Lipoprotein-associated phospholipase A2 activity and risk of heart failure: The Rotterdam study.

Abstract:

AIMS:Evidence is accumulating that inflammation plays a role in the pathophysiology of heart failure. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has pro-inflammatory properties. We investigated whether Lp-PLA2 activity is associated with heart failure. METHODS AND RESULTS:Lp-PLA2 activity was determined in a random sample of 1820 subjects from the Rotterdam Study, a population-based cohort study among persons aged 55 years and over. During a mean follow-up of 6.7 years, 94 heart failure cases occurred. We excluded participants with heart failure or coronary heart disease at baseline and we accounted for incident coronary heart disease during follow-up. We used Cox proportional hazard models to compute hazard ratios adjusted for age, sex, non-HDL cholesterol, HDL cholesterol, body mass index, systolic blood pressure, diastolic blood pressure, hypertension, diabetes mellitus, smoking, and C-reactive protein. The hazard ratio per unit increase of Lp-PLA2 activity was 1.03 [95% confidence interval (95% CI 1.01-1.05]; P for trend was 0.011. Hazard ratios for the second, third, and fourth quartiles were 1.06 (95% CI 0.55-2.04), 1.43 (95% CI 0.73-2.81), and 2.33 (95% CI 1.21-4.49), respectively, using the lowest quartile of Lp-PLA2 activity as the reference category. CONCLUSION:This study suggests that Lp-PLA2 activity is independently associated with incident heart failure.

journal_name

Eur Heart J

journal_title

European heart journal

authors

van Vark LC,Kardys I,Bleumink GS,Knetsch AM,Deckers JW,Hofman A,Stricker BH,Witteman JC

doi

10.1093/eurheartj/ehl230

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

2346-52

issue

19

eissn

0195-668X

issn

1522-9645

pii

ehl230

journal_volume

27

pub_type

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