Sustained benefit at 10-14 years follow-up after thrombolytic therapy in myocardial infarction.

Abstract:

AIMS:To investigate whether the benefit of thrombolytic therapy was sustained beyond the first decade. We report the 10-14 year outcome of 533 patients who were randomized to treatment with intracoronary streptokinase or to conventional therapy during the years 1980-1985. METHODS AND RESULTS:Details of survival and cardiac events were obtained from the civil registry, from medical records or from the patient's physician. At follow-up, 158 patients (59%) of the 269 patients allocated to thrombolytic treatment and only 129 patients (49%) of the 264 conventionally treated patients were alive. The cumulative 1-, 5- and 10-year survival rates were 91%, 81% and 69% in patients treated with streptokinase and 84%, 71% and 59% in the control group, respectively (P=0.02). Reinfarction during 10-years of follow-up was more frequent after thrombolytic therapy, particularly during the first year. Coronary bypass surgery and coronary angioplasty were more frequently performed after thrombolytic therapy. At 10 years approximately 30% of the patients were free from subsequent cardiac events. Independent determinants of mortality were elderly age, indicators of impaired residual left ventricular function, multivessel disease and an inability to perform an exercise test at the time of hospital discharge. CONCLUSION:Improved survival after thrombolytic therapy is maintained beyond the first decade. Age, left ventricular function, multivessel disease and an inability to perform an exercise test were independent predictors for long-term mortality, as they are predictors for early mortality.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Maas AC,van Domburg RT,Deckers JW,Vermeer F,Remme WJ,Kamp O,Manger Cats V,Simoons ML

doi

10.1053/euhj.1998.1443

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

819-26

issue

11

eissn

0195-668X

issn

1522-9645

pii

S0195668X98914439

journal_volume

20

pub_type

临床试验,杂志文章,随机对照试验
  • Circulating angiopoietins in idiopathic pulmonary arterial hypertension.

    abstract:AIMS:To determine the diagnostic utility of circulating angiopoietin-1 (Ang-1) and its antagonist angiopoietin-2 (Ang-2) as potential biomarkers of disease severity or response to treatment in idiopathic pulmonary arterial hypertension (IPAH). Imbalances in angiogenic factors including vascular endothelial cell growth ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq226

    authors: Kümpers P,Nickel N,Lukasz A,Golpon H,Westerkamp V,Olsson KM,Jonigk D,Maegel L,Bockmeyer CL,David S,Hoeper MM

    更新日期:2010-09-01 00:00:00

  • Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype.

    abstract:AIMS:Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism is tied with various risk factors for AAD including hypertension, atherosclerosis, and hypercholesterolaemia although direct correlation between the two rema...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa352

    authors: Yang K,Ren J,Li X,Wang Z,Xue L,Cui S,Sang W,Xu T,Zhang J,Yu J,Liu Z,Shang H,Pang J,Huang X,Chen Y,Xu F

    更新日期:2020-07-07 00:00:00

  • Acute effects of cigarette smoking on platelet-dependent thrombin generation.

    abstract:AIMS:Thrombin is an important factor in the pathogenesis of thrombotic diseases. To clarify whether smoking has an effect in platelet-dependent thrombogenesis, we studied the acute effects of smoking on platelet-dependent thrombin level in smokers. METHODS AND RESULTS:Subjects consisted of ten smokers and nine non-smo...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1999.1938

    authors: Hioki H,Aoki N,Kawano K,Homori M,Hasumura Y,Yasumura T,Maki A,Yoshino H,Yanagisawa A,Ishikawa K

    更新日期:2001-01-01 00:00:00

  • Practical aspects of preventing and managing athersclerotic disease in post-menopausal women.

