The prognostic significance of post-infarction angina pectoris and the effect of verapamil on the incidence of angina pectoris and prognosis. The Danish Study Group on Verapamil in Myocardial Infarction.

Abstract:

:The prognostic significance of angina pectoris and the effect of intervention with verapamil on the incidence of angina pectoris were studied in patients recovering from myocardial infarction and included in the Danish Verapamil Infarction Trial II. During the second week after admission patients were doubly-blindly randomized to treatment with verapamil 360 mg.day-1 or placebo. Treatment was continued for up to 18 months. At discharge angina pectoris was reported in 11% of 869 patients randomized to verapamil and in 12% of 888 randomized to placebo (ns). One month after discharge a significant increase in the prevalance of angina pectoris was reported in both the verapamil (33%) (P < 0.001) and the placebo groups (39%) (P < 0.001). The one month prevalence of angina pectoris (P = 0.03) and the 18 months overall incidence of angina pectoris (P = 0.002) were both significantly lower in the verapamil group compared with placebo. Stable angina pectoris during the first month of follow-up was a significant predictor of major events (i.e. death or reinfarction) (hazard ratio = 1.45; 95% confidence limits: 1.10, 1.89). As verapamil significantly reduced the incidence of angina pectoris during daily activities, and thereby the number of patients at high risk, the beneficial effect of verapamil in reducing major events in patients recovering from myocardial infarction is likely to be due to abolishing myocardial ischaemia.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Jespersen CM,Hansen JF,Mortensen LS

doi

10.1093/oxfordjournals.eurheartj.a060486

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

270-6

issue

2

eissn

0195-668X

issn

1522-9645

journal_volume

15

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Assessment of multiple cardiac biomarkers in non-ST-segment elevation acute coronary syndromes: observations from the MERLIN-TIMI 36 trial.

    abstract:AIMS:The aim of this study is to simultaneously evaluate the incremental prognostic value of multiple cardiac biomarkers reflecting different underlying pathophysiological processes in a well-characterized population of patients with non-ST-segment acute coronary syndrome (NSTE-ACS). METHODS AND RESULTS:We measured ca...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehq468

    authors: Scirica BM,Sabatine MS,Jarolim P,Murphy SA,de Lemos JL,Braunwald E,Morrow DA

    更新日期:2011-03-01 00:00:00

  • The codex of science: honesty, precision, and truth--and its violations.

    abstract::Science has made enormous achievements for our understanding of the world and for everyday life: we now know that we live on a spherical planet of the solar system, we understand the origin of the species, we can take a train, survive myocardial infarction, and fly to the moon. This has been made possible thanks to a ...

    journal_title:European heart journal

    pub_type: 历史文章,杂志文章

    doi:10.1093/eurheartj/eht063

    authors: Lüscher TF

    更新日期:2013-04-01 00:00:00

  • Survival after coronary artery bypass grafting. Experience from 4661 patients.

    abstract::The duration of the reduction of mortality after coronary artery bypass grafting (CABG) is an important issue and this study was undertaken to evaluate time in relation to excess mortality among CABG patients compared with the general population. Survival was analysed in 4661 patients who had undergone their first iso...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060654

    authors: Ståhle E,Bergström R,Holmberg L,Edlund B,Nyström SO,Sjögren I,Hansson HE

    更新日期:1994-09-01 00:00:00

  • Stent thrombosis and restenosis: what have we learned and where are we going? The Andreas Grüntzig Lecture ESC 2014.

    abstract::Modern-day stenting procedures leverage advances in pharmacotherapy and device innovation. Patients treated with contemporary antiplatelet agents, peri-procedural antithrombin therapy and new-generation drug-eluting stents (DES) have excellent outcomes over the short to medium term. Indeed, coupled with the reducing c...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehv511

    authors: Byrne RA,Joner M,Kastrati A

    更新日期:2015-12-14 00:00:00

  • Prospective, randomized trial of bioresorbable scaffolds vs. everolimus-eluting stents in patients undergoing coronary stenting for myocardial infarction: the Intracoronary Scaffold Assessment a Randomized evaluation of Absorb in Myocardial Infarction (IS

