Abstract:
Aim:Studies have reported less favourable outcomes in women compared with men after primary percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI). Whether sex-specific differences in the magnitude or prognostic impact of infarct size or post-infarction cardiac function explain this finding is unknown. Methods and results:We pooled patient-level data from 10 randomized primary PCI trials in which infarct size was measured within 1 month (median 4 days) by either cardiac magnetic resonance imaging or technetium-99m sestamibi single-photon emission computed tomography. We assessed the association between sex, infarct size, and left ventricular ejection fraction (LVEF) and the composite rate of death or heart failure (HF) hospitalization within 1 year. Of 2632 patients with STEMI undergoing primary PCI, 587 (22.3%) were women. Women were older than men and had a longer delay between symptom onset and reperfusion. Infarct size did not significantly differ between women and men, and women had higher LVEF. Nonetheless, women had a higher 1-year rate of death or HF hospitalization compared to men, and while infarct size was a strong independent predictor of 1-year death or HF hospitalization (P < 0.0001), no interaction was present between sex and infarct size or LVEF on the risk of death or HF hospitalization. Conclusions:In this large-scale, individual patient-level pooled analysis of patients with STEMI undergoing primary PCI, women had a higher 1-year rate of death or HF hospitalization compared to men, a finding not explained by sex-specific differences in the magnitude or prognostic impact of infarct size or by differences in post-infarction cardiac function.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Kosmidou I,Redfors B,Selker HP,Thiele H,Patel MR,Udelson JE,Magnus Ohman E,Eitel I,Granger CB,Maehara A,Kirtane A,Généreux P,Jenkins PL,Ben-Yehuda O,Mintz GS,Stone GWdoi
10.1093/eurheartj/ehx159subject
Has Abstractpub_date
2017-06-01 00:00:00pages
1656-1663issue
21eissn
0195-668Xissn
1522-9645pii
3605323journal_volume
38pub_type
杂志文章,meta分析,评审abstract:AIMS:To assess the diagnostic accuracy of 256-row computed tomographic angiography (CTA) in patients with suspected coronary artery disease (CAD). Non-invasive imaging of the coronary artery by CTA has increasingly been used in recent years. The accuracy of 256-row CTA has not yet been studied. We sought to assess the ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehq072
更新日期:2010-08-01 00:00:00
abstract::The haemodynamic side-effects of ionic (amidotrizoate) and non-ionic (iopamidol) contrast media after injection into the right atrium were compared in experimental and clinical studies. Pulmonary hypertension was induced in 10 dogs by embolization of the pulmonary vascular bed with agar-agar solution (mean pulmonary a...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/oxfordjournals.eurheartj.a062219
更新日期:1987-12-01 00:00:00
abstract::In 70 patients, tricuspid regurgitation was diagnosed with Doppler by recording reverse flow in systole originating at the tricuspid orifice, directed into the right atrium. The peak velocities were recorded, and the peak pressure drop from the right ventricle to the right atrium in systole was calculated from the sim...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062126
更新日期:1986-08-01 00:00:00
abstract:AIMS:To evaluate the effects of cardiac resynchronization therapy (CRT) on long-term survival of patients without baseline left ventricular (LV) mechanical dyssynchrony. METHODS AND RESULTS:A total of 290 heart failure patients (age 67 ± 10 years, 77% males) without significant baseline LV dyssynchrony (<60 ms as asse...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehr468
更新日期:2012-04-01 00:00:00
abstract::After years of stagnant finances for research, moves are under way to increase research funds in Europe. ...
journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:2011-09-01 00:00:00
abstract::The European Myocardial Infarction Project (E.M.I.P.) participants have evaluated out-of-hospital coronary care services in different cities within the E.E.C. and concluded that these facilities would support a study within these European centres on pre-hospital intervention in myocardial infarction. Based on a pilot ...
journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:1988-02-01 00:00:00
abstract::We now have conclusive data that ACE inhibitors reduce mortality, morbidity, and symptoms in patients with low ejection fraction and/or heart failure. Therefore, ACE inhibitors should be routinely used in all such patients, as long as there are no clear contraindications. Routine use of ACE inhibitors will lead to pro...
