Deficiency of type 1 cannabinoid receptors worsens acute heart failure induced by pressure overload in mice.

Abstract:

AIMS:We investigated the influence of type one cannabinoid receptor (CB1) deficiency on acute heart failure (AHF) and the underlying mechanism. Acute heart failure syndrome is an important clinical problem because of its high morbidity and mortality rates. Activation of CB1 induces vascular dilation and reinforces the properties of morphine, long-standing therapies for AHF syndrome, but the effect of endogenous CB1 activation on AHF is largely unknown. METHODS AND RESULTS:Acute heart failure mouse model characterized by hypertension and pulmonary oedema was created by using transverse aortic constriction (TAC). Mortality, echocardiography, haemodynamic, morphology, and circulatory catecholamine levels in response to TAC were evaluated in CB1 knockout (KO) and wild-type mice. Type one cannabinoid receptor KO mice had a much higher mortality rate at 1 week after TAC attributable to AHF (65 vs. 11%, P< 0.001). One hour after TAC, CB1 KO mice had significant larger lung weight to body weight ratio (LW/BW, 14.53 + 1.09 mg/g in KO vs. 10.42 + 0.36 mg/g in WT, P < 0.01) and higher plasma epinephrine levels (9720 + 1226 pg/mL vs. 6378 + 832 pg/mL, P < 0.05). Pharmacological activation of CB1 reduced LW/BW in wild-type mice. Administration of epinephrine to wild-type TAC mice significantly increased left ventricular end-diastolic pressure and LW/BW, while CB1 agonists reduced the LW/BW and the plasma levels of catecholamine and increased myocardial activity of AMP-activated protein kinase. CONCLUSION:Endogenous activation of CB1 in mice has cardiac protection in AHF, which is attributable to the inhibition of excessive sympathetic activation.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Liao Y,Bin J,Asakura M,Xuan W,Chen B,Huang Q,Xu D,Ledent C,Takashima S,Kitakaze M

doi

10.1093/eurheartj/ehr246

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

3124-33

issue

24

eissn

0195-668X

issn

1522-9645

pii

ehr246

journal_volume

33

pub_type

杂志文章
  • Predictive value of high sensitivity C-reactive protein in patients with ST-elevation myocardial infarction treated with percutaneous coronary intervention.

    abstract:AIMS:To evaluate the predictive value of high sensitivity (hs) C-reactive protein levels on long-term survival in patients with ST-elevation myocardial infarction (STEMI) treated with primary PCI. METHODS AND RESULTS:We conducted a retrospective analysis of 758 STEMI patients (from January 2003 to December 2005), with...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehm338

    authors: Ortolani P,Marzocchi A,Marrozzini C,Palmerini T,Saia F,Taglieri N,Baldazzi F,Silenzi S,Bacchi-Reggiani ML,Guastaroba P,Grilli R,Branzi A

    更新日期:2008-05-01 00:00:00

  • Prediction of outcome by neurohumoral activation, the six-minute walk test and the Minnesota Living with Heart Failure Questionnaire in an outpatient cohort with congestive heart failure.

    abstract:AIMS:To compare the precursor of atrial and brain natriuretic peptide (N-ANP, N-BNP), brain natriuretic peptide (BNP), big endothelin-1, the 6-min walk test and the Minnesota Living with Heart Failure Questionnaire (LHFQ) with regard to short-term outcome in an ambulatory heart failure population. METHODS AND RESULTS:...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2001.3115

    authors: Hülsmann M,Berger R,Sturm B,Bojic A,Woloszczuk W,Bergler-Klein J,Pacher R

    更新日期:2002-06-01 00:00:00

  • Electrocardiographic left ventricular hypertrophy in GUSTO IV ACS: an important risk marker of mortality in women.

    abstract:AIM:To examine the association of left ventricular hypertrophy (LVH) on admission electrocardiography with adverse outcomes in acute coronary syndrome (ACS) patients. METHODS AND RESULTS:A total of 7443 non-ST-elevation ACS patients in Global Utilization of STrategies to Open occluded arteries (GUSTO) IV ACS trial had...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehm223

    authors: Westerhout CM,Lauer MS,James S,Fu Y,Wallentin L,Armstrong PW,GUSTO IV ACS Investigators.