    abstract:Aims:Bioresorbable scaffolds (BRS) provide short-term coronary artery scaffolding and drug delivery. Although prior trials showed a higher rate of device failure compared with conventional drug-eluting stents (DES), only a single trial investigated patients undergoing percutaneous coronary intervention (PCI) for acute ...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehy710

    authors: Byrne RA,Alfonso F,Schneider S,Maeng M,Wiebe J,Kretov E,Bradaric C,Rai H,Cuesta J,Rivero F,Hoppmann P,Schlichtenmaier J,Christiansen EH,Cassese S,Joner M,Schunkert H,Laugwitz KL,Kastrati A

    更新日期:2019-01-07 00:00:00

  • The impact of valve surgery on short- and long-term mortality in left-sided infective endocarditis: do differences in methodological approaches explain previous conflicting results?

    abstract:AIMS:The aim of this study was to evaluate the effect of valve surgery (VS) in infective endocarditis (IE) on 5-year mortality and to evaluate whether conflicting results reported by previous studies could be due to differences in their methodological approaches. METHODS AND RESULTS:Four hundred and forty-nine patient...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehp008

    authors: Bannay A,Hoen B,Duval X,Obadia JF,Selton-Suty C,Le Moing V,Tattevin P,Iung B,Delahaye F,Alla F,AEPEI Study Group.

    更新日期:2011-08-01 00:00:00

  • MicroRNA profiling unveils hyperglycaemic memory in the diabetic heart.

    abstract:AIMS:Recent randomized trials suggest that intensive glycaemic control fails to reduce heart failure-related events in patients with diabetes. The molecular cues underlying persistent myocardial damage despite normoglycaemia restoration remain elusive. MicroRNAs (miRNAs), a class of small non-coding RNAs, orchestrate t...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehv599

    authors: Costantino S,Paneni F,Lüscher TF,Cosentino F

    更新日期:2016-02-07 00:00:00

  • Atherogenic risk reduction in patients with dyslipidaemia. comparison between bezafibrate and lovastatin.

    abstract:OBJECTIVE:To examine the atherogenic risk-reducing effect of bezafibrate and lovastatin. DESIGN, SETTING, PATIENTS, INTERVENTIONS:Double-blind, randomized clinical trial of male and female patients with moderate hypercholesterolaemia with or without hypertriglyceridaemia. Two months dietary treatment followed by 400 m...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a060769

    authors: Sinzinger H,Pirich C,Kondor P,Etti H

    更新日期:1995-11-01 00:00:00

  • Drug- and disease-induced changes of human cardiac beta 1- and beta 2-adrenoceptors.

    abstract::Cardiac beta-adrenoceptor density and subtype distribution has been determined in different kinds of heart failure. A decrease in cardiac beta-adrenoceptor function appears to be a general phenomenon in all kinds of heart failure. However, cardiac beta 1- and beta 2-adrenoceptors seem to be differentially affected in ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/10.suppl_b.38

    authors: Brodde OE,Zerkowski HR,Borst HG,Maier W,Michel MC

    更新日期:1989-06-01 00:00:00

  • The Belgian Improvement Study on Oral Anticoagulation Therapy: a randomized clinical trial.

    abstract:AIMS:In Belgium, general practitioners (GPs) mainly manage oral anticoagulation therapy. To improve the quality of oral anticoagulation management by GPs and to compare different models and interventions, a randomized clinical trial was performed. METHODS AND RESULTS:Stratified randomization divided 66 GP-practices in...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehi327

    authors: Claes N,Buntinx F,Vijgen J,Arnout J,Vermylen J,Fieuws S,Van Loon H

    更新日期:2005-10-01 00:00:00

  • Diabetes clinical trials: helped or hindered by the current shift in regulatory requirements?

    abstract::Glycaemic control is an inadequate surrogate marker of cardiovascular event reduction in patients with type 2 diabetes. Clinical trials to date have been unsuccessful in identifying a therapeutic approach that addresses the underlying problem in diabetes (glycaemic control) and reduces cardiovascular risk. The potenti...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehr437

    authors: Zannad F,Stough WG,Pocock SJ,Sleight P,Cushman WC,Cleland JG,McMurray JJ,Lonn E,Geller NL,Wedel H,Abadie E,Alonso-Garcia A,Pitt B

