Abstract:
:Although indicated by several experimental studies, the presence of a renin-angiotensin system has not been demonstrated in the human heart. The influence of a local renin-angiotensin system on the coronary vessels may be difficult to establish after oral or intravenous administration of an angiotensin converting-enzyme inhibitor, since coronary blood flow depends greatly on the loading conditions of the left ventricle. To avoid such a situation, our study consisted in a direct bilateral intracoronary infusion of enalaprilat in patients with dilated cardiomyopathy and normal coronary arteries (mean ejection fraction = 32 +/- 11%, n = 12). This intracoronary infusion (0.05 mg min-1, 1 ml min-1 in each coronary artery) resulted in no significant change of the systemic resistances (20.6 +/- 5.6 to 22.0 +/- 5.1 mmHg l-1 min), rate-pressure product (10,974 +/- 2630 to 10,214 +/- 2486) or myocardial oxygen consumption (21.08 +/- 6.37 to 22.10 +/- 6.42 ml min-1). Despite these steady haemodynamic conditions, intracoronary enalaprilat provoked a significant elevation of coronary sinus blood flow (181 +/- 73 to 214 +/- 79 ml min-1, P less than 0.001) with a reduction of coronary resistance (0.51 +/- 0.17 to 0.41 +/- 0.15 mmHg ml-1 min, P less than 0.001), and no significant alteration in plasma renin activity or plasma aldosterone. The results of this intracoronary infusion of enalaprilat demonstrate that this angiotensin converting-enzyme inhibitor has significant coronary vasodilator properties, which can be evidenced without stimulating the peripheral renin-angiotensin system.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Foult JM,Tavolaro O,Antony I,Nitenberg Adoi
10.1093/eurheartj/10.suppl_f.97subject
Has Abstractpub_date
1989-11-01 00:00:00pages
97-100eissn
0195-668Xissn
1522-9645journal_volume
10 Suppl Fpub_type
杂志文章abstract:AIMS:In this study, we compared the clinical outcomes of elderly patients with unprotected left main coronary artery (ULMCA) stenosis treated with either coronary artery bypass grafting (CABG) or drug-eluting stent (DES). METHODS AND RESULTS:From January 2003 to April 2006, 259 patients with ULMCA stenosis and age > o...
journal_title:European heart journal
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journal_title:European heart journal
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journal_title:European heart journal
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更新日期:2005-05-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/oxfordjournals.eurheartj.a059403
更新日期:1989-10-01 00:00:00
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doi:10.1093/oxfordjournals.eurheartj.a061465
更新日期:1983-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:European heart journal
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doi:10.1093/oxfordjournals.eurheartj.a059576
更新日期:1989-09-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1093/eurheartj/12.suppl_f.10
更新日期:1991-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-10-07 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/oxfordjournals.eurheartj.a014910
更新日期:1996-04-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062493
更新日期:1988-03-01 00:00:00
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pub_type: 杂志文章
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doi:10.1093/oxfordjournals.eurheartj.a014998
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更新日期:2007-05-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1987-06-01 00:00:00
abstract::From January 1978 to August 1983, 41 prosthetic valve thromboses in 34 patients were operated upon in our service. They comprised 15 aortic, 25 mitral and one tricuspid valve thromboses. Seven patients had massive thrombus with dysfunction of the prosthesis; others had small and disseminated thrombi on their prosthesi...
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pub_type: 杂志文章
doi:10.1093/eurheartj/5.suppl_d.39
更新日期:1984-10-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2018-08-01 00:00:00
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更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2006-11-01 00:00:00
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更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1053/euhj.2000.2582
更新日期:2001-08-01 00:00:00