The relationship between diuretic dose, and the haemodynamic response to captopril in patients with cardiac failure.


:The effect of diuretic dose on the haemodynamic response to captopril was assessed in nine patients with chronic cardiac failure. Each patient was given an intravenous dose of captopril while maintained on (a) a low dose diuretic regime, and (b) a high dose diuretic regime. Activity of the renin angiotensin aldosterone system, as assessed by plasma concentrations of these hormones, was greater when patients were receiving the higher dose diuretic regime. The magnitude of haemodynamic response produced by intravenous captopril was greater when the patients were maintained on the high dose diuretic regime, although no significant correlation was found between resting plasma renin activity and resting plasma angiotensin II concentration and the change produced by captopril in any haemodynamic response on either diuretic regime. An increased dosage of loop diuretic potentiates the haemodynamic effects of captopril in patients with cardiac failure. Reduction of diuretic dose prior to introduction of captopril may protect against severe first dose hypotension.


Eur Heart J


European heart journal


Flapan AD,Davies E,Williams BC,Shaw TR,Edwards CR




Has Abstract


1992-07-01 00:00:00












  • Endocardial mapping of atrial fibrillation in the human right atrium using a non-contact catheter.

    abstract:BACKGROUND:Endocardial mapping of atrial fibrillation in humans is limited by its low resolution and by complexities in the arrhythmia and atrial anatomy. METHODS AND RESULTS:A catheter mounted non-contact multielectrode was deployed in the right atrium of 11 patients with atrial fibrillation and used to reconstruct 3...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Schilling RJ,Kadish AH,Peters NS,Goldberger J,Davies DW

    更新日期:2000-04-01 00:00:00

  • Comparison between abnormalities in segmental endocardial motion and abnormalities in segmental wall thickening after anterior myocardial infarction. A cine-magnetic resonance study.

    abstract::In this study, two patterns of regional contract on of the left ventricle have been studied: endocardial motion and wall thickening, in order to check which of these was the most affected after myocardial infarction. The clinical relevance of this comparison was to assess which parameter of the regional contraction ab...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Germain P,Roul G,Constantinesco A,Coulbois PM,Baruthio J,Mossard JM,Bareiss P,Sacrez A

    更新日期:1996-09-01 00:00:00

  • DNA testing for hypertrophic cardiomyopathy: a cost-effectiveness model.

    abstract::Aims To explore the cost-effectiveness of alternative methods of screening family members for hypertrophic cardiomyopathy (HCM), the most common monogenic cardiac disorder and the most frequent cause of sudden cardiac death (SCD) in young people. Methods and results Economic decision model comparing cascade screening ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Wordsworth S,Leal J,Blair E,Legood R,Thomson K,Seller A,Taylor J,Watkins H

    更新日期:2010-04-01 00:00:00

  • Strain rate imaging for functional quantification of the left atrium: atrial deformation predicts the maintenance of sinus rhythm after catheter ablation of atrial fibrillation.

    abstract:AIMS:The aim of the study was to investigate the atrial myocardial deformation properties using ultrasound strain rate (SR) imaging in patients after catheter ablation of atrial fibrillation (AF) and to compare its prognostic value in maintaining sinus rhythm. METHODS AND RESULTS:A total of 118 patients with AF (74 pa...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Schneider C,Malisius R,Krause K,Lampe F,Bahlmann E,Boczor S,Antz M,Ernst S,Kuck KH

    更新日期:2008-06-01 00:00:00

  • Spectral turbulence analysis of the signal-averaged electrocardiogram for predicting inducible sustained monomorphic ventricular tachycardia in patients with and without bundle branch block.

    abstract::Spectral turbulence analysis of the signal-averaged electrocardiogram is a new method for identifying patients prone to sustained monomorphic ventricular tachycardia. In contrast to analysis in the time domain, it has been claimed to be applicable in patients with bundle branch block. The aim of this study was to asse...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Englund A,Andersson M,Bergfeldt L

    更新日期:1995-12-01 00:00:00

  • Neurohormonal and clinical sex differences in heart failure.

