Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension.

Abstract:

AIMS:This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH). METHODS AND RESULTS:In 64 patients, cardiac magnetic resonance, right heart catheterization, and the six-minute walk test (6MWT) were performed at baseline and after 1-year follow-up. RV structure and function were analysed as predictors of mortality. During a mean follow-up of 32 months, 19 patients died. A low stroke volume (SV), RV dilatation, and impaired left ventricular (LV) filling independently predicted mortality. In addition, a further decrease in SV, progressive RV dilatation, and further decrease in LV end-diastolic volume (LVEDV) at 1-year follow-up were the strongest predictors of mortality. According to Kaplan-Meier survival curves, survival was lower in patients with an inframedian SV index or= 84 mL/m(2), and an inframedian LVEDV

journal_name

Eur Heart J

journal_title

European heart journal

authors

van Wolferen SA,Marcus JT,Boonstra A,Marques KM,Bronzwaer JG,Spreeuwenberg MD,Postmus PE,Vonk-Noordegraaf A

doi

10.1093/eurheartj/ehl477

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

1250-7

issue

10

eissn

0195-668X

issn

1522-9645

pii

ehl477

journal_volume

28

pub_type

杂志文章
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