    更新日期:2012-05-01 00:00:00

  • Cardiac resynchronization therapy non-responder to responder conversion rate in the more response to cardiac resynchronization therapy with MultiPoint Pacing (MORE-CRT MPP) study: results from Phase I.

    abstract:AIMS:To assess the impact of MultiPoint™ Pacing (MPP)-programmed according to the physician's discretion-in non-responders to standard biventricular pacing after 6 months. METHODS AND RESULTS:The study enrolled 1921 patients receiving a quadripolar cardiac resynchronization therapy (CRT) system capable of MPP™ therapy...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehz109

    authors: Leclercq C,Burri H,Curnis A,Delnoy PP,Rinaldi CA,Sperzel J,Lee K,Calò L,Vicentini A,Concha JF,Thibault B

    更新日期:2019-09-14 00:00:00

  • The effect of verapamil on major events in patients with impaired cardiac function recovering from acute myocardial infarction. The Danish Study Group on Verapamil in Myocardial Infarction.

    abstract::In the Danish Verapamil Infarction Trial II (DAVIT II) intervention with verapamil significantly decreased the first major event rate (i.e. reinfarction or death) in patients recovering from acute myocardial infarction. As calcium channel antagonists might have a detrimental effect in patients with heart failure, the ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/14.4.540

    authors: Jespersen CM

    更新日期:1993-04-01 00:00:00

  • Association between the low activity genotype of catechol-O-methyltransferase and myocardial infarction in a hypertensive population.

    abstract:AIM:Estrogens regulate several biological processes involved in the pathogenesis of myocardial infarction. Catechol-O-methyltransferase (COMT) is a key enzyme in the degradation of estrogens. There is a functional polymorphism in the COMT gene (Val158Met), affecting the activity of the enzyme. We investigated if the lo...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ehj.2003.12.026

    authors: Eriksson AL,Skrtic S,Niklason A,Hultén LM,Wiklund O,Hedner T,Ohlsson C

    更新日期:2004-03-01 00:00:00

  • Everolimus-eluting bioresorbable vascular scaffolds for treatment of patients presenting with ST-segment elevation myocardial infarction: BVS STEMI first study.

    abstract:AIMS:We evaluated the feasibility and the acute performance of the everolimus-eluting bioresorbable vascular scaffolds (BVS) for the treatment of patients presenting with ST-segment elevation myocardial infarction (STEMI). METHODS AND RESULTS:The present investigation is a prospective, single-arm, single-centre study,...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht546

    authors: Diletti R,Karanasos A,Muramatsu T,Nakatani S,Van Mieghem NM,Onuma Y,Nauta ST,Ishibashi Y,Lenzen MJ,Ligthart J,Schultz C,Regar E,de Jaegere PP,Serruys PW,Zijlstra F,van Geuns RJ

    更新日期:2014-03-01 00:00:00

  • Cardiac hypertrophy and function in asymptomatic acromegaly.

    abstract::Heart disease frequently occurs in advanced acromegaly. In order to investigate cardiac mass and function in acromegaly in the absence of obvious cardiac disease, we performed Doppler echocardiography in 15 asymptomatic acromegalic patients (six of them had systemic hypertension). The data were compared with those of ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors: Morvan D,Komajda M,Grimaldi A,Turpin G,Grosgogeat Y

    更新日期:1991-06-01 00:00:00

  • Tricuspid regurgitation diagnosis and treatment.

    abstract::Tricuspid regurgitation (TR) is the most common lesion of the tricuspid valve (TV). Mild TR is common and usually is benign. However, moderate or severe TR can lead to irreversible myocardial damage and adverse outcomes. Despite these findings, few patients with significant TR undergo surgery. The treatment of functio...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehv487

    authors: Arsalan M,Walther T,Smith RL 2nd,Grayburn PA

    更新日期:2017-03-01 00:00:00

  • Stress echocardiography: personnel and technical equipment.

