Relationship between HDL-cholesterol and apolipoprotein A1 and the severity of coronary artery disease.

Abstract:

INTRODUCTION:We investigated whether apolipoprotein A1 (ApoA1) could better identify patients with severe vessel damage than HDL-cholesterol in a population with recent acute myocardial infarction (AMI). METHODS:One hundred and forty-one male patients (mean age: 54.3 +/- 7.3 years) who had undergone coronary angiography within 3 weeks of an AMI were studied. Coronary angiography data were evaluated both anatomically (as single, double or multivessel disease) and by means of the Gensini score. The main lipid parameters were evaluated on admission to the Coronary Care Unit. RESULTS:ApoA1 and the ApoA1/ApoB ratio (A1/B) mean values were significantly (P < 0.05) different when patients were divided on the basis of HDL-cholesterol cut-off value (35.0 mg.dl-1); when divided on the basis of Gensini score (< or = 18 or > 18), there was a statistically significant difference for ApoA1 (P < 0.01), HDL-cholesterol and A1/B (P < 0.05): only this latter was able to discriminate between the two groups. The mean ApoA1 and A1/B (P < 0.01), Gensini score (P < 0.001) and total cholesterol/HDL-cholesterol (P < 0.05) values of patients in the single-vessel disease group differ from those both of double- and multivessel disease groups. A1/B is also able to discriminate between single- and double-vessel disease. DISCUSSION:Our results confirm that ApoA1 and ApoA1/ApoB ratio are better than HDL-cholesterol in assessing the severity of coronary damage.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Garfagnini A,Devoto G,Rosselli P,Boggiano P,Venturini M

doi

10.1093/oxfordjournals.eurheartj.a060937

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

465-70

issue

4

eissn

0195-668X

issn

1522-9645

journal_volume

16

pub_type

杂志文章
  • Risk stratification in asymptomatic severe aortic stenosis: a critical appraisal.

    abstract::Aortic stenosis is one of the most common forms of acquired valvular heart disease. The development of symptoms, namely syncope, angina, or heart failure, in patients with severe aortic stenosis predicts a high likelihood of mortality. Aortic valve replacement is the current standard of care. In truly asymptomatic pat...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehs190

    authors: Bhattacharyya S,Hayward C,Pepper J,Senior R

    更新日期:2012-10-01 00:00:00

  • Emergency angioplasty of the left main coronary artery.

    abstract::During urgent cardiac catheterization total occlusion of a severe left main coronary artery stenosis occurred, leading to profound cardiogenic shock. The patient survived, after prompt left main coronary angioplasty was performed, followed by emergency coronary bypass surgery. ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059437

    authors: Groves PH,Ikram S,Hayward MW,Hall RJ

    更新日期:1989-12-01 00:00:00

  • Acute and long-term haemodynamic and neurohumoral response to nisoldipine vs captopril in patients with heart failure: a randomized double-blind study.

    abstract::To study the haemodynamic and neurohumoral effects of nisoldipine (2 X 10 mg) vs captopril (3 X 25 mg), 24 patients with heart failure (New York Heart Association class II and III) due to coronary artery disease were treated in a randomized double-blind trial over 3 months. Both drugs were well tolerated. Clinical sta...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a059786

    authors: Schofer J,Hobuss M,Aschenberg W,Tews A

    更新日期:1990-08-01 00:00:00

  • Associations between vascular risk factors and brain MRI indices in UK Biobank.

    abstract:AIMS:Several factors are known to increase risk for cerebrovascular disease and dementia, but there is limited evidence on associations between multiple vascular risk factors (VRFs) and detailed aspects of brain macrostructure and microstructure in large community-dwelling populations across middle and older age. METH...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehz100

    authors: Cox SR,Lyall DM,Ritchie SJ,Bastin ME,Harris MA,Buchanan CR,Fawns-Ritchie C,Barbu MC,de Nooij L,Reus LM,Alloza C,Shen X,Neilson E,Alderson HL,Hunter S,Liewald DC,Whalley HC,McIntosh AM,Lawrie SM,Pell JP,Tucker-Drob

    更新日期:2019-07-21 00:00:00

  • Persistent diastolic dysfunction despite complete systolic functional recovery after reperfused acute myocardial infarction demonstrated by tagged magnetic resonance imaging.

    abstract:AIMS:This study was designed to characterise both the systolic and diastolic mechanical properties of regions with different degrees of myocardial ischaemic injury after reperfused acute myocardial infarction (AMI). METHODS AND RESULTS:Fourteen dogs underwent 90-min coronary artery occlusion followed by reperfusion. I...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ehj.2004.06.024

    authors: Azevedo CF,Amado LC,Kraitchman DL,Gerber BL,Osman NF,Rochitte CE,Edvardsen T,Lima JA

