Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans.

Abstract:

AIMS:microRNA (miRNA) is reported to be present in the blood of humans and has been increasingly suggested as a biomarker for diseases. We aim to determine the potential of cardiac-specific miRNAs in circulation to serve as biomarkers for acute myocardial infarction (AMI). METHODS AND RESULTS:By verifying their tissue expression patterns with real-time polymerase chain reaction (PCR) analysis, muscle-enriched miRNAs (miR-1, miR-133a, and miR-499) and cardiac-specific miR-208a were selected as candidates for this study. With miRNA microarray and real-time PCR analyses, miR-1, miR-133a, and miR-499 were present with very low abundance, and miR-208a was absent in the plasma from healthy people. In the AMI rats, the plasma levels of these miRNAs were significantly increased. Especially, miR-208a in plasma was undetected at 0 h, but was significantly increased to a detectable level as early as 1 h after coronary artery occlusion. Further evaluation of the miRNA levels in plasma from AMI patients (n = 33) demonstrated that all four miRNA levels were substantially higher than those from healthy people (n = 30, P < 0.01), patients with non-AMI coronary heart disease (n = 16, P < 0.01), or patients with other cardiovascular diseases (n = 17, P < 0.01). Notably, miR-208a remained undetectable in non-AMI patients, but was easily detected in 90.9% AMI patients and in 100% AMI patients within 4 h of the onset of symptoms. By receiver operating characteristic curve analysis, among the four miRNAs investigated, miR-208a revealed the higher sensitivity and specificity for diagnosing AMI. CONCLUSION:Elevated cardiac-specific miR-208a in plasma may be a novel biomarker for early detection of myocardial injury in humans.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Wang GK,Zhu JQ,Zhang JT,Li Q,Li Y,He J,Qin YW,Jing Q

doi

10.1093/eurheartj/ehq013

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

659-66

issue

6

eissn

0195-668X

issn

1522-9645

pii

ehq013

journal_volume

31

pub_type

杂志文章
  • Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation.

    abstract:AIMS:Transplant-associated coronary artery disease (TxCAD) is a major cause of post-transplant graft failure. The aim of this study was to investigate a possible role of mannose-binding lectin (MBL) deficiency and complement activation in TxCAD. METHODS AND RESULTS:In a prospective study of heart transplant recipients...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehi198

    authors: Fiane AE,Ueland T,Simonsen S,Scott H,Endresen K,Gullestad L,Geiran OR,Haraldsen G,Heggelund L,Andreassen AK,Wergeland R,Frøland S,Aukrust P,Mollnes TE

    更新日期:2005-08-01 00:00:00

  • Arginase I enhances atherosclerotic plaque stabilization by inhibiting inflammation and promoting smooth muscle cell proliferation.

    abstract:AIMS:The aim of this study was to investigate the effect of Arginase I (ArgI) on plaque stabilization in unruptured atherosclerotic plaque and explore its mechanism. METHODS AND RESULTS:The atherosclerotic plaque model was established in New Zealand rabbits by balloon injury of abdominal arteries and a high cholestero...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht329

    authors: Wang XP,Zhang W,Liu XQ,Wang WK,Yan F,Dong WQ,Zhang Y,Zhang MX

    更新日期:2014-04-01 00:00:00

  • Evidence for obesity paradox in patients with acute coronary syndromes: a report from the Swedish Coronary Angiography and Angioplasty Registry.

    abstract:AIMS:The obesity paradox refers to the epidemiological evidence that obesity compared with normal weight is associated with counter-intuitive improved health in a variety of disease conditions. The aim of this study was to investigate the relationship between body mass index (BMI) and mortality in patients with acute c...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehs217

    authors: Angerås O,Albertsson P,Karason K,Råmunddal T,Matejka G,James S,Lagerqvist B,Rosengren A,Omerovic E

    更新日期:2013-02-01 00:00:00

  • Biological signals of cardiac hypertrophy.

