Abstract:
:In 16 people with essential hypertension, heart rate (HR), blood pressure (BP) and relative cardiac volumes were measured at rest and during submaximal upright exercise before and after 10 mg of sublingual nifedipine using radionuclide ventriculography. In 10 patients who had had no previous therapy (BP 152/103 +/- 5/3 mmHg) nifedipine produced a fall in BP of 6/12 +/- 3/3 mmHg (SEM) and a rise in HR of 15 +/- 5 bpm (P less than 0.001). This was associated with a rise in LVEF of 0.07 +/- 0.02 (P less than 0.005) and in cardiac output of 44 +/- 9%, presumably as a result of ventricular offloading. The cardiac response to exercise given the different starting values, was unchanged by nifedipine. Thus the HR was 101 +/- 6 bpm at rest after nifedipine and on exercise rose to 124 +/- 6 bpm (P less than 0.001): stroke volume was +22 +/- 8% at rest after nifedipine and rose to +43 +/- 12% on exercise. Thus cardiac output which had increased by 44 +/- 9% after nifedipine increased by 100 +/- 10% from the initial value. In 6 patients pre-treated with atenolol (100 mg) and with similar resting BP (158/101 +/- 5/4 mmHg) there was a fall in BP of 32/15 +/- 3/2 mmHg after nifedipine which was greater than in the previously untreated group (P less than 0.01). In this group HR increased by 8 +/- 3 bpm (P less than 0.05). Following nifedipine the exercise response was similar given the different starting values.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Wathen CG,Hannan WJ,Turnbull LW,Muir ALdoi
10.1093/oxfordjournals.eurheartj.a061863subject
Has Abstractpub_date
1985-04-01 00:00:00pages
358-64issue
4eissn
0195-668Xissn
1522-9645journal_volume
6pub_type
杂志文章abstract::To examine whether increases in heart rate might be a common trigger of angina at rest, changes in heart rate, blood pressure and rate-pressure product during pain were compared with the ischaemic threshold (heart rate with ST segment shift > = 1 mm), determined by atrial pacing, in 272 patients with unstable angina. ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.9.1170
更新日期:1993-09-01 00:00:00
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journal_title:European heart journal
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doi:10.1093/eurheartj/9.suppl_h.29
更新日期:1988-06-01 00:00:00
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journal_title:European heart journal
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更新日期:2013-02-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060375
更新日期:1994-01-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:
更新日期:1998-07-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
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更新日期:1993-09-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.2002.3264
更新日期:2002-11-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1016/j.ehj.2004.06.038
更新日期:2004-09-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/16.suppl_k.4
更新日期:1995-11-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehr345
更新日期:2012-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/eurheartj/ehs060
更新日期:2014-12-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/16.suppl_h.13
更新日期:1995-08-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehn521
更新日期:2009-02-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/17.suppl_b.39
更新日期:1996-04-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/11.suppl_b.139
更新日期:1990-04-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,meta分析
doi:10.1093/eurheartj/ehy813
更新日期:2019-02-14 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a014946
更新日期:1996-05-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061637
更新日期:1984-03-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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doi:10.1093/oxfordjournals.eurheartj.a015124
更新日期:1997-01-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062107
更新日期:1986-07-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:1998-10-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062036
更新日期:1986-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a014672
更新日期:1996-01-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-01-21 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章
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更新日期:2000-07-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.6.751
更新日期:1993-06-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1992-10-01 00:00:00