    更新日期:2004-08-01 00:00:00

  • A case of right coronary artery occlusion, caused by blunt chest trauma and treated with acute coronary artery bypass surgery.

    abstract::A 37-year-old man sustained occlusion of the right coronary artery after a bicycle accident with blunt chest trauma over the left scapula. Acute coronary angiography was performed because of chest pain and ST-segment elevation. Despite surgically successful acute revascularization the patient developed a transmural in...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060033

    authors: Gustavsson CG,Albrechtsson U,Forslind K,Ståhl E,White T

    更新日期:1992-01-01 00:00:00

  • Short-term effects of Italian smoking regulation on rates of hospital admission for acute myocardial infarction.

    abstract:AIMS:We used the hospital discharge records of Piedmont region (northern Italy) to evaluate whether a national law banning smoking in public resulted in a short-term reduction in hospital admissions for acute myocardial infarction (AMI). METHODS AND RESULTS:Rates of admission for AMI before the ban (October-December 2...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehl201

    authors: Barone-Adesi F,Vizzini L,Merletti F,Richiardi L

    更新日期:2006-10-01 00:00:00

  • Potent inhibition of thrombin with a monoclonal antibody against tissue factor (Sunol-cH36): results of the PROXIMATE-TIMI 27 trial.

    abstract:AIMS:Exposure of tissue factor (TF) is a critical proximal step in the pathogenesis of acute coronary syndromes. Sunol-cH36, a chimaeric monoclonal antibody to TF, blocks binding of factor X to the TF:VIIa complex. This report describes the first completed trial of Sunol-cH36 in humans. METHODS AND RESULTS:We assessed...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/eurheartj/ehi094

    authors: Morrow DA,Murphy SA,McCabe CH,Mackman N,Wong HC,Antman EM

    更新日期:2005-04-01 00:00:00

  • Electrophysiologic properties of falipamil (AQA-39)--a new bradycardiac agent.

    abstract::Falipamil hydrochloride (AQA 39) is a new antiarrhythmic agent structurally related to verapamil. We evaluated the electrophysiologic properties of intravenous falipamil (1.5 mg kg-1 within 20 minutes) in 12 patients. The spontaneous cycle length was significantly (P less than 0.001) prolonged (+79 +/- 59 ms). Atriove...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062198

    authors: Lévy S,Mètge M,Hilaire J,Cointe R,Bru P,Eychenne JL,Gérard R

    更新日期:1987-11-01 00:00:00

  • Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury.

    abstract:AIMS:Emerging evidence indicates that nuclear receptors play a critical regulatory role in cardiovascular physiology/pathology. Recently, farnesoid-X-receptor (FXR), a member of the metabolic nuclear receptor superfamily, has been demonstrated to be expressed in vascular cells, with important roles in vascular physiolo...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehs011

    authors: Pu J,Yuan A,Shan P,Gao E,Wang X,Wang Y,Lau WB,Koch W,Ma XL,He B

    更新日期:2013-06-01 00:00:00

  • Cardiovascular neural regulation during and after prolonged high altitude exposure.

    abstract::Eight young healthy male subjects, members of a Himalayan expedition, underwent 24 h Holter monitoring before departure, after 1 and 4 weeks at high altitude (5000 m) and after return to sea level. At high altitude, the circadian reciprocal changes in low and high frequency (LF, HF) were absent, with no significant re...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060415

    authors: Ponchia A,Noventa D,Bertaglia M,Carretta R,Zaccaria M,Miraglia G,Pascotto P,Buja G

    更新日期:1994-11-01 00:00:00

  • Aldosterone and heart failure.

    abstract::In untreated congestive heart failure, aldosterone plasma concentrations are elevated in proportion to the severity of the disease and are further increased by the use of diuretic treatment. Angiotensin II, plasma potassium concentration, and corticotropin are the major stimulators of aldosterone synthesis. During ang...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/16.suppl_n.98

    authors: Zannad F

    更新日期:1995-12-01 00:00:00

  • Impact of aspirin with or without clopidogrel on postoperative bleeding and blood transfusion in coronary surgical patients treated prophylactically with a low-dose of aprotinin.

    abstract:AIMS:Aspirin combined with clopidogrel is the treatment of choice for acute coronary syndromes. Although the maintenance of aspirin until surgery does not affect postoperative bleeding after coronary artery bypass graft (CABG) surgery, the latter may be dramatically increased when clopidogrel is continued over a period...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehm049

    authors: Ouattara A,Bouzguenda H,Le Manach Y,Léger P,Mercadier A,Leprince P,Bonnet N,Montalescot G,Riou B,Coriat P

    更新日期:2007-04-01 00:00:00

  • Late potentials after acute myocardial infarction. Performance of different criteria for the prediction of arrhythmic complications.