    abstract::In recent years, stress echocardiography has gained broad acceptance as a non-invasive method for the diagnosis of coronary artery disease. Facing different protocols, dosages and instrumentation, official guidelines for the performance, standardization and quality control of stress echocardiograms are needed; however...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/18.suppl_d.43

    authors: Ketteler T,Krahwinkel W,Gödke J,Wolfertz J,Scheuble L,Hoffmeister T,Gülker H

    更新日期:1997-06-01 00:00:00

  • Strategies to attenuate micro-vascular obstruction during P-PCI: the randomized reperfusion facilitated by local adjunctive therapy in ST-elevation myocardial infarction trial.

    abstract:BACKGROUND:Microvascular obstruction (MVO) following primary percutaneous coronary intervention (PPCI) treatment of ST-segment elevation myocardial infarction (STEMI) contributes to infarct expansion, left ventricular (LV) remodelling, and worse clinical outcomes. The REFLO-STEMI trial tested whether intra-coronary (IC...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehw136

    authors: Nazir SA,McCann GP,Greenwood JP,Kunadian V,Khan JN,Mahmoud IZ,Blackman DJ,Been M,Abrams KR,Shipley L,Wilcox R,Adgey AA,Gershlick AH

    更新日期:2016-06-21 00:00:00

  • Association of fetuin-A levels with the progression of aortic valve calcification in non-dialyzed patients.

    abstract:AIMS:Fetuin-A has been identified as a potent circulating inhibitor of ectopic calcification. We investigated the relationship between baseline fetuin-A serum levels and the rate of progression of aortic valve calcification (AVC) in non-dialyzed patients with aortic valve disease (AVD). METHODS AND RESULTS:Seventy-sev...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehp158

    authors: Koos R,Brandenburg V,Mahnken AH,Mühlenbruch G,Stanzel S,Günther RW,Floege J,Jahnen-Dechent W,Kelm M,Kühl HP

    更新日期:2009-08-01 00:00:00

  • Molecular imaging-guided repair after acute myocardial infarction by targeting the chemokine receptor CXCR4.

    abstract:AIMS :Balance between inflammatory and reparative leucocytes allows optimal healing after myocardial infarction (MI). Interindividual heterogeneity evokes variable functional outcome complicating targeted therapy. We aimed to characterize infarct chemokine CXC-motif receptor 4 (CXCR4) expression using positron emission...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa598

    authors: Hess A,Derlin T,Koenig T,Diekmann J,Wittneben A,Wang Y,Wester HJ,Ross TL,Wollert KC,Bauersachs J,Bengel FM,Thackeray JT

    更新日期:2020-10-01 00:00:00

  • QT dispersion and RR variations on 12-lead ECGs in patients with congestive heart failure secondary to idiopathic dilated cardiomyopathy.

    abstract::Increased QT dispersion, which has been proposed as a marker of ventricular repolarization inhomogeneity, may predispose to ventricular arrhythmias. Data on QT dispersion in patients with congestive heart failure are scarce. In this study, conventional 12-lead ECGs were recorded in 135 consecutive patients with conges...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a014843

    authors: Fei L,Goldman JH,Prasad K,Keeling PJ,Reardon K,Camm AJ,McKenna WJ

    更新日期:1996-02-01 00:00:00

  • Functional significance of angiotensin receptors in human myocardium. Significant differences between atrial and ventricular myocardium.

    abstract::We studied the effects of angiotensin (Ang) I and II in a variety of isolated human cardiac tissues contracting under physiological conditions (37 degrees C, 60 beats.min-1). Ang I and II consistently increased the peak developed force of human atrial muscles by 30-40%, an effect that was completely blocked by 10(-6) ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/15.suppl_d.88

    authors: Holubarsch C,Schmidt-Schweda S,Knorr A,Duis J,Pieske B,Ruf T,Fasol R,Hasenfuss G,Just H

    更新日期:1994-12-01 00:00:00

  • Why does atrial fibrillation occur?

    abstract::Atrial fibrillation is often associated with atrial enlargement and stretch is known to cause electrophysiological alterations. Acute stretch may, depending on the moment at which it is applied, cause action potential shortening or induce both early and delayed afterdepolarizations which, when large enough, may initia...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/18.suppl_c.12

    authors: Janse MJ

    更新日期:1997-05-01 00:00:00

  • Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS).