    abstract:AIMS:Despite disparities in pathophysiology and disease manifestation between male and female patients with heart failure, studies focusing on sex differences in biomarkers are scarce. The purpose of this study was to assess sex-specific variation in clinical characteristics and biomarker levels to gain more understand...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Meyer S,van der Meer P,van Deursen VM,Jaarsma T,van Veldhuisen DJ,van der Wal MH,Hillege HL,Voors AA

    更新日期:2013-08-01 00:00:00

  • Impaired myocardial perfusion reserve and fibrosis in Friedreich ataxia: a mitochondrial cardiomyopathy with metabolic syndrome.

    abstract:AIMS:Cardiomyopathy produces significant mortality in patients with Friedreich ataxia (FA), a genetic disorder that produces intra-mitochondrial iron accumulation. We sought to test the hypothesis that abnormal myocardial perfusion reserve and fibrosis represent early manifestations of cardiomyopathy. METHODS AND RESU...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Raman SV,Phatak K,Hoyle JC,Pennell ML,McCarthy B,Tran T,Prior TW,Olesik JW,Lutton A,Rankin C,Kissel JT,Al-Dahhak R

    更新日期:2011-03-01 00:00:00

  • A mechanism of cardiac pain suppression by spinal cord stimulation: implications for patients with angina pectoris.

    abstract::Clinical reports show that electrical stimulation of the spinal cord reduces symptoms of angina pectoris, but so far have not provided evidence on the mechanisms involved. The hypothesis for this study was that inhibition of spinothalamic tract transmission may account for this result. Extracellular potentials of 28 s...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Chandler MJ,Brennan TJ,Garrison DW,Kim KS,Schwartz PJ,Foreman RD

    更新日期:1993-01-01 00:00:00

  • Is pulsed Doppler echocardiography an adequate method to evaluate left ventricular function during filling in hypertensive patients?

    abstract::Pulsed Doppler tracings of the mitral inflow are often proposed to describe left ventricular function during filling in hypertensive patients. The tracings are determined by the complex interaction of left atrial pressure and left ventricular relaxation, diastolic compliance and contractility of the left atrium. They ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Diebold B,Cohen A,Zelinsky R,Raffoul H,Foucher A,Guermonprez JL,Peronneau P

    更新日期:1990-11-01 00:00:00

  • Myocardial hydatid cyst ruptured into the pericardium: cross-sectional echocardiographic study and surgical treatment.

    abstract::We describe a patient with a large intramyocardial hydatid cyst lying in the postero-lateral segment of the left ventricle near the atrioventricular groove level which ruptured into the pericardial sac, resulting in cardiac tamponade. Cross-sectional echocardiographic examination from a modified four-chamber apical vi...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: De Martini M,Nador F,Binda A,Arpesani A,Odero A,Lotto A

    更新日期:1988-07-01 00:00:00

  • Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis.

    abstract:AIMS:Targeting interleukin-1 (IL-1) represents a novel therapeutic approach to atherosclerosis. CANTOS demonstrated the benefits of IL-1β neutralization in patients post-myocardial infarction with residual inflammatory risk. Yet, some mouse data have shown a prominent role of IL-1α rather than IL-1β in atherosclerosis,...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Vromman A,Ruvkun V,Shvartz E,Wojtkiewicz G,Santos Masson G,Tesmenitsky Y,Folco E,Gram H,Nahrendorf M,Swirski FK,Sukhova GK,Libby P

    更新日期:2019-08-07 00:00:00

  • Happy heart syndrome: role of positive emotional stress in takotsubo syndrome.

    abstract:AIMS:Takotsubo syndrome (TTS) is typically provoked by negative stressors such as grief, anger, or fear leading to the popular term 'broken heart syndrome'. However, the role of positive emotions triggering TTS remains unclear. The aim of the present study was to analyse the prevalence and characteristics of patients w...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Ghadri JR,Sarcon A,Diekmann J,Bataiosu DR,Cammann VL,Jurisic S,Napp LC,Jaguszewski M,Scherff F,Brugger P,Jäncke L,Seifert B,Bax JJ,Ruschitzka F,Lüscher TF,Templin C,InterTAK Co-investigators:.

