Ischaemic threshold and haemodynamic changes during angina at rest in patients with unstable angina.

abstract：AIMS:Thrombin plays a key role in the clinical syndrome of unstable angina. We investigated the safety and efficacy of five dose levels of efegatran sulphate, a direct thrombin inhibitor, compared to heparin in patients with unstable angina. METHODS:Four hundred and thirty-two patients with unstable angina were enroll...

journal_title：European heart journal

authors： Klootwijk P,Lenderink T,Meij S,Boersma H,Melkert R,Umans VA,Stibbe J,Müller EJ,Poortermans KJ,Deckers JW,Simoons ML

更新日期：1999-08-01 00:00:00

abstract：AIMS:Cardiac biomarkers are routinely elevated after uncomplicated cardiac surgery to levels considered diagnostic of myocardial infarction in ambulatory populations. We investigated the diagnostic power of electrocardiogram (ECG) and cardiac biomarker criteria to predict clinically relevant myocardial injury using ben...

journal_title：European heart journal

authors： Muehlschlegel JD,Perry TE,Liu KY,Nascimben L,Fox AA,Collard CD,Avery EG,Aranki SF,D'Ambra MN,Shernan SK,Body SC,CABG Genomics Investigators.

更新日期：2009-07-01 00:00:00

abstract：AIMS:Combined quantitative coronary angiography and intracoronary Doppler flow velocity measurements were performed to study the underlying haemodynamic mechanisms leading to myocardial ischaemia in patients with myocardial bridging in the absence of coronary artery disease. METHODS AND RESULTS:In 42 symptomatic patie...

journal_title：European heart journal

authors： Schwarz ER,Klues HG,vom Dahl J,Klein I,Krebs W,Hanrath P

更新日期：1997-03-01 00:00:00

abstract：:Streptococcus adjacens and S. defectivus are two recently individualized species of viridans streptococci. Both species were previously designated as nutritionally variant streptococci and characterized by their growth as small satellite colonies supported by 'helper' bacteria, or requiring complex media enriched with...

journal_title：European heart journal

authors： Bouvet A

更新日期：1995-04-01 00:00:00

abstract：AIMS:There have been substantial declines in cerebrovascular disease mortality across much of Europe, mirroring trends in deaths from cardiovascular disease as a whole. No study has investigated trends in cerebrovascular disease, and its subtypes within all European countries. This study aimed to examine sex-specific t...

journal_title：European heart journal

authors： Shah R,Wilkins E,Nichols M,Kelly P,El-Sadi F,Wright FL,Townsend N

更新日期：2019-03-01 00:00:00

abstract：:A 37-year-old man sustained occlusion of the right coronary artery after a bicycle accident with blunt chest trauma over the left scapula. Acute coronary angiography was performed because of chest pain and ST-segment elevation. Despite surgically successful acute revascularization the patient developed a transmural in...

journal_title：European heart journal

authors： Gustavsson CG,Albrechtsson U,Forslind K,Ståhl E,White T

更新日期：1992-01-01 00:00:00

abstract：AIMS:Pericardial effusion (PE) is a common finding in cardiac patients with chronic heart failure. The prognostic relevance of a small, haemodynamically non-compromising PE in such patients, however, remains to be determined. METHODS AND RESULTS:All patients referred to our heart failure clinic and having a baseline e...

journal_title：European heart journal

authors： Fröhlich GM,Keller P,Schmid F,Wolfrum M,Osranek M,Falk C,Noll G,Enseleit F,Reinthaler M,Meier P,Lüscher TF,Ruschitzka F,Tanner FC

更新日期：2013-05-01 00:00:00

abstract：AIMS:The results of the West of Scotland Coronary Prevention Study (WOSCOPS) demonstrated the clinical benefit of using pravastatin for the primary prevention of cardiovascular disease in hypercholesterolaemic men. To inform decision makers, who must also consider costs, this study assesses the economic efficiency of s...

journal_title：European heart journal

authors： Caro J,Klittich W,McGuire A,Ford I,Pettitt D,Norrie J,Shepherd J

更新日期：1999-02-01 00:00:00

abstract：:It is not yet clear whether 99mTc-methoxyisobutyl-isonitrile (MIBI)-uptake is a reliable indicator of myocardial viability, and a threshold value, differentiating viable from scarred myocardium, in comparison to a morphological and functional standard of reference has not been defined. MIBI-uptake was quantified in 80...

journal_title：European heart journal

authors： Baer FM,Smolarz K,Theissen P,Voth E,Schicha H,Sechtem U

更新日期：1994-01-01 00:00:00

abstract：AIMS:Although cerebral blood flow (CBF) is known to be low in patients with advanced systolic heart failure (HF), little is known of the prognostic significance of this observation. We investigated whether CBF might be associated with the development of adverse outcomes in systolic HF, and whether it might provide prog...