    abstract::Chronic increases in haemodynamic load modify the expression of cardiac genes, leading to a new phenotype better adapted to the new functional demand. Several mechanisms such as the global activation of genes, the modulation of single genes and/or differential expression of multigene families may account for these mod...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/11.suppl_g.1

    authors: Samuel JL,Dubus I,Contard F,Schwartz K,Rappaport L

    更新日期:1990-11-01 00:00:00

  • Thrombolytic therapy in Europe: current status.

    abstract::Thrombolytic therapy is a practical, effective approach to the management of acute myocardial infarction that is widely used in Europe today. Early European trials demonstrated a clear reduction in mortality in patients who received thrombolytic therapy compared with those given conventional treatment. The findings of...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/17.suppl_e.21

    authors: Vahanian A

    更新日期:1996-09-01 00:00:00

  • Unprotected left main revascularization in patients with acute coronary syndromes.

    abstract:AIMS:In acute coronary syndromes (ACS), the optimal revascularization strategy for unprotected left main coronary disease (ULMCD) has been little studied. The objectives of the present study were to describe the practice of ULMCD revascularization in ACS patients and its evolution over an 8-year period, analyse the pro...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehp353

    authors: Montalescot G,Brieger D,Eagle KA,Anderson FA Jr,FitzGerald G,Lee MS,Steg PG,Avezum A,Goodman SG,Gore JM,GRACE Investigators.

    更新日期:2009-10-01 00:00:00

  • Cardiovascular disease risk factors in relation to suicide mortality in Asia: prospective cohort study of over one million Korean men and women.

    abstract:AIMS:A potential role for cardiovascular disease (CVD) risk factors in the aetiology of suicide has not been comprehensively examined. In addition to being small in scale and poorly characterized, existing studies very rarely sample Asian populations in whom risk factor-suicide relationships may plausibly differ to Cau...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr229

    authors: Jee SH,Kivimaki M,Kang HC,Park IS,Samet JM,Batty GD

    更新日期:2011-11-01 00:00:00

  • Role of programmed ventricular stimulation in patients with Brugada syndrome: a meta-analysis of worldwide published data.

    abstract:AIMS:Brugada syndrome (BS) is an ion channelopathy with the risk of sudden cardiac death. The role of programmed ventricular stimulation (PVS) in risk stratification has been controversially discussed. Therefore, we performed a meta-analysis on the prognostic role of PVS in BS. METHODS AND RESULTS:A Medline search unt...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/eurheartj/ehm116

    authors: Paul M,Gerss J,Schulze-Bahr E,Wichter T,Vahlhaus C,Wilde AA,Breithardt G,Eckardt L

    更新日期:2007-09-01 00:00:00

  • Effects of growth hormone on circulating cytokine network, and left ventricular contractile performance and geometry in patients with idiopathic dilated cardiomyopathy.

    abstract:BACKGROUND:Recent experimental and clinical data indicate that abnormal central and peripheral immune reactions contribute to the progression of chronic heart failure, and that immunomodulation may be an important therapeutic approach in this syndrome. Aims We sought to study the effects of growth hormone (GH) administ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0195-668x(03)00480-9

    authors: Adamopoulos S,Parissis JT,Paraskevaidis I,Karatzas D,Livanis E,Georgiadis M,Karavolias G,Mitropoulos D,Degiannis D,Kremastinos DT

    更新日期:2003-12-01 00:00:00

  • Altered limbic and autonomic processing supports brain-heart axis in Takotsubo syndrome.

    abstract:AIMS:Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction often triggered by emotional or physical stress. Severe activation of the sympathetic nervous system with catecholamine release caused by a dysfunctional limbic system has been proposed as a potential mechanism. We hypothesize that bra...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehz068

    authors: Templin C,Hänggi J,Klein C,Topka MS,Hiestand T,Levinson RA,Jurisic S,Lüscher TF,Ghadri JR,Jäncke L

