Effects of diuretics on renal excretory function.

Abstract:

:From a clinicopharmacological standpoint, the urinary excretory potency of diuretics should be assessed comparatively, on the basis of placebo-controlled changes in 24 h natriuresis, following single oral doses administered to healthy adult subjects who are in steady-state habitual external sodium balance. The potency of 30 diuretic formulations has been evaluated. Two formulations of loop diuretics (muzolimine 20 mg and torasemide 2.5 mg) are non-diuretic. The majority of the other formulations of loop diuretics studied (e.g. furosemide 40 mg and torasemide 5 and 10 mg) are comparatively less potent than most of the common formulations of early distal tubular diuretics studied (e.g. hydrochlorothiazide 25 and 50 mg, xipamide 10, 20 and 40 mg). Hydrochlorothiazide 25 mg and furosemide 80 mg have similar potencies. The presence of a rebound in natriuresis between 6 and 24 h after administration of loop diuretics make the majority of the common formulations of these drugs less potent than most common formulations of thiazide-type diuretics.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Reyes AJ

doi

10.1093/eurheartj/13.suppl_g.15

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

15-21

eissn

0195-668X

issn

1522-9645

journal_volume

13 Suppl G

pub_type

临床试验,杂志文章,随机对照试验
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    更新日期:1988-01-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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    doi:10.1093/oxfordjournals.eurheartj.a061061

    authors: Ge J,Haude M,Görge G,Liu F,Erbel R

    更新日期:1995-08-01 00:00:00

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    pub_type: 临床试验,杂志文章

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    更新日期:2013-07-01 00:00:00

  • Prognostic value of left ventricular volume response during dobutamine stress echocardiography.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015139

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    更新日期:1997-10-01 00:00:00

  • Exercise echocardiography performed early and late after percutaneous transluminal coronary angioplasty for prediction of restenosis.

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    更新日期:1995-12-01 00:00:00

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    pub_type: 杂志文章

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

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    更新日期:2012-09-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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    pub_type: 杂志文章,多中心研究,随机对照试验

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    doi:10.1093/oxfordjournals.eurheartj.a060109

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    更新日期:1992-11-01 00:00:00

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    doi:10.1093/eurheartj/14.8.1011

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    更新日期:1993-08-01 00:00:00

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