Pharmacokinetics of organic nitrates in man: an overview.

abstract：:Electrophysiological properties were studied in a heterotopic heart transplant model developed in 44 dogs (Group I). Cycle length was 359.5 +/- 55.2 ms in the recipient heart and 500.9 +/- 77.9 ms in the donor heart (P less than 0.001). Sinoatrial conduction time was 38.6 +/- 13.6 ms in the recipient heart and 38.6 +/...

journal_title：European heart journal

authors： Alvarez L,Escudero C,Alzueta J,Silva L,Márquez-Montes J,Castillo-Olivares JL

更新日期：1990-06-01 00:00:00

abstract：AIMS:To document tracking patterns, if any, over time, of classical cardiovascular risk factors in men and women participants in the Vorarlberg Health Monitoring and Promotion Programme (VHM&PP) METHODS AND RESULTS: 67,413 men and 82,237 women underwent a total of 45,4448 standardised examinations in the 15 year period...

journal_title：European heart journal

authors： Ulmer H,Kelleher C,Diem G,Concin H

更新日期：2003-06-01 00:00:00

abstract：:This report describes the results of right ventricle endomyocardial biopsies from 26 subjects (mean age 27 +/- 10 years) with premature ventricular beats and normal cardiac anatomy and mechanical function. Light microscopy examination revealed normal myocardium in 10 subjects (38%), acute myocarditis in two (7%), bord...

journal_title：European heart journal

authors： Di Biase M,Chiddo A,Caruso G,Tritto M,Marchese A,Rizzon P

更新日期：1992-06-01 00:00:00

abstract：AIMS:To examine the relations between genetic loci, plasma lipoprotein(a) [Lp(a)] levels, and cardiovascular disease (CVD) risk among diabetic patients and compare with the observations in the general population. METHODS AND RESULTS:In two prospective cohorts of patients with type 2 diabetes (n= 2308) from the Nurses'...

journal_title：European heart journal

authors： Qi Q,Workalemahu T,Zhang C,Hu FB,Qi L

更新日期：2012-02-01 00:00:00

abstract：AIMS:The purpose of this study was to identify novel genetic variants influencing circulating asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) levels and to evaluate whether they have a prognostic value on cardiovascular mortality. METHODS AND RESULTS:We conducted a genome-wide association stud...

journal_title：European heart journal

authors： Seppälä I,Kleber ME,Lyytikäinen LP,Hernesniemi JA,Mäkelä KM,Oksala N,Laaksonen R,Pilz S,Tomaschitz A,Silbernagel G,Boehm BO,Grammer TB,Koskinen T,Juonala M,Hutri-Kähönen N,Alfthan G,Viikari JS,Kähonen M,Raitakari OT,

更新日期：2014-02-01 00:00:00

abstract：AIMS:Major bleeding after percutaneous coronary intervention (PCI) is an independent risk factor for early and late mortality. We developed and validated a risk score predictive of major bleeding after PCI using the femoral approach. METHODS AND RESULTS:Baseline clinical and procedural variables from two contemporary,...

journal_title：European heart journal

authors： Nikolsky E,Mehran R,Dangas G,Fahy M,Na Y,Pocock SJ,Lincoff AM,Stone GW

更新日期：2007-08-01 00:00:00

abstract：:Diagnosis of myocarditis has improved with the application of new techniques such as immunohistochemistry, polymerase chain reaction, in situ hybridization and Southern blot in endomyocardial biopsies. Treatment of inflammatory heart disease is still difficult and not yet validated by a study with patient numbers suff...

journal_title：European heart journal

authors： Maisch B,Hufnagel G,Schönian U,Hengstenberg C

更新日期：1995-12-01 00:00:00

abstract：AIMS:The cardiac extracellular matrix is highly involved in regulating inflammation, remodelling, and function of the heart. Whether matrix alterations relate to the degree of inflammation, fibrosis, and overall rejection in the human transplanted heart remained, until now, unknown. METHODS AND RESULTS:Expression of m...

journal_title：European heart journal

authors： Vanhoutte D,van Almen GC,Van Aelst LN,Van Cleemput J,Droogné W,Jin Y,Van de Werf F,Carmeliet P,Vanhaecke J,Papageorgiou AP,Heymans S

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Patients with known or suspected coronary disease are often investigated to facilitate risk assessment. We sought to examine the cost-effectiveness of strategies based on exercise echocardiography and exercise electrocardiography. METHODS AND RESULTS:We studied 7656 patients undergoing exercise testing; of ...

journal_title：European heart journal

authors： Marwick TH,Shaw L,Case C,Vasey C,Thomas JD

更新日期：2003-06-01 00:00:00

abstract：:To investigate the haemodynamic changes after physical training in patients with left ventricular aneurysm, 60 uncomplicated patients, mean age 51 +/- 10 years, underwent a maximal ergometric test in the supine position with haemodynamic monitoring (Swan-Ganz catheter) 37 +/- 10 days from acute myocardial infarction a...

