Sustained-release diltiazem versus metoprolol in stable angina pectoris.

Abstract:

:The efficacy of sustained-release diltiazem (diltiazem-SR) 120 mg b.i.d. was compared with metoprolol 100 mg b.i.d. in 12 patients with stable angina. Following a 1-week placebo period, patients received diltiazem-SR or metoprolol in two 3-week treatment periods, in a randomized double-blind crossover design. Total exercise time was increased more with diltiazem-SR than with metoprolol (1.2 min vs 0.4 min, P = 0.02), although the reduction in frequency of weekly anginal attacks was equal with both drugs (5 +/- 3 with placebo to 1 +/- 1 with both drugs). The difference between diltiazem-SR and metoprolol may, in part, be due to the fact that the tests were performed 12 h after drug administration. The diltiazem plasma levels were in the therapeutic range; metoprolol plasma levels, in contrast, were all below the therapeutic range. In addition, the patients might be tired out earlier during beta-blockade therapy, because a greater increase in exercise time with diltiazem-SR compared with metoprolol was found in those patients in whom the exercise endpoint changed from angina to fatigue. Thus, diltiazem-SR effectively reduces the frequency of anginal attacks when given twice daily, and improves exercise capacity to a greater extent than metoprolol 12 h after last dose.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Posma JL,van Dijk RB,Lie KI

doi

10.1093/oxfordjournals.eurheartj.a059403

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

923-7

issue

10

eissn

0195-668X

issn

1522-9645

journal_volume

10

pub_type

临床试验,杂志文章,随机对照试验
  • Abnormalities of left ventricular flow following mitral valve replacement: a colour flow Doppler study.

    abstract::Left ventricular flow patterns were studied at rest by colour flow Doppler echocardiography in 33 patients with mitral tilting-disc prostheses (group 1), in 38 patients with mitral tissue prostheses (group 2) and in 18 healthy volunteers (controls). A 'crossed' flow pattern was seen in 14 patients with mechanical (42%...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060494

    authors: Maire R,Ikram S,Odemuyiwa O,Groves PH,Lo SV,Banning AP,Hall RJ

    更新日期:1994-03-01 00:00:00

  • Effect of breathing oxygen-enriched air on exercise performance in patients with precapillary pulmonary hypertension: randomized, sham-controlled cross-over trial.

    abstract:Aims:The purpose of the current trial was to test the hypothesis that breathing oxygen-enriched air increases exercise performance of patients with pulmonary arterial or chronic thrombo-embolic pulmonary hypertension (PAH/CTEPH) and to investigate involved mechanisms. Methods and results:Twenty-two patients with PAH/C...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehx099

    authors: Ulrich S,Hasler ED,Saxer S,Furian M,Müller-Mottet S,Keusch S,Bloch KE

    更新日期:2017-04-14 00:00:00

  • Mononuclear cell secretome protects from experimental autoimmune myocarditis.

    abstract:AIMS:Supernatants of serum-free cultured mononuclear cells (MNC) contain a mix of immunomodulating factors (secretome), which have been shown to attenuate detrimental inflammatory responses following myocardial ischaemia. Inflammatory dilated cardiomyopathy (iDCM) is a common cause of heart failure in young patients. E...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehs459

    authors: Hoetzenecker K,Zimmermann M,Hoetzenecker W,Schweiger T,Kollmann D,Mildner M,Hegedus B,Mitterbauer A,Hacker S,Birner P,Gabriel C,Gyöngyösi M,Blyszczuk P,Eriksson U,Ankersmit HJ

    更新日期:2015-03-14 00:00:00

  • Cardiac anatomy, function and metabolism in elite cyclists assessed by magnetic resonance imaging and spectroscopy.

    abstract::We investigated whether left ventricular hypertrophy in elite cyclists is associated with functional changes or abnormal energy metabolism. Left ventricular hypertrophy is a powerful risk factor for sudden cardiac death with different prognostic significance among the various geometric forms. Cyclists may have a combi...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015046

    authors: Pluim BM,Chin JC,De Roos A,Doornbos J,Siebelink HM,Van der Laarse A,Vliegen HW,Lamerichs RM,Bruschke AV,Van der Wall EE

    更新日期:1996-08-01 00:00:00

  • No effect of PCSK9 inhibitor alirocumab on the incidence of diabetes in a pooled analysis from 10 ODYSSEY Phase 3 studies.

    abstract:AIMS:Statins have modest adverse effects on glycaemic control. Alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, lowers low-density lipoprotein cholesterol. This study assessed the effects of alirocumab on new-onset diabetes and pre-diabetes incidence in individuals without diabetes at baseline. M...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehw292

    authors: Colhoun HM,Ginsberg HN,Robinson JG,Leiter LA,Müller-Wieland D,Henry RR,Cariou B,Baccara-Dinet MT,Pordy R,Merlet L,Eckel RH

