Abstract:
AIMS:We aimed to assess the increased risk of death and severe vascular events in elderly individuals with subclinical or manifest peripheral arterial disease (PAD), evidenced by low ankle brachial index (ABI < 0.9) in primary care. METHODS AND RESULTS:In this monitored prospective observational study, 6880 representative unselected patients aged >or=65 years were followed up over 3 years by 344 primary care physicians. Main outcome measures were mortality or a combined endpoint of mortality and severe vascular events. In total, 20 127 patient-years were observed. In the group of PAD patients (n=1230), 134 patients died; in the group without PAD (n=5591), 237 patients died [multivariate hazard ratio (HR) 2.0; 95% confidence interval 1.6-2.5, P<0.001]. Compared with an ABI>or=1.1, the risk of death increased linearly in the lower ABI categories: ABI 0.7-0.89, HR 1.7 (1.2-2.4, P<0.001); ABI<0.5, HR 3.6 (2.4-5.4, P<0.001). CONCLUSION:Patients with a low ABI (PAD), who can be readily identified in a primary care setting, have a substantially increased risk of death and severe vascular events. Patients with an ABI between 1.1 and 0.9 should be considered and followed up as borderline PAD cases. Particular attention should be paid to patients with PAD and previous vascular events, as their risk is markedly increased.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Diehm C,Lange S,Darius H,Pittrow D,von Stritzky B,Tepohl G,Haberl RL,Allenberg JR,Dasch B,Trampisch HJdoi
10.1093/eurheartj/ehl092subject
Has Abstractpub_date
2006-07-01 00:00:00pages
1743-9issue
14eissn
0195-668Xissn
1522-9645pii
ehl092journal_volume
27pub_type
杂志文章,多中心研究abstract::It is only in the last few years that the broad-spectrum antiarrhythmic properties of sotalol have become increasingly recognized. Racemic sotalol has potent beta-blocking and class III antiarrhythmic properties, and it has been reported that this drug is able to control supraventricular and ventricular arrhythmias. R...
journal_title:European heart journal
pub_type: 杂志文章,评审
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更新日期:1993-11-01 00:00:00
abstract:AIMS:There is growing need for the identification of novel non-invasive methodologies for the identification of individuals at risk for adverse cardiovascular (CV) events. We examined whether endothelial dysfunction, as detected by non-invasive peripheral arterial tonometry (EndoPAT), can predict late CV events. METHO...
journal_title:European heart journal
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doi:10.1093/eurheartj/ehq010
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doi:10.1093/eurheartj/14.6.751
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2013-08-01 00:00:00
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doi:10.1093/eurheartj/5.suppl_a.33
更新日期:1984-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061755
更新日期:1985-01-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061891
更新日期:1985-06-01 00:00:00
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journal_title:European heart journal
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doi:10.1093/oxfordjournals.eurheartj.a062518
更新日期:1988-04-01 00:00:00
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doi:10.1093/eurheartj/ehz667
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.1999.1525
更新日期:1999-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/eurheartj/ehm175
更新日期:2007-07-01 00:00:00
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doi:10.1093/oxfordjournals.eurheartj.a059530
更新日期:1989-06-01 00:00:00
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更新日期:2010-03-01 00:00:00
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更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2011-05-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/8.suppl_b.133
更新日期:1987-05-01 00:00:00
abstract::The effects of a single oral dose of nisoldipine, 10 mg, were investigated in two groups of patients. Firstly, the effects of nisoldipine on exercise left ventricular function were assessed in 20 patients with chronic stable angina and coronary disease. Secondly, the effects of nisoldipine on the left ventricular resp...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/8.suppl_k.27
更新日期:1987-11-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062282
更新日期:1987-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060217
更新日期:1992-04-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehn347
更新日期:2009-03-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060270
更新日期:1992-06-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
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更新日期:1992-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/10.suppl_f.97
更新日期:1989-11-01 00:00:00
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更新日期:2013-09-01 00:00:00