    abstract:AIMS:Large randomized trials have shown that beta-blockers reduce mortality and hospital admissions in patients with heart failure. The effects of beta-blockers in elderly patients with a broad range of left ventricular ejection fraction are uncertain. The SENIORS study was performed to assess effects of the beta-block...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehi115

    authors: Flather MD,Shibata MC,Coats AJ,Van Veldhuisen DJ,Parkhomenko A,Borbola J,Cohen-Solal A,Dumitrascu D,Ferrari R,Lechat P,Soler-Soler J,Tavazzi L,Spinarova L,Toman J,Böhm M,Anker SD,Thompson SG,Poole-Wilson PA,SENIORS In

    更新日期:2005-02-01 00:00:00

  • Trans-septal catheterization for radiofrequency catheter ablation of cardiac arrhythmias. Results and safety of a simplified method.

    abstract:AIM:This study reports on the results and safety of a simplified method of trans-septal catheterization for radiofrequency catheter ablation of cardiac arrhythmias. METHODS AND RESULTS:Over 5 years, 411 patients underwent trans-septal catheterization for radiofrequency catheter ablation: 388 patients had a left-sided ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1998.0979

    authors: De Ponti R,Zardini M,Storti C,Longobardi M,Salerno-Uriarte JA

    更新日期:1998-06-01 00:00:00

  • Discrepancy between systolic and diastolic dysfunction of the left ventricle in patients with Duchenne muscular dystrophy.

    abstract::To assess the systolic and diastolic dysfunction of the left ventricle (LV) in relation to age and the severity of impairment in Duchenne muscular dystrophy (DMD), we performed M-mode, two-dimensional and pulsed-wave Doppler echocardiography in 45 male subjects with DMD aged 8 to 25 years and in 40 age-matched healthy...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.5.669

    authors: Takenaka A,Yokota M,Iwase M,Miyaguchi K,Hayashi H,Saito H

    更新日期:1993-05-01 00:00:00

  • Prognosis and treatment of atrial fibrillation patients by European cardiologists: one year follow-up of the EURObservational Research Programme-Atrial Fibrillation General Registry Pilot Phase (EORP-AF Pilot registry).

    abstract:BACKGROUND:The EURObservational Research Programme-Atrial Fibrillation General Registry Pilot Phase (EORP-AF Pilot) provides systematic collection of contemporary data regarding the management and treatment of 3119 subjects with AF from 9 member European Society of Cardiology (ESC) countries. In this analysis, we repor...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehu374

    authors: Lip GY,Laroche C,Ioachim PM,Rasmussen LH,Vitali-Serdoz L,Petrescu L,Darabantiu D,Crijns HJ,Kirchhof P,Vardas P,Tavazzi L,Maggioni AP,Boriani G

    更新日期:2014-12-14 00:00:00

  • Management of acute coronary syndromes. Variations in practice and outcome; findings from the Global Registry of Acute Coronary Events (GRACE).

    abstract:AIMS:Despite advances in the treatment of acute coronary syndromes based on randomized trial data and published guidelines, the extent to which such treatments are applied in practice remains uncertain. Data from clinical trials derive from selected geographical areas and in highly selected populations of patients, and...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2001.3081

    authors: Fox KA,Goodman SG,Klein W,Brieger D,Steg PG,Dabbous O,Avezum A

    更新日期:2002-08-01 00:00:00

  • Alinidine as a model of the mode of action of specific bradycardic agents on SA node activity.

    abstract::Three different bradycardic agents, alinidine, AQ-A39 and UL-FS49 increase the intrinsic cycle length of the isolated SA node preparation of the rabbit. This increase is mainly caused by a decrease in rate of diastolic depolarization. One of these agents, alinidine, was used to study the underlying ionic mechanism of ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/8.suppl_l.25

    authors: van Ginneken AC,Bouman LN,Jongsma HJ,Duivenvoorden JJ,Opthof T,Giles WR

    更新日期:1987-12-01 00:00:00