journal_title：European heart journal

authors： Kim MS,Kim JS,Yun SC,Lee CW,Song JK,Park SW,Park SJ,Kim JJ

更新日期：2012-02-01 00:00:00

abstract：:Adolescent CD-1 mice inoculated with coxsackievirus B3 (CVB3m) will develop acute myocarditis with focal lesions by 7 days post-inoculation (p.i.). Administration of murine sera containing anti-CVB3m-neutralizing antibodies into CVB3m-inoculated mice at 3 days p.i. will exacerbate myocarditis, suggesting the presence ...

journal_title：European heart journal

authors： Gauntt CJ,Arizpe HM,Higdon AL,Rozek MM,Crawley R,Cunningham MW

更新日期：1991-08-01 00:00:00

abstract：:A patient with a three-year history of recurrent pulmonary embolism is presented. Thromboembolic pulmonary hypertension was proven in the final stage of disease in the presence of repeated episodes of systemic embolic events. Paradoxical embolism was assumed to be present on the basis of blood-gas analysis and contras...

journal_title：European heart journal

authors： Lang I,Steurer G,Weissel M,Burghuber OC

更新日期：1988-06-01 00:00:00

abstract：:Recently, it has been suggested that oxidized low density lipoprotein (LDL) plays an important role in atherogenesis by facilitating the accumulation of lipids in macrophages. In vitro studies from our laboratory have shown that oxidized LDL is recognized not only by a specific receptor, but also by a receptor which r...

journal_title：European heart journal

authors： Kita T,Ishii K,Yokode M,Kume N,Nagano Y,Arai H,Kawai C

更新日期：1990-08-01 00:00:00

abstract：AIMS:In animal models of obesity and diabetes mellitus, myocardial TG accumulation is associated with decreased myocardial function. In the physiologically ageing heart, myocardial triglyceride (TG) accumulation may also occur due to reduced myocardial fatty acid oxidation. The role of myocardial TG in the ageing human...

journal_title：European heart journal

authors： van der Meer RW,Rijzewijk LJ,Diamant M,Hammer S,Schär M,Bax JJ,Smit JW,Romijn JA,de Roos A,Lamb HJ

更新日期：2008-06-01 00:00:00

abstract：:Although several randomized trials have been performed to compare the outcomes of percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass surgery (CABG) in patients with multivessel disease, there is little data available on angiographic follow-up results. The present substudy of the German an...

journal_title：European heart journal

authors： Rupprecht HJ,Hamm C,Ischinger T,Dietz U,Reimers J,Meyer J

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:The calculation of valve resistance (R) rather than aortic valve area (AVA) has been proposed for the assessment of aortic stenosis (AS), based on the claim that it is less flow-dependent. Even more importantly, valve resistance has been reported to distinguish between truly severe and "pseudosevere" AS in p...

journal_title：European heart journal

authors： Mascherbauer J,Schima H,Rosenhek R,Czerny M,Maurer G,Baumgartner H

更新日期：2004-05-01 00:00:00

abstract：:There is no certain way of obtaining one of the European Society of Cardiology grants for research or clinical training offered each year, but Prof. Stavros Konstantinides (Centre for Thrombosis and Haemostasis, Johannes Gutenberg University, Mainz, Germany), who chairs the European Society of Cardiology Credentials C...

journal_title：European heart journal

authors：

更新日期：2014-05-14 00:00:00

abstract：:Can intracoronary thrombolytic therapy (ITT) reduce the infarct size and improve regional and global left ventricular function and if so how long after recanalization does this improvement develop? 42 patients were treated with ITT, of whom 25 showed successful recanalization (group A) and 17 had persistent occlusion ...

journal_title：European heart journal

authors： Widimský P,Cervenka V,Gregor P,Vísek V,Sládková T,Dvorák J,Hrdlicka S

更新日期：1985-09-01 00:00:00

abstract：:The Doppler ultrasonic estimation of cardiac output in man is reviewed. Minimal requirements for accurate measurements are discussed, and the published results of reproducibility studies and validation studies are summarized and analysed. Analysis of Doppler records has a coefficient of repeat determination of 5-8% fo...

journal_title：European heart journal

authors： Coats AJ

更新日期：1990-12-01 00:00:00

abstract：:The effect of sublingually administered nitroglycerin (0.5 mg) on distribution of blood volume in 16 patients with congestive heart failure (NYHA class II and III), randomly assigned to placebo (N = 8) or nitroglycerin (N = 8) was studied 20 minutes after in vivo labelling of red blood cells with 99m-Tc pertechnetate....