    更新日期:2016-10-14 00:00:00

  • Left atrial ball thrombus in combined mitral-aortic valve disease.

    abstract::This report describes a patient with left atrial ball thrombus which was detected during echocardiographic evaluation of combined mitral-aortic valve disease. Surgical correction was performed entirely on the basis of the echocardiographic diagnosis. ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060161

    authors: Schäfer RO,Evers G,Morgan P,Thiel H

    更新日期:1992-02-01 00:00:00

  • Accelerating impact of diabetes mellitus on mortality in the years following an acute myocardial infarction. TRACE Study Group. Trandolapril Cardiac Evaluation.

    abstract:AIMS:The development of risk associated with diabetes mellitus during long-term follow-up after a myocardial infarction has not been studied in detail. We have studied time-related changes of risk of death during 10 years of follow-up in a cohort of patients not treated with thrombolytic therapy (the Glostrup cohort) a...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1999.1530

    authors: Melchior T,Kober L,Madsen CR,Seibaek M,Jensen GV,Hildebrandt P,Torp-Pedersen C

    更新日期:1999-07-01 00:00:00

  • Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension.

    abstract:AIMS:This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH). METHODS AND RESULTS:In 64 patients, cardiac magnetic resonance, right heart catheterization, and the six-minute walk test (6MWT) were performed at basel...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehl477

    authors: van Wolferen SA,Marcus JT,Boonstra A,Marques KM,Bronzwaer JG,Spreeuwenberg MD,Postmus PE,Vonk-Noordegraaf A

    更新日期:2007-05-01 00:00:00

  • Common carotid artery intima-media thickness is as good as carotid intima-media thickness of all carotid artery segments in improving prediction of coronary heart disease risk in the Atherosclerosis Risk in Communities (ARIC) study.

    abstract:AIMS:Carotid intima-media thickness (CIMT) and plaque information can improve coronary heart disease (CHD) risk prediction when added to traditional risk factors (TRF). However, obtaining adequate images of all carotid artery segments (A-CIMT) may be difficult. Of A-CIMT, the common carotid artery intima-media thicknes...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehr192

    authors: Nambi V,Chambless L,He M,Folsom AR,Mosley T,Boerwinkle E,Ballantyne CM

    更新日期:2012-01-01 00:00:00

  • Cardioprotective effect of calcineurin inhibition in an animal model of renal disease.

    abstract:AIMS:Chronic kidney disease is directly associated with cardiovascular complications. Heart remodelling, including fibrosis, hypertrophy, and decreased vascularization, is frequently present in renal diseases. Our objective was to investigate the impact of calcineurin inhibitors (CNI) on cardiac remodelling and functio...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq436

    authors: Di Marco GS,Reuter S,Kentrup D,Ting L,Ting L,Grabner A,Jacobi AM,Pavenstädt H,Baba HA,Tiemann K,Brand M

    更新日期:2011-08-01 00:00:00

  • Associations between vascular risk factors and brain MRI indices in UK Biobank.

    abstract:AIMS:Several factors are known to increase risk for cerebrovascular disease and dementia, but there is limited evidence on associations between multiple vascular risk factors (VRFs) and detailed aspects of brain macrostructure and microstructure in large community-dwelling populations across middle and older age. METH...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehz100

    authors: Cox SR,Lyall DM,Ritchie SJ,Bastin ME,Harris MA,Buchanan CR,Fawns-Ritchie C,Barbu MC,de Nooij L,Reus LM,Alloza C,Shen X,Neilson E,Alderson HL,Hunter S,Liewald DC,Whalley HC,McIntosh AM,Lawrie SM,Pell JP,Tucker-Drob

    更新日期:2019-07-21 00:00:00

  • Cardiac electrophysiology in New Zealand: a small but vital speciality.

    abstract::Dr Martin Stiles talks about the electrophysiology scene in NZ with Iona MacDonald. ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors: MacDonald I

    更新日期:2012-06-01 00:00:00

  • Identification of pacemaker dependent patients by serial decremental rate inhibition.

    abstract::In a study of the concept of pacemaker dependence, 86 patients who had permanent ventricular demand (VVI) pacemakers implanted for more than six months and were in predominantly paced rhythm underwent repeated interruption of pacing both abruptly and after gradual reduction of paced rate. Non-invasive pace slowing was...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061777

    authors: Crick JC,Rokas S,Sowton E

    更新日期:1985-10-01 00:00:00

  • Neurohormonal and clinical sex differences in heart failure.

    abstract:AIMS:Despite disparities in pathophysiology and disease manifestation between male and female patients with heart failure, studies focusing on sex differences in biomarkers are scarce. The purpose of this study was to assess sex-specific variation in clinical characteristics and biomarker levels to gain more understand...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/eht152

    authors: Meyer S,van der Meer P,van Deursen VM,Jaarsma T,van Veldhuisen DJ,van der Wal MH,Hillege HL,Voors AA