    更新日期:2016-10-01 00:00:00

  • BDNFVal66met polymorphism: a potential bridge between depression and thrombosis.

    abstract:Aims:Epidemiological studies strongly suggest a link between stress, depression, and cardiovascular diseases (CVDs); the mechanistic correlation, however, is poorly understood. A single-nucleotide polymorphism in the BDNF gene (BDNFVal66Met), associated with depression and anxiety, has been proposed as a genetic risk f...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Amadio P,Colombo GI,Tarantino E,Gianellini S,Ieraci A,Brioschi M,Banfi C,Werba JP,Parolari A,Lee FS,Tremoli E,Barbieri SS

    更新日期:2017-05-07 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Warner TD

    更新日期:1993-11-01 00:00:00

  • Local slow potential preceding the surface QRS complex detected at the subvalvular mitral annulus in patients with a left-sided concealed accessory pathway. Incidence, electrophysiological characteristics and the possible mechanism, with demonstration of

    abstract:AIM:We sought to evaluate the incidence and electrophysiological features of the local slow potential preceding the surface QRS complex (pre-QRS potential) which was detected more frequently at successful sites of catheter ablation of left parietal concealed accessory pathways, than at unsuccessful sites. METHODS AND ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Miyauchi Y,Kobayashi Y,Ino T,Atarashi H

    更新日期:1999-12-01 00:00:00

  • Renovascular hypertension: screening and modern management.

    abstract::The diagnosis and management of patients with renovascular disease and hypertension continue to elude healthcare providers. The advent of novel imaging and interventional techniques, and increased understanding of the pathways leading to irreversible renal injury and renovascular hypertension, have ushered in commenda...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Baumgartner I,Lerman LO

    更新日期:2011-07-01 00:00:00

  • Heart failure syndrome. Rationale for current drug treatment.

    abstract::In the initial phase of heart failure, cardiac output and pressure are maintained by increasing sympathetic drive and by cell hypertrophy. Elevated end-diastolic volume, a reduced ejection fraction and a higher filling pressure also occur. Only in more severe heart failure, when cardiac output cannot be maintained, do...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Burkart F

    更新日期:1995-07-01 00:00:00

  • Use of coronary angiography and revascularization procedures following acute myocardial infarction. A European perspective.

    abstract:AIMS:There is little evidence to inform routine practice in the use of coronary angiography and revascularization procedures after acute myocardial infarction. Large differences in the uptake of these procedures have been reported but representative data are scarce. Outcome studies have produced opposing conclusions co...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析


    authors: Woods KL,Ketley D,Agusti A,Hagn C,Kala R,Karatzas NB,Leizorowicz A,Reikvam A,Schilling J,Seabra-Gomes R,Vasiliauskas D,Wilhelmsen L

    更新日期:1998-09-01 00:00:00

  • Initial experience with implantation of internal cardioverter/defibrillators under local anaesthesia by electrophysiologists.

    abstract::This study was designed to evaluate the implantation of internal cardioverter/defibrillators under local anaesthesia by electrophysiologists and to compare this to our former experience of implants with general anaesthesia. Forty-seven internal cardioverter/defibrillators were implanted at our institution by electroph...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章


    authors: Schmitt C,Alt E,Plewan A,Schömig A

    更新日期:1996-11-01 00:00:00

  • N-methylethanolamine attenuates cardiac fibrosis and improves diastolic function: inhibition of phospholipase D as a possible mechanism.

    abstract:AIM:Ventricular fibrosis is promoted by many effectors that chronically activate phospholipase D (PLD), and induces cardiac dysfunction and heart failure in cardiovascular diseases. Since ethanolamine is a product of PLD, we hypothesised that an administration of an analogue of ethanolamine, N-methylethanolamine (MEA),...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Yamamoto K,Takahashi Y,Mano T,Sakata Y,Nishikawa N,Yoshida J,Oishi Y,Hori M,Miwa T,Inoue S,Masuyama T

    更新日期:2004-07-01 00:00:00

  • Prevalence and mechanism of streptokinase-induced platelet stimulation. Effect of acetylsalicylic acid.

