Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis.

Abstract:

AIMS:Targeting interleukin-1 (IL-1) represents a novel therapeutic approach to atherosclerosis. CANTOS demonstrated the benefits of IL-1β neutralization in patients post-myocardial infarction with residual inflammatory risk. Yet, some mouse data have shown a prominent role of IL-1α rather than IL-1β in atherosclerosis, or even a deleterious effect of IL-1 on outward arterial remodelling in atherosclerosis-susceptible mice. To shed light on these disparate results, this study investigated the effect of neutralizing IL-1α or/and IL-1β isoforms starting either early in atherogenesis or later in ApoE-/- mice with established atheroma. METHODS AND RESULTS:The neutralization of IL-1α or of both IL-1 isoforms impaired outward remodelling during early atherogenesis as assessed by micro-computed tomographic and histologic assessment. In contrast, the neutralization of IL-1β did not impair outward remodelling either during early atherogenesis or in mice with established lesions. Interleukin-1β inhibition promoted a slant of blood monocytes towards a less inflammatory state during atherogenesis, reduced the size of established atheromata, and increased plasma levels of IL-10 without limiting outward remodelling of brachiocephalic arteries. CONCLUSION:This study established a pivotal role for IL-1α in the remodelling of arteries during early experimental atherogenesis, whereas IL-1β drives inflammation during atherogenesis and the evolution of advanced atheroma in mice.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Vromman A,Ruvkun V,Shvartz E,Wojtkiewicz G,Santos Masson G,Tesmenitsky Y,Folco E,Gram H,Nahrendorf M,Swirski FK,Sukhova GK,Libby P

doi

10.1093/eurheartj/ehz008

subject

Has Abstract

pub_date

2019-08-07 00:00:00

pages

2482-2491

issue

30

eissn

0195-668X

issn

1522-9645

pii

5304405

journal_volume

40

pub_type

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