    abstract::Factors that exacerbate the risk of atherosclerotic plaque formation include cigarette smoking, hypertension, hypercholesterolaemia, sedentary lifestyle, and oestrogen deficiency. The potentially important role of oestrogen deficiency in this process is evidenced by the significant increase in cardiovascular risk obse...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/17.suppl_d.32

    authors: Sullivan JM

    更新日期:1996-08-01 00:00:00

  • A multicentre, double-blind randomized crossover comparative study on the efficacy and safety of dofetilide vs sotalol in patients with inducible sustained ventricular tachycardia and ischaemic heart disease.

    abstract:BACKGROUND:Antiarrhythmic drugs are still used for the treatment of ventricular tachyarrhythmias, in combination with implantable cardioverter-defibrillators or without them. AIM OF THE STUDY:In a double-blind randomized crossover design, the short- and long-term efficacy and safety of oral dofetilide or oral sotalol ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1053/euhj.2001.2679

    authors: Boriani G,Lubinski A,Capucci A,Niederle R,Kornacewicz-Jack Z,Wnuk-Wojnar AM,Borggrefe M,Brachmann J,Biffi M,Butrous GS,Ventricular Arrhythmias Dofetilide Investigators.

    更新日期:2001-12-01 00:00:00

  • Acute intervention with captopril during thrombolysis in patients with first anterior myocardial infarction. Results from the Captopril and Thrombolysis Study (CATS).

    abstract::The study was designed to examine the safety and efficacy of acute interventional use of captopril on left ventricular volumes, ventricular arrhythmias and neurohormones during thrombolysis in patients with a first anterior myocardial infarction, within 6 h of onset of symptoms. Left ventricular dysfunction and progno...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a060608

    authors: Kingma JH,van Gilst WH,Peels CH,Dambrink JH,Verheugt FW,Wielenga RP

    更新日期:1994-07-01 00:00:00

  • A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor.

    abstract:AIMS:Genome-wide association studies have previously identified INSIG2 as a candidate gene for plasma low-density lipoprotein cholesterol (LDL-c). However, we suspect a role for CCDC93 in the same locus because of its involvement in the recycling of the LDL-receptor (LDLR). METHODS AND RESULTS:Characterization of the ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehz727

    authors: Rimbert A,Dalila N,Wolters JC,Huijkman N,Smit M,Kloosterhuis N,Riemsma M,van der Veen Y,Singla A,van Dijk F,Biobank-Based Integrative Omics Studies Consortium.,Frikke-Schmidt R,Burstein E,Tybjærg-Hansen A,van de Sluis B,Kui

    更新日期:2020-03-01 00:00:00

  • Triglycerides, a major coronary risk factor in elderly men. A study of men born in 1913.

    abstract::We examined two 'cohorts' of elderly men, 60 and 67 years old. The two 'cohorts' overlapped to a large extent in terms of numbers but not in the follow-up periods. The mean have been followed-up for 7 and 8 years respectively. Among the 748 60-year-old men without prior myocardial infarction the 7-year incidence of co...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors: Welin L,Eriksson H,Larsson B,Ohlson LO,Svärdsudd K,Tibblin G,Wilhelmsen L

    更新日期:1991-06-01 00:00:00

  • Effects of inhibition of nitric oxide synthesis in patients with coronary artery disease and stable angina.

    abstract:AIMS:Inhibition of nitric oxide synthesis causes a decrease in the basal diameter of normal distal epicardial coronary arteries in normal subjects. The effects of inhibition of nitric oxide in atheromatous coronary arteries is unknown. This study assessed the effects of the inhibition of nitric oxide synthesis in epica...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015304

    authors: Tousoulis D,Davies GJ,Tentolouris C,Crake T,Lefroy DC,Toutouzas P

    更新日期:1997-04-01 00:00:00

  • Cardioprotective effect of calcineurin inhibition in an animal model of renal disease.

    abstract:AIMS:Chronic kidney disease is directly associated with cardiovascular complications. Heart remodelling, including fibrosis, hypertrophy, and decreased vascularization, is frequently present in renal diseases. Our objective was to investigate the impact of calcineurin inhibitors (CNI) on cardiac remodelling and functio...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq436

    authors: Di Marco GS,Reuter S,Kentrup D,Ting L,Ting L,Grabner A,Jacobi AM,Pavenstädt H,Baba HA,Tiemann K,Brand M