    abstract::It was recently shown that streptokinase may induce clot formation in vivo by immunoglobulin G mediated platelet stimulation. We evaluated the in vitro effect of streptokinase on platelet function in 103 subjects, of whom 52 were < or = 30 years and 51 were > or = 50 years old. Although streptokinase inhibited platele...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Terres W,Krüger K,Bleifeld W

    更新日期:1992-11-01 00:00:00

  • Survival after coronary artery bypass grafting. Experience from 4661 patients.

    abstract::The duration of the reduction of mortality after coronary artery bypass grafting (CABG) is an important issue and this study was undertaken to evaluate time in relation to excess mortality among CABG patients compared with the general population. Survival was analysed in 4661 patients who had undergone their first iso...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Ståhle E,Bergström R,Holmberg L,Edlund B,Nyström SO,Sjögren I,Hansson HE

    更新日期:1994-09-01 00:00:00

  • Is the A1166C polymorphism of the angiotensin II type 1 receptor involved in cardiovascular disease?

    abstract::Peptides produced by the renin-angiotensin system play a major role in the development and progression of various cardiovascular diseases. One of these peptides, angiotensin II, is a potent vasoconstrictor that exerts most of its effects through the human AT1 receptor. Following the discovery of a functional variation...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: van Geel PP,Pinto YM,Buikema H,van Gilst WH

    更新日期:1998-07-01 00:00:00

  • Angiotensin converting enzyme insertion/deletion polymorphism and the risk of heart failure in hypertensive subjects.

    abstract:AIMS:Cardiac angiotensin-I converting enzyme (ACE) activity is influenced by the ACE I/D polymorphism. Evidence suggests that the DD-genotype may be a risk factor for cardiac hypertrophy and heart failure, especially in hypertensive subjects. We assessed the relation between the ACE I/D polymorphism and the risk of inc...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Schut AF,Bleumink GS,Stricker BH,Hofman A,Witteman JC,Pols HA,Deckers JW,Deinum J,van Duijn CM

    更新日期:2004-12-01 00:00:00

  • What is the role of the coronary circulation in congestive heart failure?

    abstract::Manifestations of congestive heart failure are frequently observed in patients with coronary disease. However, they may be predominant in patients who have sustained prior myocardial infarction, in whom left ventricular aneurysm or papillary muscle dysfunction may induce left ventricular dysfunction. A small group of ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Bertrand ME,Lablanche JM,Thieuleux FA,Tilmant PY

    更新日期:1983-01-01 00:00:00

  • Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes.

    abstract:AIMS:To examine the relations between genetic loci, plasma lipoprotein(a) [Lp(a)] levels, and cardiovascular disease (CVD) risk among diabetic patients and compare with the observations in the general population. METHODS AND RESULTS:In two prospective cohorts of patients with type 2 diabetes (n= 2308) from the Nurses'...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Qi Q,Workalemahu T,Zhang C,Hu FB,Qi L

    更新日期:2012-02-01 00:00:00

  • Angiogenesis in myocardial infarction. An acute or chronic process?

    abstract:BACKGROUND:In the acute phase of myocardial infarction (acute MI) marked endothelial damage occurs within the first 24h following thrombolysis with streptokinase. We investigated whether this is associated with a change in levels of vascular endothelial growth factor (VEGF, possibly marking angiogenesis) in the first 2...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Chung NA,Lydakis C,Belgore F,Blann AD,Lip GY

    更新日期:2002-10-01 00:00:00

  • Influence of heart rate, respiration and recipient atrial contraction on pulsed wave transmitral Doppler flow indices in orthotopic heart transplant recipients.

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    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Mannaerts H,Balk A,Roelandt J

    更新日期:1997-10-01 00:00:00

  • Experimental evidence for beta adrenergic blocking properties of propafenone and for their potential clinical relevance.

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    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Malfatto G,Pessano P,Zaza A,Schwartz PJ

    更新日期:1993-09-01 00:00:00

  • Acute and long-term haemodynamic and neurohumoral response to nisoldipine vs captopril in patients with heart failure: a randomized double-blind study.

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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Schofer J,Hobuss M,Aschenberg W,Tews A

    更新日期:1990-08-01 00:00:00