journal_title：European heart journal

authors： Giordano A,Giannuzzi P,Tavazzi L

更新日期：1988-04-01 00:00:00

abstract：:Modern-day stenting procedures leverage advances in pharmacotherapy and device innovation. Patients treated with contemporary antiplatelet agents, peri-procedural antithrombin therapy and new-generation drug-eluting stents (DES) have excellent outcomes over the short to medium term. Indeed, coupled with the reducing c...

journal_title：European heart journal

authors： Byrne RA,Joner M,Kastrati A

更新日期：2015-12-14 00:00:00

abstract：AIMS:Aldosterone plays a crucial role in cardiovascular disease. 'Systemic' inhibition of its mineralocorticoid receptor (MR) decreases atherosclerosis by reducing inflammation and oxidative stress. Obesity, an important cardiovascular risk factor, is an inflammatory disease associated with increased plasma aldosterone...

journal_title：European heart journal

authors： Schäfer N,Lohmann C,Winnik S,van Tits LJ,Miranda MX,Vergopoulos A,Ruschitzka F,Nussberger J,Berger S,Lüscher TF,Verrey F,Matter CM

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Electrocardiographic abnormalities and premature ventricular contractions are common in athletes and are generally benign. However, the specific outcome of high-level endurance athletes with frequent and complex ventricular arrhythmias is unclear. Also, information on the predictive accuracy of different inv...

journal_title：European heart journal

authors： Heidbüchel H,Hoogsteen J,Fagard R,Vanhees L,Ector H,Willems R,Van Lierde J

更新日期：2003-08-01 00:00:00

abstract：AIMS:Growing data suggest that antibiotic exposure is associated with a long-lasting alteration in gut microbiota, and may be related to subsequent cardiovascular disease (CVD). We investigated associations of life-stage and duration of antibiotic exposure during adulthood with subsequent CVD events. METHODS AND RESUL...

journal_title：European heart journal

authors： Heianza Y,Zheng Y,Ma W,Rimm EB,Albert CM,Hu FB,Rexrode KM,Manson JE,Qi L

更新日期：2019-12-14 00:00:00

abstract：:The present review summarizes the available information on the effects of the three major classes of antianginal agents (nitrates, calcium and beta-blockers) on myocardial energy metabolism. It also discusses the role of some new molecules (L-carnitine, trimetazidine and ranolazine) that have been proposed as an alter...

journal_title：European heart journal

authors： Chierchia SL,Fragasso G

更新日期：1993-11-01 00:00:00

abstract：AIMS:Within the framework of the HYENA (hypertension and exposure to noise near airports) project we investigated the effect of short-term changes of transportation or indoor noise levels on blood pressure (BP) and heart rate (HR) during night-time sleep in 140 subjects living near four major European airports. METHOD...

journal_title：European heart journal

authors： Haralabidis AS,Dimakopoulou K,Vigna-Taglianti F,Giampaolo M,Borgini A,Dudley ML,Pershagen G,Bluhm G,Houthuijs D,Babisch W,Velonakis M,Katsouyanni K,Jarup L,HYENA Consortium.

更新日期：2008-03-01 00:00:00

abstract：AIMS:To evaluate the effectiveness of Dietary Approaches to Stop Hypertension (DASH) by one-off dietary counselling on reducing cardiovascular risk factors among Chinese Grade 1 hypertensive patients in primary care. METHODS AND RESULTS:A parallel-group, randomized controlled trial (ChiCTR-TRC-13003014) was conducted ...

journal_title：European heart journal

authors： Wong MC,Wang HH,Kwan MW,Fong BC,Chan WM,Zhang DX,Li ST,Yan BP,Coats AJ,Griffiths SM

更新日期：2015-10-07 00:00:00

abstract：AIM:The purpose of our study was to evaluate the relative impact of bivalirudin on bleeding outcomes associated with trans-radial interventions (TRI) in real world practice. METHODS AND RESULTS:Data for patients undergoing percutaneous coronary intervention (PCI) between January 2010 and March 2014 at the 47 hospitals...

journal_title：European heart journal

authors： Perdoncin E,Seth M,Dixon S,Cannon L,Khandelwal A,Riba A,David S,Wohns D,Gurm H

更新日期：2016-06-21 00:00:00

abstract：AIMS:We examined the left lateral ridge (LLR) between the orifices of the left pulmonary veins and the left atrial appendage for a better understanding of its structural composition relevant to ablations for atrial fibrillation (AF). METHODS AND RESULTS:The LLR and its surrounding areas were studied in 40 heart specim...

journal_title：European heart journal

authors： Cabrera JA,Ho SY,Climent V,Sánchez-Quintana D

更新日期：2008-02-01 00:00:00

abstract：:Coronary heart disease (CHD) is the leading cause of death and disability in Europe. For patients presenting with an acute ST-segment elevation myocardial infarction (STEMI), timely myocardial reperfusion using either thrombolytic therapy or primary percutaneous coronary intervention (PPCI) is the most effective thera...