    更新日期:2011-08-01 00:00:00

  • Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study.

    abstract:AIMS:A higher intake of fruits and vegetables has been associated with a lower risk of ischaemic heart disease (IHD), but there is some uncertainty about the interpretation of this association. The objective was to assess the relation between fruit and vegetable intake and risk of mortality from IHD in the European Pro...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehq465

    authors: Crowe FL,Roddam AW,Key TJ,Appleby PN,Overvad K,Jakobsen MU,Tjønneland A,Hansen L,Boeing H,Weikert C,Linseisen J,Kaaks R,Trichopoulou A,Misirli G,Lagiou P,Sacerdote C,Pala V,Palli D,Tumino R,Panico S,Bueno-de-Mesqu

    更新日期:2011-05-01 00:00:00

  • Lentiginosis and right atrial myxoma.

    abstract::A right atrial myxoma was detected by cross-sectional echocardiography in a 21-year-old woman with cutaneous lentiginosis. The lentigines were present mainly on the right side of the trunk. ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059563

    authors: Göksel S,Kural T

    更新日期:1989-08-01 00:00:00

  • Impaired myocardial perfusion reserve and fibrosis in Friedreich ataxia: a mitochondrial cardiomyopathy with metabolic syndrome.

    abstract:AIMS:Cardiomyopathy produces significant mortality in patients with Friedreich ataxia (FA), a genetic disorder that produces intra-mitochondrial iron accumulation. We sought to test the hypothesis that abnormal myocardial perfusion reserve and fibrosis represent early manifestations of cardiomyopathy. METHODS AND RESU...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq443

    authors: Raman SV,Phatak K,Hoyle JC,Pennell ML,McCarthy B,Tran T,Prior TW,Olesik JW,Lutton A,Rankin C,Kissel JT,Al-Dahhak R

    更新日期:2011-03-01 00:00:00

  • Novel therapeutic concepts: the epidemic of cardiovascular disease in the developing world: global implications.

    abstract::The epidemic of cardiovascular disease (CVD) is a global phenomenon, and the magnitude of its increase in incidence and prevalence in low- and middle-income countries (LIMIC) has potentially major implications for those high-income countries that characterize much of the developed world. Cardiovascular disease remains...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehq030

    authors: Gersh BJ,Sliwa K,Mayosi BM,Yusuf S

    更新日期:2010-03-01 00:00:00

  • Substantial between-hospital variation in outcome following first emergency admission for heart failure.

    abstract:BACKGROUND:Following hospitalization with a range of cardiovascular disorders, substantial variation has been noted in clinical outcome, both between and within countries. OBJECTIVES:To examine the variation, between hospitals, in the clinical outcomes of death and readmission following hospitalization with heart fail...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2001.2890

    authors: Stewart S,Demers C,Murdoch DR,McIntyre K,MacLeod ME,Kendrick S,Capewell S,McMurray JJ

    更新日期:2002-04-01 00:00:00

  • Acute administration of captopril lowers the natriuretic and diuretic response to a loop diuretic in patients with chronic cardiac failure.

    abstract::Angiotensin-converting enzyme inhibitors suppress plasma concentrations of the sodium retaining hormones angiotensin II and aldosterone. This action should potentiate the natriuretic and diuretic effects of loop diuretics. Some studies indicate, however, that the introduction of angiotensin-converting enzyme inhibitor...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/12.8.924

    authors: Flapan AD,Davies E,Waugh C,Williams BC,Shaw TR,Edwards CR

    更新日期:1991-08-01 00:00:00

  • Left ventricular dysfunction, exercise capacity and activity recommendations.