    更新日期:2007-09-01 00:00:00

  • Troponin I and cardiovascular risk prediction in the general population: the BiomarCaRE consortium.

    abstract:AIMS:Our aims were to evaluate the distribution of troponin I concentrations in population cohorts across Europe, to characterize the association with cardiovascular outcomes, to determine the predictive value beyond the variables used in the ESC SCORE, to test a potentially clinically relevant cut-off value, and to ev...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehw172

    authors: Blankenberg S,Salomaa V,Makarova N,Ojeda F,Wild P,Lackner KJ,Jørgensen T,Thorand B,Peters A,Nauck M,Petersmann A,Vartiainen E,Veronesi G,Brambilla P,Costanzo S,Iacoviello L,Linden G,Yarnell J,Patterson CC,Everett BM

    更新日期:2016-08-07 00:00:00

  • Non-invasive assessment of cardiac physiology by tissue Doppler echocardiography. A comparison with invasive haemodynamics.

    abstract:BACKGROUND:Tissue Doppler echocardiography reveals characteristic patterns of myocardial velocities within systole and diastole which are not well understood. AIM:The purpose of this study was to determine the relationship of myocardial velocity patterns, as assessed by tissue Doppler echocardiography, to the contract...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015236

    authors: Zamorano J,Wallbridge DR,Ge J,Drozd J,Nesser J,Erbel R

    更新日期:1997-02-01 00:00:00

  • Neurohormonal and clinical sex differences in heart failure.

    abstract:AIMS:Despite disparities in pathophysiology and disease manifestation between male and female patients with heart failure, studies focusing on sex differences in biomarkers are scarce. The purpose of this study was to assess sex-specific variation in clinical characteristics and biomarker levels to gain more understand...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/eht152

    authors: Meyer S,van der Meer P,van Deursen VM,Jaarsma T,van Veldhuisen DJ,van der Wal MH,Hillege HL,Voors AA

    更新日期:2013-08-01 00:00:00

  • The long-term impact of the angiotensin-converting enzyme inhibitor trandolapril on mortality and hospital admissions in patients with left ventricular dysfunction after a myocardial infarction: follow-up to 12 years.

    abstract:AIMS:To investigate the long-term benefits of treatment with angiotensin-converting enzyme (ACE)-inhibitors in patients with myocardial infarction (MI) and left ventricular dysfunction (LVD). METHODS AND RESULTS:In the trandolapril cardiac evaluation (TRACE) study, 1749 patients with LVD (ejection fraction< or =35%) w...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehi021

    authors: Buch P,Rasmussen S,Abildstrom SZ,Køber L,Carlsen J,Torp-Pedersen C,TRACE investigators.

    更新日期:2005-01-01 00:00:00

  • Acute kidney injury following transcatheter aortic valve implantation: predictive factors, prognostic value, and comparison with surgical aortic valve replacement.

    abstract:AIMS:Very few data exist on the occurrence of acute kidney injury (AKI) associated with transcatheter aortic valve implantation (TAVI). The objectives of the present study were (i) to determine the incidence, predictive factors, and prognostic value of AKI following TAVI, and (ii) to compare the occurrence of AKI in TA...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehp552

    authors: Bagur R,Webb JG,Nietlispach F,Dumont E,De Larochellière R,Doyle D,Masson JB,Gutiérrez MJ,Clavel MA,Bertrand OF,Pibarot P,Rodés-Cabau J

    更新日期:2010-04-01 00:00:00

  • Role of angiotensin converting enzyme inhibitors in patients with left ventricular dysfunction and congestive heart failure.

    abstract::We now have conclusive data that ACE inhibitors reduce mortality, morbidity, and symptoms in patients with low ejection fraction and/or heart failure. Therefore, ACE inhibitors should be routinely used in all such patients, as long as there are no clear contraindications. Routine use of ACE inhibitors will lead to pro...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析

    doi:10.1093/eurheartj/15.suppl_b.9

    authors: McKelvie R,McConachie D,Yusuf S

    更新日期:1994-05-01 00:00:00

  • Plasma concentrations of platelet-specific proteins in young female acute myocardial infarction survivors and their age-matched female controls.