journal_title：European heart journal

authors： Fröhlich GM,Meier P,White SK,Yellon DM,Hausenloy DJ

更新日期：2013-06-01 00:00:00

abstract：:Peptides produced by the renin-angiotensin system play a major role in the development and progression of various cardiovascular diseases. One of these peptides, angiotensin II, is a potent vasoconstrictor that exerts most of its effects through the human AT1 receptor. Following the discovery of a functional variation...

journal_title：European heart journal

authors： van Geel PP,Pinto YM,Buikema H,van Gilst WH

更新日期：1998-07-01 00:00:00

abstract：:The author reviews statistical methods commonly applied in economic evaluations that rely on individual patient-level data. The paper includes a review of foundational concepts, unique characteristics of health economic data, and methods developed to address them. The paper then highlights issues that should be consid...

journal_title：European heart journal

authors： Reed SD

更新日期：2014-07-01 00:00:00

abstract：AIMS:Brain natriuretic peptide (BNP), left ventricular (LV) systolic function, and mitral filling pattern (MFP) are prognostic indicators in patients with heart failure (HF). This study evaluated the potential role of E/Ea for predicting cardiovascular (CV) events in patients with suspected HF. This non-invasive measur...

journal_title：European heart journal

authors： Whalley GA,Wright SP,Pearl A,Gamble GD,Walsh HJ,Richards M,Doughty RN

更新日期：2008-02-01 00:00:00

abstract：:Transesophageal echocardiographic evaluation of right and left pulmonary arteries, up to the origin of their lobar branches, was prospectively performed with a single plane probe in 32 consecutive patients (18 M, 14 F, aged 55.5 +/- 14.6, from 32 to 80 years) with clinical or echocardiographic suspicion of pulmonary e...

journal_title：European heart journal

authors： Pruszczyk P,Torbicki A,Kuch-Wocial A,Chlebus M,Miśkiewicz ZC,Jedrusik P

更新日期：1995-04-01 00:00:00

abstract：:In recent years, stress echocardiography has gained broad acceptance as a non-invasive method for the diagnosis of coronary artery disease. Facing different protocols, dosages and instrumentation, official guidelines for the performance, standardization and quality control of stress echocardiograms are needed; however...

journal_title：European heart journal

authors： Ketteler T,Krahwinkel W,Gödke J,Wolfertz J,Scheuble L,Hoffmeister T,Gülker H

更新日期：1997-06-01 00:00:00

abstract：:Out of 84,609 Europeans in the ERICA sample (EHJ 9, Suppl I) 18,931 had adequate 6-year follow-up data so that coronary heart disease (CHD) mortality could be assessed in relation to five risk factors (age, cholesterol, systolic blood pressure, body mass index and cigarette smoking) measured at baseline. In view of kn...

journal_title：European heart journal

authors：

更新日期：1991-03-01 00:00:00

abstract：:Recently, it has been suggested that oxidized low density lipoprotein (LDL) plays an important role in atherogenesis by facilitating the accumulation of lipids in macrophages. In vitro studies from our laboratory have shown that oxidized LDL is recognized not only by a specific receptor, but also by a receptor which r...

journal_title：European heart journal

authors： Kita T,Ishii K,Yokode M,Kume N,Nagano Y,Arai H,Kawai C

更新日期：1990-08-01 00:00:00

abstract：AIMS:We recently found that resting muscle sympathetic nerve activity is inversely related to peak oxygen uptake (VO(2) peak) in patients with heart failure, suggesting a peripheral neurogenic limit to exercise in heart failure. No such relationship was observed in healthy controls. To determine whether this observatio...

journal_title：European heart journal

authors： Notarius CF,Azevedo ER,Parker JD,Floras JS

更新日期：2002-05-01 00:00:00

abstract：AIMS:To investigate the association between neutrophil count, outcomes, and benefit of clopidogrel therapy in ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS:Baseline neutrophil count was measured in 2865 patients in CLARITY-TIMI 28, a randomized trial of clopidogrel vs. placebo in STEMI patients under...

journal_title：European heart journal

authors： O'Donoghue M,Morrow DA,Cannon CP,Guo W,Murphy SA,Gibson CM,Sabatine MS

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Maximal hyperaemia is paramount in the diagnosis of patients with coronary artery disease. However in these patients, enhanced alpha-adrenergic microvascular vasoconstriction may preclude adenosine to induce maximal hyperaemia. AIM:To assess the presence and the clinical relevance of residual microvascular ...

journal_title：European heart journal

authors： Barbato E,Bartunek J,Aarnoudse W,Vanderheyden M,Staelens F,Wijns W,Heyndrickx GR,Pijls NH,De Bruyne B

更新日期：2004-11-01 00:00:00