journal_title:European heart journal
pub_type: 杂志文章,meta分析
doi:10.1093/eurheartj/15.suppl_b.9
更新日期:1994-05-01 00:00:00
abstract::Twenty-three patients who had undergone aortic valve replacement with a mechanical aortic valve prosthesis (ball-valve: 17, tilting-disc: 6) were investigated by retrograde left ventricular catheterization using a 6 F pigtail catheter. Twelve of these 23 patients also had had combined aortic and mitral valve replaceme...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/8.7.689
更新日期:1987-07-01 00:00:00
abstract:AIMS:Through a 4-year follow-up of the abstracts submitted to the European Society of Cardiology Congress in 2006, we aimed at identifying factors predicting high-quality research, appraising the quality of the peer review and editorial processes, and thereby revealing potential ways to improve future research, peer re...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehs113
更新日期:2012-12-01 00:00:00
abstract:AIMS:Adenosine stress computed tomography myocardial perfusion imaging (CTP) is an emerging non-invasive method for detecting myocardial ischaemia. Its value when compared with fractional flow reserve (FFR), a highly accurate index of ischaemia, is unknown. Our aim was to determine the diagnostic accuracy of CTP and it...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehr268
更新日期:2012-01-01 00:00:00
abstract:AIMS:In mechanical heart valve recipients, low-dose international normalized ratio (INR) self-management of oral anticoagulants can reduce the risk of developing thrombo-embolic events and improve long-term survival compared with INR control by a general practitioner. Here, we present data on the safety of low-dose INR...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/ehm391
更新日期:2007-10-01 00:00:00
abstract::The effects of dexamethasone on cultured rat beating heart cells experimentally infected with coxsackievirus B2 were investigated at an early stage (1-3 days) post challenge. Changes in the release of the cardiac enzyme, aspartate amino-transferase (AST), beating %, cytopathic effect (CPE), virus titre, ultrastructure...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/12.suppl_d.39
更新日期:1991-08-01 00:00:00
abstract:AIMS:A higher intake of fruits and vegetables has been associated with a lower risk of ischaemic heart disease (IHD), but there is some uncertainty about the interpretation of this association. The objective was to assess the relation between fruit and vegetable intake and risk of mortality from IHD in the European Pro...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehq465
更新日期:2011-05-01 00:00:00
abstract:AIMS:we investigated the relationship between sublingual perfused capillary density (PCD) as a measure of tissue perfusion and outcome (i.e. occurrence of organ failure and mortality) in patients with cardiogenic shock from acute myocardial infarction. METHODS AND RESULTS:we performed a prospective study in 68 patient...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehq324
更新日期:2010-12-01 00:00:00
abstract:AIMS:Previous analyses suggest only modest agreement between local site and core-laboratory (core-lab) electrocardiogram (ECG) interpretation in patients with acute coronary syndromes (ACSs); however, this has not been well examined outside of clinical trial populations. METHODS AND RESULTS:Patients (n = 5277 from 51 ...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehm503
更新日期:2008-01-01 00:00:00
abstract::The generation of abnormal gradients between the apical cavity and the subaortic valvular region of the left ventricle in patients with hypertrophic cardiomyopathy (HCM) has traditionally been equated to a dynamic obstruction to left ventricular outflow. To examine this concept in more detail, left ventricular ejectio...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/4.suppl_f.23
更新日期:1983-11-01 00:00:00
abstract:AIMS:Patients with pulmonary hypertension (PHT) are often excluded from surgical therapies for tricuspid regurgitation (TR). Transcatheter tricuspid valve repair (TTVR) with the MitraClip™ technique is a novel treatment option for these patients. We aimed to assess the role of PHT in severe TR and its implications for ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehaa138
更新日期:2020-08-01 00:00:00
abstract:AIMS:Collagen degradation in atherosclerotic plaques with thin fibrous caps renders them more prone to rupture. Fibroblast activation protein (FAP) plays a role in arthritis and tumour formation through its collagenase activity. However, the significance of FAP in thin-cap human fibroatheromata remains unknown. METHOD...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehq519
更新日期:2011-11-01 00:00:00
abstract::We have previously shown that transdermal nitroglycerin may induce an increase in the activity of the adrenergic and the renin-angiotensin-aldosterone systems (SRAA) in patients with chronic stable angina pectoris (SA); when the activation of these systems is more pronounced, the antianginal effect of this drug seems ...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/14.12.1701
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to describe the frequencies of various diagnoses in patients admitted with acute chest pain, but without acute myocardial infarction, and to evaluate a non-invasive screening programme for these patients. PATIENTS:A total of 204 consecutive non-acute myocardial infarction patien...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a014998
更新日期:1996-07-01 00:00:00
abstract:AIMS:The risk of stroke is greater among women with atrial fibrillation (AF) than men. Warfarin protects against stroke, but treatment-related bleeding occurs more often in women than in men. METHODS AND RESULTS:SPORTIF III (open label, n=3410) and V (double-blind, n=3922) included 2257 women with AF and one or more s...