journal_title：European heart journal

authors： Schneider AJ,Teule GJ,Groeneveld AB,Nauta J,Luth WJ,Thijs LG

更新日期：1987-10-01 00:00:00

abstract：AIMS:The Tako-Tsubo cardiomyopathy (TTC) is characterized by a transient contractile dysfunction that has been assigned to excessive catecholamine levels after episodes of severe emotional or physical stress. Several studies have indicated that beta-adrenoceptor stimulation is associated with alteration in gene express...

journal_title：European heart journal

authors： Nef HM,Möllmann H,Troidl C,Kostin S,Voss S,Hilpert P,Behrens CB,Rolf A,Rixe J,Weber M,Hamm CW,Elsässer A

更新日期：2009-09-01 00:00:00

abstract：Aims:Catheter-based renal artery denervation (RDN) has been shown to lower blood pressure (BP) in certain patients with uncontrolled hypertension. Isolated systolic hypertension (ISH) (systolic BP [SBP] ≥140 mmHg and diastolic BP <90 mmHg), characterized by increased vascular stiffness, is the predominant hypertensive ...

journal_title：European heart journal

authors： Mahfoud F,Bakris G,Bhatt DL,Esler M,Ewen S,Fahy M,Kandzari D,Kario K,Mancia G,Weber M,Böhm M

更新日期：2017-01-07 00:00:00

abstract：Aims:The choice between initiating a non-vitamin K antagonist oral anticoagulant (NOAC) and a vitamin K antagonist (VKA) in patients with atrial fibrillation (AF) may be challenging. To assist in this decision, we developed a risk score to identify patients for whom a therapeutic benefit of NOACs over VKA is predicted....

journal_title：European heart journal

authors： Fanola CL,Giugliano RP,Ruff CT,Trevisan M,Nordio F,Mercuri MF,Antman EM,Braunwald E

更新日期：2017-03-21 00:00:00

abstract：:In the interpretation of the effect of a drug or intervention in a single patient, it is desirable to know the spontaneous fluctuations of the variable under study. A few studies have determined pulmonary haemodynamic variability in acute and short-term intervals. It seems reasonable to adopt a confidence limit of 6 m...

journal_title：European heart journal

authors： Schrijen F,Jezková J

更新日期：1988-09-01 00:00:00

abstract：:Aortic stenosis is one of the most common forms of acquired valvular heart disease. The development of symptoms, namely syncope, angina, or heart failure, in patients with severe aortic stenosis predicts a high likelihood of mortality. Aortic valve replacement is the current standard of care. In truly asymptomatic pat...

journal_title：European heart journal

authors： Bhattacharyya S,Hayward C,Pepper J,Senior R

更新日期：2012-10-01 00:00:00

abstract：:The aim of this study was to investigate the haemodynamic effects of amrinone in patients with pulmonary hypertension and impaired right ventricular function. Twelve patients with mitral stenosis (NYHA classification III and IV) took part in the study. The haemodynamic measurements were performed in the steady state u...

journal_title：European heart journal

authors： Hess W,Arnold B,Veit S

更新日期：1986-09-01 00:00:00

abstract：AIMS:No-reflow after a primary percutaneous coronary intervention (PCI) is associated with a high incidence of left ventricular (LV) failure and a poor prognosis. Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor peptide and an important modulator of neutrophil function. Elevated systemic ET-1 levels ...

journal_title：European heart journal

authors： Niccoli G,Lanza GA,Shaw S,Romagnoli E,Gioia D,Burzotta F,Trani C,Mazzari MA,Mongiardo R,De Vita M,Rebuzzi AG,Lüscher TF,Crea F

更新日期：2006-08-01 00:00:00

abstract：:Between 1968 and 1984, 78 patients (mean age 43, range 14 to 65 years) underwent combined aortic, mitral and tricuspid surgery (22 triple valve replacements, 56 aortic valve replacements with tricuspid conservative surgery and mitral valve replacement (N = 48), or commissuroplasty (N = 8). Pre-operative consequences o...

journal_title：European heart journal

authors： Michel PL,Houdart E,Ghanem G,Badaoui G,Hage A,Acar J

更新日期：1987-05-01 00:00:00

abstract：:In untreated congestive heart failure, aldosterone plasma concentrations are elevated in proportion to the severity of the disease and are further increased by the use of diuretic treatment. Angiotensin II, plasma potassium concentration, and corticotropin are the major stimulators of aldosterone synthesis. During ang...

journal_title：European heart journal

authors： Zannad F

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Recent identification of mutations in the beta-myosin heavy chain gene (MYH7), a major responsible gene for HCM, has provided the opportunity to characterize genotype-phenotype correlation in HCM families. In this study we analysed the phenotypic expression of two beta-myosin heavy chain (beta MHC) mutations...

journal_title：European heart journal

authors： Marian AJ,Mares A Jr,Kelly DP,Yu QT,Abchee AB,Hill R,Roberts R

更新日期：1995-03-01 00:00:00