Fasting plasma glucose in non-diabetic participants and the risk for incident cardiovascular events, diabetes, and mortality: results from WOSCOPS 15-year follow-up.

Abstract:

AIMS:The evidence base for fasting plasma glucose (FPG) in the non-diabetic range as a risk factor for cardiovascular disease (CVD) is inconclusive. We investigated this question in the West of Scotland Coronary Prevention Study (WOSCOPS). METHODS AND RESULTS:In WOSCOPS, we related FPG in 6447 men (mean age 55 years) with hypercholesterolaemia, but no history of CVD or diabetes, to the risk of cardiovascular events and mortality over 14.7 years of follow-up; 2381 non-fatal/fatal cardiovascular events and 1244 deaths occurred. Participants were divided into fifths of baseline FPG, Q1 (< or =4.3 mmol/L) to Q5 (>5.1-6.9 mmol/L). Q2 was designated the referent based on previous studies which have suggested a J-shaped relationship between FPG and CVD. Compared with Q2 (>4.3-4.6 mmol/L), men in Q5 had no elevated risk for cardiovascular events [hazard ratio (HR) 0.95 (0.83-1.08)], or all-cause mortality [HR 0.96 (0.80-1.15)] in fully adjusted analyses despite a significant risk for incident diabetes [HR 22.05 (10.75-45.22)]. After further dividing Q5 into fifths, Q5a-e, individuals in Q5e (FPG 5.8-6.9 mmol/L) were also not at increased risk of cardiovascular events [HR 1.05 (0.82-1.35)] or other endpoints compared with Q2. All results were similar using Q1 as the referent. CONCLUSION:Elevations in FPG in the non-diabetic range were not associated with long-term risk of cardiovascular events in middle-aged men in WOSCOPS. These data suggest that the current FPG cutoff for diagnosing diabetes also appropriately identifies western men at risk of CVD.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Preiss D,Welsh P,Murray HM,Shepherd J,Packard C,Macfarlane P,Cobbe S,Ford I,Sattar N

doi

10.1093/eurheartj/ehq095

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

1230-6

issue

10

eissn

0195-668X

issn

1522-9645

pii

ehq095

journal_volume

31

pub_type

杂志文章,多中心研究,随机对照试验
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    authors: Perdoncin E,Seth M,Dixon S,Cannon L,Khandelwal A,Riba A,David S,Wohns D,Gurm H

    更新日期:2016-06-21 00:00:00

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    pub_type: 杂志文章

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    更新日期:1998-04-01 00:00:00

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    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehq308

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    pub_type: 杂志文章

    doi:10.1093/eurheartj/8.7.793

    authors: Doi YL,Yamada M,Hamashige N,Yonezawa Y,Odawara H,Ozawa T

    更新日期:1987-07-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060150

    authors: Vignati G,Mauri L,Lunati M,Gasparini M,Figini A

    更新日期:1992-02-01 00:00:00

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章

    doi:10.1016/s0195-668x(03)00385-3

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    更新日期:2003-09-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/16.suppl_b.75

    authors: Francioli P

    更新日期:1995-04-01 00:00:00

  • Acute effects of gallopamil on left ventricular systolic and diastolic function in patients with ischaemic heart disease.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/12.9.1006

    authors: Di Mario C,Iavernaro A,Cucchini F

    更新日期:1991-09-01 00:00:00

  • Long-term clinical outcome and performance of transcatheter aortic valve replacement with a self-expandable bioprosthesis.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehz925

    authors: Testa L,Latib A,Brambilla N,De Marco F,Fiorina C,Adamo M,Giannini C,Angelillis M,Barbanti M,Sgroi C,Poli A,Ferrara E,Bruschi G,Russo CF,Matteo M,De Felice F,Musto C,Curello S,Colombo A,Tamburino C,Petronio AS,Be

    更新日期:2020-05-21 00:00:00

  • Physical activity levels, ownership of goods promoting sedentary behaviour and risk of myocardial infarction: results of the INTERHEART study.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr432

    authors: Held C,Iqbal R,Lear SA,Rosengren A,Islam S,Mathew J,Yusuf S

    更新日期:2012-02-01 00:00:00

  • Physiological variation in the termination window of re-entry tachycardia studied by non-invasive programmed stimulation.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062605

    authors: Schmidinger H,Sowton E

    更新日期:1988-09-01 00:00:00

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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1053/euhj.1999.1483

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    更新日期:1999-10-01 00:00:00

  • A double-blind comparison of the long-term efficacy of a potassium channel opener and a calcium antagonist in stable angina pectoris.

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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/14.suppl_b.30

    authors: Guermonprez JL,Blin P,Peterlongo F

    更新日期:1993-07-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

    authors: Viallard JF,Bonoron-Adele S,Dos Santos P,Coste P,Besse P

    更新日期:1993-11-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq013

    authors: Wang GK,Zhu JQ,Zhang JT,Li Q,Li Y,He J,Qin YW,Jing Q

    更新日期:2010-03-01 00:00:00

  • Changes of fluid-dynamic parameters in peripheral stenoses with transcutaneous interventions.

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    pub_type: 杂志文章

    doi:10.1093/eurheartj/16.suppl_j.60

    authors: Wellnhofer E,Biamino G,Sauer HU,Trebeljahr A,Stalke J,Ragg C,Oswald H,Gotze S,Fleck E,Felix R

    更新日期:1995-10-01 00:00:00

  • Personalized cardiovascular disease prevention by applying individualized prediction of treatment effects.

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    pub_type: 杂志文章

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    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/17.suppl_g.14

    authors: Chierchia SL,Fragasso G

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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.ehj.2004.07.020

    authors: Zrenner B,Dong J,Schreieck J,Deisenhofer I,Estner H,Luani B,Karch M,Schmitt C

    更新日期:2004-12-01 00:00:00

  • Changes in cardiac function after effective treatment of hypertensive emergencies with i.v. clonidine.

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    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061605

    authors: Masotti G,Scarti L,Poggesi L,Bisi G,Gallini C,Neri Serneri GG

    更新日期:1984-12-01 00:00:00

  • Electrophysiologic properties of falipamil (AQA-39)--a new bradycardiac agent.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062198

    authors: Lévy S,Mètge M,Hilaire J,Cointe R,Bru P,Eychenne JL,Gérard R

    更新日期:1987-11-01 00:00:00

  • The consistency of the treatment effect of an ACE-inhibitor based treatment regimen in patients with vascular disease or high risk of vascular disease: a combined analysis of individual data of ADVANCE, EUROPA, and PROGRESS trials.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehp103

    authors: Brugts JJ,Ninomiya T,Boersma E,Remme WJ,Bertrand M,Ferrari R,Fox K,MacMahon S,Chalmers J,Simoons ML

    更新日期:2009-06-01 00:00:00