    abstract::The steady state plasma concentrations of the two platelet-specific proteins beta-thromboglobulin (BTG) and platelet factor 4 (PF4) were determined in two groups of females: 36 acute myocardial infarction (AMI) survivors, and 38 age-matched control subjects. For the AMI patients the mean BTG and PF4 values were 57 +/-...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061465

    authors: Kutti J,Johansson S,Eriksson KA,Sigvaldason A,Vedin A,Wadenvik H,Wilhelmsson C

    更新日期:1983-05-01 00:00:00

  • Association of cyclooxygenase-2 genetic variant with cardiovascular disease.

    abstract:AIM:A genetic variant (rs20417) of the PTGS2 gene, encoding for COX-2, has been associated with decreased COX-2 activity and a decreased risk of cardiovascular disease (CVD). However, this genetic association and the role of COX-2 in CVD remain controversial. METHODS AND RESULTS:The association of rs20417 with CVD was...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehu168

    authors: Ross S,Eikelboom J,Anand SS,Eriksson N,Gerstein HC,Mehta S,Connolly SJ,Rose L,Ridker PM,Wallentin L,Chasman DI,Yusuf S,Paré G

    更新日期:2014-09-01 00:00:00

  • Renal effects of low dose prazosin in patients with congestive heart failure.

    abstract::Activation of the sympathetic nervous system may contribute to the renal vasoconstriction and sodium retention seen in congestive heart failure. Previous studies in congestive heart failure patients employing large doses of prazosin that lowered systemic blood pressure have been generally disappointing. The renal haem...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/eurheartj/14.9.1245

    authors: Lang CC,Choy AM,Rahman AR,Struthers AD

    更新日期:1993-09-01 00:00:00

  • Phenotypic variability of cardiovascular manifestations in Marfan Syndrome. Possible role of hyperhomocysteinemia and C677T MTHFR gene polymorphism.

    abstract:AIMS:The aim of this study was to evaluate (1) homocysteinemia and the prevalence of the C677T MTHFR polymorphism in Marfan patients and (2) whether the severity of cardiovascular manifestations is associated with homocysteinemia and/or C677T polymorphism. METHODS AND RESULTS:We studied 107 patients subdivided into th...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ehj.2003.08.020

    authors: Giusti B,Porciani MC,Brunelli T,Evangelisti L,Fedi S,Gensini GF,Abbate R,Sani G,Yacoub M,Pepe G

    更新日期:2003-11-01 00:00:00

  • Common carotid artery intima-media thickness is as good as carotid intima-media thickness of all carotid artery segments in improving prediction of coronary heart disease risk in the Atherosclerosis Risk in Communities (ARIC) study.

    abstract:AIMS:Carotid intima-media thickness (CIMT) and plaque information can improve coronary heart disease (CHD) risk prediction when added to traditional risk factors (TRF). However, obtaining adequate images of all carotid artery segments (A-CIMT) may be difficult. Of A-CIMT, the common carotid artery intima-media thicknes...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehr192

    authors: Nambi V,Chambless L,He M,Folsom AR,Mosley T,Boerwinkle E,Ballantyne CM

    更新日期:2012-01-01 00:00:00

  • Development and validation of a prognostic risk score for major bleeding in patients undergoing percutaneous coronary intervention via the femoral approach.

    abstract:AIMS:Major bleeding after percutaneous coronary intervention (PCI) is an independent risk factor for early and late mortality. We developed and validated a risk score predictive of major bleeding after PCI using the femoral approach. METHODS AND RESULTS:Baseline clinical and procedural variables from two contemporary,...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehm194

    authors: Nikolsky E,Mehran R,Dangas G,Fahy M,Na Y,Pocock SJ,Lincoff AM,Stone GW

    更新日期:2007-08-01 00:00:00

  • Intracoronary infusion of mononuclear cells from bone marrow or peripheral blood compared with standard therapy in patients after acute myocardial infarction treated by primary percutaneous coronary intervention: results of the randomized controlled HEBE

    abstract:AIMS:Previous trials that investigated cell therapy as an adjunctive therapy after acute myocardial infarction (AMI) have shown conflicting results. We designed a randomized controlled trial to determine the effect of intracoronary infusion of mononuclear cells from bone marrow (BM) or peripheral blood in patients with...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehq449

    authors: Hirsch A,Nijveldt R,van der Vleuten PA,Tijssen JG,van der Giessen WJ,Tio RA,Waltenberger J,ten Berg JM,Doevendans PA,Aengevaeren WR,Zwaginga JJ,Biemond BJ,van Rossum AC,Piek JJ,Zijlstra F,HEBE Investigators.