    abstract::In order to compare different criteria for the definition of late potentials in patients after myocardial infarction, three signal averaged ECG variables, duration of the signal-averaged QRS complex (QRS), root-mean-square voltage of the terminal 40 ms (RMS-40), and the duration of low amplitude signals less than 40 m...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060222

    authors: Malik M,Odemuyiwa O,Poloniecki J,Kulakowski P,Farrell T,Staunton A,Camm AJ

    更新日期:1992-05-01 00:00:00

  • Clinical relevance of vegetation localization by transoesophageal echocardiography in infective endocarditis.

    abstract::Infective endocarditis is associated with significant morbidity and mortality, with valvular destruction and congestive heart failure being more common in patients with echocardiographically discernible vegetations. The transoesophageal approach affords consistently high quality images with excellent structural resolu...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060195

    authors: Rohmann S,Erbel R,Görge G,Makowski T,Mohr-Kahaly S,Nixdorff U,Drexler M,Meyer J

    更新日期:1992-04-01 00:00:00

  • Prevalence and natural course of ectopic atrial tachycardia.

    abstract:AIMS:The purpose of this study was to calculate the prevalence of ectopic atrial tachycardia in a population of young asymptomatic males and to assess its natural course both in asymptomatic subjects and in symptomatic hospital patients. METHODS AND RESULTS:12-lead electrocardiograms (ECG) of 3554 consecutive males ap...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1998.1313

    authors: Poutiainen AM,Koistinen MJ,Airaksinen KE,Hartikainen EK,Kettunen RV,Karjalainen JE,Huikuri HV

    更新日期:1999-05-01 00:00:00

  • Advanced heart failure: feasibility study of long-term continuous axial flow pump support.

    abstract:AIMS:A lack of donor hearts has stimulated interest in using blood pumps to treat severe heart failure. We tested the hypothesis that a new continuous flow circulatory assist device could be employed safely to relieve symptoms of heart failure and evaluated the potential to prolong life. METHODS AND RESULTS:An intraca...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehi163

    authors: Siegenthaler MP,Westaby S,Frazier OH,Martin J,Banning A,Robson D,Pepper J,Poole-Wilson P,Beyersdorf F

    更新日期:2005-05-01 00:00:00

  • Epidemiology of desmin and cardiac actin gene mutations in a european population of dilated cardiomyopathy.

    abstract:AIMS:Although dilated cardiomyopathy is the most frequent form of cardiomyopathy, its aetiology is still poorly understood. In about 20-30% of cases the disease is familial with a large predominance of autosomal dominant transmission. Ten different chromosomal loci have been described for autosomal dominant forms of di...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2000.2245

    authors: Tesson F,Sylvius N,Pilotto A,Dubosq-Bidot L,Peuchmaurd M,Bouchier C,Benaiche A,Mangin L,Charron P,Gavazzi A,Tavazzi L,Arbustini E,Komajda M

    更新日期:2000-11-01 00:00:00

  • Comparative study of echo- and angiocardiographically determined regional left ventricular wall motion in recent myocardial infarction.

    abstract::We have studied regional left ventricular (LV) wall motion with M-mode, cross-sectional (2D) echocardiography and LV angiography in 50 patients with a recent myocardial infarction. Regional LV wall motion was evaluated according to a 9-segment model. 2D echocardiography permitted information from all, M-mode echocardi...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061703

    authors: Lindvall K,Hamsten A,Landou C,Szamosi A,de Faire U

    更新日期:1984-07-01 00:00:00

  • Delivery of care for adult patients with congenital heart disease in Europe: results from the Euro Heart Survey.

    abstract:AIMS:The increasing number of adults with congenital heart disease (CHD) has prompted the development of recommendations for the management of these patients and for the organization of their healthcare. The aim of this report is to describe the delivery of care in Europe for adults with congenital cardiac anomalies. ...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehi858

    authors: Moons P,Engelfriet P,Kaemmerer H,Meijboom FJ,Oechslin E,Mulder BJ,Expert Committee of Euro Heart Survey on Adult Congenital Heart Disease.

