Is atrial fibrillation an inflammatory disorder?

Abstract:

:There is mounting evidence to support the influence of inflammation in the pathogenesis of atrial fibrillation (AF). Indeed, AF is associated with increased levels of known inflammatory markers, even after adjustment for confounding factors. The renin-angiotensin-aldosterone system (RAAS) appears to play a key role in this process. Atrial biopsies from patients with AF have also confirmed the presence of inflammation. Furthermore, there is preliminary evidence to support a number of drug therapies that have the potential to reduce the clinical burden of AF. In this review, we present an overview of the evidence supporting a link between inflammation and AF, and some of the drug therapies, such as the angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, steroids, fish oils, and vitamin C, that might be efficacious in the prevention of AF by modulating inflammatory pathways.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Boos CJ,Anderson RA,Lip GY

doi

10.1093/eurheartj/ehi645

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

136-49

issue

2

eissn

0195-668X

issn

1522-9645

pii

ehi645

journal_volume

27

pub_type

杂志文章,评审
  • Spectral mapping of the electrocardiogram with Fourier transform for identification of patients with sustained ventricular tachycardia and coronary artery disease.

    abstract::In time domain analysis, detection of late potentials is limited by high pass filtering, noise interference and the necessity to exclude patients with bundle branch block. We therefore used frequency analysis with Fourier transform of multiple segments of the surface electrocardiogram (25 segments, size 80 ms, time sh...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059488

    authors: Haberl R,Jilge G,Pulter R,Steinbeck G

    更新日期:1989-04-01 00:00:00

  • Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF.

    abstract:Aims:To date, clinical evidence of microvascular dysfunction in patients with heart failure (HF) with preserved ejection fraction (HFpEF) has been limited. We aimed to investigate the prevalence of coronary microvascular dysfunction (CMD) and its association with systemic endothelial dysfunction, HF severity, and myoca...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehy531

    authors: Shah SJ,Lam CSP,Svedlund S,Saraste A,Hage C,Tan RS,Beussink-Nelson L,Ljung Faxén U,Fermer ML,Broberg MA,Gan LM,Lund LH

    更新日期:2018-10-01 00:00:00

  • Abnormalities of left ventricular flow following mitral valve replacement: a colour flow Doppler study.

    abstract::Left ventricular flow patterns were studied at rest by colour flow Doppler echocardiography in 33 patients with mitral tilting-disc prostheses (group 1), in 38 patients with mitral tissue prostheses (group 2) and in 18 healthy volunteers (controls). A 'crossed' flow pattern was seen in 14 patients with mechanical (42%...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060494

    authors: Maire R,Ikram S,Odemuyiwa O,Groves PH,Lo SV,Banning AP,Hall RJ

    更新日期:1994-03-01 00:00:00

  • Effect of uniformly prolonged, and increased basic dispersion of repolarization on premature dispersion on ventricular surface in dogs: role of action potential duration and activation time differences.

    abstract::Strong experimental evidence links ventricular fibrillation to an increased temporal dispersion of the recovery of excitability. The effect of an overall prolongation of repolarization and an increased basic dispersion of repolarization on premature dispersion was studied on ventricular surface in 10 dogs. Our observa...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/6.suppl_d.15

    authors: Amlie JP,Kuo CS,Munakata K,Reddy PS,Surawicz B

    更新日期:1985-11-01 00:00:00

  • First month course of left ventricular asynergy after intracoronary thrombolysis in acute myocardial infarction. A longitudinal echocardiographic study.

    abstract::Can intracoronary thrombolytic therapy (ITT) reduce the infarct size and improve regional and global left ventricular function and if so how long after recanalization does this improvement develop? 42 patients were treated with ITT, of whom 25 showed successful recanalization (group A) and 17 had persistent occlusion ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061937

    authors: Widimský P,Cervenka V,Gregor P,Vísek V,Sládková T,Dvorák J,Hrdlicka S

    更新日期:1985-09-01 00:00:00

  • Transdermal nitroglycerin in angina pectoris.