journal_title:European heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1093/eurheartj/ehl103
更新日期:2006-08-01 00:00:00
abstract::Factors that exacerbate the risk of atherosclerotic plaque formation include cigarette smoking, hypertension, hypercholesterolaemia, sedentary lifestyle, and oestrogen deficiency. The potentially important role of oestrogen deficiency in this process is evidenced by the significant increase in cardiovascular risk obse...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/17.suppl_d.32
更新日期:1996-08-01 00:00:00
abstract:AIMS:Increased left ventricular wall thickness (LVWT) is a common finding in cardiology. It is not known how often hereditary transthyretin-related familial amyloid cardiomyopathy (mTTR-FAC) is responsible for LVWT. Several therapeutic modalities for mTTR-FAC are currently in clinical trials; thus, it is important to e...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1093/eurheartj/ehv583
更新日期:2016-06-14 00:00:00
abstract::The aim of our study was to examine if echocardiography can reproducibly be used in a multicentre study to select high risk patients with reduced left ventricular function early after an acute myocardial infarction (MI). In the TRAndolapril Cardiac Evaluation Study (TRACE) patients with reduced left ventricular systol...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/oxfordjournals.eurheartj.a060443
更新日期:1994-12-01 00:00:00
abstract::To examine whether increases in heart rate might be a common trigger of angina at rest, changes in heart rate, blood pressure and rate-pressure product during pain were compared with the ischaemic threshold (heart rate with ST segment shift > = 1 mm), determined by atrial pacing, in 272 patients with unstable angina. ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.9.1170
更新日期:1993-09-01 00:00:00
abstract:AIMS:Recent randomized clinical trials have reported a reduction in restenosis with intracoronary stents and have suggested that this restenosis reduction is a result of the higher immediate luminal gain, in comparison to conventional percutaneous transluminal coronary angioplasty (PTCA). The hypothesis of this study i...
journal_title:European heart journal
pub_type: 临床试验,杂志文章
doi:10.1053/euhj.1997.0614
更新日期:1998-02-01 00:00:00
abstract::The objectives of this study were to assess the impact of the new 'Shahal' (pre-hospital cardiac service) on subscribers' 'decision time'. A professional 24-h mobile emergency cardiac service has been set up, monitored by intensive care nurses via a central computerized operation unit. All subscribers carry a cardiobe...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/16.1.129
更新日期:1995-01-01 00:00:00
abstract::Recent studies have illustrated that in addition to the well known risk factors, such as lipoproteins, smoking, hypertension, there are others that cause atherosclerosis and myocardial infarction. Our knowledge of atherosclerotic lesions has increased. We now know that atherosclerotic changes are due to inflammatory c...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:
更新日期:1993-12-01 00:00:00
abstract::During the long-term follow-up of patients with hypertrophic cardiomyopathy (HCM), some patients develop left ventricular (LV) wall motion abnormalities in the absence of fixed coronary artery disease. The purpose of this study is to clarify which clinical features in patients with HCM seem to influence gradual develo...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.12.1629
更新日期:1993-12-01 00:00:00
abstract:AIMS:To identify changes in multidirectional strain and strain rate (SR) in patients with aortic stenosis (AS). METHODS AND RESULTS:A total of 420 patients (age 66.1 ± 14.5 years, 60.7% men) with aortic sclerosis, mild, moderate, and severe AS with preserved left ventricular (LV) ejection fraction [(EF), ≥50%] were in...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehr084
更新日期:2011-06-01 00:00:00