    更新日期:2011-07-01 00:00:00

  • Multilevel disease of the conduction system.

    abstract::We found that the incidence and distribution of conduction system disease simultaneously affecting several levels of the system had been incompletely described. We therefore analysed all patients in whom conduction disease had been diagnosed and a complete electrophysiological study of the conduction system had been m...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061429

    authors: Rasmussen K,Myhre ES,Gunnes P,Wang H

    更新日期:1983-02-01 00:00:00

  • Cardiovascular neural regulation during and after prolonged high altitude exposure.

    abstract::Eight young healthy male subjects, members of a Himalayan expedition, underwent 24 h Holter monitoring before departure, after 1 and 4 weeks at high altitude (5000 m) and after return to sea level. At high altitude, the circadian reciprocal changes in low and high frequency (LF, HF) were absent, with no significant re...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060415

    authors: Ponchia A,Noventa D,Bertaglia M,Carretta R,Zaccaria M,Miraglia G,Pascotto P,Buja G

    更新日期:1994-11-01 00:00:00

  • Cardiac centres of excellence. 'Royal Brompton': the specialist centre in London that specialist centres consult.

    abstract::It may be diagnosing Thalassaemia with magnetic resonance, navigating catheters round tight corners with magnets, or treating Marfan's syndrome with the Brompton Sheath--but if it is state of the art and it works, the Royal Brompton & Harefield NHS Foundation Trust, London, will almost certainly have pioneered it, rep...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:2011-06-01 00:00:00

  • From abstract to impact in cardiovascular research: factors predicting publication and citation.

    abstract:AIMS:Through a 4-year follow-up of the abstracts submitted to the European Society of Cardiology Congress in 2006, we aimed at identifying factors predicting high-quality research, appraising the quality of the peer review and editorial processes, and thereby revealing potential ways to improve future research, peer re...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehs113

    authors: Winnik S,Raptis DA,Walker JH,Hasun M,Speer T,Clavien PA,Komajda M,Bax JJ,Tendera M,Fox K,Van de Werf F,Mundow C,Lüscher TF,Ruschitzka F,Matter CM

    更新日期:2012-12-01 00:00:00

  • Molecular determinants of myocardial hypertrophy and failure: alternative pathways for beneficial and maladaptive hypertrophy.

    abstract::The implementation of molecular biological approaches has led to the discovery of single genetic variations that contribute to the development of cardiac failure. In the present review, the characteristics that are invariably associated with the development of failure in experimental animals and clinical studies are d...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/s0195-668x(02)00829-1

    authors: Lips DJ,deWindt LJ,van Kraaij DJ,Doevendans PA

    更新日期:2003-05-01 00:00:00

  • Therapeutic use of adenosine for terminating spontaneous paroxysmal supraventricular tachycardia.

    abstract::Intravenous adenosine proved effective in eight out of ten episodes of acute spontaneous supraventricular tachycardia. AV node blockade induced by adenosine occurred 20 s after injection, and disappeared very quickly. Side-effects were transient and never serious. Therefore, it is thought that adenosine can be propose...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061734

    authors: Munoz A,Leenhardt A,Sassine A,Galley P,Puech P

    更新日期:1984-09-01 00:00:00

  • Ratio of transmitral early filling velocity to early diastolic strain rate predicts long-term risk of cardiovascular morbidity and mortality in the general population.