    abstract::The transdermal nitroglycerin patches have been very successful nitrate formulations since their introduction in 1982. Nevertheless, considerable controversy regarding efficacy and tolerance has arisen. Nitroglycerin has multiple mechanisms of action in angina pectoris. Transdermal nitroglycerin in ointment formulatio...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/10.suppl_a.11

    authors: Abrams J

    更新日期:1989-05-01 00:00:00

  • Pneumococcal endocarditis.

    abstract::Among 369 patients with native valve infective endocarditis observed during a 14-year period, 17 were related to S: pneumoniae. Fourteen of them were observed in the last 7 years. At the time of admission 13 exhibited purulent meningitis, 6 of them being comatose. An apparent portal of entry was present in 13 patients...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/5.suppl_c.77

    authors: Wolff M,Regnier B,Witchitz S,Gibert C,Amoudry C,Vachon F

    更新日期:1984-10-01 00:00:00

  • Variable response to atrial pacing after intravenous propranolol in patients with stable exertional angina.

    abstract::The effect of propranolol administration on regional coronary haemodynamics were investigated in 14 patients with stable exertional angina and isolated left anterior descending artery disease. Thermodilution was used to measure great cardiac vein flow (GCVF) and anterior regional coronary resistance (ARCR) under contr...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059640

    authors: De Servi S,Ferrario M,Ghio S,Cioffi P,Angoli L,Bramucci E,Aimè E,Montericcio V,Specchia G

    更新日期:1990-11-01 00:00:00

  • Afterload reduction by nifedipine--the acute haemodynamic response to exercise in hypertensive subjects.

    abstract::In 16 people with essential hypertension, heart rate (HR), blood pressure (BP) and relative cardiac volumes were measured at rest and during submaximal upright exercise before and after 10 mg of sublingual nifedipine using radionuclide ventriculography. In 10 patients who had had no previous therapy (BP 152/103 +/- 5/...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061863

    authors: Wathen CG,Hannan WJ,Turnbull LW,Muir AL

    更新日期:1985-04-01 00:00:00

  • Clinical characteristics, diagnosis, and risk stratification of pulmonary hypertension in severe tricuspid regurgitation and implications for transcatheter tricuspid valve repair.

    abstract:AIMS:Patients with pulmonary hypertension (PHT) are often excluded from surgical therapies for tricuspid regurgitation (TR). Transcatheter tricuspid valve repair (TTVR) with the MitraClip™ technique is a novel treatment option for these patients. We aimed to assess the role of PHT in severe TR and its implications for ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa138

    authors: Lurz P,Orban M,Besler C,Braun D,Schlotter F,Noack T,Desch S,Karam N,Kresoja KP,Hagl C,Borger M,Nabauer M,Massberg S,Thiele H,Hausleiter J,Rommel KP

    更新日期:2020-08-01 00:00:00

  • Contractility sensor-guided optimization of cardiac resynchronization therapy: results from the RESPOND-CRT trial.

    abstract:Aims:Although cardiac resynchronization therapy (CRT) is effective in patients with systolic heart failure (HF) and a wide QRS interval, a substantial proportion of patients remain non-responsive. The SonR contractility sensor embedded in the right atrial lead enables individualized automatic optimization of the atriov...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehw526

    authors: Brugada J,Delnoy PP,Brachmann J,Reynolds D,Padeletti L,Noelker G,Kantipudi C,Rubin Lopez JM,Dichtl W,Borri-Brunetto A,Verhees L,Ritter P,Singh JP,RESPOND CRT Investigators.

