Abstract:
:The efficacy of sustained-release diltiazem (diltiazem-SR) 120 mg b.i.d. was compared with metoprolol 100 mg b.i.d. in 12 patients with stable angina. Following a 1-week placebo period, patients received diltiazem-SR or metoprolol in two 3-week treatment periods, in a randomized double-blind crossover design. Total exercise time was increased more with diltiazem-SR than with metoprolol (1.2 min vs 0.4 min, P = 0.02), although the reduction in frequency of weekly anginal attacks was equal with both drugs (5 +/- 3 with placebo to 1 +/- 1 with both drugs). The difference between diltiazem-SR and metoprolol may, in part, be due to the fact that the tests were performed 12 h after drug administration. The diltiazem plasma levels were in the therapeutic range; metoprolol plasma levels, in contrast, were all below the therapeutic range. In addition, the patients might be tired out earlier during beta-blockade therapy, because a greater increase in exercise time with diltiazem-SR compared with metoprolol was found in those patients in whom the exercise endpoint changed from angina to fatigue. Thus, diltiazem-SR effectively reduces the frequency of anginal attacks when given twice daily, and improves exercise capacity to a greater extent than metoprolol 12 h after last dose.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Posma JL,van Dijk RB,Lie KIdoi
10.1093/oxfordjournals.eurheartj.a059403subject
Has Abstractpub_date
1989-10-01 00:00:00pages
923-7issue
10eissn
0195-668Xissn
1522-9645journal_volume
10pub_type
临床试验,杂志文章,随机对照试验abstract::Left ventricular flow patterns were studied at rest by colour flow Doppler echocardiography in 33 patients with mitral tilting-disc prostheses (group 1), in 38 patients with mitral tissue prostheses (group 2) and in 18 healthy volunteers (controls). A 'crossed' flow pattern was seen in 14 patients with mechanical (42%...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060494
更新日期:1994-03-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,随机对照试验
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更新日期:2017-04-14 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a015046
更新日期:1996-08-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060161
更新日期:1992-02-01 00:00:00
abstract:AIMS:The development of risk associated with diabetes mellitus during long-term follow-up after a myocardial infarction has not been studied in detail. We have studied time-related changes of risk of death during 10 years of follow-up in a cohort of patients not treated with thrombolytic therapy (the Glostrup cohort) a...
journal_title:European heart journal
pub_type: 杂志文章
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更新日期:1999-07-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehl477
更新日期:2007-05-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究
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journal_title:European heart journal
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doi:10.1093/eurheartj/ehq436
更新日期:2011-08-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:2012-06-01 00:00:00
abstract::In a study of the concept of pacemaker dependence, 86 patients who had permanent ventricular demand (VVI) pacemakers implanted for more than six months and were in predominantly paced rhythm underwent repeated interruption of pacing both abruptly and after gradual reduction of paced rate. Non-invasive pace slowing was...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061777
更新日期:1985-10-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2013-08-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
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更新日期:2017-03-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/eht077
更新日期:2013-07-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a014795
更新日期:1996-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/eurheartj/14.suppl_e.80
更新日期:1993-09-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
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journal_title:European heart journal
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1983-03-01 00:00:00
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更新日期:2012-08-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究
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更新日期:2014-03-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究
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更新日期:2010-01-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
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更新日期:2019-02-07 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/s0195-668x(03)00485-8
更新日期:2003-10-01 00:00:00
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journal_title:European heart journal
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doi:10.1093/eurheartj/ehz233
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a014946
更新日期:1996-05-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
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更新日期:2014-11-21 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/5.suppl_a.89
更新日期:1984-03-01 00:00:00