    更新日期:2013-08-01 00:00:00

  • Tricuspid regurgitation diagnosis and treatment.

    abstract::Tricuspid regurgitation (TR) is the most common lesion of the tricuspid valve (TV). Mild TR is common and usually is benign. However, moderate or severe TR can lead to irreversible myocardial damage and adverse outcomes. Despite these findings, few patients with significant TR undergo surgery. The treatment of functio...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehv487

    authors: Arsalan M,Walther T,Smith RL 2nd,Grayburn PA

    更新日期:2017-03-01 00:00:00

  • Combined non-invasive functional and anatomical diagnostic work-up in clinical practice: the magnetic resonance and computed tomography in suspected coronary artery disease (MARCC) study.

    abstract:AIMS:The combined use of cardiac computed tomography (CT) coronary angiography (CTCA) and myocardial perfusion imaging allows the non-invasive evaluation of coronary morphology and function. Cardiovascular magnetic resonance (CMR) imaging has several advantages: it can simultaneously assess myocardial perfusion, ventri...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht077

    authors: Groothuis JG,Beek AM,Brinckman SL,Meijerink MR,van den Oever ML,Hofman MB,van Kuijk C,van Rossum AC

    更新日期:2013-07-01 00:00:00

  • Left ventricular hypertrophy and geometry in a population sample of elderly males.

    abstract:BACKGROUND:Recent studies have shown that left ventricular geometric adaptation to hypertension is complex. The spectrum of geometric adaptations in a general population and its relationship to systolic and diastolic function has, however, not been investigated. OBJECTIVES AND METHODS:This echocardiographic and Dopple...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a014795

    authors: Andrén B,Lind L,Hedenstierna G,Lithell H

    更新日期:1996-12-01 00:00:00

  • Late potentials in arrhythmogenic right ventricular dysplasia. Prevalence, diagnostic and prognostic values.

    abstract::A time-domain signal-averaged ECG was performed in 52 patients with arrhythmogenic right ventricular dysplasia (ARVD) proven by angiography, in 45 control subjects with normal hearts, and in 132 patients with various types of ventricular arrhythmias and no evidence of cardiac disease during routine cardiac examination...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.suppl_e.80

    authors: Leclercq JF,Coumel P

    更新日期:1993-09-01 00:00:00

  • Myocardial reperfusion injury: looking beyond primary PCI.

    abstract::Coronary heart disease (CHD) is the leading cause of death and disability in Europe. For patients presenting with an acute ST-segment elevation myocardial infarction (STEMI), timely myocardial reperfusion using either thrombolytic therapy or primary percutaneous coronary intervention (PPCI) is the most effective thera...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/eht090

    authors: Fröhlich GM,Meier P,White SK,Yellon DM,Hausenloy DJ

    更新日期:2013-06-01 00:00:00

  • Time-to-treatment significantly affects the extent of ST-segment resolution and myocardial blush in patients with acute myocardial infarction treated by primary angioplasty.

    abstract:AIMS:The prognostic role of time-to-treatment in primary angioplasty is still a matter of debate. The aim of our study was to evaluate the relationship between time-to-treatment and myocardial perfusion in patients with ST-segment-elevation myocardial infarction (STEMI) treated by primary angioplasty. METHODS AND RESU...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ehj.2004.03.021

    authors: De Luca G,van 't Hof AW,de Boer MJ,Ottervanger JP,Hoorntje JC,Gosselink AT,Dambrink JH,Zijlstra F,Suryapranata H

    更新日期:2004-06-01 00:00:00

  • Lack of influence of propranolol and metoprolol on walking distance in patients with chronic intermittent claudication.

    abstract::Ten patients with chronic intermittent claudication were included in a double-blind, randomized cross-over study of placebo, propranolol 80 mg b.i.d. and metoprolol 100 mg b.i.d., each given for two months. At the end of each treatment period, the patients were tested on a treadmill and the time to first claudication ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a061440

    authors: Bogaert MG,Clement DL

    更新日期:1983-03-01 00:00:00

  • Psoriasis and risk of atrial fibrillation and ischaemic stroke: a Danish Nationwide Cohort Study.

    abstract:AIMS:Psoriasis is a chronic inflammatory disease and inflammation contributes to the pathogenesis of atrial fibrillation (AF) and ischaemic stroke. We therefore investigated the risk of these endpoints in patients with psoriasis. METHODS AND RESULTS:Cohort study of the entire Danish population followed from 1997 to 20...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr285

    authors: Ahlehoff O,Gislason GH,Jørgensen CH,Lindhardsen J,Charlot M,Olesen JB,Abildstrøm SZ,Skov L,Torp-Pedersen C,Hansen PR

