Abstract:
AIMS:microRNA (miRNA) is reported to be present in the blood of humans and has been increasingly suggested as a biomarker for diseases. We aim to determine the potential of cardiac-specific miRNAs in circulation to serve as biomarkers for acute myocardial infarction (AMI). METHODS AND RESULTS:By verifying their tissue expression patterns with real-time polymerase chain reaction (PCR) analysis, muscle-enriched miRNAs (miR-1, miR-133a, and miR-499) and cardiac-specific miR-208a were selected as candidates for this study. With miRNA microarray and real-time PCR analyses, miR-1, miR-133a, and miR-499 were present with very low abundance, and miR-208a was absent in the plasma from healthy people. In the AMI rats, the plasma levels of these miRNAs were significantly increased. Especially, miR-208a in plasma was undetected at 0 h, but was significantly increased to a detectable level as early as 1 h after coronary artery occlusion. Further evaluation of the miRNA levels in plasma from AMI patients (n = 33) demonstrated that all four miRNA levels were substantially higher than those from healthy people (n = 30, P < 0.01), patients with non-AMI coronary heart disease (n = 16, P < 0.01), or patients with other cardiovascular diseases (n = 17, P < 0.01). Notably, miR-208a remained undetectable in non-AMI patients, but was easily detected in 90.9% AMI patients and in 100% AMI patients within 4 h of the onset of symptoms. By receiver operating characteristic curve analysis, among the four miRNAs investigated, miR-208a revealed the higher sensitivity and specificity for diagnosing AMI. CONCLUSION:Elevated cardiac-specific miR-208a in plasma may be a novel biomarker for early detection of myocardial injury in humans.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Wang GK,Zhu JQ,Zhang JT,Li Q,Li Y,He J,Qin YW,Jing Qdoi
10.1093/eurheartj/ehq013subject
Has Abstractpub_date
2010-03-01 00:00:00pages
659-66issue
6eissn
0195-668Xissn
1522-9645pii
ehq013journal_volume
31pub_type
杂志文章abstract:AIMS:Transplant-associated coronary artery disease (TxCAD) is a major cause of post-transplant graft failure. The aim of this study was to investigate a possible role of mannose-binding lectin (MBL) deficiency and complement activation in TxCAD. METHODS AND RESULTS:In a prospective study of heart transplant recipients...
journal_title:European heart journal
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doi:10.1093/eurheartj/ehi198
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更新日期:2013-02-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/11.suppl_g.1
更新日期:1990-11-01 00:00:00
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doi:10.1093/eurheartj/17.suppl_e.21
更新日期:1996-09-01 00:00:00
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更新日期:2009-10-01 00:00:00
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更新日期:2011-11-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,meta分析,评审
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更新日期:2007-09-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061061
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doi:10.1016/j.ehj.2004.01.016
更新日期:2004-03-01 00:00:00
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doi:10.1053/euhj.1999.1938
更新日期:2001-01-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/eurheartj/14.suppl_g.6
更新日期:1993-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060937
更新日期:1995-04-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/oxfordjournals.eurheartj.a060237
更新日期:1992-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2015-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/eurheartj/4.suppl_f.145
更新日期:1983-11-01 00:00:00
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doi:10.1053/euhj.1998.1479
更新日期:1999-09-01 00:00:00
abstract:: ...
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pub_type: 评论,杂志文章
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doi:
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验,评审
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062324
更新日期:1987-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/eurheartj/12.12.1321
更新日期:1991-12-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061605
更新日期:1984-12-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.2000.2300
更新日期:2001-10-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/16.suppl_i.7
更新日期:1995-08-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/s0195-668x(03)00282-3
更新日期:2003-08-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehp125
更新日期:2009-06-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061656
更新日期:1984-04-01 00:00:00