    更新日期:2006-06-01 00:00:00

  • Antibiotic treatment of streptococcal and enterococcal endocarditis: an overview.

    abstract::The management of streptococcal and enterococcal endocarditis has changed in recent years with the development of effective new regimens that are easier to administer, but resistance to commonly used antibiotics has appeared, especially among enterococci. Beta-lactam antibiotics either alone or in combination are suit...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/16.suppl_b.75

    authors: Francioli P

    更新日期:1995-04-01 00:00:00

  • Coronary vasodilation induced by intracoronary enalaprilat: an argument for the role of a local renin-angiotensin system in patients with dilated cardiomyopathy.

    abstract::Although indicated by several experimental studies, the presence of a renin-angiotensin system has not been demonstrated in the human heart. The influence of a local renin-angiotensin system on the coronary vessels may be difficult to establish after oral or intravenous administration of an angiotensin converting-enzy...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/10.suppl_f.97

    authors: Foult JM,Tavolaro O,Antony I,Nitenberg A

    更新日期:1989-11-01 00:00:00

  • The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function.

    abstract:AIMS:In animal models of obesity and diabetes mellitus, myocardial TG accumulation is associated with decreased myocardial function. In the physiologically ageing heart, myocardial triglyceride (TG) accumulation may also occur due to reduced myocardial fatty acid oxidation. The role of myocardial TG in the ageing human...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehn207

    authors: van der Meer RW,Rijzewijk LJ,Diamant M,Hammer S,Schär M,Bax JJ,Smit JW,Romijn JA,de Roos A,Lamb HJ

    更新日期:2008-06-01 00:00:00

  • Adenosine test in the diagnosis of unexplained syncope: marker of conducting tissue disease or neurally mediated syncope?

    abstract::Adenosine test (supine administration of a 20 mg intravenous bolus with electrocardiographic and blood pressure monitoring) has been endorsed by the European Society of Cardiology guidelines on syncope management as an 'experimental' test in the diagnosis of unexplained syncope. The test is quick and cheap, but there ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehi844

    authors: Parry SW,Nath S,Bourke JP,Bexton RS,Kenny RA

    更新日期:2006-06-01 00:00:00

  • The Belgian Heart Disease Prevention Project: 10-year mortality follow-up.

    abstract::The Belgian Heart Disease Prevention Project was a controlled, randomized multifactorial intervention trial in middle-aged men which lasted 6 years. Significant net differences between intervention and control groups were observed in change in risk profile, in total mortality and in CHD incidence. The net difference i...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a062491

    authors: De Backer G,Kornitzer M,Dramaix M,Kittel F,Thilly C,Graffar M,Vuylsteek K

    更新日期:1988-03-01 00:00:00

  • Felodipine in chronic stable angina: a randomized, double-blind, placebo-controlled, crossover study.

    abstract::To investigate the antianginal efficacy and tolerability of felodipine, a new dihydropyridine calcium antagonist, 20 patients with stable exertional angina, not completely controlled by beta-blocker monotherapy, entered a randomized, double-blind, placebo-controlled, crossover study. Patients on standard beta-blocker ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a059628

    authors: Sangiorgio P,Di Pasquale G,Savonitto S,Urbinati S,Rubboli A,Cavallotti G,Pinelli G,Bracchetti D

    更新日期:1990-11-01 00:00:00

  • The effect of habitual sustained endurance exercise on cardiac structure and function.

    abstract::We performed echocardiographic evaluation of 20 male veteran endurance runners (mean age 56 +/- 7 years) and compared them with a group of age-matched controls. All the runners had run at least 25 miles per week for more than 25 years. Although only four athletes showed voltage ECG evidence of left ventricular hypertr...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059585

    authors: Northcote RJ,McKillop G,Todd IC,Canning GP

    更新日期:1990-01-01 00:00:00

  • Cardiovascular disease in Europe: epidemiological update.

    abstract::This overview provides a Europe-wide update on the current burden of cardiovascular disease, and specifically of coronary heart disease and stroke. Cardiovascular disease continues to cause a large proportion of deaths and disability in Europe, and places a substantial burden on the health care systems and economies o...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht356

    authors: Nichols M,Townsend N,Scarborough P,Rayner M

    更新日期:2013-10-01 00:00:00

  • Effect of revascularizing viable myocardium on left ventricular diastolic function in patients with ischaemic cardiomyopathy.

    abstract:AIMS:In patients with ischaemic left ventricular (LV) dysfunction and viable myocardium, revascularization improves systolic function. Diastolic dysfunction is also present in such patients; however, whether revascularization improves diastolic function also is largely unknown. METHODS:Twenty-six patients with chronic...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehp125

    authors: Carluccio E,Biagioli P,Alunni G,Murrone A,Leonelli V,Pantano P,Vincenti G,Giombolini C,Ragni T,Reboldi G,Gentile F,Ambrosio G

    更新日期:2009-06-01 00:00:00

  • Risk indicators for death in patients treated for hypertension; emphasis on consequences for airline pilots.

    abstract::The treatment of hypertensive aircrew should also include changes in dietary habits, and advice against smoking. Relaxation exercises and changes in life style may prove of benefit. Increasing age, hypertension and smoking multiply to give a risk of cardiovascular event which merits careful assessment. ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/5.suppl_a.33

    authors: Bulpitt CJ

    更新日期:1984-03-01 00:00:00