Electrophysiologic properties of falipamil (AQA-39)--a new bradycardiac agent.

Abstract:

:Falipamil hydrochloride (AQA 39) is a new antiarrhythmic agent structurally related to verapamil. We evaluated the electrophysiologic properties of intravenous falipamil (1.5 mg kg-1 within 20 minutes) in 12 patients. The spontaneous cycle length was significantly (P less than 0.001) prolonged (+79 +/- 59 ms). Atrioventricular conduction was significantly (P less than 0.001) shorter due to AH interval shortening (-17 +/- 14 ms), most probably related to an anticholinergic effect. Similarly, the anterograde Wenckebach point occurred at a significantly (P less than 0.06) higher rate after falipamil (+10 +/- 7 beats min-1). No statistically significant effect was noted on the refractory periods of the AV node, although there was a trend to shortening. The refractoriness of the right atrium and ventricle was significantly prolonged. It is concluded that falipamil is a bradycardiac agent with electrophysiologic properties quite different from those of verapamil and similar to those of class IA antiarrhythmic agents.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Lévy S,Mètge M,Hilaire J,Cointe R,Bru P,Eychenne JL,Gérard R

doi

10.1093/oxfordjournals.eurheartj.a062198

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

1236-40

issue

11

eissn

0195-668X

issn

1522-9645

journal_volume

8

pub_type

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