    更新日期:2019-04-14 00:00:00

  • Silent healing of spontaneous plaque disruption demonstrated by intracoronary ultrasound.

    abstract::Intracoronary ultrasound was performed at diagnostic coronary angiography and 10 days later in a 45-year-old patient with a 3-day history of acute inferior myocardial infarction. Coronary angiography showed considerable stenosis (80%) in the distal right coronary artery (RCA) (pre the crux) and what appeared to be a d...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061061

    authors: Ge J,Haude M,Görge G,Liu F,Erbel R

    更新日期:1995-08-01 00:00:00

  • The natural history of myocardium awaiting revascularisation in patients with impaired left ventricular function.

    abstract:AIMS:Our aim was to follow changes in myocardial function and physiology in patients awaiting coronary artery bypass surgery (CABG) and relate changes to post-revascularisation functional response. METHODS AND RESULTS:In 21 patients with CAD and LV dysfunction, myocardial glucose utilisation (MGU) and blood flow (MBF)...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ehj.2004.01.016

    authors: Pitt M,Dutka D,Pagano D,Camici P,Bonser R

    更新日期:2004-03-01 00:00:00

  • Acute effects of cigarette smoking on platelet-dependent thrombin generation.

    abstract:AIMS:Thrombin is an important factor in the pathogenesis of thrombotic diseases. To clarify whether smoking has an effect in platelet-dependent thrombogenesis, we studied the acute effects of smoking on platelet-dependent thrombin level in smokers. METHODS AND RESULTS:Subjects consisted of ten smokers and nine non-smo...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1999.1938

    authors: Hioki H,Aoki N,Kawano K,Homori M,Hasumura Y,Yasumura T,Maki A,Yoshino H,Yanagisawa A,Ishikawa K

    更新日期:2001-01-01 00:00:00

  • Myocardial cytoprotection during percutaneous transluminal coronary angioplasty.

    abstract::Transluminal coronary angioplasty (PTCA) is a well defined controlled model inducing regional myocardial ischaemia in man. Direct cardiac anti-ischaemic effects of anti-anginal drugs can be assessed by intracoronary injection of small doses which do not affect systemic parameters. Trimetazidine (TMZ) has recently been...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/eurheartj/14.suppl_g.6

    authors: Kober G,Pennaforte S,Buck T,Sievert H,Vallbracht C

    更新日期:1993-11-01 00:00:00

  • Relationship between HDL-cholesterol and apolipoprotein A1 and the severity of coronary artery disease.

    abstract:INTRODUCTION:We investigated whether apolipoprotein A1 (ApoA1) could better identify patients with severe vessel damage than HDL-cholesterol in a population with recent acute myocardial infarction (AMI). METHODS:One hundred and forty-one male patients (mean age: 54.3 +/- 7.3 years) who had undergone coronary angiograp...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060937

    authors: Garfagnini A,Devoto G,Rosselli P,Boggiano P,Venturini M

    更新日期:1995-04-01 00:00:00

  • Investigation of impaired coronary vasodilator reserve in the guinea pig heart with pressure induced hypertrophy.

    abstract::Impaired coronary reserve and increased minimal coronary resistance have been documented in several animal models of left ventricular hypertrophy. There is controversy whether the increased minimal coronary resistance is due to vascular or extravascular causes. To test the hypothesis that pressure-overloaded left vent...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/oxfordjournals.eurheartj.a060237

    authors: O'Gorman DJ,Thomas P,Turner MA,Sheridan DJ

    更新日期:1992-05-01 00:00:00

  • Causes-of-death analysis of patients with cardiac resynchronization therapy: an analysis of the CeRtiTuDe cohort study.

