The prognostic significance of post-infarction angina pectoris and the effect of verapamil on the incidence of angina pectoris and prognosis. The Danish Study Group on Verapamil in Myocardial Infarction.


:The prognostic significance of angina pectoris and the effect of intervention with verapamil on the incidence of angina pectoris were studied in patients recovering from myocardial infarction and included in the Danish Verapamil Infarction Trial II. During the second week after admission patients were doubly-blindly randomized to treatment with verapamil 360 or placebo. Treatment was continued for up to 18 months. At discharge angina pectoris was reported in 11% of 869 patients randomized to verapamil and in 12% of 888 randomized to placebo (ns). One month after discharge a significant increase in the prevalance of angina pectoris was reported in both the verapamil (33%) (P < 0.001) and the placebo groups (39%) (P < 0.001). The one month prevalence of angina pectoris (P = 0.03) and the 18 months overall incidence of angina pectoris (P = 0.002) were both significantly lower in the verapamil group compared with placebo. Stable angina pectoris during the first month of follow-up was a significant predictor of major events (i.e. death or reinfarction) (hazard ratio = 1.45; 95% confidence limits: 1.10, 1.89). As verapamil significantly reduced the incidence of angina pectoris during daily activities, and thereby the number of patients at high risk, the beneficial effect of verapamil in reducing major events in patients recovering from myocardial infarction is likely to be due to abolishing myocardial ischaemia.


Eur Heart J


European heart journal


Jespersen CM,Hansen JF,Mortensen LS




Has Abstract


1994-02-01 00:00:00












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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Manhenke C,Ueland T,Jugdutt BI,Godang K,Aukrust P,Dickstein K,Ørn S

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:2003-07-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章,多中心研究,随机对照试验


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    pub_type: 杂志文章,多中心研究


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    更新日期:2016-05-14 00:00:00

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    pub_type: 杂志文章


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    更新日期:2010-03-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章


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    更新日期:2011-01-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章


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    更新日期:1998-10-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


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    pub_type: 杂志文章


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    更新日期:2003-06-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:1995-01-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章


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    更新日期:1986-09-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Flammer AJ,Sudano I,Wolfrum M,Thomas R,Enseleit F,Périat D,Kaiser P,Hirt A,Hermann M,Serafini M,Lévêques A,Lüscher TF,Ruschitzka F,Noll G,Corti R

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    pub_type: 杂志文章,多中心研究


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    更新日期:2018-03-21 00:00:00

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    pub_type: 杂志文章,多中心研究,随机对照试验


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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:European heart journal

    pub_type: 杂志文章


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    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


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    journal_title:European heart journal

    pub_type: 杂志文章


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    更新日期:2012-02-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Lindvall K,Hamsten A,Landou C,Szamosi A,de Faire U

    更新日期:1984-07-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


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    更新日期:2017-04-14 00:00:00

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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Schneider AJ,Teule GJ,Groeneveld AB,Nauta J,Luth WJ,Thijs LG

    更新日期:1987-10-01 00:00:00