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Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study.

Abstract：

AIMS:A higher intake of fruits and vegetables has been associated with a lower risk of ischaemic heart disease (IHD), but there is some uncertainty about the interpretation of this association. The objective was to assess the relation between fruit and vegetable intake and risk of mortality from IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study. METHODS AND RESULTS:After an average of 8.4 years of follow-up, there were 1636 deaths from IHD among 313 074 men and women without previous myocardial infarction or stroke from eight European countries. Participants consuming at least eight portions (80 g each) of fruits and vegetables a day had a 22% lower risk of fatal IHD [relative risk (RR) = 0.78, 95% confidence interval (CI): 0.65-0.95] compared with those consuming fewer than three portions a day. After calibration of fruit and vegetable intake to account for differences in dietary assessment between the participating centres, a one portion (80 g) increment in fruit and vegetable intake was associated with a 4% lower risk of fatal IHD (RR = 0.96, 95% CI: 0.92-1.00, P for trend = 0.033). CONCLUSION:Results from this large observational study suggest that a higher intake of fruits and vegetables is associated with a reduced risk of IHD mortality. Whether this association is causal and, if so, the biological mechanism(s) by which fruits and vegetables operate to lower IHD risks remains unclear.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Crowe FL,Roddam AW,Key TJ,Appleby PN,Overvad K,Jakobsen MU,Tjønneland A,Hansen L,Boeing H,Weikert C,Linseisen J,Kaaks R,Trichopoulou A,Misirli G,Lagiou P,Sacerdote C,Pala V,Palli D,Tumino R,Panico S,Bueno-de-Mesqu

doi

10.1093/eurheartj/ehq465

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

1235-43

issue

10

eissn

0195-668X

issn

1522-9645

pii

ehq465

journal_volume

32

pub_type

杂志文章,多中心研究

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