    abstract:AIMS:The choice of resynchronization therapy between with (CRT-D) and without (CRT-P) a defibrillator remains a contentious issue. Cause-of-death analysis among CRT-P, compared with CRT-D, patients could help evaluate the extent to which CRT-P patients would have additionally benefited from a defibrillator in a daily c...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehv455

    authors: Marijon E,Leclercq C,Narayanan K,Boveda S,Klug D,Lacaze-Gadonneix J,Defaye P,Jacob S,Piot O,Deharo JC,Perier MC,Mulak G,Hermida JS,Milliez P,Gras D,Cesari O,Hidden-Lucet F,Anselme F,Chevalier P,Maury P,Sadoul N,

    更新日期:2015-11-01 00:00:00

  • Clinical course and prognosis of patients with typical and atypical hypertrophic obstructive and with hypertrophic non-obstructive cardiomyopathy.

    abstract::In a total of 339 patients with hypertrophic cardiomyopathies (typical HOCM, n = 224; atypical HOCM, n = 30; HNCM, n = 80) the clinical course, the Sokolow-Lyon index in the ECG and the prognosis as demonstrated by cumulative survival rates were analysed to get more differentiated information for the characterization ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/4.suppl_f.145

    authors: Loogen F,Kuhn H,Gietzen F,Lösse B,Schulte HD,Bircks W

    更新日期:1983-11-01 00:00:00

  • Extent, determinants and clinical importance of pressure recovery in patients with aortic valve stenosis.

    abstract:AIMS:In experimental studies the recovery of pressure distal to stenotic valve orifices has been well described. We evaluated the extent, determinants, and clinical importance of pressure recovery in patients with aortic valve stenosis. METHODS AND RESULTS:The study was performed in 37 patients with aortic valve steno...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1998.1479

    authors: Schöbel WA,Voelker W,Haase KK,Karsch KR

    更新日期:1999-09-01 00:00:00

  • Once more unto the breach: endothelial permeability and atherogenesis.

    abstract:: ...

    journal_title:European heart journal

    pub_type: 评论,杂志文章

    doi:10.1093/eurheartj/ehz081

    authors: Libby P

    更新日期:2019-03-14 00:00:00

  • Cardiac centres of excellence. 'Royal Brompton': the specialist centre in London that specialist centres consult.

    abstract::It may be diagnosing Thalassaemia with magnetic resonance, navigating catheters round tight corners with magnets, or treating Marfan's syndrome with the Brompton Sheath--but if it is state of the art and it works, the Royal Brompton & Harefield NHS Foundation Trust, London, will almost certainly have pioneered it, rep...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:2011-06-01 00:00:00

  • Evaluation of recombinant hirudin (CGP 39,393/TMREVASC) in the prevention of restenosis after percutaneous transluminal coronary angioplasty. Rationale and design of the HELVETICA trial, a multicentre randomized double blind heparin controlled study.

    abstract::One of the main areas of interest in interventional cardiology is the understanding, and ultimate prevention of restenosis after an initially successful percutaneous transluminal coronary angioplasty. Restenosis is the recurrence of luminal narrowing following angioplasty, and still frustrates the late results in the ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验,评审

    doi:10.1093/eurheartj/16.suppl_l.56

    authors: Herrman JP,Simon R,Umans VA,Peerboom PF,Keane D,Rijnierse JJ,Bach D,Kobi P,Kerry R,Close P

    更新日期:1995-11-01 00:00:00

  • Coronary angioplasty for treatment of unstable angina with transient marked ST-segment elevation.

    abstract::The immediate and short-term results of coronary angioplasty were analysed in 16 patients who presented with chest pain at rest associated with transient marked ST-segment elevation (greater than or equal to 0.5 mV). The number of in hospital ischaemic attacks was on average 2.8 (range 1-8). All patients had at least ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062324

    authors: de Feyter PJ,Serruys PW,van den Brand M,Soward A

    更新日期:1987-06-01 00:00:00

  • Successful catheter ablation by radiofrequency energy of posteroseptal accessory pathway in a patient with drug refractory Wolff-Parkinson-White syndrome.

