Abstract:
AIMS:Obesity is a recognized risk factor for atrial fibrillation (AF), partly because of the association between body mass index (BMI) and atrial volume. We aimed to determine whether other factors relating to body size were related to AF. METHODS AND RESULTS:Data were derived from a random population sample of 6903 men (mean age 51.5 years) who underwent a single midlife evaluation as part of the multifactor Swedish Primary Prevention Study. A total of 1253 men (18.2%) had a subsequent hospital discharge diagnosis (principal or secondary) of AF during a maximum follow-up of 34.3 years. Body surface area (BSA) at age 20 (calculated from recalled weight and measured height) was strongly related to subsequent AF (P < 0.0001), as were midlife BMI and weight gain from age 20 to midlife (P < 0.0001). In a Cox regression model which adjusted for midlife BMI, weight gain and other risk factors, hazard ratios (HR) [95% confidence intervals (CI)] for AF for the second, third, and fourth quartile of BSA at age 20, compared with the lowest quartile, were 1.47 (95% CI, 1.22-1.76), 1.66 (95% CI, 1.38-2.00), and 2.22 (95% CI, 1.82-2.70) (P for trend <0.0001). CONCLUSION:Large body size in youth, in an era when obesity was rare, as well as weight gain from age 20 to midlife, were both independently related to the development of AF. Given the current trends not only for obesity but also for height, a substantial increase in the incidence of AF is likely.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Rosengren A,Hauptman PJ,Lappas G,Olsson L,Wilhelmsen L,Swedberg Kdoi
10.1093/eurheartj/ehp076subject
Has Abstractpub_date
2009-05-01 00:00:00pages
1113-20issue
9eissn
0195-668Xissn
1522-9645pii
ehp076journal_volume
30pub_type
杂志文章,随机对照试验abstract::The reperfusion era has dramatically and irrevocably transformed the management of ST-segment elevation myocardial infarction (STEMI). For the patient treated with fibrinolysis as the initial reperfusion strategy, subsequent options which are the subject of some controversy and the focus of this review are (i) facilit...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/ehm222
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abstract:AIMS:To investigate whether the benefit of thrombolytic therapy was sustained beyond the first decade. We report the 10-14 year outcome of 533 patients who were randomized to treatment with intracoronary streptokinase or to conventional therapy during the years 1980-1985. METHODS AND RESULTS:Details of survival and ca...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-06-01 00:00:00
abstract::Twenty-one patients with stable effort angina pectoris were randomized in a crossover study to 4 weeks traditional Chinese acupuncture or placebo tablet treatment. The patients had at least five anginal attacks per week in spite of intensive treatment. Acupuncture was given three times per week at main points Neiguan ...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/oxfordjournals.eurheartj.a059865
更新日期:1991-02-01 00:00:00
abstract::A group of investigators met for two days in Santorini, Greece, to discuss progress in the field of identification and treatment of high risk/vulnerable atherosclerotic plaques and patients. Many differences in the manner in which terms are being utilized were noted. It was recognized that increased understanding of t...
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/eurheartj/9.suppl_n.169
更新日期:1988-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-02-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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更新日期:1993-09-01 00:00:00
abstract::MitraClip therapy consists of percutaneous edge-to-edge coaptation of the mitral leaflets that is analogous to the surgical Alfieri technique. The safety profile of the MitraClip device is favourable, and survival outcomes in high-surgical-risk patients are superior to historical controls. However, questions remain re...
journal_title:European heart journal
pub_type: 杂志文章,评审
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更新日期:2011-10-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.1999.1867
更新日期:2000-05-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2017-11-07 00:00:00
abstract::Antiarrhythmic agents may depress cardiac contractility and worsen heart failure. Flecainide is an effective antiarrhythmic drug, but when administered orally in patients with left ventricular (LV) dysfunction, its effect on LV function is unknown. To assess the effects of flecainide on cardiac function, LV ejection f...
journal_title:European heart journal
pub_type: 临床试验,杂志文章
doi:10.1093/eurheartj/8.7.754
更新日期:1987-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/eurheartj/ehs004
更新日期:2012-05-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/12.7.766
更新日期:1991-07-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/oxfordjournals.eurheartj.a014745
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:The EURObservational Research Programme-Atrial Fibrillation General Registry Pilot Phase (EORP-AF Pilot) provides systematic collection of contemporary data regarding the management and treatment of 3119 subjects with AF from 9 member European Society of Cardiology (ESC) countries. In this analysis, we repor...
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pub_type: 杂志文章,多中心研究
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更新日期:2014-12-14 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062359
更新日期:1987-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2010-04-01 00:00:00
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更新日期:2014-02-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1994-02-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1992-06-01 00:00:00
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更新日期:2015-07-14 00:00:00
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更新日期:1995-11-01 00:00:00
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更新日期:2006-04-01 00:00:00
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更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1990-08-01 00:00:00