    abstract::There is lack of consistent correlation between left ventricular function at rest, haemodynamic measurements at rest, symptomatic status and exercise tolerance. Haemodynamic data appear comparable in patients whose exercise tolerance is limited clinically by fatigue and by breathlessness. Selected patients with left v...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/9.suppl_f.63

    authors: Wenger NK

    更新日期:1988-04-01 00:00:00

  • Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I.

    abstract:AIMS:Cardiac hypertrophy is a common and often lethal complication of arterial hypertension. Elevation of myocyte cyclic GMP levels by local actions of endogenous atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) or by pharmacological inhibition of phosphodiesterase-5 was shown to counter-regulate p...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr445

    authors: Frantz S,Klaiber M,Baba HA,Oberwinkler H,Völker K,Gaβner B,Bayer B,Abeβer M,Schuh K,Feil R,Hofmann F,Kuhn M

    更新日期:2013-04-01 00:00:00

  • Acute effects of gallopamil on left ventricular systolic and diastolic function in patients with ischaemic heart disease.

    abstract::In 13 patients with chronic stable angina, left ventricular pressures were measured by catheter-tip micromanometer, and left cineventriculography was performed at matched atrial paced rates before and 20 min after administration of intravenous gallopamil (3 mg). Mean plasma concentration of gallopamil at the second ha...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/12.9.1006

    authors: Di Mario C,Iavernaro A,Cucchini F

    更新日期:1991-09-01 00:00:00

  • Electrocardiographic patterns during Holter monitoring in patients with first and second degree A-V block due to 'dual A-V nodal pathways'.

    abstract::The electrocardiographic patterns, observed during 24-h Holter monitoring, of 10 patients (mean age 35 +/- 22 years) with first and second degree A-V block due to dual A-V nodal pathways are reported. Recordings were selected according to the presence of: sudden and persistent prolongation of the PR interval: sudden n...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059904

    authors: Di Biase M,Tritto M,Sabato G,Pitzalis MV,Rizzon P

    更新日期:1991-03-01 00:00:00

  • The second Euro Heart Survey on acute coronary syndromes: Characteristics, treatment, and outcome of patients with ACS in Europe and the Mediterranean Basin in 2004.

    abstract:AIMS:Our study aimed to examine the management of acute coronary syndromes (ACS) in Europe and the Mediterranean basin, and to compare adherence to guidelines with that reported in the first Euro Heart Survey on ACS (EHS-ACS-I), 4 years earlier. METHODS AND RESULTS:In a prospective survey conducted in 2004 (EHS-ACS-II...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehl196

    authors: Mandelzweig L,Battler A,Boyko V,Bueno H,Danchin N,Filippatos G,Gitt A,Hasdai D,Hasin Y,Marrugat J,Van de Werf F,Wallentin L,Behar S,Euro Heart Survey Investigators.

    更新日期:2006-10-01 00:00:00

  • Shock in acute myocardial infarction: the Cape Horn for trials?

    abstract::Despite therapeutic improvements, cardiogenic shock (CS) remains the most common cause of death in patients with acute myocardial infarction (AMI). In addition to percutaneous coronary intervention, inotropes, fluids, adjunctive medication, intra-aortic balloon counterpulsation, and also assist devices are widely used...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehq220

    authors: Thiele H,Allam B,Chatellier G,Schuler G,Lafont A

    更新日期:2010-08-01 00:00:00

  • Myocardial infarction and the myocyte IGF1 autocrine system.

    abstract::To determine the effects of acute myocardial infarction on the extent and distribution of mural stress on surviving myocardial tissue, coronary artery occlusion was surgically produced in rats. Following haemodynamic measurements in vivo, the characteristics of cardiac anatomy were determined and found to consist of a...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/16.suppl_n.37

    authors: Anversa P,Reiss K,Kajstura J,Cheng W,Li P,Sonnenblick EH,Olivetti G

    更新日期:1995-12-01 00:00:00

  • A call to action.