    更新日期:2017-03-07 00:00:00

  • Obesity and weight loss are inversely related to mortality and cardiovascular outcome in prediabetes and type 2 diabetes: data from the ORIGIN trial.

    abstract:AIMS:The association of body weight and weight change with mortality and cardiovascular (CV) outcome in patients with diabetes mellitus (DM) is not clearly established. We assessed the relationship between weight, weight change, and outcomes in patients with established CV risk factors and type 2 DM or pre-diabetes. M...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa293

    authors: Doehner W,Gerstein HC,Ried J,Jung H,Asbrand C,Hess S,Anker SD

    更新日期:2020-07-21 00:00:00

  • A randomized controlled trial of dapagliflozin on left ventricular hypertrophy in people with type two diabetes: the DAPA-LVH trial.

    abstract:AIM:We tested the hypothesis that dapagliflozin may regress left ventricular hypertrophy (LVH) in people with type 2 diabetes (T2D). METHODS AND RESULTS:We randomly assigned 66 people (mean age 67 ± 7 years, 38 males) with T2D, LVH, and controlled blood pressure (BP) to receive dapagliflozin 10 mg once daily or placeb...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa419

    authors: Brown AJM,Gandy S,McCrimmon R,Houston JG,Struthers AD,Lang CC

    更新日期:2020-09-21 00:00:00

  • The effect of nadolol on heart rate and the standard deviation of the RR intervals.

    abstract::The aim of this study was to evaluate the effect of nadolol in modifying the standard deviation of RR intervals (SDRR) and the coefficient of variance (CV) in 47 patients characterized by symptomatic, frequent (> 30 h-1) and reproducible premature ventricular contractions (PVCs). Sixteen patients had suffered a previo...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060895

    authors: Pitzalis MV,Mastropasqua F,Massari F,Totaro P,Passantino A,Rizzon P

    更新日期:1995-02-01 00:00:00

  • Effect of exercise training in patients with an implantable cardioverter defibrillator.

    abstract:AIMS:Little research exists on exercise performance and training in patients with an implemented cardioverter defibrillator (ICD) and only in a limited number of patients. This study aims to investigate the effect of exercise training in ICD patients in comparison to the effects in other cardiac patients without an ICD...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ehj.2004.04.034

    authors: Vanhees L,Kornaat M,Defoor J,Aufdemkampe G,Schepers D,Stevens A,Van Exel H,Van Den Beld J,Heidbüchel H,Fagard R

    更新日期:2004-07-01 00:00:00

  • Management of the patient with left ventricular hypertrophy.

    abstract::The management of left ventricular hypertrophy (LVH) presupposes that the patient is identified by echocardiography and is carefully evaluated for risk stratification, taking into consideration possible associated complications. The role of non-pharmacological treatment is limited, except in obese patients. Drug treat...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/14.suppl_d.22

    authors: de Divitiis O,Celentano A,De Simone G,Di Somma S,Galderisi M,Liguori V,de Divitiis M,Petitto M

    更新日期:1993-07-01 00:00:00

  • Lipoprotein-associated phospholipase A2 activity and risk of heart failure: The Rotterdam study.

    abstract:AIMS:Evidence is accumulating that inflammation plays a role in the pathophysiology of heart failure. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has pro-inflammatory properties. We investigated whether Lp-PLA2 activity is associated with heart failure. METHODS AND RESULTS:Lp-PLA2 activity was determined in a ra...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehl230

    authors: van Vark LC,Kardys I,Bleumink GS,Knetsch AM,Deckers JW,Hofman A,Stricker BH,Witteman JC

    更新日期:2006-10-01 00:00:00

  • Management and outcome of patients with established coronary artery disease: the Euro Heart Survey on coronary revascularization.

    abstract:AIMS:The purpose of the Euro Heart Survey Programme of the European Society of Cardiology is to evaluate to which extent clinical practice endorses existing guidelines as well as to identify differences in population profiles, patient management, and outcome across Europe. The current survey focuses on the invasive dia...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehi238

    authors: Lenzen MJ,Boersma E,Bertrand ME,Maier W,Moris C,Piscione F,Sechtem U,Stahle E,Widimsky P,de Jaegere P,Scholte op Reimer WJ,Mercado N,Wijns W,European Society of Cardiology.

