Abstract:
AIMS:Elevated blood pressure (EBP) is the most prevalent and potentially modifiable risk factor for AF, yet little is known of its atrial effects. We aimed to characterize the atrial electrical and structural changes in a chronic ovine model of EBP after prenatal corticosteroid exposure. METHODS AND RESULTS:Twelve sheep with chronically EBP (mean arterial pressure 94+/-3 mmHg) and six controls (71+/-4 mmHg, P<0.01) underwent acute open chest electrophysiologic and pathologic studies. We measured refractoriness at the atrial appendages at 3 cycle lengths (CL); conduction velocities at Bachmann's bundle, both atrial appendages and free walls at 4 CLs; conduction heterogeneity; atrial wavelength and AF duration. We performed light microscopy (LM) and electron microscopy (EM) and collagen and apoptosis studies. EBP was associated with widespread conduction abnormalities, shortening of atrial wavelength, and increased AF. There was no significant change in refractoriness. LM demonstrated atrial myocyte hypertrophy and myolysis in all EBP sheep and focal scarring in six. EM demonstrated mitochondrial and nuclear enlargement and increased collagen fibrils in EBP sheep, findings not present in any controls. Atrial collagen and apoptosis were increased in EBP animals. CONCLUSION:This study demonstrates that chronically, EBP is associated with significant atrial electrical and structural remodelling. These changes may explain the increased propensity to atrial arrhythmias observed with long-standing EBP.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Kistler PM,Sanders P,Dodic M,Spence SJ,Samuel CS,Zhao C,Charles JA,Edwards GA,Kalman JMdoi
10.1093/eurheartj/ehl360subject
Has Abstractpub_date
2006-12-01 00:00:00pages
3045-56issue
24eissn
0195-668Xissn
1522-9645pii
ehl360journal_volume
27pub_type
杂志文章abstract:AIMS:Morphological characteristics of non-significant coronary plaques (NSCPs) that develop rapid progression have not been fully elucidated. The aim of this study was to clarify the morphological characteristics of NSCPs in patients with coronary artery disease (CAD) using intravascular optical coherence tomography (O...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehr284
更新日期:2012-01-01 00:00:00
abstract:Aims:It has previously been demonstrated that the ratio of early mitral inflow velocity to global diastolic strain rate (E/e'sr) is a significant predictor of cardiac events in specific patient populations. The utility of this measurement to predict cardiovascular events in a general population has not been evaluated. ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehy164
更新日期:2019-02-07 00:00:00
abstract::Since fatty acids provide the majority of myocardial energy requirements under basal conditions, an alteration in the global or regional utilization of these substrates may be an early indicator of myocardial disease. To determine areas of potential clinical utility of fatty acid imaging, we synthesized a radioiodinat...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/6.suppl_b.85
更新日期:1985-08-01 00:00:00
abstract:AIMS:To investigate whether Atorvastatin (Ator) treatment improves the cardiac micro-environment that facilitates survival and differentiation of bone-marrow-derived mesenchymal stem cells (MSCs) implanted in the post-infarct myocardium. METHODS AND RESULTS:Myocardial infarction was created by coronary ligation and im...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehn167
更新日期:2008-06-01 00:00:00
abstract:Aims:Congenital heart defects (CHD) affect almost 1% of all live born children and the number of adults with CHD is increasing. In families where CHD has occurred previously, estimates of recurrence risk, and the type of recurring malformation are important for counselling and clinical decision-making, but the recurren...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehx314
更新日期:2018-03-21 00:00:00
abstract:AIMS:Hyponatraemia has been shown to be an independent predictor of mortality in selected patients with heart failure enrolled in clinical trials. The predictive value of hyponatraemia has not been evaluated in unselected patients hospitalized with heart failure. METHODS AND RESULTS:OPTIMIZE-HF is a registry and perfo...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehl542
更新日期:2007-04-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a015079
更新日期:1996-09-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehr472
更新日期:2012-08-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehq519
更新日期:2011-11-01 00:00:00
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doi:10.1093/eurheartj/ehz783
更新日期:2020-10-14 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/16.1.43
更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1093/eurheartj/ehx144
更新日期:2017-08-21 00:00:00
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更新日期:2010-03-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehl120
更新日期:2006-10-01 00:00:00
abstract:AIMS:To study the implications of European guidelines on the use of antihypertensives and/or lipid-lowering drugs (LLDs) for primary prevention in a Norwegian population. METHODS AND RESULTS:The Tromsø study is a population-based study in the municipality Tromsø, Norway (from 1974 to till now). This analysis includes ...
journal_title:European heart journal
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doi:10.1093/eurheartj/ehi556
更新日期:2005-12-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1053/euhj.1998.1092
更新日期:1998-10-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehx045
更新日期:2017-06-21 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehv301
更新日期:2015-09-21 00:00:00
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doi:10.1093/eurheartj/ehq296
更新日期:2010-11-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1983-03-01 00:00:00
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doi:10.1016/j.ehj.2004.05.029
更新日期:2004-09-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehx050
更新日期:2018-02-14 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061847
更新日期:1985-03-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.1997.0858
更新日期:1998-05-01 00:00:00
abstract:AIMS:Induced pluripotent stem cells (iPSCs) provide a unique opportunity for the generation of patient-specific cells for use in disease modelling, drug screening, and regenerative medicine. The aim of this study was to compare human-induced pluripotent stem cells (hiPSCs) derived from different somatic cell sources re...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehs203
更新日期:2013-09-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062107
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND:Recent studies have shown that left ventricular geometric adaptation to hypertension is complex. The spectrum of geometric adaptations in a general population and its relationship to systolic and diastolic function has, however, not been investigated. OBJECTIVES AND METHODS:This echocardiographic and Dopple...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a014795
更新日期:1996-12-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/5.suppl_e.117
更新日期:1984-11-01 00:00:00
abstract::In a small field with an abundance of journals, the Journal of Interventional Cardiology is carving out its niche with articles about technologies on the horizon. ...
journal_title:European heart journal
pub_type: 新闻
doi:
更新日期:2012-07-01 00:00:00
abstract:AIMS:We aimed to assess the increased risk of death and severe vascular events in elderly individuals with subclinical or manifest peripheral arterial disease (PAD), evidenced by low ankle brachial index (ABI < 0.9) in primary care. METHODS AND RESULTS:In this monitored prospective observational study, 6880 representa...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehl092
更新日期:2006-07-01 00:00:00