    abstract::Acute myocardial infarction remains the principal cause of death in people aged over 40 years, despite the reductions in coronary heart disease (CHD) mortality that have been observed over the past 25 years in many European countries. Consequently, there is considerable potential to decrease further the risk of cardio...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors: Shepherd J

    更新日期:1998-10-01 00:00:00

  • Impaired myocardial perfusion and perfusion reserve associated with increased coronary resistance in persistent idiopathic atrial fibrillation.

    abstract:AIMS:Patients with atrial fibrillation (AF) present with symptoms of myocardial ischaemia despite exclusion of coronary artery disease. A small vessel disease has been suggested. We quantified myocardial perfusion, perfusion reserve, and coronary vascular resistance (CVR) in AF patients using positron emission tomograp...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehm246

    authors: Range FT,Schäfers M,Acil T,Schäfers KP,Kies P,Paul M,Hermann S,Brisse B,Breithardt G,Schober O,Wichter T

    更新日期:2007-09-01 00:00:00

  • Effects of gaseous and solid constituents of air pollution on endothelial function.

    abstract::Ambient air pollution is a leading cause of non-communicable disease globally. The largest proportion of deaths and morbidity due to air pollution is now known to be due to cardiovascular disorders. Several particulate and gaseous air pollutants can trigger acute events (e.g. myocardial infarction, stroke, heart failu...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehy481

    authors: Münzel T,Gori T,Al-Kindi S,Deanfield J,Lelieveld J,Daiber A,Rajagopalan S

    更新日期:2018-10-07 00:00:00

  • The diagnoses of patients admitted with acute chest pain but without myocardial infarction.

    abstract:OBJECTIVE:The purpose of this study was to describe the frequencies of various diagnoses in patients admitted with acute chest pain, but without acute myocardial infarction, and to evaluate a non-invasive screening programme for these patients. PATIENTS:A total of 204 consecutive non-acute myocardial infarction patien...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a014998

    authors: Fruergaard P,Launbjerg J,Hesse B,Jørgensen F,Petri A,Eiken P,Aggestrup S,Elsborg L,Mellemgaard K

    更新日期:1996-07-01 00:00:00

  • Elevation of asymmetric dimethylarginine in patients with unstable angina and recurrent cardiovascular events.

    abstract:AIMS:We investigated the role of asymmetric dimethylarginine (ADMA) for clinical outcome of patients with unstable angina. METHODS AND RESULTS:Forty-five patients with stable angina, 36 patients with unstable angina, and 40 healthy controls were included in this study. Coronary artery disease (CAD) patients were prosp...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehi287

    authors: Krempl TK,Maas R,Sydow K,Meinertz T,Böger RH,Kähler J

    更新日期:2005-09-01 00:00:00

  • A comparison between coronary artery bypass grafting surgery and drug eluting stent for the treatment of unprotected left main coronary artery disease in elderly patients (aged > or =75 years).

    abstract:AIMS:In this study, we compared the clinical outcomes of elderly patients with unprotected left main coronary artery (ULMCA) stenosis treated with either coronary artery bypass grafting (CABG) or drug-eluting stent (DES). METHODS AND RESULTS:From January 2003 to April 2006, 259 patients with ULMCA stenosis and age > o...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehm403

    authors: Palmerini T,Barlocco F,Santarelli A,Bacchi-Reggiani L,Savini C,Baldini E,Alessi L,Ruffini M,Di Credico G,Piovaccari G,Di Bartolomeo R,Marzocchi A,Branzi A,De Servi S

    更新日期:2007-11-01 00:00:00

  • Effects of multiple ischaemic events on human myocardium--an ultrastructural study.

    abstract::Chronically ischaemic myocardium from patients with coronary heart disease was investigated by light and electron microscopy using tissue biopsies taken during cardiac surgery. Light microscopy showed a significantly increased amount of fibrotic material, cell size was variable. By electron microscopy, the most obviou...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/9.suppl_a.141

    authors: Schaper J

    更新日期:1988-01-01 00:00:00