    abstract::A 45-year-old patient with the Wolff-Parkinson-White syndrome suffering from recurrent intractable reciprocating atrioventricular tachycardia (RAVT) is reported. He used amiodarone, sotalol, quinidine, propafenone and flecainide unsuccessfully. An electrophysiological study (EPS) performed with four catheters localize...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/12.12.1321

    authors: Delise P,Bonso A,Raviele A,Cazzin R,Di Pede F,Piccolo E

    更新日期:1991-12-01 00:00:00

  • Changes in cardiac function after effective treatment of hypertensive emergencies with i.v. clonidine.

    abstract::Clonidine administration by i.v. infusion in 12 patients with hypertension emergencies (diastolic blood pressure over 130 mmHg) resulted in the normalization of blood pressure (BP) in all patients. Lowering of BP was associated with a reduction in total and lower limb vascular resistance. Heart rate showed a slight an...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061605

    authors: Masotti G,Scarti L,Poggesi L,Bisi G,Gallini C,Neri Serneri GG

    更新日期:1984-12-01 00:00:00

  • Management of atrial fibrillation: discrepancy between guideline recommendations and actual practice exposes patients to risk for complications.

    abstract:AIMS:To assess compliance to guidelines in the management of patients with atrial fibrillation. METHODS AND RESULTS:A total of 728 questionnaires were mailed to physicians with the intention of studying 'theoretical' compliance to practice guidelines. A retrospective evaluation of 200 records from consecutive patients...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2000.2300

    authors: Frykman V,Beerman B,Rydén L,Rosenqvist M,Medical Products Agency.,Swedish Society of Cardiology.

    更新日期:2001-10-01 00:00:00

  • Coronary vascular reserve in humans: a critical review of methods of evaluation and of interpretation of the results.

    abstract::The concept of coronary vascular reserve stems from the description of coronary autoregulation by Mosher in 1964. Schematically, the coronary blood flow at rest depends on the determinants of myocardial oxygen demand (heart rate, contractility and ventricular load). If maximal coronary vasodilation is produced, it res...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/16.suppl_i.7

    authors: Nitenberg A,Antony I

    更新日期:1995-08-01 00:00:00

  • High prevalence of right ventricular involvement in endurance athletes with ventricular arrhythmias. Role of an electrophysiologic study in risk stratification.

    abstract:BACKGROUND:Electrocardiographic abnormalities and premature ventricular contractions are common in athletes and are generally benign. However, the specific outcome of high-level endurance athletes with frequent and complex ventricular arrhythmias is unclear. Also, information on the predictive accuracy of different inv...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0195-668x(03)00282-3

    authors: Heidbüchel H,Hoogsteen J,Fagard R,Vanhees L,Ector H,Willems R,Van Lierde J

    更新日期:2003-08-01 00:00:00

  • Effect of revascularizing viable myocardium on left ventricular diastolic function in patients with ischaemic cardiomyopathy.

    abstract:AIMS:In patients with ischaemic left ventricular (LV) dysfunction and viable myocardium, revascularization improves systolic function. Diastolic dysfunction is also present in such patients; however, whether revascularization improves diastolic function also is largely unknown. METHODS:Twenty-six patients with chronic...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehp125

    authors: Carluccio E,Biagioli P,Alunni G,Murrone A,Leonelli V,Pantano P,Vincenti G,Giombolini C,Ragni T,Reboldi G,Gentile F,Ambrosio G

    更新日期:2009-06-01 00:00:00

  • Nonparoxysmal atrioventricular junctional rhythm. A clinical and electrophysiologic study.

    abstract::The patient, a 74-year-old man, developed a persistent nonparoxysmal junctional accelerated rhythm at rate of 60-75 beats min-1 because of chronic depressed sinus node function. Intravenous atropine resulted in no change of junctional pacemaker rate but i.v. isoproterenol significantly accelerated it suggesting that a...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061656

    authors: Santinelli V,Chiariello M,Condorelli M

    更新日期:1984-04-01 00:00:00