    更新日期:2005-06-01 00:00:00

  • The effects of physical training in post-myocardial infarction patients with exercise-induced silent ischaemia.

    abstract::To assess the clinical significance of monitoring during physical training in post-myocardial infarction (MI) patients with asymptomatic exercise-induced ischaemia, we studied 232 patients who were survivors of first recent acute MI and consecutively admitted to the same CCU, who underwent an exercise test (ET) and co...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/9.suppl_n.176

    authors: Opasich C,Riccardi G,Assandri J,Calsamiglia G,Forni R,La Rovere M,Cobelli F,De Servi S,Specchia G

    更新日期:1988-12-01 00:00:00

  • Calcium antagonist induced vasodilation in peripheral, coronary and cerebral vasculature as important factors in the treatment of elderly hypertensives.

    abstract::Increased arteriolar tone is the pathophysiological hallmark of essential hypertension and is determined by the intracellular free calcium concentration in the vascular smooth muscle cell. Calcium influx is an important determinant of vasoconstriction and excess calcium influx-dependent vasoconstriction has been shown...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/8.suppl_k.49

    authors: Erne P,Conen D,Kiowski W,Bolli P,Müller FB,Bühler FR

    更新日期:1987-11-01 00:00:00

  • Sudden death in cardiac sarcoidosis: an analysis of nationwide clinical and cause-of-death registries.

    abstract:AIMS:The present study was done to assess the role of sudden cardiac death (SCD) among the presenting manifestations of and fatalities from cardiac sarcoidosis (CS). METHODS AND RESULTS:We analysed altogether 351 cases of CS presenting from year 1998 through 2015 in Finland. There were 262 patients with a clinical dia...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehz428

    authors: Ekström K,Lehtonen J,Nordenswan HK,Mäyränpää MI,Räisänen-Sokolowski A,Kandolin R,Simonen P,Pietilä-Effati P,Alatalo A,Utriainen S,Rissanen TT,Haataja P,Kokkonen J,Vihinen T,Miettinen H,Kaikkonen K,Kerola T,Kupari M

    更新日期:2019-10-01 00:00:00

  • Determination of left ventricular inflow by pulsed Doppler echocardiography: influence of mitral orifice area and blood velocity measurements.

    abstract::Pulsed Doppler echocardiography was performed in 30 patients to assess the influence of mitral orifice area and velocity on the determination of mitral stroke volume and inflow. Aortic forward stroke volume and outflow were measured at the centre of the aortic annulus, and compared with mitral flow measurements calcul...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059821

    authors: Tribouilloy C,Slama M,Shen WF,Choquet D,Delonca J,Mertl C,Dufosse H,Lesbre JP

    更新日期:1991-01-01 00:00:00

  • Sudden cardiac death in hypertrophic cardiomyopathy. Variability in phenotypic expression of beta-myosin heavy chain mutations.

    abstract:BACKGROUND:Recent identification of mutations in the beta-myosin heavy chain gene (MYH7), a major responsible gene for HCM, has provided the opportunity to characterize genotype-phenotype correlation in HCM families. In this study we analysed the phenotypic expression of two beta-myosin heavy chain (beta MHC) mutations...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060920

    authors: Marian AJ,Mares A Jr,Kelly DP,Yu QT,Abchee AB,Hill R,Roberts R

    更新日期:1995-03-01 00:00:00

  • High prevalence of right ventricular involvement in endurance athletes with ventricular arrhythmias. Role of an electrophysiologic study in risk stratification.

    abstract:BACKGROUND:Electrocardiographic abnormalities and premature ventricular contractions are common in athletes and are generally benign. However, the specific outcome of high-level endurance athletes with frequent and complex ventricular arrhythmias is unclear. Also, information on the predictive accuracy of different inv...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0195-668x(03)00282-3

    authors: Heidbüchel H,Hoogsteen J,Fagard R,Vanhees L,Ector H,Willems R,Van Lierde J