    abstract:Aims:It has previously been demonstrated that the ratio of early mitral inflow velocity to global diastolic strain rate (E/e'sr) is a significant predictor of cardiac events in specific patient populations. The utility of this measurement to predict cardiovascular events in a general population has not been evaluated. ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehy164

    authors: Lassen MCH,Biering-Sørensen SR,Olsen FJ,Skaarup KG,Tolstrup K,Qasim AN,Møgelvang R,Jensen JS,Biering-Sørensen T

    更新日期:2019-02-07 00:00:00

  • Red alert for women's heart: the urgent need for more research and knowledge on cardiovascular disease in women: proceedings of the workshop held in Brussels on gender differences in cardiovascular disease, 29 September 2010.

    abstract::A recent report of the EuroHeart project has shown that women are still underrepresented in many cardiovascular clinical trials, while important gender differences are present within most areas of heart disease. As the burden of cardiovascular disease is increasing in middle-aged women relative to men, a more profound...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehr048

    authors: Maas AH,van der Schouw YT,Regitz-Zagrosek V,Swahn E,Appelman YE,Pasterkamp G,Ten Cate H,Nilsson PM,Huisman MV,Stam HC,Eizema K,Stramba-Badiale M

    更新日期:2011-06-01 00:00:00

  • Effects of multiple ischaemic events on human myocardium--an ultrastructural study.

    abstract::Chronically ischaemic myocardium from patients with coronary heart disease was investigated by light and electron microscopy using tissue biopsies taken during cardiac surgery. Light microscopy showed a significantly increased amount of fibrotic material, cell size was variable. By electron microscopy, the most obviou...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/9.suppl_a.141

    authors: Schaper J

    更新日期:1988-01-01 00:00:00

  • Genetic variation at the coronary artery disease risk locus GUCY1A3 modifies cardiovascular disease prevention effects of aspirin.

    abstract:AIMS:Efficacy of aspirin in primary prevention of cardiovascular disease (CVD) may be influenced by a common allele in guanylate cyclase GUCY1A3, which has been shown to modify platelet function and increase CVD risk. METHODS AND RESULTS:We investigated whether homozygotes of the GUCY1A3 rs7692387 risk (G) allele bene...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehz384

    authors: Hall KT,Kessler T,Buring JE,Passow D,Sesso HD,Zee RYL,Ridker PM,Chasman DI,Schunkert H

    更新日期:2019-11-01 00:00:00

  • Different mechanisms of mitral regurgitation in acute and chronic forms of coronary heart disease.

    abstract::Contradictory two-dimensional echocardiographic findings have been reported in relation to the role of prolapse of the mitral valve and lack of systolic leaflet coaptation in mitral regurgitation secondary to coronary heart disease. A prospective study of 22 patients with chronic coronary heart disease and mitral regu...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061521

    authors: Ballester M,Tasca R,Marin L,Rees S,Rickards A,McDonald L

    更新日期:1983-08-01 00:00:00

  • Thrombolytic therapy in Europe: current status.

    abstract::Thrombolytic therapy is a practical, effective approach to the management of acute myocardial infarction that is widely used in Europe today. Early European trials demonstrated a clear reduction in mortality in patients who received thrombolytic therapy compared with those given conventional treatment. The findings of...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/17.suppl_e.21

    authors: Vahanian A

    更新日期:1996-09-01 00:00:00

  • Accessory pathway reciprocating tachycardia.

    abstract::Patients who have an accessory pathway (AP) of atrioventricular (AV) conduction may develop circus movement tachycardia otherwise known as atrioventricular re-entrant tachycardia (AVRT). Orthodromic AVRT is the most common form. It occurs as a result of antegrade conduction through the normal AV conduction system and ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

    authors: Obel OA,Camm AJ

    更新日期:1998-05-01 00:00:00

  • Duration and life-stage of antibiotic use and risk of cardiovascular events in women.

    abstract:AIMS:Growing data suggest that antibiotic exposure is associated with a long-lasting alteration in gut microbiota, and may be related to subsequent cardiovascular disease (CVD). We investigated associations of life-stage and duration of antibiotic exposure during adulthood with subsequent CVD events. METHODS AND RESUL...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehz231

    authors: Heianza Y,Zheng Y,Ma W,Rimm EB,Albert CM,Hu FB,Rexrode KM,Manson JE,Qi L

    更新日期:2019-12-14 00:00:00