Percutaneous edge-to-edge MitraClip therapy in the management of mitral regurgitation.

Abstract:

:MitraClip therapy consists of percutaneous edge-to-edge coaptation of the mitral leaflets that is analogous to the surgical Alfieri technique. The safety profile of the MitraClip device is favourable, and survival outcomes in high-surgical-risk patients are superior to historical controls. However, questions remain regarding long-term efficacy and durability. In the U.S.A., the MitraClip device has been studied in a safety and feasibility trial, a randomized pivotal trial against surgical mitral valve repair, and a non-randomized high-risk registry. In addition, the MitraClip now has over 2 years of CE-mark approval and a rapidly expanding clinical experience in Europe, primarily in patients at high risk for surgery. A dedicated multidisciplinary team is necessary, as well as thoughtful patient selection, familiarity with the technical aspects of the procedure including transesophageal ultrasound imaging and post-procedure monitoring. Currently available clinical data are herein reviewed, with emphasis on the current role of MitraClip therapy in relation to existing surgical techniques. Since the MitraClip procedure is still relatively new, continued investigation is required to further define patient populations that will benefit most.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Rogers JH,Franzen O

doi

10.1093/eurheartj/ehr101

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

2350-7

issue

19

eissn

0195-668X

issn

1522-9645

pii

ehr101

journal_volume

32

pub_type

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