventricular performance during exercise. Measurements were therefore made during exercise testing in 102 consecutive male patients with suspected coronary disease prior to cardiac catheterization. These were subsequently divided into four groups: group A, no...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.2.150
更新日期:1993-02-01 00:00:00
abstract:AIMS:Transthyretin amyloidosis (ATTR amyloidosis) is a heterogeneous disorder with cardiac, neurologic, and mixed phenotypes. We describe the phenotypic and genotypic profiles of this disease in continental Western Europe as it appears from the Transthyretin Amyloidosis Survey (THAOS). METHODS AND RESULTS:THAOS is an ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehz173
更新日期:2019-04-01 00:00:00
abstract:AIMS:Cardiomyopathies are a heterogeneous group of disorders associated with premature death due to ventricular arrhythmia or heart failure. The purpose of this study was to examine the characteristics of patients enrolled in the pilot phase of the EURObservational Research Programme (EORP) cardiomyopathy registry. ME...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehv497
更新日期:2016-01-07 00:00:00
abstract::Eleven patients with an atrioventricular accessory pathway were studied by programmed electrical stimulation to determine if reentrant tachycardia could be prevented by delivery of either a single atrial extrastimulus, applied at a critical time after the tachycardia-initiating stimulus (or stimuli), or a train of sti...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061756
更新日期:1985-01-01 00:00:00
abstract::Isolated quadricuspid aortic valve is very rare. The identification of this malformation can be made by cross-sectional echocardiography. Two cases of quadricuspid aortic valve diagnosed by cross-sectional echocardiography are described. ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062440
更新日期:1988-11-01 00:00:00
abstract:AIMS:The Tako-Tsubo cardiomyopathy (TTC) is characterized by a transient contractile dysfunction that has been assigned to excessive catecholamine levels after episodes of severe emotional or physical stress. Several studies have indicated that beta-adrenoceptor stimulation is associated with alteration in gene express...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehp240
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Mortality from cardiac surgery is an essential indicator of quality and forms the basis of treatment strategy decisions in eligible patients. No contemporary complete data on unselected adult cardiac surgery patients are available in Germany. METHODS AND RESULTS:A registry was started in June 1997 of all pa...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.1999.1634
更新日期:2000-01-01 00:00:00
abstract:Aim:Hypertrophic cardiomyopathy (HCM) exhibits genetic heterogeneity that is dominated by variation in eight sarcomeric genes. Genetic variation in a large number of non-sarcomeric genes has also been implicated in HCM but not formally assessed. Here we used very large case and control cohorts to determine the extent t...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehw603
更新日期:2017-12-07 00:00:00
abstract::Sequential alterations of left ventricular volumes and haemodynamics were studied in 29 patients between 4 days and 4 weeks after myocardial infarction. Left ventricular volume was determined by single photon emission computerized tomography (SPECT), infarct size by creatine kinase (CK) analysis, angiography and thall...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/11.suppl_b.139
更新日期:1990-04-01 00:00:00
abstract:AIMS:Real-time MRI creates images with superb tissue contrast that may enable radiation-free catheterization. Simple procedures are the first step towards novel interventional procedures. We aim to perform comprehensive transfemoral diagnostic right heart catheterization in an unselected cohort of patients entirely usi...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehs189
更新日期:2013-02-01 00:00:00
abstract:AIMS:Statins have modest adverse effects on glycaemic control. Alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, lowers low-density lipoprotein cholesterol. This study assessed the effects of alirocumab on new-onset diabetes and pre-diabetes incidence in individuals without diabetes at baseline. M...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehw292
更新日期:2016-10-14 00:00:00
abstract::Chronically ischaemic myocardium from patients with coronary heart disease was investigated by light and electron microscopy using tissue biopsies taken during cardiac surgery. Light microscopy showed a significantly increased amount of fibrotic material, cell size was variable. By electron microscopy, the most obviou...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/9.suppl_a.141
更新日期:1988-01-01 00:00:00
abstract:AIMS:Despite disparities in pathophysiology and disease manifestation between male and female patients with heart failure, studies focusing on sex differences in biomarkers are scarce. The purpose of this study was to assess sex-specific variation in clinical characteristics and biomarker levels to gain more understand...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/eht152
更新日期:2013-08-01 00:00:00
abstract::The haemodynamic effects of intravenous frusemide (1 mg/kg) were studied in 22 male patients with left ventricular failure following acute myocardial infarction. Radiographic pulmonary oedema was present in all patients and their average left heart filling pressure was 20 mmHg. Bolus injection of the drug was followed...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061382
更新日期:1983-10-01 00:00:00
abstract::The diagnosis of prosthetic valve thrombosis (PVT) may be difficult in cases without valve obstruction. The aim of this study was to evaluate the diagnostic accuracy of 111indium-labelled autologous platelet imaging in the detection of PVT. We studied 41 patients with 45 prostheses, mechanical (37) or biological (8), ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a059721
更新日期:1990-05-01 00:00:00
abstract:Aims:To elucidate the effects of intensive LDL-C lowering treatment with a standard dose of statin and ezetimibe in patients with dyslipidaemia and high risk of coronary events, targeting LDL-C less than 70 mg/dL (1.8 mmol/L), compared with standard LDL-C lowering lipid monotherapy targeting less than 100 mg/dL (2.6 mm...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/ehx162
更新日期:2017-08-01 00:00:00
abstract::The European Myocardial Infarction Project (E.M.I.P.) participants have evaluated out-of-hospital coronary care services in different cities within the E.E.C. and concluded that these facilities would support a study within these European centres on pre-hospital intervention in myocardial infarction. Based on a pilot ...
journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:1988-02-01 00:00:00
abstract:AIMS:To quantify the prevalence of coronary artery calcification (CAC) in relation to cardiovascular risk factors in marathon runners, and to study its role for myocardial damage and coronary events. METHODS AND RESULTS:In 108 apparently healthy male marathon runners aged >or=50 years, with >or=5 marathon competitions...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehn163
更新日期:2008-08-01 00:00:00