    更新日期:2003-08-01 00:00:00

  • Valve replacement in octogenarians: increased early mortality but good long-term result.

    abstract::Between January 1983 and December 1990, 20 patients aged 80 years or older underwent valvular surgery. The patients' ages varied from 80 to 87 years (mean, 82 +/- 1.5 years). The indication for operation was aortic stenosis in 19 patients, and mitral insufficiency after previous mitral valve replacement with a biopros...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060205

    authors: Pasic M,Carrel T,Laske A,Bauer E,Turina J,Jenni R,von Segesser L,Turina M

    更新日期:1992-04-01 00:00:00

  • Associations between vascular risk factors and brain MRI indices in UK Biobank.

    abstract:AIMS:Several factors are known to increase risk for cerebrovascular disease and dementia, but there is limited evidence on associations between multiple vascular risk factors (VRFs) and detailed aspects of brain macrostructure and microstructure in large community-dwelling populations across middle and older age. METH...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehz100

    authors: Cox SR,Lyall DM,Ritchie SJ,Bastin ME,Harris MA,Buchanan CR,Fawns-Ritchie C,Barbu MC,de Nooij L,Reus LM,Alloza C,Shen X,Neilson E,Alderson HL,Hunter S,Liewald DC,Whalley HC,McIntosh AM,Lawrie SM,Pell JP,Tucker-Drob

    更新日期:2019-07-21 00:00:00

  • No effect of PCSK9 inhibitor alirocumab on the incidence of diabetes in a pooled analysis from 10 ODYSSEY Phase 3 studies.

    abstract:AIMS:Statins have modest adverse effects on glycaemic control. Alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, lowers low-density lipoprotein cholesterol. This study assessed the effects of alirocumab on new-onset diabetes and pre-diabetes incidence in individuals without diabetes at baseline. M...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehw292

    authors: Colhoun HM,Ginsberg HN,Robinson JG,Leiter LA,Müller-Wieland D,Henry RR,Cariou B,Baccara-Dinet MT,Pordy R,Merlet L,Eckel RH

    更新日期:2016-10-14 00:00:00

  • Tropheryma whippelii endocarditis confirmed by polymerase chain reaction.

    abstract::This report concerns a patient with cardiac manifestation of Whipple's disease. For the first time, the gene that encodes the 16s rRNA of Tropheryma whippelii was identified in a native aortic valve by means of a polymerase chain reaction technique. DNA amplification gives evidence of Tropheryma whippelii as a causati...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060928

    authors: Wendler D,Mendoza E,Schleiffer T,Zander M,Maier M

    更新日期:1995-03-01 00:00:00

  • Acellular therapeutic approach for heart failure: in vitro production of extracellular vesicles from human cardiovascular progenitors.

    abstract:Aims:We have shown that extracellular vesicles (EVs) secreted by embryonic stem cell-derived cardiovascular progenitor cells (Pg) recapitulate the therapeutic effects of their parent cells in a mouse model of chronic heart failure (CHF). Our objectives are to investigate whether EV released by more readily available ce...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehy012

    authors: El Harane N,Kervadec A,Bellamy V,Pidial L,Neametalla HJ,Perier MC,Lima Correa B,Thiébault L,Cagnard N,Duché A,Brunaud C,Lemitre M,Gauthier J,Bourdillon AT,Renault MP,Hovhannisyan Y,Paiva S,Colas AR,Agbulut O,Hagège

    更新日期:2018-05-21 00:00:00

  • Should we SHIFT our thinking about digoxin? Observations on ivabradine and heart rate reduction in heart failure.

    abstract:AIMS:The importance of heart rate in the pathophysiology of heart failure with reduced LVEF has recently attracted attention. In particular, the findings of the Systolic Heart failure treatment with the I(f) inhibitor ivabradine Trial (SHIFT) have put special emphasis on heart rate reduction with ivabradine for improve...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehs004

    authors: Castagno D,Petrie MC,Claggett B,McMurray J

    更新日期:2012-05-01 00:00:00