    更新日期:2012-08-01 00:00:00

  • Early diastolic strain rate in relation to systolic and diastolic function and prognosis in acute myocardial infarction: a two-dimensional speckle-tracking study.

    abstract:AIMS:Diastolic dysfunction in acute myocardial infarction (MI) is associated with adverse outcome. Recently, the ratio of early mitral inflow velocity (E) to global diastolic strain rate (e'sr) has been proposed as a marker of elevated LV filling pressure. However, the prognostic value of this measure has not been demo...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/eht179

    authors: Ersbøll M,Andersen MJ,Valeur N,Mogensen UM,Fakhri Y,Thune JJ,Møller JE,Hassager C,Søgaard P,Køber L

    更新日期:2014-03-01 00:00:00

  • Do systemic risk factors impact invasive findings from virtual histology? Insights from the international virtual histology registry.

    abstract:AIMS:Cardiovascular risk factors such as elevated serum lipid levels are important in the development of coronary atherosclerosis. Radiofrequency (RF) analysis of intravascular ultrasound [IVUS, Virtual histology (VH)] offers a unique tool to study the composition of coronary atherosclerotic plaque in vivo. We used dat...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehp428

    authors: Philipp S,Böse D,Wijns W,Marso SP,Schwartz RS,König A,Lerman A,Garcia-Garcia HM,Serruys PW,Erbel R

    更新日期:2010-01-01 00:00:00

  • Ratio of transmitral early filling velocity to early diastolic strain rate predicts long-term risk of cardiovascular morbidity and mortality in the general population.

    abstract:Aims:It has previously been demonstrated that the ratio of early mitral inflow velocity to global diastolic strain rate (E/e'sr) is a significant predictor of cardiac events in specific patient populations. The utility of this measurement to predict cardiovascular events in a general population has not been evaluated. ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehy164

    authors: Lassen MCH,Biering-Sørensen SR,Olsen FJ,Skaarup KG,Tolstrup K,Qasim AN,Møgelvang R,Jensen JS,Biering-Sørensen T

    更新日期:2019-02-07 00:00:00

  • Predictors of major bleeding in acute coronary syndromes: the Global Registry of Acute Coronary Events (GRACE).

    abstract:AIMS:There have been no large observational studies attempting to identify predictors of major bleeding in patients with acute coronary syndromes (ACS), particularly from a multinational perspective. The objective of our study was thus to develop a prediction rule for the identification of patients with ACS at higher r...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0195-668x(03)00485-8

    authors: Moscucci M,Fox KA,Cannon CP,Klein W,López-Sendón J,Montalescot G,White K,Goldberg RJ

    更新日期:2003-10-01 00:00:00

  • Frequency, predictors, and prognosis of ejection fraction improvement in heart failure: an echocardiogram-based registry study.

    abstract:AIMS:To identify variables predicting ejection fraction (EF) recovery and characterize prognosis of heart failure (HF) patients with EF recovery (HFrecEF). METHODS AND RESULTS:Retrospective study of adults referred for ≥2 echocardiograms separated by ≥6 months between 2008 and 2016 at the two largest echocardiography ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehz233

    authors: Ghimire A,Fine N,Ezekowitz JA,Howlett J,Youngson E,McAlister FA

    更新日期:2019-07-01 00:00:00

  • Use of transthoracic Doppler echocardiography combined with clinical and electrocardiographic data to predict acute pulmonary embolism.

    abstract::Transthoracic echocardiography and continuous wave Doppler were prospectively performed in 132 out-patients with suspicion of pulmonary embolism, and who had no previous history of severe cardiac or pulmonary disease. Bedside echocardiography determined diagnosis other than pulmonary embolism in 55 patients. Further s...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a014946

    authors: Nazeyrollas P,Metz D,Jolly D,Maillier B,Jennesseaux C,Maes D,Chabert JP,Chapoutot L,Elaerts J

    更新日期:1996-05-01 00:00:00

  • Marathon run: cardiovascular adaptation and cardiovascular risk.

    abstract::The first marathon run as an athletic event took place in the context of the Olympic Games in 1896 in Athens, Greece. Today, participation in a 'marathon run' has become a global phenomenon attracting young professional athletes as well as millions of mainly middle-aged amateur athletes worldwide each year. One of the...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht502

    authors: Predel HG

    更新日期:2014-11-21 00:00:00

  • Atrial fibrillation.

    abstract::Atrial fibrillation is a common arrhythmia and one which may cause pilot incapacitation. In many cases there may be no more than one episode and there will be no organic heart disease. Prediction of the risk of recurrence is not possible. Atrial fibrillation in both paroxysmal and persistent forms should be disqualify...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/5.suppl_a.89

    authors: Bennett D

    更新日期:1984-03-01 00:00:00